3-hydroxyisobutyryl-coenzyme a hydrolase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

3-hydroxyisobutyryl-coenzyme a hydrolase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HL04_LEIBR

TriTrypDb:

LbrM.32.3900 , LBRM2903_320048400

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HL04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL04

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	3
GO:0006520	amino acid metabolic process	3	3
GO:0006573	valine metabolic process	5	3
GO:0006574	valine catabolic process	6	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009056	catabolic process	2	3
GO:0009063	amino acid catabolic process	4	3
GO:0009081	branched-chain amino acid metabolic process	4	3
GO:0009083	branched-chain amino acid catabolic process	5	3
GO:0009987	cellular process	1	3
GO:0016054	organic acid catabolic process	4	3
GO:0019752	carboxylic acid metabolic process	5	3
GO:0043436	oxoacid metabolic process	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0044248	cellular catabolic process	3	3
GO:0044281	small molecule metabolic process	2	3
GO:0044282	small molecule catabolic process	3	3
GO:0046395	carboxylic acid catabolic process	5	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3
GO:1901565	organonitrogen compound catabolic process	4	3
GO:1901575	organic substance catabolic process	3	3
GO:1901605	alpha-amino acid metabolic process	4	3
GO:1901606	alpha-amino acid catabolic process	5	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	22
GO:0003860	3-hydroxyisobutyryl-CoA hydrolase activity	6	22
GO:0016289	CoA hydrolase activity	5	22
GO:0016787	hydrolase activity	2	22
GO:0016788	hydrolase activity, acting on ester bonds	3	22
GO:0016790	thiolester hydrolase activity	4	22
GO:0016853	isomerase activity	2	8
GO:0016829	lyase activity	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	253	257	PF00656	0.269
CLV_C14_Caspase3-7	298	302	PF00656	0.181
CLV_NRD_NRD_1	106	108	PF00675	0.330
CLV_NRD_NRD_1	349	351	PF00675	0.370
CLV_NRD_NRD_1	67	69	PF00675	0.417
CLV_PCSK_KEX2_1	106	108	PF00082	0.330
CLV_PCSK_KEX2_1	289	291	PF00082	0.324
CLV_PCSK_KEX2_1	332	334	PF00082	0.442
CLV_PCSK_KEX2_1	67	69	PF00082	0.414
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.437
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.330
CLV_PCSK_PC7_1	63	69	PF00082	0.417
CLV_PCSK_SKI1_1	23	27	PF00082	0.302
CLV_PCSK_SKI1_1	77	81	PF00082	0.406
CLV_Separin_Metazoa	347	351	PF03568	0.185
DEG_Nend_UBRbox_1	1	4	PF02207	0.515
DOC_PP4_FxxP_1	139	142	PF00568	0.288
DOC_USP7_MATH_1	206	210	PF00917	0.446
DOC_USP7_MATH_1	309	313	PF00917	0.273
DOC_WW_Pin1_4	274	279	PF00397	0.293
DOC_WW_Pin1_4	7	12	PF00397	0.513
LIG_14-3-3_CanoR_1	106	113	PF00244	0.449
LIG_14-3-3_CanoR_1	2	11	PF00244	0.517
LIG_14-3-3_CanoR_1	218	227	PF00244	0.330
LIG_14-3-3_CanoR_1	23	28	PF00244	0.292
LIG_14-3-3_CanoR_1	290	299	PF00244	0.305
LIG_14-3-3_CanoR_1	46	52	PF00244	0.412
LIG_14-3-3_CanoR_1	67	71	PF00244	0.401
LIG_BRCT_BRCA1_1	154	158	PF00533	0.417
LIG_BRCT_BRCA1_1	311	315	PF00533	0.181
LIG_FHA_1	152	158	PF00498	0.417
LIG_FHA_1	187	193	PF00498	0.295
LIG_FHA_1	22	28	PF00498	0.341
LIG_FHA_1	280	286	PF00498	0.331
LIG_FHA_2	228	234	PF00498	0.368
LIG_FHA_2	78	84	PF00498	0.369
LIG_Integrin_RGD_1	304	306	PF01839	0.417
LIG_Integrin_RGD_1	63	65	PF01839	0.417
LIG_LIR_Apic_2	136	142	PF02991	0.402
LIG_LIR_Gen_1	155	166	PF02991	0.417
LIG_LIR_Gen_1	195	205	PF02991	0.193
LIG_LIR_Gen_1	306	315	PF02991	0.374
LIG_LIR_Nem_3	155	161	PF02991	0.384
LIG_LIR_Nem_3	189	194	PF02991	0.298
LIG_LIR_Nem_3	195	200	PF02991	0.256
LIG_LIR_Nem_3	306	310	PF02991	0.342
LIG_PDZ_Class_2	357	362	PF00595	0.467
LIG_PTB_Apo_2	85	92	PF02174	0.376
LIG_SH2_CRK	307	311	PF00017	0.369
LIG_SH2_NCK_1	307	311	PF00017	0.417
LIG_SH2_PTP2	191	194	PF00017	0.417
LIG_SH2_SRC	191	194	PF00017	0.291
LIG_SH2_STAT5	169	172	PF00017	0.291
LIG_SH2_STAT5	191	194	PF00017	0.276
LIG_SH2_STAT5	48	51	PF00017	0.333
LIG_SH2_STAT5	60	63	PF00017	0.234
LIG_SH3_3	221	227	PF00018	0.429
LIG_SUMO_SIM_anti_2	268	274	PF11976	0.364
LIG_SUMO_SIM_par_1	23	28	PF11976	0.417
LIG_SUMO_SIM_par_1	281	286	PF11976	0.412
LIG_TYR_ITSM	187	194	PF00017	0.330
LIG_WRC_WIRS_1	300	305	PF05994	0.330
MOD_CK1_1	125	131	PF00069	0.386
MOD_CK1_1	3	9	PF00069	0.620
MOD_CK2_1	227	233	PF00069	0.417
MOD_CK2_1	25	31	PF00069	0.222
MOD_CK2_1	337	343	PF00069	0.371
MOD_Cter_Amidation	65	68	PF01082	0.369
MOD_GlcNHglycan	119	122	PF01048	0.427
MOD_GlcNHglycan	2	5	PF01048	0.557
MOD_GlcNHglycan	220	223	PF01048	0.390
MOD_GlcNHglycan	233	236	PF01048	0.209
MOD_GlcNHglycan	267	270	PF01048	0.328
MOD_GSK3_1	14	21	PF00069	0.439
MOD_GSK3_1	152	159	PF00069	0.417
MOD_GSK3_1	227	234	PF00069	0.325
MOD_GSK3_1	25	32	PF00069	0.331
MOD_GSK3_1	290	297	PF00069	0.401
MOD_GSK3_1	3	10	PF00069	0.634
MOD_GSK3_1	97	104	PF00069	0.428
MOD_NEK2_1	105	110	PF00069	0.330
MOD_NEK2_1	170	175	PF00069	0.295
MOD_NEK2_1	231	236	PF00069	0.448
MOD_NEK2_1	265	270	PF00069	0.413
MOD_NEK2_1	279	284	PF00069	0.252
MOD_OFUCOSY	16	22	PF10250	0.363
MOD_PIKK_1	105	111	PF00454	0.338
MOD_PIKK_1	141	147	PF00454	0.333
MOD_PK_1	337	343	PF00069	0.181
MOD_PKA_2	105	111	PF00069	0.330
MOD_PKA_2	66	72	PF00069	0.417
MOD_Plk_1	134	140	PF00069	0.423
MOD_Plk_4	152	158	PF00069	0.318
MOD_Plk_4	295	301	PF00069	0.380
MOD_Plk_4	310	316	PF00069	0.250
MOD_ProDKin_1	274	280	PF00069	0.293
MOD_ProDKin_1	7	13	PF00069	0.496
MOD_SUMO_rev_2	69	79	PF00179	0.417
TRG_ENDOCYTIC_2	169	172	PF00928	0.308
TRG_ENDOCYTIC_2	191	194	PF00928	0.417
TRG_ENDOCYTIC_2	307	310	PF00928	0.369
TRG_ER_diArg_1	105	107	PF00400	0.330
TRG_NES_CRM1_1	318	331	PF08389	0.323
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.330

