Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL08_LEIBR

TriTrypDb:

LbrM.32.3950 , LBRM2903_320049100

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.498
CLV_NRD_NRD_1	104	106	PF00675	0.683
CLV_NRD_NRD_1	5	7	PF00675	0.564
CLV_NRD_NRD_1	65	67	PF00675	0.543
CLV_PCSK_KEX2_1	104	106	PF00082	0.483
CLV_PCSK_SKI1_1	12	16	PF00082	0.493
CLV_PCSK_SKI1_1	127	131	PF00082	0.559
CLV_PCSK_SKI1_1	67	71	PF00082	0.450
DOC_CYCLIN_yCln2_LP_2	53	59	PF00134	0.650
DOC_MAPK_gen_1	123	131	PF00069	0.618
DOC_MAPK_gen_1	44	53	PF00069	0.587
DOC_MAPK_MEF2A_6	44	53	PF00069	0.579
DOC_MAPK_NFAT4_5	46	54	PF00069	0.648
DOC_MAPK_RevD_3	23	38	PF00069	0.558
DOC_PP1_RVXF_1	65	72	PF00149	0.492
DOC_PP1_RVXF_1	79	86	PF00149	0.441
DOC_PP2B_LxvP_1	25	28	PF13499	0.419
DOC_USP7_UBL2_3	119	123	PF12436	0.705
DOC_USP7_UBL2_3	130	134	PF12436	0.589
DOC_USP7_UBL2_3	44	48	PF12436	0.603
DOC_USP7_UBL2_3	7	11	PF12436	0.638
DOC_WW_Pin1_4	52	57	PF00397	0.569
LIG_14-3-3_CanoR_1	104	113	PF00244	0.539
LIG_FHA_1	126	132	PF00498	0.728
LIG_FHA_1	97	103	PF00498	0.476
LIG_FHA_2	106	112	PF00498	0.746
LIG_LIR_Nem_3	58	63	PF02991	0.517
LIG_NRP_CendR_1	132	135	PF00754	0.512
LIG_SH3_3	25	31	PF00018	0.545
LIG_SUMO_SIM_par_1	23	29	PF11976	0.414
MOD_CK1_1	112	118	PF00069	0.567
MOD_Cter_Amidation	132	135	PF01082	0.512
MOD_GlcNHglycan	90	93	PF01048	0.497
MOD_GSK3_1	105	112	PF00069	0.611
MOD_GSK3_1	26	33	PF00069	0.594
MOD_GSK3_1	88	95	PF00069	0.471
MOD_NEK2_1	36	41	PF00069	0.589
MOD_PK_1	109	115	PF00069	0.501
MOD_PKA_1	104	110	PF00069	0.592
MOD_PKA_1	12	18	PF00069	0.554
MOD_PKA_2	104	110	PF00069	0.655
MOD_PKA_2	39	45	PF00069	0.603
MOD_ProDKin_1	52	58	PF00069	0.564
MOD_SUMO_rev_2	64	69	PF00179	0.542
TRG_ENDOCYTIC_2	60	63	PF00928	0.518
TRG_ER_diArg_1	103	105	PF00400	0.490
TRG_ER_diLys_1	130	135	PF00400	0.531
TRG_NLS_MonoExtC_3	36	41	PF00514	0.616
TRG_NLS_MonoExtN_4	4	10	PF00514	0.601

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE6	Leptomonas seymouri	83%	100%
A0A0S4IS54	Bodo saltans	66%	84%
A0A1X0NSL1	Trypanosomatidae	72%	100%
A0A3S5H7T4	Leishmania donovani	81%	100%
A0A422P317	Trypanosoma rangeli	71%	100%
A4I8I9	Leishmania infantum	82%	100%
D0AAM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	76%	100%
E9B3E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q4Q1	Leishmania major	82%	100%
V5DME8	Trypanosoma cruzi	69%	100%