BT1 family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

BT1 family protein

Gene product:

BT1 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HL09_LEIBR

TriTrypDb:

LbrM.32.3960 , LBRM2903_320049200

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HL09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL09

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0008643	carbohydrate transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.524
CLV_C14_Caspase3-7	456	460	PF00656	0.663
CLV_NRD_NRD_1	225	227	PF00675	0.403
CLV_NRD_NRD_1	290	292	PF00675	0.248
CLV_NRD_NRD_1	436	438	PF00675	0.242
CLV_NRD_NRD_1	66	68	PF00675	0.306
CLV_PCSK_KEX2_1	225	227	PF00082	0.504
CLV_PCSK_KEX2_1	290	292	PF00082	0.248
CLV_PCSK_KEX2_1	436	438	PF00082	0.242
CLV_PCSK_KEX2_1	65	67	PF00082	0.319
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.313
CLV_PCSK_SKI1_1	169	173	PF00082	0.499
CLV_PCSK_SKI1_1	191	195	PF00082	0.381
CLV_PCSK_SKI1_1	354	358	PF00082	0.404
CLV_PCSK_SKI1_1	67	71	PF00082	0.299
DEG_APCC_DBOX_1	65	73	PF00400	0.499
DOC_CYCLIN_RxL_1	188	198	PF00134	0.462
DOC_MAPK_FxFP_2	259	262	PF00069	0.263
DOC_MAPK_gen_1	222	231	PF00069	0.539
DOC_MAPK_gen_1	65	71	PF00069	0.494
DOC_MAPK_HePTP_8	351	363	PF00069	0.304
DOC_MAPK_MEF2A_6	354	363	PF00069	0.366
DOC_MAPK_RevD_3	422	437	PF00069	0.238
DOC_MAPK_RevD_3	50	66	PF00069	0.194
DOC_PP1_RVXF_1	94	101	PF00149	0.185
DOC_PP2B_LxvP_1	111	114	PF13499	0.354
DOC_PP4_FxxP_1	194	197	PF00568	0.462
DOC_PP4_FxxP_1	259	262	PF00568	0.270
DOC_USP7_MATH_1	135	139	PF00917	0.486
DOC_USP7_MATH_1	245	249	PF00917	0.216
DOC_USP7_MATH_1	457	461	PF00917	0.576
DOC_USP7_MATH_1	90	94	PF00917	0.195
DOC_WW_Pin1_4	186	191	PF00397	0.430
DOC_WW_Pin1_4	465	470	PF00397	0.586
LIG_14-3-3_CanoR_1	136	140	PF00244	0.385
LIG_14-3-3_CanoR_1	301	305	PF00244	0.499
LIG_14-3-3_CanoR_1	403	413	PF00244	0.185
LIG_Actin_WH2_2	387	405	PF00022	0.194
LIG_BRCT_BRCA1_1	302	306	PF00533	0.499
LIG_eIF4E_1	319	325	PF01652	0.354
LIG_eIF4E_1	81	87	PF01652	0.304
LIG_FHA_1	1	7	PF00498	0.513
LIG_FHA_1	106	112	PF00498	0.415
LIG_FHA_1	158	164	PF00498	0.322
LIG_FHA_1	325	331	PF00498	0.301
LIG_FHA_1	347	353	PF00498	0.349
LIG_FHA_1	393	399	PF00498	0.428
LIG_FHA_1	93	99	PF00498	0.335
LIG_FHA_2	127	133	PF00498	0.499
LIG_FHA_2	373	379	PF00498	0.499
LIG_FHA_2	403	409	PF00498	0.263
LIG_GBD_Chelix_1	174	182	PF00786	0.282
LIG_IRF3_LxIS_1	330	337	PF10401	0.185
LIG_LIR_Gen_1	249	259	PF02991	0.320
LIG_LIR_Gen_1	303	314	PF02991	0.305