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P500	Leptomonas seymouri	66%	100%
A0A0N0P5E1	Leptomonas seymouri	36%	98%
A0A1X0NSC5	Trypanosomatidae	41%	99%
A0A1X0NTE8	Trypanosomatidae	42%	100%
A0A1X0NTM5	Trypanosomatidae	42%	100%
A0A381MRJ9	Leishmania infantum	87%	100%
A0A3Q8IDG7	Leishmania donovani	88%	100%
A0A3Q8IHF8	Leishmania donovani	39%	98%
A0A3Q8ITQ0	Leishmania donovani	87%	100%
A2VDC2	Xenopus laevis	34%	94%
A4HL05	Leishmania braziliensis	97%	99%
A4HL06	Leishmania braziliensis	40%	97%
A4I8I5	Leishmania infantum	88%	99%
A4I8I6	Leishmania infantum	39%	98%
C9ZLJ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0AAN2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
E9B3E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	98%
O74802	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	84%
P28817	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	72%
Q1PEY5	Arabidopsis thaliana	27%	96%
Q28FR6	Xenopus tropicalis	33%	94%
Q2HJ73	Bos taurus	34%	94%
Q4Q4Q4	Leishmania major	39%	100%
Q4Q4Q5	Leishmania major	88%	100%
Q4Q4Q6	Leishmania major	87%	100%
Q55GS6	Dictyostelium discoideum	31%	95%
Q58EB4	Danio rerio	32%	95%
Q5XF59	Arabidopsis thaliana	32%	90%
Q5XIE6	Rattus norvegicus	34%	94%
Q5ZJ60	Gallus gallus	33%	94%
Q6NMB0	Arabidopsis thaliana	26%	96%
Q6NVY1	Homo sapiens	32%	94%
Q8QZS1	Mus musculus	33%	94%
Q8RXN4	Arabidopsis thaliana	26%	89%
Q9LK08	Arabidopsis thaliana	29%	87%
Q9LKJ1	Arabidopsis thaliana	29%	96%
Q9SHJ8	Arabidopsis thaliana	28%	94%
Q9T0K7	Arabidopsis thaliana	28%	86%
V5BQZ7	Trypanosoma cruzi	40%	94%