Transmembrane protein 18

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transmembrane protein 18, putative

Species:

Leishmania braziliensis

UniProt:

A4HL10_LEIBR

TriTrypDb:

LbrM.32.3970 , LBRM2903_320049300

Length:

206

Annotations

LeishMANIAdb annotations

Part of the eukaryotic TMEM18 family, consisting of conserved 3TM nuclear membrane proteins.. Localization: Perinuclear (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0031090	organelle membrane	3	1
GO:0031965	nuclear membrane	4	1

Expansion

Sequence features

A4HL10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.607
CLV_NRD_NRD_1	178	180	PF00675	0.275
CLV_NRD_NRD_1	186	188	PF00675	0.399
CLV_PCSK_KEX2_1	173	175	PF00082	0.244
CLV_PCSK_KEX2_1	178	180	PF00082	0.244
CLV_PCSK_KEX2_1	186	188	PF00082	0.374
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.244
CLV_PCSK_PC7_1	174	180	PF00082	0.300
CLV_PCSK_PC7_1	182	188	PF00082	0.416
CLV_PCSK_SKI1_1	32	36	PF00082	0.589
DEG_Nend_Nbox_1	1	3	PF02207	0.395
DOC_MAPK_MEF2A_6	164	172	PF00069	0.538
DOC_PP4_FxxP_1	127	130	PF00568	0.337
DOC_USP7_MATH_1	114	118	PF00917	0.362
DOC_USP7_MATH_1	199	203	PF00917	0.700
DOC_USP7_MATH_1	40	44	PF00917	0.454
LIG_14-3-3_CanoR_1	164	169	PF00244	0.580
LIG_Actin_WH2_2	145	162	PF00022	0.361
LIG_Actin_WH2_2	42	57	PF00022	0.373
LIG_BIR_III_4	197	201	PF00653	0.559
LIG_BRCT_BRCA1_1	66	70	PF00533	0.273
LIG_CaM_NSCaTE_8	82	89	PF13499	0.413
LIG_DCNL_PONY_1	1	4	PF03556	0.313
LIG_deltaCOP1_diTrp_1	124	127	PF00928	0.248
LIG_EH1_1	162	170	PF00400	0.570
LIG_eIF4E_1	146	152	PF01652	0.403
LIG_eIF4E_1	163	169	PF01652	0.394
LIG_FHA_1	138	144	PF00498	0.325
LIG_LIR_Apic_2	124	130	PF02991	0.337
LIG_LIR_Nem_3	67	73	PF02991	0.242
LIG_LIR_Nem_3	87	93	PF02991	0.257
LIG_NRBOX	104	110	PF00104	0.327
LIG_Pex14_1	66	70	PF04695	0.244
LIG_REV1ctd_RIR_1	68	76	PF16727	0.337
LIG_SH2_CRK	163	167	PF00017	0.588
LIG_SH2_CRK	61	65	PF00017	0.311
LIG_SH2_NCK_1	61	65	PF00017	0.301
LIG_SH2_STAT5	134	137	PF00017	0.244
LIG_SH2_STAT5	146	149	PF00017	0.281
LIG_SH2_STAT5	156	159	PF00017	0.468
LIG_SH2_STAT5	73	76	PF00017	0.254
LIG_SUMO_SIM_par_1	106	111	PF11976	0.416
LIG_UBA3_1	168	173	PF00899	0.478
MOD_CK1_1	3	9	PF00069	0.281
MOD_CK1_1	45	51	PF00069	0.405
MOD_GlcNHglycan	110	113	PF01048	0.418
MOD_GlcNHglycan	194	197	PF01048	0.420
MOD_GSK3_1	133	140	PF00069	0.287
MOD_GSK3_1	82	89	PF00069	0.238
MOD_N-GLC_1	26	31	PF02516	0.451
MOD_N-GLC_1	64	69	PF02516	0.499
MOD_NEK2_1	108	113	PF00069	0.363
MOD_NEK2_1	26	31	PF00069	0.382
MOD_NEK2_1	86	91	PF00069	0.226
MOD_Plk_4	137	143	PF00069	0.374
MOD_Plk_4	164	170	PF00069	0.574
MOD_Plk_4	45	51	PF00069	0.381
MOD_SUMO_rev_2	195	205	PF00179	0.745
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.374
TRG_ENDOCYTIC_2	156	159	PF00928	0.483
TRG_ENDOCYTIC_2	163	166	PF00928	0.448
TRG_ENDOCYTIC_2	61	64	PF00928	0.300
TRG_ER_diArg_1	177	179	PF00400	0.538
TRG_ER_diLys_1	203	206	PF00400	0.655
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.219

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIZ0	Leptomonas seymouri	52%	100%
A0A0S4IU15	Bodo saltans	33%	100%
A0A1X0NRY6	Trypanosomatidae	43%	100%
A0A3R7KYB3	Trypanosoma rangeli	38%	100%
A0A3S7X686	Leishmania donovani	79%	100%
A4I8J1	Leishmania infantum	79%	100%
D0AAM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q4P9	Leishmania major	77%	100%