Putative enolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative enolase

Gene product:

enolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HL13_LEIBR

TriTrypDb:

LbrM.32.4000 , LBRM2903_320049600

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0000015	phosphopyruvate hydratase complex	3	3
GO:0032991	protein-containing complex	1	3
GO:1902494	catalytic complex	2	3

Expansion

Sequence features

A4HL13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL13

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	3
GO:0006082	organic acid metabolic process	3	3
GO:0006090	pyruvate metabolic process	7	3
GO:0006091	generation of precursor metabolites and energy	3	3
GO:0006096	glycolytic process	5	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006163	purine nucleotide metabolic process	5	3
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006753	nucleoside phosphate metabolic process	4	3
GO:0006757	obsolete ATP generation from ADP	4	3
GO:0006793	phosphorus metabolic process	3	3
GO:0006796	phosphate-containing compound metabolic process	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009117	nucleotide metabolic process	5	3
GO:0009132	nucleoside diphosphate metabolic process	5	3
GO:0009135	purine nucleoside diphosphate metabolic process	6	3
GO:0009141	nucleoside triphosphate metabolic process	5	3
GO:0009144	purine nucleoside triphosphate metabolic process	6	3
GO:0009150	purine ribonucleotide metabolic process	6	3
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	3
GO:0009185	ribonucleoside diphosphate metabolic process	6	3
GO:0009199	ribonucleoside triphosphate metabolic process	6	3
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	3
GO:0009259	ribonucleotide metabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016052	carbohydrate catabolic process	4	3
GO:0016310	phosphorylation	5	3
GO:0019637	organophosphate metabolic process	3	3
GO:0019693	ribose phosphate metabolic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0032787	monocarboxylic acid metabolic process	6	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044281	small molecule metabolic process	2	3
GO:0046031	ADP metabolic process	7	3
GO:0046034	ATP metabolic process	7	3
GO:0046483	heterocycle metabolic process	3	3
GO:0046939	obsolete nucleotide phosphorylation	6	3
GO:0055086	nucleobase-containing small molecule metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0072521	purine-containing compound metabolic process	4	3
GO:1901135	carbohydrate derivative metabolic process	3	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901575	organic substance catabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004634	phosphopyruvate hydratase activity	5	8
GO:0016829	lyase activity	2	8
GO:0016835	carbon-oxygen lyase activity	3	8
GO:0016836	hydro-lyase activity	4	8
GO:0000287	magnesium ion binding	5	3
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.435
CLV_C14_Caspase3-7	248	252	PF00656	0.450
CLV_C14_Caspase3-7	94	98	PF00656	0.510
CLV_NRD_NRD_1	180	182	PF00675	0.375
CLV_NRD_NRD_1	291	293	PF00675	0.342
CLV_NRD_NRD_1	294	296	PF00675	0.342
CLV_NRD_NRD_1	501	503	PF00675	0.518
CLV_NRD_NRD_1	590	592	PF00675	0.503
CLV_NRD_NRD_1	595	597	PF00675	0.587
CLV_NRD_NRD_1	606	608	PF00675	0.610
CLV_PCSK_FUR_1	292	296	PF00082	0.268
CLV_PCSK_KEX2_1	180	182	PF00082	0.375
