Putative kinetoplast DNA-associated protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HL15_LEIBR

TriTrypDb:

LbrM.32.4020 , LBRM2903_320049800

Length:

143

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.672
CLV_NRD_NRD_1	3	5	PF00675	0.719
CLV_NRD_NRD_1	42	44	PF00675	0.570
CLV_NRD_NRD_1	48	50	PF00675	0.576
CLV_NRD_NRD_1	57	59	PF00675	0.529
CLV_NRD_NRD_1	87	89	PF00675	0.569
CLV_NRD_NRD_1	9	11	PF00675	0.548
CLV_PCSK_FUR_1	55	59	PF00082	0.537
CLV_PCSK_KEX2_1	3	5	PF00082	0.719
CLV_PCSK_KEX2_1	42	44	PF00082	0.474
CLV_PCSK_KEX2_1	57	59	PF00082	0.607
CLV_PCSK_KEX2_1	9	11	PF00082	0.548
CLV_PCSK_SKI1_1	111	115	PF00082	0.590
CLV_PCSK_SKI1_1	120	124	PF00082	0.573
CLV_PCSK_SKI1_1	28	32	PF00082	0.723
CLV_PCSK_SKI1_1	4	8	PF00082	0.622
CLV_PCSK_SKI1_1	49	53	PF00082	0.660
CLV_PCSK_SKI1_1	57	61	PF00082	0.571
DEG_Nend_Nbox_1	1	3	PF02207	0.743
DOC_CKS1_1	130	135	PF01111	0.497
DOC_CKS1_1	44	49	PF01111	0.549
DOC_PP2B_LxvP_1	103	106	PF13499	0.438
DOC_USP7_UBL2_3	114	118	PF12436	0.668
DOC_USP7_UBL2_3	119	123	PF12436	0.658
DOC_USP7_UBL2_3	135	139	PF12436	0.459
DOC_USP7_UBL2_3	19	23	PF12436	0.414
DOC_USP7_UBL2_3	31	35	PF12436	0.541
DOC_USP7_UBL2_3	98	102	PF12436	0.466
DOC_WW_Pin1_4	129	134	PF00397	0.505
DOC_WW_Pin1_4	43	48	PF00397	0.665
DOC_WW_Pin1_4	9	14	PF00397	0.635
LIG_14-3-3_CanoR_1	128	133	PF00244	0.612
LIG_14-3-3_CanoR_1	3	9	PF00244	0.644
LIG_14-3-3_CanoR_1	42	47	PF00244	0.464
LIG_14-3-3_CanoR_1	57	62	PF00244	0.543
LIG_FHA_1	22	28	PF00498	0.645
LIG_LIR_Gen_1	12	21	PF02991	0.623
LIG_LIR_Gen_1	65	75	PF02991	0.622
LIG_LIR_Gen_1	76	83	PF02991	0.493
LIG_LIR_Nem_3	12	17	PF02991	0.615
LIG_LIR_Nem_3	38	44	PF02991	0.381
LIG_LIR_Nem_3	60	64	PF02991	0.583
LIG_LIR_Nem_3	65	70	PF02991	0.458
LIG_LIR_Nem_3	76	81	PF02991	0.391
LIG_LYPXL_yS_3	61	64	PF13949	0.582
LIG_PCNA_yPIPBox_3	84	94	PF02747	0.518
LIG_SH2_CRK	41	45	PF00017	0.592
LIG_SH2_STAP1	74	78	PF00017	0.408
LIG_SH3_3	56	62	PF00018	0.568
LIG_SH3_3	76	82	PF00018	0.349
LIG_TYR_ITIM	59	64	PF00017	0.582
MOD_CDK_SPxK_1	129	135	PF00069	0.507
MOD_CDK_SPxK_1	43	49	PF00069	0.551
MOD_CDK_SPxxK_3	43	50	PF00069	0.668
MOD_CK1_1	12	18	PF00069	0.495
MOD_CK1_1	129	135	PF00069	0.496
MOD_CK2_1	42	48	PF00069	0.673
MOD_GlcNHglycan	99	102	PF01048	0.539
MOD_N-GLC_1	126	131	PF02516	0.501
MOD_NEK2_1	2	7	PF00069	0.654
MOD_NEK2_1	21	26	PF00069	0.363
MOD_NEK2_1	97	102	PF00069	0.542
MOD_PKA_1	123	129	PF00069	0.503
MOD_PKA_1	35	41	PF00069	0.383
MOD_PKA_1	42	48	PF00069	0.427
MOD_PKA_1	57	63	PF00069	0.581
MOD_PKA_2	2	8	PF00069	0.711
MOD_PKA_2	42	48	PF00069	0.454
MOD_PKA_2	57	63	PF00069	0.521
MOD_PKB_1	55	63	PF00069	0.573
MOD_Plk_1	126	132	PF00069	0.500
MOD_ProDKin_1	129	135	PF00069	0.507
MOD_ProDKin_1	43	49	PF00069	0.665
MOD_ProDKin_1	9	15	PF00069	0.635
MOD_SUMO_rev_2	134	142	PF00179	0.479
MOD_SUMO_rev_2	45	52	PF00179	0.534
TRG_ENDOCYTIC_2	41	44	PF00928	0.654
TRG_ENDOCYTIC_2	61	64	PF00928	0.377
TRG_ENDOCYTIC_2	67	70	PF00928	0.554
TRG_ER_diArg_1	2	4	PF00400	0.739
TRG_ER_diArg_1	41	43	PF00400	0.438
TRG_ER_diArg_1	55	58	PF00400	0.502
TRG_ER_diArg_1	8	10	PF00400	0.558
TRG_ER_diLys_1	139	143	PF00400	0.546
TRG_NLS_Bipartite_1	111	127	PF00514	0.518
TRG_NLS_MonoExtN_4	120	127	PF00514	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W1	Leptomonas seymouri	35%	100%
A0A1X0NSD7	Trypanosomatidae	47%	79%
A0A3Q8IGK7	Leishmania donovani	40%	100%
A0A3Q8ITR1	Leishmania donovani	80%	100%
A0A422P329	Trypanosoma rangeli	47%	75%
A4HL14	Leishmania braziliensis	34%	100%
A4I8J5	Leishmania infantum	40%	100%
A4I8J6	Leishmania infantum	80%	100%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B3F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4P4	Leishmania major	85%	100%
Q4Q4P5	Leishmania major	40%	100%
Q8IS98	Crithidia fasciculata	61%	100%
Q9TY83	Crithidia fasciculata	37%	100%
Q9TY84	Crithidia fasciculata	36%	100%