SHQ1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SHQ1 protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL18_LEIBR

TriTrypDb:

LbrM.32.4050 , LBRM2903_320050200

Length:

577

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL18

Function

Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	12
GO:0000493	box H/ACA snoRNP assembly	8	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051082	unfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.708
CLV_C14_Caspase3-7	260	264	PF00656	0.493
CLV_C14_Caspase3-7	87	91	PF00656	0.389
CLV_NRD_NRD_1	195	197	PF00675	0.412
CLV_NRD_NRD_1	444	446	PF00675	0.237
CLV_PCSK_KEX2_1	194	196	PF00082	0.393
CLV_PCSK_KEX2_1	444	446	PF00082	0.237
CLV_PCSK_PC7_1	191	197	PF00082	0.441
CLV_PCSK_SKI1_1	18	22	PF00082	0.448
CLV_PCSK_SKI1_1	291	295	PF00082	0.580
CLV_PCSK_SKI1_1	379	383	PF00082	0.248
CLV_PCSK_SKI1_1	444	448	PF00082	0.237
CLV_PCSK_SKI1_1	468	472	PF00082	0.251
CLV_PCSK_SKI1_1	478	482	PF00082	0.221
CLV_PCSK_SKI1_1	484	488	PF00082	0.205
CLV_PCSK_SKI1_1	493	497	PF00082	0.237
DEG_APCC_DBOX_1	101	109	PF00400	0.513
DEG_APCC_DBOX_1	17	25	PF00400	0.488
DEG_APCC_DBOX_1	373	381	PF00400	0.491
DEG_APCC_DBOX_1	553	561	PF00400	0.387
DEG_Nend_Nbox_1	1	3	PF02207	0.407
DOC_CKS1_1	1	6	PF01111	0.385
DOC_CYCLIN_RxL_1	374	385	PF00134	0.499
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.384
DOC_MAPK_DCC_7	249	258	PF00069	0.416
DOC_MAPK_DCC_7	374	382	PF00069	0.504
DOC_MAPK_DCC_7	554	562	PF00069	0.365
DOC_MAPK_gen_1	100	108	PF00069	0.477
DOC_MAPK_gen_1	191	199	PF00069	0.468
DOC_MAPK_gen_1	357	364	PF00069	0.494
DOC_MAPK_gen_1	374	382	PF00069	0.514
DOC_MAPK_MEF2A_6	249	258	PF00069	0.416
DOC_MAPK_MEF2A_6	357	364	PF00069	0.528
DOC_MAPK_MEF2A_6	374	382	PF00069	0.394
DOC_MAPK_MEF2A_6	478	487	PF00069	0.564
DOC_PP1_RVXF_1	377	383	PF00149	0.460
DOC_PP1_RVXF_1	47	53	PF00149	0.328
DOC_PP2B_LxvP_1	353	356	PF13499	0.386
DOC_PP2B_LxvP_1	375	378	PF13499	0.459
DOC_PP2B_LxvP_1	381	384	PF13499	0.421
DOC_PP4_FxxP_1	303	306	PF00568	0.491
DOC_PP4_FxxP_1	565	568	PF00568	0.376
DOC_USP7_MATH_1	112	116	PF00917	0.711
DOC_USP7_MATH_1	144	148	PF00917	0.718
DOC_USP7_MATH_1	201	205	PF00917	0.304
DOC_USP7_MATH_1	330	334	PF00917	0.601
DOC_USP7_MATH_1	544	548	PF00917	0.553
DOC_USP7_MATH_2	152	158	PF00917	0.434
DOC_WW_Pin1_4	131	136	PF00397	0.610
DOC_WW_Pin1_4	41	46	PF00397	0.482
DOC_WW_Pin1_4	420	425	PF00397	0.437
LIG_14-3-3_CanoR_1	102	106	PF00244	0.504
LIG_14-3-3_CanoR_1	18	28	PF00244	0.450
LIG_14-3-3_CanoR_1	291	296	PF00244	0.575
LIG_14-3-3_CanoR_1	473	478	PF00244	0.438
LIG_14-3-3_CanoR_1	554	558	PF00244	0.521
LIG_14-3-3_CanoR_1	63	67	PF00244	0.394
LIG_BIR_III_2	273	277	PF00653	0.486
LIG_BIR_III_2	289	293	PF00653	0.600
LIG_BIR_III_4	217	221	PF00653	0.423
LIG_BIR_III_4	263	267	PF00653	0.441
LIG_BRCT_BRCA1_1	156	160	PF00533	0.398