CLV_PCSK_KEX2_1	290	292	PF00082	0.356
CLV_PCSK_KEX2_1	294	296	PF00082	0.342
CLV_PCSK_KEX2_1	501	503	PF00082	0.483
CLV_PCSK_KEX2_1	590	592	PF00082	0.498
CLV_PCSK_KEX2_1	595	597	PF00082	0.593
CLV_PCSK_KEX2_1	606	608	PF00082	0.635
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.528
CLV_PCSK_PC1ET2_1	606	608	PF00082	0.714
CLV_PCSK_PC7_1	290	296	PF00082	0.370
CLV_PCSK_PC7_1	591	597	PF00082	0.439
CLV_PCSK_SKI1_1	332	336	PF00082	0.427
CLV_PCSK_SKI1_1	36	40	PF00082	0.622
CLV_PCSK_SKI1_1	454	458	PF00082	0.590
CLV_PCSK_SKI1_1	502	506	PF00082	0.489
DEG_APCC_DBOX_1	210	218	PF00400	0.413
DEG_COP1_1	356	365	PF00400	0.363
DEG_SPOP_SBC_1	308	312	PF00917	0.476
DOC_CYCLIN_RxL_1	128	139	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	465	468	PF00134	0.437
DOC_MAPK_DCC_7	229	238	PF00069	0.478
DOC_MAPK_gen_1	178	188	PF00069	0.263
DOC_MAPK_gen_1	294	304	PF00069	0.552
DOC_MAPK_gen_1	427	437	PF00069	0.500
DOC_MAPK_gen_1	501	508	PF00069	0.441
DOC_MAPK_MEF2A_6	178	186	PF00069	0.344
DOC_MAPK_MEF2A_6	229	238	PF00069	0.478
DOC_MAPK_MEF2A_6	257	265	PF00069	0.469
DOC_MAPK_MEF2A_6	344	353	PF00069	0.276
DOC_MAPK_MEF2A_6	501	508	PF00069	0.441
DOC_PP2B_LxvP_1	464	467	PF13499	0.481
DOC_PP2B_PxIxI_1	473	479	PF00149	0.261
DOC_PP2B_PxIxI_1	78	84	PF00149	0.283
DOC_USP7_MATH_1	107	111	PF00917	0.744
DOC_USP7_MATH_1	127	131	PF00917	0.465
DOC_USP7_MATH_1	26	30	PF00917	0.461
DOC_USP7_MATH_1	308	312	PF00917	0.523
DOC_USP7_MATH_1	546	550	PF00917	0.458
DOC_USP7_UBL2_3	598	602	PF12436	0.580
DOC_WW_Pin1_4	152	157	PF00397	0.572
DOC_WW_Pin1_4	205	210	PF00397	0.529
DOC_WW_Pin1_4	456	461	PF00397	0.544
LIG_14-3-3_CanoR_1	211	221	PF00244	0.450
LIG_14-3-3_CanoR_1	25	35	PF00244	0.505
LIG_14-3-3_CanoR_1	257	265	PF00244	0.324
LIG_14-3-3_CanoR_1	454	460	PF00244	0.470
LIG_14-3-3_CanoR_1	501	507	PF00244	0.432
LIG_Actin_WH2_2	331	346	PF00022	0.341
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_CaM_NSCaTE_8	144	151	PF13499	0.428
LIG_EH1_1	13	21	PF00400	0.350
LIG_eIF4E_1	231	237	PF01652	0.431
LIG_EVH1_1	578	582	PF00568	0.522
LIG_FHA_1	237	243	PF00498	0.401
LIG_FHA_1	267	273	PF00498	0.475
LIG_FHA_1	28	34	PF00498	0.356
LIG_FHA_1	333	339	PF00498	0.408
LIG_FHA_1	357	363	PF00498	0.502
LIG_FHA_1	503	509	PF00498	0.430
LIG_FHA_1	553	559	PF00498	0.525
LIG_FHA_1	581	587	PF00498	0.582
LIG_FHA_1	68	74	PF00498	0.363
LIG_FHA_1	83	89	PF00498	0.370
LIG_FHA_2	109	115	PF00498	0.710
LIG_FHA_2	370	376	PF00498	0.466
LIG_LIR_Apic_2	228	234	PF02991	0.369
LIG_LIR_Gen_1	115	126	PF02991	0.418
LIG_LIR_Gen_1	259	270	PF02991	0.424
LIG_LIR_Gen_1	381	392	PF02991	0.307
LIG_LIR_Nem_3	115	121	PF02991	0.604
LIG_LIR_Nem_3	259	265	PF02991	0.422
LIG_LIR_Nem_3	37	43	PF02991	0.546
LIG_LIR_Nem_3	381	387	PF02991	0.285
LIG_LIR_Nem_3	4	10	PF02991	0.450
LIG_LIR_Nem_3	470	476	PF02991	0.550
LIG_LIR_Nem_3	482	486	PF02991	0.357
LIG_LIR_Nem_3	577	581	PF02991	0.539
LIG_Pex14_2	39	43	PF04695	0.550
LIG_REV1ctd_RIR_1	36	45	PF16727	0.508
LIG_SH2_CRK	118	122	PF00017	0.503
LIG_SH2_CRK	483	487	PF00017	0.363
LIG_SH2_GRB2like	10	13	PF00017	0.327
LIG_SH2_GRB2like	56	59	PF00017	0.312
LIG_SH2_NCK_1	118	122	PF00017	0.503
LIG_SH2_PTP2	137	140	PF00017	0.412
LIG_SH2_PTP2	262	265	PF00017	0.415
LIG_SH2_SRC	137	140	PF00017	0.370
LIG_SH2_STAP1	10	14	PF00017	0.469
LIG_SH2_STAT5	137	140	PF00017	0.385
LIG_SH2_STAT5	187	190	PF00017	0.353
LIG_SH2_STAT5	262	265	PF00017	0.415
LIG_SH2_STAT5	402	405	PF00017	0.380
