WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL19_LEIBR

TriTrypDb:

LbrM.32.4060 , LBRM2903_320050300

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0034708	methyltransferase complex	4	11
GO:0035097	histone methyltransferase complex	3	11
GO:0048188	Set1C/COMPASS complex	4	11
GO:0140513	nuclear protein-containing complex	2	11
GO:1902494	catalytic complex	2	11
GO:1990234	transferase complex	3	11

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Expansion

Sequence features

A4HL19

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL19

Function

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Biological processes
Term	Name	Level	Count
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	4
GO:0008152	metabolic process	1	4
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018023	peptidyl-lysine trimethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1

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Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0005488	binding	1	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.422
CLV_PCSK_KEX2_1	180	182	PF00082	0.543
CLV_PCSK_KEX2_1	194	196	PF00082	0.502
CLV_PCSK_KEX2_1	247	249	PF00082	0.434
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.322
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.484
CLV_PCSK_SKI1_1	131	135	PF00082	0.365
CLV_PCSK_SKI1_1	181	185	PF00082	0.403
CLV_PCSK_SKI1_1	194	198	PF00082	0.386
CLV_PCSK_SKI1_1	217	221	PF00082	0.473

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC17	Leptomonas seymouri	70%	93%
A0A0S4IL54	Bodo saltans	31%	82%
A0A1X0NRZ4	Trypanosomatidae	52%	100%
A0A3S7X6A1	Leishmania donovani	90%	100%
A0A422P323	Trypanosoma rangeli	53%	99%
A4I8K0	Leishmania infantum	90%	100%
D0AAL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B3G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q4P0	Leishmania major	91%	100%
V5BR02	Trypanosoma cruzi	52%	89%

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