Mitochondrial inner membrane protease subunit 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL11_LEIBR

TriTrypDb:

LbrM.32.3980 , LBRM2903_320049400

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	19	27	PF00400	0.343
DOC_CKS1_1	79	84	PF01111	0.508
DOC_MAPK_gen_1	61	69	PF00069	0.500
DOC_PP2B_LxvP_1	67	70	PF13499	0.651
DOC_PP4_FxxP_1	11	14	PF00568	0.360
DOC_WW_Pin1_4	10	15	PF00397	0.363
DOC_WW_Pin1_4	148	153	PF00397	0.456
DOC_WW_Pin1_4	54	59	PF00397	0.485
DOC_WW_Pin1_4	75	80	PF00397	0.515
LIG_14-3-3_CanoR_1	110	118	PF00244	0.670
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_CSL_BTD_1	79	82	PF09270	0.490
LIG_FHA_1	110	116	PF00498	0.536
LIG_Integrin_isoDGR_2	104	106	PF01839	0.575
LIG_LIR_Apic_2	8	14	PF02991	0.368
LIG_LIR_Gen_1	2	11	PF02991	0.475
LIG_LIR_Gen_1	38	46	PF02991	0.557
LIG_LIR_Gen_1	96	107	PF02991	0.500
LIG_LIR_Nem_3	2	7	PF02991	0.488
LIG_LIR_Nem_3	38	44	PF02991	0.588
LIG_LIR_Nem_3	55	59	PF02991	0.496
LIG_LIR_Nem_3	96	102	PF02991	0.501
LIG_PDZ_Class_1	150	155	PF00595	0.583
LIG_Pex14_2	7	11	PF04695	0.375
LIG_PTB_Apo_2	101	108	PF02174	0.572
LIG_PTB_Apo_2	68	75	PF02174	0.560
LIG_PTB_Phospho_1	68	74	PF10480	0.557
LIG_SH2_GRB2like	74	77	PF00017	0.667
LIG_SH2_STAT5	36	39	PF00017	0.567
LIG_SH2_STAT5	52	55	PF00017	0.479
LIG_SH2_STAT5	74	77	PF00017	0.579
LIG_SH2_STAT5	99	102	PF00017	0.641
LIG_SH3_3	146	152	PF00018	0.521
LIG_SH3_3	76	82	PF00018	0.504
LIG_SH3_4	61	68	PF00018	0.627
LIG_TRAF2_1	120	123	PF00917	0.516
MOD_CDC14_SPxK_1	151	154	PF00782	0.469
MOD_CDK_SPK_2	78	83	PF00069	0.521
MOD_CDK_SPxK_1	148	154	PF00069	0.461
MOD_CDK_SPxxK_3	54	61	PF00069	0.497
MOD_CK1_1	140	146	PF00069	0.495
MOD_CK1_1	78	84	PF00069	0.552
MOD_GSK3_1	10	17	PF00069	0.423
MOD_GSK3_1	109	116	PF00069	0.593
MOD_GSK3_1	137	144	PF00069	0.598
MOD_N-GLC_1	75	80	PF02516	0.533
MOD_NEK2_1	142	147	PF00069	0.527
MOD_PKA_2	109	115	PF00069	0.560
MOD_Plk_4	113	119	PF00069	0.669
MOD_ProDKin_1	10	16	PF00069	0.354
MOD_ProDKin_1	148	154	PF00069	0.461
MOD_ProDKin_1	54	60	PF00069	0.493
MOD_ProDKin_1	75	81	PF00069	0.516
TRG_ENDOCYTIC_2	41	44	PF00928	0.528
TRG_ENDOCYTIC_2	99	102	PF00928	0.652
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.573
TRG_PTS1	152	155	PF00515	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W3	Leptomonas seymouri	76%	100%
A0A1X0NRY2	Trypanosomatidae	70%	100%
A0A3Q8IGB2	Leishmania donovani	84%	100%
A0A3R7N368	Trypanosoma rangeli	59%	100%
A4I8J2	Leishmania infantum	84%	100%
D0AAM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9B3F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q4P8	Leishmania major	83%	100%
V5DME5	Trypanosoma cruzi	63%	100%