Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL03_LEIBR

TriTrypDb:

LbrM.32.3890 , LBRM2903_320048300

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.433
CLV_NRD_NRD_1	12	14	PF00675	0.353
CLV_NRD_NRD_1	163	165	PF00675	0.359
CLV_NRD_NRD_1	199	201	PF00675	0.427
CLV_NRD_NRD_1	246	248	PF00675	0.344
CLV_NRD_NRD_1	342	344	PF00675	0.362
CLV_NRD_NRD_1	383	385	PF00675	0.656
CLV_NRD_NRD_1	4	6	PF00675	0.556
CLV_PCSK_KEX2_1	12	14	PF00082	0.361
CLV_PCSK_KEX2_1	163	165	PF00082	0.497
CLV_PCSK_KEX2_1	201	203	PF00082	0.433
CLV_PCSK_KEX2_1	212	214	PF00082	0.312
CLV_PCSK_KEX2_1	383	385	PF00082	0.597
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.433
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.312
CLV_PCSK_SKI1_1	402	406	PF00082	0.484
DEG_SCF_TRCP1_1	109	114	PF00400	0.270
DEG_SPOP_SBC_1	18	22	PF00917	0.437
DOC_CYCLIN_RxL_1	399	409	PF00134	0.468
DOC_MAPK_gen_1	247	253	PF00069	0.306
DOC_MAPK_gen_1	303	311	PF00069	0.285
DOC_PP4_FxxP_1	122	125	PF00568	0.415
DOC_USP7_MATH_1	151	155	PF00917	0.493
DOC_USP7_MATH_1	18	22	PF00917	0.274
DOC_USP7_MATH_1	232	236	PF00917	0.442
DOC_USP7_MATH_1	276	280	PF00917	0.561
DOC_USP7_MATH_1	284	288	PF00917	0.494
DOC_USP7_MATH_1	84	88	PF00917	0.351
DOC_WW_Pin1_4	271	276	PF00397	0.302
DOC_WW_Pin1_4	360	365	PF00397	0.477
DOC_WW_Pin1_4	372	377	PF00397	0.442
DOC_WW_Pin1_4	384	389	PF00397	0.663
DOC_WW_Pin1_4	52	57	PF00397	0.498
LIG_14-3-3_CanoR_1	101	105	PF00244	0.334
LIG_14-3-3_CanoR_1	12	18	PF00244	0.422
LIG_14-3-3_CanoR_1	258	268	PF00244	0.247
LIG_Actin_WH2_2	88	103	PF00022	0.378
LIG_deltaCOP1_diTrp_1	66	72	PF00928	0.300
LIG_FHA_1	178	184	PF00498	0.530
LIG_FHA_1	260	266	PF00498	0.437
LIG_FHA_1	294	300	PF00498	0.495
LIG_FHA_1	323	329	PF00498	0.317
LIG_FHA_1	333	339	PF00498	0.329
LIG_FHA_1	53	59	PF00498	0.575
LIG_FHA_2	157	163	PF00498	0.481
LIG_FHA_2	18	24	PF00498	0.261
LIG_LIR_Gen_1	267	276	PF02991	0.396
LIG_LIR_Nem_3	226	231	PF02991	0.398
LIG_LIR_Nem_3	267	271	PF02991	0.286
LIG_LIR_Nem_3	29	35	PF02991	0.438
LIG_LIR_Nem_3	66	72	PF02991	0.386
LIG_PDZ_Wminus1_1	423	425	PF00595	0.459
LIG_SH2_CRK	189	193	PF00017	0.402
LIG_SH2_NCK_1	138	142	PF00017	0.261
LIG_SH2_NCK_1	15	19	PF00017	0.424
LIG_SH2_NCK_1	189	193	PF00017	0.402
LIG_SH2_SRC	138	141	PF00017	0.268
LIG_SH2_SRC	370	373	PF00017	0.483
LIG_SH2_STAT5	228	231	PF00017	0.373
LIG_SH2_STAT5	32	35	PF00017	0.428
LIG_SH2_STAT5	38	41	PF00017	0.475
LIG_SH3_3	243	249	PF00018	0.456
LIG_SH3_3	55	61	PF00018	0.374
LIG_SUMO_SIM_anti_2	325	332	PF11976	0.402
LIG_SUMO_SIM_anti_2	411	417	PF11976	0.501
LIG_SUMO_SIM_par_1	269	274	PF11976	0.491
LIG_SUMO_SIM_par_1	334	340	PF11976	0.339
