Putative 3-hydroxyisobutyryl-coenzyme A hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

enoyl-CoA hydratase/isomerase family protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HL06_LEIBR

TriTrypDb:

LbrM.32.3920 , LBRM2903_320048600

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL06

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006573	valine metabolic process	5	1
GO:0006574	valine catabolic process	6	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009063	amino acid catabolic process	4	1
GO:0009081	branched-chain amino acid metabolic process	4	1
GO:0009083	branched-chain amino acid catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0016054	organic acid catabolic process	4	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046395	carboxylic acid catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1
GO:1901606	alpha-amino acid catabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	6	12
GO:0016289	CoA hydrolase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016790	thiolester hydrolase activity	4	12
GO:0016829	lyase activity	2	6
GO:0016853	isomerase activity	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.280
CLV_C14_Caspase3-7	344	348	PF00656	0.237
CLV_PCSK_KEX2_1	288	290	PF00082	0.320
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.444
CLV_PCSK_SKI1_1	198	202	PF00082	0.144
CLV_PCSK_SKI1_1	21	25	PF00082	0.294
CLV_PCSK_SKI1_1	216	220	PF00082	0.119
CLV_PCSK_SKI1_1	289	293	PF00082	0.261
CLV_PCSK_SKI1_1	321	325	PF00082	0.219
CLV_PCSK_SKI1_1	86	90	PF00082	0.299
DEG_Nend_UBRbox_1	1	4	PF02207	0.476
DOC_ANK_TNKS_1	156	163	PF00023	0.230
DOC_CKS1_1	217	222	PF01111	0.237
DOC_CKS1_1	293	298	PF01111	0.360
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.237
DOC_MAPK_DCC_7	157	165	PF00069	0.230
DOC_MAPK_gen_1	173	182	PF00069	0.283
DOC_MAPK_MEF2A_6	157	165	PF00069	0.230
DOC_MAPK_MEF2A_6	175	184	PF00069	0.145
DOC_PP2B_LxvP_1	136	139	PF13499	0.144
DOC_PP2B_LxvP_1	158	161	PF13499	0.348
DOC_USP7_MATH_1	200	204	PF00917	0.434
DOC_USP7_MATH_1	52	56	PF00917	0.263
DOC_USP7_MATH_1	6	10	PF00917	0.429
DOC_USP7_UBL2_3	288	292	PF12436	0.373
DOC_WW_Pin1_4	216	221	PF00397	0.237
DOC_WW_Pin1_4	273	278	PF00397	0.285
DOC_WW_Pin1_4	292	297	PF00397	0.360
DOC_WW_Pin1_4	77	82	PF00397	0.150
LIG_14-3-3_CanoR_1	128	136	PF00244	0.209
LIG_14-3-3_CanoR_1	157	161	PF00244	0.352
LIG_14-3-3_CanoR_1	21	26	PF00244	0.260
LIG_14-3-3_CanoR_1	351	360	PF00244	0.470
LIG_14-3-3_CanoR_1	44	50	PF00244	0.425
LIG_14-3-3_CanoR_1	7	13	PF00244	0.431
LIG_Actin_WH2_2	160	177	PF00022	0.226
LIG_APCC_ABBA_1	143	148	PF00400	0.219
LIG_eIF4E_1	17	23	PF01652	0.275
LIG_FHA_1	124	130	PF00498	0.144
LIG_FHA_1	184	190	PF00498	0.285
LIG_FHA_1	219	225	PF00498	0.389
LIG_FHA_1	241	247	PF00498	0.241
LIG_FHA_1	259	265	PF00498	0.364
LIG_FHA_1	279	285	PF00498	0.312
LIG_FHA_1	37	43	PF00498	0.448
LIG_FHA_1	97	103	PF00498	0.324
LIG_FHA_2	293	299	PF00498	0.407
LIG_FHA_2	335	341	PF00498	0.250
LIG_FHA_2	351	357	PF00498	0.386
LIG_LIR_Apic_2	152	156	PF02991	0.212
LIG_LIR_Apic_2	215	220	PF02991	0.237
LIG_LIR_Apic_2	347	352	PF02991	0.259
LIG_LIR_Gen_1	337	346	PF02991	0.202
LIG_LIR_Nem_3	232	236	PF02991	0.438
LIG_LIR_Nem_3	337	341	PF02991	0.175
LIG_SH2_CRK	166	170	PF00017	0.237
LIG_SH2_CRK	217	221	PF00017	0.237
LIG_SH2_NCK_1	217	221	PF00017	0.317
LIG_SH2_STAT5	113	116	PF00017	0.215
LIG_SH2_STAT5	239	242	PF00017	0.159
LIG_SH2_STAT5	304	307	PF00017	0.333
LIG_SH2_STAT5	349	352	PF00017	0.301
LIG_SH2_STAT5	46	49	PF00017	0.331
LIG_SH2_STAT5	57	60	PF00017	0.215
LIG_SH3_3	356	362	PF00018	0.295
LIG_SH3_3	44	50	PF00018	0.319
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.144
LIG_SUMO_SIM_par_1	247	253	PF11976	0.144
LIG_SUMO_SIM_par_1	280	285	PF11976	0.406
LIG_UBA3_1	22	29	PF00899	0.231
LIG_UBA3_1	248	256	PF00899	0.239
LIG_WRC_WIRS_1	272	277	PF05994	0.237
MOD_CK1_1	232	238	PF00069	0.237
MOD_CK2_1	292	298	PF00069	0.333
MOD_CK2_1	334	340	PF00069	0.341
MOD_GlcNHglycan	190	193	PF01048	0.353
MOD_GlcNHglycan	8	11	PF01048	0.394
MOD_GSK3_1	119	126	PF00069	0.144
MOD_GSK3_1	225	232	PF00069	0.304
MOD_GSK3_1	240	247	PF00069	0.185
MOD_GSK3_1	254	261	PF00069	0.282
MOD_GSK3_1	271	278	PF00069	0.214
MOD_GSK3_1	57	64	PF00069	0.376
MOD_LATS_1	19	25	PF00433	0.352
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	167	172	PF00069	0.285
MOD_NEK2_2	52	57	PF00069	0.231
MOD_PIKK_1	304	310	PF00454	0.345
MOD_PKA_2	1	7	PF00069	0.420
MOD_PKA_2	156	162	PF00069	0.352
MOD_PKA_2	350	356	PF00069	0.551
MOD_Plk_1	244	250	PF00069	0.214
MOD_Plk_4	149	155	PF00069	0.313
MOD_Plk_4	244	250	PF00069	0.224
MOD_Plk_4	52	58	PF00069	0.352
MOD_Plk_4	97	103	PF00069	0.340
MOD_ProDKin_1	216	222	PF00069	0.237
MOD_ProDKin_1	273	279	PF00069	0.285
MOD_ProDKin_1	292	298	PF00069	0.360
MOD_ProDKin_1	77	83	PF00069	0.150
MOD_SUMO_for_1	300	303	PF00179	0.144
MOD_SUMO_rev_2	191	200	PF00179	0.144
MOD_SUMO_rev_2	91	100	PF00179	0.233
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.207
TRG_DiLeu_BaLyEn_6	260	265	PF01217	0.144
TRG_ENDOCYTIC_2	166	169	PF00928	0.301
TRG_ENDOCYTIC_2	239	242	PF00928	0.365
TRG_NES_CRM1_1	241	253	PF08389	0.144
TRG_NES_CRM1_1	37	49	PF08389	0.144
TRG_Pf-PMV_PEXEL_1	321	326	PF00026	0.212
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.318

