GYF_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL07_LEIBR

TriTrypDb:

LbrM.32.3940 , LBRM2903_320049000

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.626
CLV_C14_Caspase3-7	379	383	PF00656	0.576
CLV_C14_Caspase3-7	83	87	PF00656	0.474
CLV_NRD_NRD_1	172	174	PF00675	0.489
CLV_NRD_NRD_1	250	252	PF00675	0.471
CLV_NRD_NRD_1	39	41	PF00675	0.508
CLV_NRD_NRD_1	523	525	PF00675	0.437
CLV_NRD_NRD_1	527	529	PF00675	0.376
CLV_NRD_NRD_1	642	644	PF00675	0.521
CLV_NRD_NRD_1	713	715	PF00675	0.583
CLV_PCSK_KEX2_1	172	174	PF00082	0.585
CLV_PCSK_KEX2_1	250	252	PF00082	0.524
CLV_PCSK_KEX2_1	39	41	PF00082	0.619
CLV_PCSK_KEX2_1	527	529	PF00082	0.400
CLV_PCSK_KEX2_1	634	636	PF00082	0.408
CLV_PCSK_KEX2_1	72	74	PF00082	0.522
CLV_PCSK_PC1ET2_1	634	636	PF00082	0.408
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.522
CLV_PCSK_SKI1_1	124	128	PF00082	0.568
CLV_PCSK_SKI1_1	165	169	PF00082	0.485
CLV_PCSK_SKI1_1	251	255	PF00082	0.391
CLV_PCSK_SKI1_1	290	294	PF00082	0.563
CLV_PCSK_SKI1_1	439	443	PF00082	0.638
CLV_PCSK_SKI1_1	503	507	PF00082	0.433
CLV_PCSK_SKI1_1	527	531	PF00082	0.414
CLV_PCSK_SKI1_1	57	61	PF00082	0.553
CLV_PCSK_SKI1_1	681	685	PF00082	0.618
CLV_PCSK_SKI1_1	700	704	PF00082	0.498
DEG_APCC_DBOX_1	25	33	PF00400	0.550
DEG_Nend_Nbox_1	1	3	PF02207	0.560
DEG_SCF_FBW7_1	529	536	PF00400	0.486
DEG_SPOP_SBC_1	581	585	PF00917	0.601
DOC_AGCK_PIF_3	725	728	PF00069	0.616
DOC_CYCLIN_RxL_1	602	615	PF00134	0.615
DOC_CYCLIN_yCln2_LP_2	660	666	PF00134	0.494
DOC_MAPK_DCC_7	26	34	PF00069	0.527
DOC_MAPK_gen_1	26	34	PF00069	0.582
DOC_MAPK_gen_1	39	45	PF00069	0.544
DOC_MAPK_gen_1	524	531	PF00069	0.408
DOC_MAPK_MEF2A_6	562	570	PF00069	0.691
DOC_PP1_RVXF_1	248	255	PF00149	0.390
DOC_PP1_RVXF_1	525	532	PF00149	0.389
DOC_PP1_RVXF_1	642	649	PF00149	0.626
DOC_USP7_MATH_1	236	240	PF00917	0.515
DOC_USP7_MATH_1	282	286	PF00917	0.629
DOC_USP7_MATH_1	345	349	PF00917	0.795
DOC_USP7_MATH_1	533	537	PF00917	0.613
DOC_USP7_UBL2_3	293	297	PF12436	0.486
DOC_USP7_UBL2_3	674	678	PF12436	0.536
DOC_USP7_UBL2_3	681	685	PF12436	0.476
DOC_WW_Pin1_4	27	32	PF00397	0.571
DOC_WW_Pin1_4	333	338	PF00397	0.500
DOC_WW_Pin1_4	415	420	PF00397	0.546
DOC_WW_Pin1_4	483	488	PF00397	0.365
DOC_WW_Pin1_4	529	534	PF00397	0.531
DOC_WW_Pin1_4	577	582	PF00397	0.496
LIG_14-3-3_CanoR_1	57	66	PF00244	0.509
LIG_Actin_WH2_2	390	408	PF00022	0.564
LIG_BRCT_BRCA1_1	131	135	PF00533	0.547
LIG_EVH1_2	41	45	PF00568	0.645
