Putative kinetoplast-associated protein p18-2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplast-associated protein p18-2, putative

Species:

Leishmania braziliensis

UniProt:

A4HL14_LEIBR

TriTrypDb:

LbrM.32.4010 , LBRM2903_320049700

Length:

132

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	7	13	PF00089	0.485
CLV_NRD_NRD_1	113	115	PF00675	0.573
CLV_NRD_NRD_1	123	125	PF00675	0.591
CLV_NRD_NRD_1	130	132	PF00675	0.663
CLV_NRD_NRD_1	42	44	PF00675	0.547
CLV_NRD_NRD_1	68	70	PF00675	0.513
CLV_PCSK_KEX2_1	113	115	PF00082	0.529
CLV_PCSK_KEX2_1	117	119	PF00082	0.511
CLV_PCSK_KEX2_1	28	30	PF00082	0.438
CLV_PCSK_KEX2_1	42	44	PF00082	0.494
CLV_PCSK_KEX2_1	49	51	PF00082	0.536
CLV_PCSK_KEX2_1	68	70	PF00082	0.564
CLV_PCSK_KEX2_1	72	74	PF00082	0.606
CLV_PCSK_KEX2_1	85	87	PF00082	0.394
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.508
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.506
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.427
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.377
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.622
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.409
CLV_PCSK_PC7_1	68	74	PF00082	0.362
CLV_PCSK_SKI1_1	114	118	PF00082	0.578
CLV_PCSK_SKI1_1	125	129	PF00082	0.741
CLV_PCSK_SKI1_1	49	53	PF00082	0.608
CLV_PCSK_SKI1_1	68	72	PF00082	0.604
CLV_PCSK_SKI1_1	73	77	PF00082	0.556
CLV_PCSK_SKI1_1	88	92	PF00082	0.311
CLV_PCSK_SKI1_1	99	103	PF00082	0.400
DEG_Nend_Nbox_1	1	3	PF02207	0.709
DOC_MAPK_gen_1	72	83	PF00069	0.600
DOC_MAPK_gen_1	85	92	PF00069	0.398
DOC_MAPK_MEF2A_6	4	11	PF00069	0.516
DOC_PP1_RVXF_1	89	95	PF00149	0.368
DOC_USP7_UBL2_3	113	117	PF12436	0.637
DOC_USP7_UBL2_3	121	125	PF12436	0.585
DOC_USP7_UBL2_3	128	132	PF12436	0.592
DOC_USP7_UBL2_3	72	76	PF12436	0.410
DOC_WW_Pin1_4	42	47	PF00397	0.582
DOC_WW_Pin1_4	9	14	PF00397	0.595
LIG_14-3-3_CanoR_1	124	130	PF00244	0.537
LIG_FHA_1	28	34	PF00498	0.656
LIG_LIR_Nem_3	12	17	PF02991	0.404
LIG_SH2_CRK	41	45	PF00017	0.495
LIG_SH2_STAT5	17	20	PF00017	0.400
MOD_CDK_SPxxK_3	42	49	PF00069	0.624
MOD_CK1_1	22	28	PF00069	0.384
MOD_CK2_1	42	48	PF00069	0.625
MOD_GlcNHglycan	110	113	PF01048	0.761
MOD_GlcNHglycan	25	28	PF01048	0.400
MOD_GSK3_1	101	108	PF00069	0.607
MOD_GSK3_1	119	126	PF00069	0.476
MOD_GSK3_1	19	26	PF00069	0.364
MOD_GSK3_1	56	63	PF00069	0.411
MOD_GSK3_1	93	100	PF00069	0.640
MOD_NEK2_1	2	7	PF00069	0.555
MOD_NEK2_1	21	26	PF00069	0.392
MOD_NEK2_1	97	102	PF00069	0.671
MOD_PIKK_1	2	8	PF00454	0.474
MOD_PIKK_1	60	66	PF00454	0.383
MOD_PKA_1	117	123	PF00069	0.513
MOD_PKA_2	117	123	PF00069	0.513
MOD_Plk_1	56	62	PF00069	0.527
MOD_ProDKin_1	42	48	PF00069	0.583
MOD_ProDKin_1	9	15	PF00069	0.590
MOD_SUMO_for_1	71	74	PF00179	0.499
TRG_DiLeu_BaEn_1	48	53	PF01217	0.367
TRG_ENDOCYTIC_2	41	44	PF00928	0.614
TRG_ENDOCYTIC_2	67	70	PF00928	0.611
TRG_ER_diArg_1	41	43	PF00400	0.412
TRG_ER_diArg_1	67	69	PF00400	0.502
TRG_NLS_Bipartite_1	68	89	PF00514	0.380
TRG_NLS_Bipartite_1	98	118	PF00514	0.489
TRG_NLS_MonoExtC_3	112	117	PF00514	0.523
TRG_NLS_MonoExtN_4	110	117	PF00514	0.531
TRG_NLS_MonoExtN_4	82	89	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIB3	Leptomonas seymouri	32%	100%
A0A1X0NSD7	Trypanosomatidae	32%	73%
A0A3Q8IGK7	Leishmania donovani	57%	100%
A0A3Q8ITR1	Leishmania donovani	35%	97%
A0A422P329	Trypanosoma rangeli	33%	69%
A4HL15	Leishmania braziliensis	34%	92%
A4I8J5	Leishmania infantum	57%	100%
A4I8J6	Leishmania infantum	35%	97%
E9B3F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9B3F6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q4Q4P4	Leishmania major	35%	100%
Q4Q4P5	Leishmania major	57%	100%
Q8IS98	Crithidia fasciculata	36%	99%
Q9TY83	Crithidia fasciculata	35%	100%
Q9TY84	Crithidia fasciculata	36%	100%