LIG_LIR_Gen_1	345	356	PF02991	0.299
LIG_LIR_Gen_1	375	385	PF02991	0.499
LIG_LIR_Gen_1	407	416	PF02991	0.302
LIG_LIR_Gen_1	91	102	PF02991	0.334
LIG_LIR_Nem_3	248	254	PF02991	0.325
LIG_LIR_Nem_3	303	308	PF02991	0.378
LIG_LIR_Nem_3	345	351	PF02991	0.284
LIG_LIR_Nem_3	375	380	PF02991	0.508
LIG_LIR_Nem_3	407	412	PF02991	0.329
LIG_LIR_Nem_3	468	473	PF02991	0.580
LIG_LIR_Nem_3	78	84	PF02991	0.360
LIG_LIR_Nem_3	91	97	PF02991	0.299
LIG_MLH1_MIPbox_1	302	306	PF16413	0.499
LIG_PALB2_WD40_1	43	51	PF16756	0.194
LIG_Pex14_1	315	319	PF04695	0.304
LIG_Pex14_2	261	265	PF04695	0.285
LIG_PTB_Apo_2	260	267	PF02174	0.362
LIG_PTB_Phospho_1	260	266	PF10480	0.350
LIG_SH2_CRK	252	256	PF00017	0.289
LIG_SH2_PTP2	112	115	PF00017	0.354
LIG_SH2_PTP2	341	344	PF00017	0.299
LIG_SH2_SRC	254	257	PF00017	0.299
LIG_SH2_SRC	341	344	PF00017	0.299
LIG_SH2_STAP1	252	256	PF00017	0.323
LIG_SH2_STAP1	409	413	PF00017	0.263
LIG_SH2_STAT5	112	115	PF00017	0.294
LIG_SH2_STAT5	241	244	PF00017	0.362
LIG_SH2_STAT5	254	257	PF00017	0.317
LIG_SH2_STAT5	282	285	PF00017	0.434
LIG_SH2_STAT5	319	322	PF00017	0.301
LIG_SH2_STAT5	341	344	PF00017	0.299
LIG_SH2_STAT5	41	44	PF00017	0.320
LIG_SH2_STAT5	431	434	PF00017	0.274
LIG_SH2_STAT5	54	57	PF00017	0.388
LIG_SH3_3	178	184	PF00018	0.338
LIG_SH3_3	337	343	PF00018	0.343
LIG_SUMO_SIM_anti_2	417	422	PF11976	0.194
LIG_SUMO_SIM_anti_2	447	454	PF11976	0.575
LIG_SUMO_SIM_anti_2	56	64	PF11976	0.194
LIG_SUMO_SIM_par_1	3	10	PF11976	0.339
LIG_SUMO_SIM_par_1	414	419	PF11976	0.358
LIG_SUMO_SIM_par_1	56	64	PF11976	0.194
LIG_TRAF2_1	129	132	PF00917	0.499
LIG_TRAF2_1	292	295	PF00917	0.499
LIG_TRFH_1	84	88	PF08558	0.304
LIG_TYR_ITIM	250	255	PF00017	0.289
MOD_CDK_SPK_2	186	191	PF00069	0.430
MOD_CK1_1	101	107	PF00069	0.354
MOD_CK1_1	149	155	PF00069	0.358
MOD_CK1_1	18	24	PF00069	0.400
MOD_CK1_1	285	291	PF00069	0.379
MOD_CK1_1	381	387	PF00069	0.332
MOD_CK1_1	458	464	PF00069	0.667
MOD_CK2_1	126	132	PF00069	0.508
MOD_CK2_1	372	378	PF00069	0.499
MOD_CMANNOS	213	216	PF00535	0.320
MOD_GlcNHglycan	336	339	PF01048	0.502
MOD_GlcNHglycan	390	393	PF01048	0.423
MOD_GSK3_1	101	108	PF00069	0.311
MOD_GSK3_1	126	133	PF00069	0.508
MOD_GSK3_1	135	142	PF00069	0.508
MOD_GSK3_1	14	21	PF00069	0.347
MOD_GSK3_1	246	253	PF00069	0.359
MOD_GSK3_1	324	331	PF00069	0.302
MOD_GSK3_1	388	395	PF00069	0.347
MOD_GSK3_1	88	95	PF00069	0.242
MOD_N-GLC_2	203	205	PF02516	0.312
MOD_N-GLC_2	269	271	PF02516	0.354
MOD_NEK2_1	141	146	PF00069	0.484
MOD_NEK2_1	15	20	PF00069	0.363