LIG_FHA_1	121	127	PF00498	0.608
LIG_FHA_1	178	184	PF00498	0.378
LIG_FHA_1	535	541	PF00498	0.500
LIG_FHA_1	596	602	PF00498	0.530
LIG_FHA_2	432	438	PF00498	0.593
LIG_FHA_2	81	87	PF00498	0.728
LIG_LIR_Apic_2	636	642	PF02991	0.500
LIG_LIR_Gen_1	139	149	PF02991	0.364
LIG_LIR_Gen_1	393	400	PF02991	0.453
LIG_LIR_Gen_1	44	51	PF02991	0.515
LIG_LIR_Nem_3	139	145	PF02991	0.357
LIG_LIR_Nem_3	393	397	PF02991	0.420
LIG_LIR_Nem_3	44	48	PF02991	0.513
LIG_LIR_Nem_3	484	488	PF02991	0.375
LIG_LIR_Nem_3	722	728	PF02991	0.480
LIG_MYND_3	283	287	PF01753	0.561
LIG_PCNA_yPIPBox_3	297	310	PF02747	0.418
LIG_PDZ_Class_2	723	728	PF00595	0.603
LIG_SH2_CRK	365	369	PF00017	0.394
LIG_SH2_STAP1	267	271	PF00017	0.505
LIG_SH2_STAP1	279	283	PF00017	0.505
LIG_SH2_STAP1	421	425	PF00017	0.490
LIG_SH2_STAP1	709	713	PF00017	0.472
LIG_SH2_STAT3	259	262	PF00017	0.476
LIG_SH2_STAT3	421	424	PF00017	0.376
LIG_SH2_STAT5	142	145	PF00017	0.524
LIG_SH2_STAT5	387	390	PF00017	0.394
LIG_SH2_STAT5	504	507	PF00017	0.411
LIG_SH3_2	357	362	PF14604	0.401
LIG_SH3_3	116	122	PF00018	0.591
LIG_SH3_3	354	360	PF00018	0.456
LIG_SH3_3	560	566	PF00018	0.772
LIG_SH3_3	643	649	PF00018	0.623
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.465
LIG_SUMO_SIM_par_1	269	276	PF11976	0.588
LIG_SUMO_SIM_par_1	30	36	PF11976	0.434
LIG_SUMO_SIM_par_1	395	402	PF11976	0.655
LIG_SUMO_SIM_par_1	543	548	PF11976	0.499
LIG_SUMO_SIM_par_1	95	101	PF11976	0.435
LIG_TRAF2_1	285	288	PF00917	0.577
LIG_TRAF2_1	498	501	PF00917	0.398
LIG_TRAF2_1	551	554	PF00917	0.501
LIG_TRAF2_1	557	560	PF00917	0.496
LIG_TYR_ITIM	363	368	PF00017	0.461
LIG_UBA3_1	666	674	PF00899	0.396
MOD_CDK_SPK_2	415	420	PF00069	0.546
MOD_CK1_1	208	214	PF00069	0.677
MOD_CK1_1	336	342	PF00069	0.701
MOD_CK1_1	454	460	PF00069	0.531
MOD_CK1_1	580	586	PF00069	0.519
MOD_CK1_1	651	657	PF00069	0.484
MOD_CK1_1	688	694	PF00069	0.609
MOD_CK2_1	282	288	PF00069	0.577
MOD_CK2_1	346	352	PF00069	0.497
MOD_CK2_1	431	437	PF00069	0.593
MOD_CK2_1	483	489	PF00069	0.472
MOD_Cter_Amidation	525	528	PF01082	0.426
MOD_GlcNHglycan	110	113	PF01048	0.549
MOD_GlcNHglycan	18	21	PF01048	0.591
MOD_GlcNHglycan	187	190	PF01048	0.438
MOD_GlcNHglycan	192	195	PF01048	0.375
MOD_GlcNHglycan	210	213	PF01048	0.509
MOD_GlcNHglycan	220	224	PF01048	0.558
MOD_GlcNHglycan	238	241	PF01048	0.561
MOD_GlcNHglycan	371	374	PF01048	0.437
MOD_GlcNHglycan	379	382	PF01048	0.456
MOD_GlcNHglycan	389	392	PF01048	0.422
