Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL20_LEIBR

TriTrypDb:

LbrM.32.4070 , LBRM2903_320050400

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 36

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

A4HL20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL20

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	20
GO:0016192	vesicle-mediated transport	4	20
GO:0051179	localization	1	20
GO:0051234	establishment of localization	2	20

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.373
CLV_PCSK_KEX2_1	26	28	PF00082	0.359
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.381
CLV_PCSK_SKI1_1	113	117	PF00082	0.345
DEG_Nend_UBRbox_1	1	4	PF02207	0.612
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.463
DOC_MAPK_gen_1	131	139	PF00069	0.358
DOC_MAPK_gen_1	25	34	PF00069	0.528
DOC_MAPK_MEF2A_6	153	161	PF00069	0.305
DOC_MAPK_MEF2A_6	25	34	PF00069	0.554
DOC_MAPK_NFAT4_5	27	35	PF00069	0.558
LIG_EH1_1	120	128	PF00400	0.438
LIG_FHA_1	62	68	PF00498	0.391
LIG_LIR_Gen_1	118	129	PF02991	0.418
LIG_LIR_Gen_1	154	164	PF02991	0.291
LIG_LIR_Gen_1	96	106	PF02991	0.469
LIG_LIR_Nem_3	118	124	PF02991	0.383
LIG_LIR_Nem_3	154	159	PF02991	0.290
LIG_LIR_Nem_3	96	101	PF02991	0.449
LIG_PCNA_yPIPBox_3	89	99	PF02747	0.558
LIG_Pex14_2	115	119	PF04695	0.448
LIG_Pex14_2	49	53	PF04695	0.307
LIG_SH2_CRK	121	125	PF00017	0.336
LIG_SH2_CRK	29	33	PF00017	0.436
LIG_SH2_PTP2	98	101	PF00017	0.487
LIG_SH2_SRC	138	141	PF00017	0.355
LIG_SH2_STAP1	121	125	PF00017	0.358
LIG_SH2_STAP1	70	74	PF00017	0.376
LIG_SH2_STAT5	138	141	PF00017	0.313
LIG_SH2_STAT5	35	38	PF00017	0.325
LIG_SH2_STAT5	98	101	PF00017	0.468
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.446
LIG_SUMO_SIM_par_1	122	128	PF11976	0.424
LIG_SUMO_SIM_par_1	170	176	PF11976	0.298
LIG_UBA3_1	129	136	PF00899	0.180
LIG_WRC_WIRS_1	112	117	PF05994	0.488
MOD_CK1_1	176	182	PF00069	0.503
MOD_CK1_1	78	84	PF00069	0.558
MOD_CK2_1	146	152	PF00069	0.358
MOD_CK2_1	3	9	PF00069	0.625
MOD_CK2_1	80	86	PF00069	0.561
MOD_GlcNHglycan	20	23	PF01048	0.389
MOD_GlcNHglycan	50	53	PF01048	0.523
MOD_GSK3_1	111	118	PF00069	0.346
MOD_NEK2_1	115	120	PF00069	0.370
MOD_NEK2_1	125	130	PF00069	0.302
MOD_NEK2_1	173	178	PF00069	0.358
MOD_NEK2_1	18	23	PF00069	0.518
MOD_NEK2_1	3	8	PF00069	0.515
MOD_PIKK_1	3	9	PF00454	0.649
MOD_Plk_1	146	152	PF00069	0.291
MOD_Plk_1	78	84	PF00069	0.532
MOD_Plk_4	115	121	PF00069	0.367
MOD_Plk_4	125	131	PF00069	0.285
MOD_Plk_4	146	152	PF00069	0.286
MOD_Plk_4	35	41	PF00069	0.350
MOD_Plk_4	54	60	PF00069	0.323
MOD_Plk_4	61	67	PF00069	0.363
MOD_SUMO_rev_2	21	28	PF00179	0.592
TRG_DiLeu_BaEn_2	151	157	PF01217	0.358
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.539
TRG_ENDOCYTIC_2	121	124	PF00928	0.285
TRG_ENDOCYTIC_2	29	32	PF00928	0.320
TRG_ENDOCYTIC_2	98	101	PF00928	0.461
TRG_ER_diArg_1	130	133	PF00400	0.270

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W0	Leptomonas seymouri	28%	97%
A0A0N1HVI2	Leptomonas seymouri	73%	100%
A0A0S4IRN3	Bodo saltans	25%	84%
A0A1X0NSL9	Trypanosomatidae	45%	99%
A0A1X0P478	Trypanosomatidae	20%	97%
A0A3Q8IH86	Leishmania donovani	23%	97%
A0A3Q8IHH3	Leishmania donovani	85%	100%
A0A3R7KL43	Trypanosoma rangeli	23%	97%
A0A3R7KRD8	Trypanosoma rangeli	39%	99%
A4HL21	Leishmania braziliensis	26%	97%
A4I8K1	Leishmania infantum	85%	100%
A4I8K2	Leishmania infantum	23%	97%
D0AAL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B3G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9B3G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	97%
Q4Q4N8	Leishmania major	27%	100%
Q4Q4N9	Leishmania major	83%	100%
V5BLE0	Trypanosoma cruzi	42%	99%