LIG_BRCT_BRCA1_1	164	168	PF00533	0.325
LIG_BRCT_BRCA1_1	360	364	PF00533	0.372
LIG_BRCT_BRCA1_2	164	170	PF00533	0.510
LIG_Clathr_ClatBox_1	212	216	PF01394	0.423
LIG_EH1_1	205	213	PF00400	0.451
LIG_eIF4E_1	475	481	PF01652	0.448
LIG_FHA_1	126	132	PF00498	0.632
LIG_FHA_1	136	142	PF00498	0.596
LIG_FHA_1	171	177	PF00498	0.420
LIG_FHA_1	367	373	PF00498	0.591
LIG_FHA_1	391	397	PF00498	0.441
LIG_FHA_1	465	471	PF00498	0.555
LIG_FHA_1	496	502	PF00498	0.462
LIG_FHA_1	63	69	PF00498	0.387
LIG_FHA_1	72	78	PF00498	0.330
LIG_FHA_2	187	193	PF00498	0.417
LIG_FHA_2	363	369	PF00498	0.454
LIG_FHA_2	432	438	PF00498	0.539
LIG_FHA_2	511	517	PF00498	0.520
LIG_FHA_2	85	91	PF00498	0.381
LIG_LIR_Apic_2	302	306	PF02991	0.514
LIG_LIR_Apic_2	40	45	PF02991	0.431
LIG_LIR_Apic_2	427	431	PF02991	0.462
LIG_LIR_Apic_2	497	503	PF02991	0.450
LIG_LIR_Gen_1	11	21	PF02991	0.344
LIG_LIR_Gen_1	165	176	PF02991	0.390
LIG_LIR_Gen_1	399	406	PF02991	0.439
LIG_LIR_Gen_1	44	52	PF02991	0.444
LIG_LIR_Gen_1	84	94	PF02991	0.370
LIG_LIR_Nem_3	11	17	PF02991	0.344
LIG_LIR_Nem_3	165	171	PF02991	0.385
LIG_LIR_Nem_3	36	42	PF02991	0.410
LIG_LIR_Nem_3	399	405	PF02991	0.439
LIG_LIR_Nem_3	44	50	PF02991	0.432
LIG_LIR_Nem_3	561	567	PF02991	0.386
LIG_LIR_Nem_3	84	89	PF02991	0.355
LIG_NRBOX	476	482	PF00104	0.418
LIG_PCNA_yPIPBox_3	468	481	PF02747	0.474
LIG_Pex14_2	160	164	PF04695	0.358
LIG_PTB_Apo_2	26	33	PF02174	0.385
LIG_PTB_Apo_2	88	95	PF02174	0.384
LIG_PTB_Phospho_1	88	94	PF10480	0.391
LIG_SH2_CRK	42	46	PF00017	0.442
LIG_SH2_SRC	428	431	PF00017	0.539
LIG_SH2_SRC	500	503	PF00017	0.491
LIG_SH2_SRC	94	97	PF00017	0.355
LIG_SH2_STAP1	402	406	PF00017	0.448
LIG_SH2_STAP1	436	440	PF00017	0.437
LIG_SH2_STAP1	475	479	PF00017	0.539
LIG_SH2_STAT5	130	133	PF00017	0.664
LIG_SH2_STAT5	228	231	PF00017	0.362
LIG_SH2_STAT5	42	45	PF00017	0.371
LIG_SH2_STAT5	428	431	PF00017	0.539
LIG_SH2_STAT5	47	50	PF00017	0.296
LIG_SH2_STAT5	475	478	PF00017	0.448
LIG_SH2_STAT5	500	503	PF00017	0.491
LIG_SH2_STAT5	564	567	PF00017	0.376
LIG_SH2_STAT5	76	79	PF00017	0.332
LIG_SH2_STAT5	94	97	PF00017	0.277
LIG_SH3_3	248	254	PF00018	0.489
LIG_SH3_3	343	349	PF00018	0.718
LIG_SH3_3	72	78	PF00018	0.312
LIG_SUMO_SIM_par_1	291	297	PF11976	0.574
LIG_TRAF2_1	151	154	PF00917	0.434
LIG_TRAF2_1	190	193	PF00917	0.535
LIG_TRAF2_1	276	279	PF00917	0.644
LIG_TYR_ITIM	562	567	PF00017	0.384
LIG_UBA3_1	371	376	PF00899	0.544
MOD_CK1_1	323	329	PF00069	0.629
MOD_CK1_1	333	339	PF00069	0.522
MOD_CK1_1	410	416	PF00069	0.507
MOD_CK2_1	186	192	PF00069	0.396
MOD_CK2_1	362	368	PF00069	0.448
MOD_CK2_1	382	388	PF00069	0.539
MOD_CK2_1	485	491	PF00069	0.539
MOD_GlcNHglycan	164	167	PF01048	0.409
MOD_GlcNHglycan	21	24	PF01048	0.398
MOD_GlcNHglycan	242	245	PF01048	0.679
MOD_GlcNHglycan	296	299	PF01048	0.669
MOD_GlcNHglycan	323	326	PF01048	0.701
MOD_GlcNHglycan	332	335	PF01048	0.504