MOD_GlcNHglycan	453	456	PF01048	0.767
MOD_GSK3_1	108	115	PF00069	0.610
MOD_GSK3_1	236	243	PF00069	0.446
MOD_GSK3_1	335	342	PF00069	0.632
MOD_GSK3_1	426	433	PF00069	0.482
MOD_GSK3_1	447	454	PF00069	0.687
MOD_GSK3_1	529	536	PF00069	0.507
MOD_GSK3_1	577	584	PF00069	0.512
MOD_GSK3_1	98	105	PF00069	0.481
MOD_N-GLC_1	447	452	PF02516	0.477
MOD_NEK2_1	129	134	PF00069	0.581
MOD_NEK2_1	185	190	PF00069	0.425
MOD_NEK2_1	442	447	PF00069	0.576
MOD_NEK2_1	534	539	PF00069	0.487
MOD_NEK2_1	582	587	PF00069	0.590
MOD_PIKK_1	102	108	PF00454	0.496
MOD_PIKK_1	241	247	PF00454	0.573
MOD_PIKK_1	442	448	PF00454	0.517
MOD_PIKK_1	516	522	PF00454	0.373
MOD_PKA_2	108	114	PF00069	0.600
MOD_PKA_2	129	135	PF00069	0.545
MOD_PKA_2	369	375	PF00069	0.413
MOD_PKA_2	688	694	PF00069	0.494
MOD_Plk_1	339	345	PF00069	0.518
MOD_Plk_1	442	448	PF00069	0.593
MOD_Plk_1	97	103	PF00069	0.488
MOD_Plk_2-3	44	50	PF00069	0.443
MOD_Plk_2-3	6	12	PF00069	0.385
MOD_Plk_4	346	352	PF00069	0.519
MOD_Plk_4	478	484	PF00069	0.523
MOD_Plk_4	582	588	PF00069	0.583
MOD_Plk_4	662	668	PF00069	0.498
MOD_Plk_4	721	727	PF00069	0.523
MOD_ProDKin_1	27	33	PF00069	0.568
MOD_ProDKin_1	333	339	PF00069	0.499
MOD_ProDKin_1	415	421	PF00069	0.543
MOD_ProDKin_1	483	489	PF00069	0.372
MOD_ProDKin_1	529	535	PF00069	0.542
MOD_ProDKin_1	577	583	PF00069	0.491
MOD_SUMO_for_1	707	710	PF00179	0.460
MOD_SUMO_for_1	71	74	PF00179	0.618
MOD_SUMO_rev_2	436	441	PF00179	0.634
TRG_DiLeu_BaEn_2	621	627	PF01217	0.617
TRG_DiLeu_BaEn_4	287	293	PF01217	0.406
TRG_DiLeu_LyEn_5	437	442	PF01217	0.567
TRG_ENDOCYTIC_2	142	145	PF00928	0.524
TRG_ENDOCYTIC_2	365	368	PF00928	0.395
TRG_ER_diArg_1	171	173	PF00400	0.555
TRG_ER_diArg_1	25	28	PF00400	0.510
TRG_ER_diArg_1	250	252	PF00400	0.524
TRG_ER_diArg_1	39	41	PF00400	0.508
TRG_ER_diArg_1	527	529	PF00400	0.400
TRG_NLS_MonoExtC_3	523	528	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.524
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.540
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	607	612	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P501	Leptomonas seymouri	63%	86%
A0A0S4JJK2	Bodo saltans	35%	89%
A0A1X0NRY5	Trypanosomatidae	43%	99%
A0A3S5H7T3	Leishmania donovani	81%	100%
A4I8I8	Leishmania infantum	81%	100%
D0AAM9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E9B3E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4Q2	Leishmania major	80%	100%
V5BLC8	Trypanosoma cruzi	41%	98%