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P500	Leptomonas seymouri	39%	100%
A0A0N0P5E1	Leptomonas seymouri	65%	100%
A0A1X0NSC5	Trypanosomatidae	45%	100%
A0A1X0NTE8	Trypanosomatidae	47%	100%
A0A1X0NTM5	Trypanosomatidae	47%	100%
A0A381MRJ9	Leishmania infantum	38%	100%
A0A3Q8IDG7	Leishmania donovani	38%	100%
A0A3Q8IHF8	Leishmania donovani	83%	100%
A0A3Q8ITQ0	Leishmania donovani	38%	100%
A2VDC2	Xenopus laevis	41%	97%
A4HL04	Leishmania braziliensis	40%	100%
A4HL05	Leishmania braziliensis	38%	100%
A4I8I5	Leishmania infantum	38%	100%
A4I8I6	Leishmania infantum	83%	100%
D0AAN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E8NHQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9B3E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O74802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	87%
P28817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	75%
Q1PEY5	Arabidopsis thaliana	35%	99%
Q28FR6	Xenopus tropicalis	41%	97%
Q2HJ73	Bos taurus	38%	97%
Q4Q4Q4	Leishmania major	85%	100%
Q4Q4Q5	Leishmania major	38%	100%
Q4Q4Q6	Leishmania major	38%	100%
Q55GS6	Dictyostelium discoideum	33%	98%
Q58EB4	Danio rerio	38%	98%
Q5XF59	Arabidopsis thaliana	35%	94%
Q5XIE6	Rattus norvegicus	38%	97%
Q5ZJ60	Gallus gallus	38%	97%
Q6NMB0	Arabidopsis thaliana	36%	99%
Q6NVY1	Homo sapiens	37%	97%
Q8QZS1	Mus musculus	38%	97%
Q8RXN4	Arabidopsis thaliana	32%	92%
Q9LK08	Arabidopsis thaliana	31%	90%
Q9LKJ1	Arabidopsis thaliana	36%	99%
Q9SHJ8	Arabidopsis thaliana	32%	97%
Q9T0K7	Arabidopsis thaliana	33%	89%
V5BQZ7	Trypanosoma cruzi	44%	97%