MOD_NEK2_1	204	209	PF00069	0.532
MOD_NEK2_1	214	219	PF00069	0.511
MOD_NEK2_1	239	244	PF00069	0.366
MOD_NEK2_1	309	314	PF00069	0.299
MOD_NEK2_1	324	329	PF00069	0.351
MOD_NEK2_1	334	339	PF00069	0.309
MOD_NEK2_1	347	352	PF00069	0.392
MOD_NEK2_1	372	377	PF00069	0.542
MOD_NEK2_1	402	407	PF00069	0.304
MOD_NEK2_1	6	11	PF00069	0.331
MOD_NEK2_2	164	169	PF00069	0.355
MOD_NEK2_2	82	87	PF00069	0.213
MOD_PIKK_1	101	107	PF00454	0.354
MOD_PIKK_1	407	413	PF00454	0.248
MOD_PKA_1	436	442	PF00069	0.537
MOD_PKA_2	135	141	PF00069	0.478
MOD_PKA_2	195	201	PF00069	0.668
MOD_PKA_2	300	306	PF00069	0.469
MOD_PKA_2	402	408	PF00069	0.185
MOD_PKA_2	436	442	PF00069	0.652
MOD_Plk_1	245	251	PF00069	0.243
MOD_Plk_1	372	378	PF00069	0.456
MOD_Plk_1	407	413	PF00069	0.263
MOD_Plk_1	458	464	PF00069	0.591
MOD_Plk_2-3	126	132	PF00069	0.417
MOD_Plk_4	135	141	PF00069	0.529
MOD_Plk_4	149	155	PF00069	0.438
MOD_Plk_4	15	21	PF00069	0.354
MOD_Plk_4	239	245	PF00069	0.345
MOD_Plk_4	246	252	PF00069	0.300
MOD_Plk_4	300	306	PF00069	0.507
MOD_Plk_4	347	353	PF00069	0.358
MOD_Plk_4	357	363	PF00069	0.347
MOD_Plk_4	416	422	PF00069	0.354
MOD_Plk_4	7	13	PF00069	0.354
MOD_Plk_4	75	81	PF00069	0.362
MOD_Plk_4	82	88	PF00069	0.388
MOD_ProDKin_1	186	192	PF00069	0.437
MOD_ProDKin_1	465	471	PF00069	0.586
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.263
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.194
TRG_ENDOCYTIC_2	112	115	PF00928	0.357
TRG_ENDOCYTIC_2	241	244	PF00928	0.366
TRG_ENDOCYTIC_2	252	255	PF00928	0.308
TRG_ENDOCYTIC_2	256	259	PF00928	0.308
TRG_ENDOCYTIC_2	341	344	PF00928	0.307
TRG_ENDOCYTIC_2	409	412	PF00928	0.299
TRG_ENDOCYTIC_2	84	87	PF00928	0.442
TRG_ER_diArg_1	224	226	PF00400	0.534
TRG_ER_diArg_1	290	293	PF00400	0.385
TRG_ER_diArg_1	66	68	PF00400	0.505
TRG_NES_CRM1_1	49	64	PF08389	0.282
TRG_Pf-PMV_PEXEL_1	222	227	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC7	Leptomonas seymouri	26%	86%
A0A0N1I3H1	Leptomonas seymouri	65%	69%
A0A3Q8IF44	Leishmania donovani	27%	87%
A0A3Q8ILR5	Leishmania donovani	78%	100%
A4HIW8	Leishmania braziliensis	27%	100%
A4I8J0	Leishmania infantum	78%	100%
E9AHK6	Leishmania infantum	27%	87%
E9B1F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	87%
E9B3F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
F4KIL8	Arabidopsis thaliana	22%	96%
Q4Q4Q0	Leishmania major	77%	100%
Q4Q6R0	Leishmania major	27%	100%
Q5FV41	Arabidopsis thaliana	21%	95%
Q9SKZ5	Arabidopsis thaliana	23%	85%
Q9SQN2	Arabidopsis thaliana	21%	95%