LIG_TRAF2_1	393	396	PF00917	0.672
LIG_TRAF2_2	89	94	PF00917	0.300
LIG_WW_3	375	379	PF00397	0.475
MOD_CDC14_SPxK_1	363	366	PF00782	0.482
MOD_CDC14_SPxK_1	375	378	PF00782	0.474
MOD_CDK_SPK_2	52	57	PF00069	0.371
MOD_CDK_SPxK_1	360	366	PF00069	0.481
MOD_CDK_SPxK_1	372	378	PF00069	0.445
MOD_CK1_1	279	285	PF00069	0.580
MOD_CK1_1	292	298	PF00069	0.497
MOD_CK1_1	339	345	PF00069	0.492
MOD_CK1_1	408	414	PF00069	0.410
MOD_CK1_1	41	47	PF00069	0.466
MOD_CK2_1	17	23	PF00069	0.478
MOD_CK2_1	217	223	PF00069	0.318
MOD_CK2_1	390	396	PF00069	0.605
MOD_CK2_1	403	409	PF00069	0.586
MOD_GlcNHglycan	109	112	PF01048	0.453
MOD_GlcNHglycan	15	18	PF01048	0.428
MOD_GlcNHglycan	169	172	PF01048	0.322
MOD_GlcNHglycan	219	222	PF01048	0.366
MOD_GlcNHglycan	278	281	PF01048	0.557
MOD_GlcNHglycan	325	328	PF01048	0.402
MOD_GlcNHglycan	405	408	PF01048	0.737
MOD_GlcNHglycan	43	46	PF01048	0.476
MOD_GSK3_1	100	107	PF00069	0.201
MOD_GSK3_1	13	20	PF00069	0.550
MOD_GSK3_1	232	239	PF00069	0.507
MOD_GSK3_1	24	31	PF00069	0.419
MOD_GSK3_1	289	296	PF00069	0.376
MOD_GSK3_1	314	321	PF00069	0.435
MOD_GSK3_1	332	339	PF00069	0.352
MOD_GSK3_1	390	397	PF00069	0.652
MOD_GSK3_1	80	87	PF00069	0.322
MOD_N-GLC_1	107	112	PF02516	0.485
MOD_NEK2_1	100	105	PF00069	0.389
MOD_NEK2_1	290	295	PF00069	0.410
MOD_NEK2_1	36	41	PF00069	0.405
MOD_PIKK_1	139	145	PF00454	0.448
MOD_PIKK_1	151	157	PF00454	0.437
MOD_PIKK_1	232	238	PF00454	0.437
MOD_PIKK_1	259	265	PF00454	0.263
MOD_PIKK_1	84	90	PF00454	0.399
MOD_PKA_1	73	79	PF00069	0.444
MOD_PKA_2	100	106	PF00069	0.336
MOD_PKA_2	162	168	PF00069	0.462
MOD_Plk_1	139	145	PF00069	0.403
MOD_Plk_1	28	34	PF00069	0.350
MOD_Plk_1	314	320	PF00069	0.315
MOD_Plk_4	28	34	PF00069	0.448
MOD_Plk_4	332	338	PF00069	0.355
MOD_Plk_4	346	352	PF00069	0.572
MOD_ProDKin_1	271	277	PF00069	0.305
MOD_ProDKin_1	360	366	PF00069	0.481
MOD_ProDKin_1	372	378	PF00069	0.445
MOD_ProDKin_1	384	390	PF00069	0.662
MOD_ProDKin_1	52	58	PF00069	0.480
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.254
TRG_ENDOCYTIC_2	32	35	PF00928	0.214
TRG_ER_diArg_1	11	13	PF00400	0.364
TRG_ER_diArg_1	383	386	PF00400	0.771
TRG_NLS_MonoExtC_3	199	204	PF00514	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I9	Leptomonas seymouri	53%	100%
A0A1X0NRZ3	Trypanosomatidae	33%	100%
A0A3Q8IGJ4	Leishmania donovani	78%	100%
A0A422P320	Trypanosoma rangeli	38%	100%
A4I8I3	Leishmania infantum	78%	100%
D0AAN3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B3E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q4Q8	Leishmania major	78%	100%
Q60525	Mesocricetus auratus	26%	79%
Q6NL34	Drosophila melanogaster	27%	78%
V5DMD9	Trypanosoma cruzi	36%	100%