LIG_SH2_STAT5	42	45	PF00017	0.453
LIG_SH2_STAT5	532	535	PF00017	0.419
LIG_SH3_3	474	480	PF00018	0.363
LIG_SH3_3	563	569	PF00018	0.410
LIG_SH3_3	576	582	PF00018	0.472
LIG_SUMO_SIM_anti_2	80	85	PF11976	0.258
LIG_SUMO_SIM_par_1	29	37	PF11976	0.354
LIG_SUMO_SIM_par_1	504	510	PF11976	0.442
LIG_TRAF2_1	106	109	PF00917	0.609
LIG_UBA3_1	170	178	PF00899	0.433
LIG_WRC_WIRS_1	237	242	PF05994	0.394
LIG_WW_2	579	582	PF00397	0.587
MOD_CDK_SPxK_1	205	211	PF00069	0.522
MOD_CK1_1	215	221	PF00069	0.574
MOD_CK1_1	224	230	PF00069	0.462
MOD_CK1_1	306	312	PF00069	0.548
MOD_CK1_1	82	88	PF00069	0.410
MOD_CK1_1	90	96	PF00069	0.597
MOD_CK2_1	108	114	PF00069	0.725
MOD_CK2_1	446	452	PF00069	0.501
MOD_GlcNHglycan	1	4	PF01048	0.631
MOD_GlcNHglycan	152	155	PF01048	0.456
MOD_GlcNHglycan	16	19	PF01048	0.443
MOD_GlcNHglycan	196	199	PF01048	0.549
MOD_GlcNHglycan	214	217	PF01048	0.555
MOD_GlcNHglycan	223	227	PF01048	0.507
MOD_GlcNHglycan	243	246	PF01048	0.333
MOD_GlcNHglycan	284	287	PF01048	0.456
MOD_GlcNHglycan	315	318	PF01048	0.392
MOD_GlcNHglycan	338	341	PF01048	0.460
MOD_GlcNHglycan	486	489	PF01048	0.534
MOD_GlcNHglycan	535	538	PF01048	0.399
MOD_GlcNHglycan	540	543	PF01048	0.369
MOD_GlcNHglycan	61	64	PF01048	0.561
MOD_GSK3_1	116	123	PF00069	0.538
MOD_GSK3_1	14	21	PF00069	0.406
MOD_GSK3_1	166	173	PF00069	0.340
MOD_GSK3_1	221	228	PF00069	0.482
MOD_GSK3_1	236	243	PF00069	0.326
MOD_GSK3_1	303	310	PF00069	0.464
MOD_GSK3_1	332	339	PF00069	0.421
MOD_GSK3_1	351	358	PF00069	0.284
MOD_GSK3_1	369	376	PF00069	0.548
MOD_GSK3_1	437	444	PF00069	0.471
MOD_GSK3_1	452	459	PF00069	0.617
MOD_GSK3_1	546	553	PF00069	0.418
MOD_GSK3_1	87	94	PF00069	0.500
MOD_N-GLC_1	14	19	PF02516	0.351
MOD_N-GLC_2	574	576	PF02516	0.409
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	14	19	PF00069	0.347
MOD_NEK2_1	221	226	PF00069	0.569
MOD_NEK2_1	236	241	PF00069	0.312
MOD_NEK2_1	303	308	PF00069	0.503
MOD_NEK2_1	355	360	PF00069	0.554
MOD_NEK2_1	418	423	PF00069	0.477
MOD_NEK2_1	437	442	PF00069	0.260
MOD_NEK2_1	507	512	PF00069	0.565
MOD_PIKK_1	546	552	PF00454	0.306
MOD_PKA_2	256	262	PF00069	0.501
MOD_Plk_1	144	150	PF00069	0.323
MOD_Plk_1	378	384	PF00069	0.333
MOD_Plk_1	556	562	PF00069	0.456
MOD_Plk_1	79	85	PF00069	0.413
MOD_Plk_2-3	369	375	PF00069	0.472
MOD_Plk_4	116	122	PF00069	0.518
MOD_Plk_4	166	172	PF00069	0.357
MOD_Plk_4	236	242	PF00069	0.393
MOD_Plk_4	284	290	PF00069	0.321
MOD_Plk_4	378	384	PF00069	0.519
MOD_Plk_4	437	443	PF00069	0.485
MOD_Plk_4	502	508	PF00069	0.415
MOD_Plk_4	528	534	PF00069	0.440
MOD_ProDKin_1	152	158	PF00069	0.571
MOD_ProDKin_1	205	211	PF00069	0.522
MOD_ProDKin_1	456	462	PF00069	0.544
MOD_SUMO_rev_2	29	38	PF00179	0.509
TRG_ENDOCYTIC_2	118	121	PF00928	0.590
TRG_ENDOCYTIC_2	262	265	PF00928	0.415
TRG_ENDOCYTIC_2	384	387	PF00928	0.366
TRG_ENDOCYTIC_2	483	486	PF00928	0.359
TRG_ER_diArg_1	180	182	PF00400	0.369
TRG_ER_diArg_1	289	292	PF00400	0.420
TRG_ER_diArg_1	293	295	PF00400	0.399
TRG_ER_diArg_1	430	433	PF00400	0.392
TRG_ER_diArg_1	589	591	PF00400	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4A1	Leptomonas seymouri	38%	94%
A0A1X0NS02	Trypanosomatidae	26%	100%
A0A3Q8IJR5	Leishmania donovani	73%	100%
A0A3R7RSQ9	Trypanosoma rangeli	26%	100%
A4I8J4	Leishmania infantum	72%	100%
E9B3F4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q4P6	Leishmania major	71%	100%
V5DME2	Trypanosoma cruzi	26%	100%