MOD_GlcNHglycan	408	412	PF01048	0.339
MOD_GlcNHglycan	539	542	PF01048	0.634
MOD_GSK3_1	112	119	PF00069	0.640
MOD_GSK3_1	131	138	PF00069	0.669
MOD_GSK3_1	330	337	PF00069	0.505
MOD_GSK3_1	358	365	PF00069	0.381
MOD_GSK3_1	37	44	PF00069	0.425
MOD_GSK3_1	420	427	PF00069	0.437
MOD_GSK3_1	527	534	PF00069	0.491
MOD_GSK3_1	67	74	PF00069	0.293
MOD_N-GLC_1	112	117	PF02516	0.555
MOD_N-GLC_1	34	39	PF02516	0.253
MOD_N-GLC_1	417	422	PF02516	0.291
MOD_N-GLC_1	473	478	PF02516	0.274
MOD_NEK2_1	19	24	PF00069	0.465
MOD_NEK2_1	240	245	PF00069	0.666
MOD_NEK2_1	321	326	PF00069	0.624
MOD_NEK2_1	495	500	PF00069	0.506
MOD_NEK2_2	266	271	PF00069	0.468
MOD_NEK2_2	431	436	PF00069	0.491
MOD_NEK2_2	71	76	PF00069	0.239
MOD_PIKK_1	334	340	PF00454	0.643
MOD_PIKK_1	34	40	PF00454	0.516
MOD_PIKK_1	382	388	PF00454	0.379
MOD_PIKK_1	417	423	PF00454	0.566
MOD_PIKK_1	6	12	PF00454	0.398
MOD_PKA_2	101	107	PF00069	0.509
MOD_PKA_2	358	364	PF00069	0.313
MOD_PKA_2	553	559	PF00069	0.281
MOD_PKA_2	62	68	PF00069	0.403
MOD_Plk_1	279	285	PF00069	0.684
MOD_Plk_1	34	40	PF00069	0.370
MOD_Plk_1	417	423	PF00069	0.513
MOD_Plk_1	473	479	PF00069	0.474
MOD_Plk_2-3	62	68	PF00069	0.481
MOD_Plk_4	101	107	PF00069	0.509
MOD_Plk_4	280	286	PF00069	0.700
MOD_Plk_4	291	297	PF00069	0.641
MOD_Plk_4	412	418	PF00069	0.454
MOD_Plk_4	424	430	PF00069	0.437
MOD_Plk_4	431	437	PF00069	0.437
MOD_Plk_4	495	501	PF00069	0.448
MOD_Plk_4	544	550	PF00069	0.525
MOD_Plk_4	553	559	PF00069	0.390
MOD_Plk_4	71	77	PF00069	0.319
MOD_ProDKin_1	131	137	PF00069	0.608
MOD_ProDKin_1	41	47	PF00069	0.480
MOD_ProDKin_1	420	426	PF00069	0.437
MOD_SUMO_rev_2	297	306	PF00179	0.565
MOD_SUMO_rev_2	488	495	PF00179	0.518
TRG_DiLeu_BaEn_1	280	285	PF01217	0.699
TRG_DiLeu_BaEn_1	368	373	PF01217	0.480
TRG_DiLeu_BaEn_1	491	496	PF01217	0.539
TRG_DiLeu_BaEn_4	192	198	PF01217	0.436
TRG_DiLeu_BaEn_4	280	286	PF01217	0.621
TRG_DiLeu_BaLyEn_6	303	308	PF01217	0.542
TRG_DiLeu_BaLyEn_6	376	381	PF01217	0.440
TRG_DiLeu_BaLyEn_6	465	470	PF01217	0.448
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.437
TRG_ENDOCYTIC_2	402	405	PF00928	0.437
TRG_ENDOCYTIC_2	47	50	PF00928	0.312
TRG_ENDOCYTIC_2	564	567	PF00928	0.376
TRG_ER_diArg_1	194	196	PF00400	0.514
TRG_ER_diArg_1	349	352	PF00400	0.542
TRG_ER_diArg_1	356	359	PF00400	0.440
TRG_ER_diArg_1	48	51	PF00400	0.407
TRG_ER_diArg_1	481	484	PF00400	0.469
TRG_NES_CRM1_1	67	81	PF08389	0.381
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Y0	Leptomonas seymouri	66%	99%
A0A0S4IU29	Bodo saltans	38%	100%
A0A1X0NS82	Trypanosomatidae	47%	100%
A0A3S7X679	Leishmania donovani	81%	100%
A0A422P315	Trypanosoma rangeli	50%	100%
A4I8J9	Leishmania infantum	81%	100%
D0AAM0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B3F9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q4P1	Leishmania major	81%	100%
V5BR05	Trypanosoma cruzi	50%	100%