Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL02_LEIBR

TriTrypDb:

LbrM.32.3880 , LBRM2903_320048200

Length:

320

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.473
CLV_C14_Caspase3-7	57	61	PF00656	0.684
CLV_PCSK_SKI1_1	300	304	PF00082	0.431
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.567
DOC_CYCLIN_yCln2_LP_2	303	309	PF00134	0.707
DOC_MAPK_gen_1	217	225	PF00069	0.562
DOC_PP2B_LxvP_1	102	105	PF13499	0.816
DOC_PP2B_LxvP_1	303	306	PF13499	0.685
DOC_PP4_MxPP_1	86	89	PF00568	0.562
DOC_USP7_MATH_1	129	133	PF00917	0.565
DOC_USP7_MATH_1	172	176	PF00917	0.714
DOC_USP7_MATH_1	257	261	PF00917	0.625
DOC_USP7_MATH_1	278	282	PF00917	0.628
DOC_USP7_MATH_1	307	311	PF00917	0.512
DOC_USP7_MATH_1	314	318	PF00917	0.663
DOC_USP7_MATH_1	42	46	PF00917	0.537
DOC_USP7_MATH_1	53	57	PF00917	0.693
DOC_USP7_MATH_1	61	65	PF00917	0.617
DOC_USP7_MATH_1	66	70	PF00917	0.541
DOC_USP7_MATH_1	75	79	PF00917	0.708
DOC_USP7_MATH_1	8	12	PF00917	0.796
DOC_USP7_MATH_1	97	101	PF00917	0.751
DOC_USP7_MATH_2	89	95	PF00917	0.763
DOC_WW_Pin1_4	120	125	PF00397	0.782
DOC_WW_Pin1_4	14	19	PF00397	0.705
DOC_WW_Pin1_4	209	214	PF00397	0.459
LIG_14-3-3_CanoR_1	217	225	PF00244	0.562
LIG_14-3-3_CanoR_1	231	240	PF00244	0.621
LIG_14-3-3_CanoR_1	29	37	PF00244	0.630
LIG_14-3-3_CanoR_1	300	306	PF00244	0.416
LIG_14-3-3_CterR_2	316	320	PF00244	0.538
LIG_Actin_WH2_2	254	270	PF00022	0.544
LIG_BRCT_BRCA1_1	174	178	PF00533	0.459
LIG_CaM_IQ_9	238	253	PF13499	0.529
LIG_CSL_BTD_1	210	213	PF09270	0.596
LIG_EH1_1	136	144	PF00400	0.609
LIG_FHA_1	185	191	PF00498	0.417
LIG_FHA_1	75	81	PF00498	0.575
LIG_FHA_2	101	107	PF00498	0.586
LIG_FHA_2	71	77	PF00498	0.575
LIG_GBD_Chelix_1	295	303	PF00786	0.659
LIG_IBAR_NPY_1	38	40	PF08397	0.510
LIG_LIR_Gen_1	212	223	PF02991	0.436
LIG_LIR_Nem_3	212	218	PF02991	0.523
LIG_Pex14_1	211	215	PF04695	0.585
LIG_SH2_CRK	215	219	PF00017	0.565
LIG_SH2_STAP1	43	47	PF00017	0.713
LIG_SH2_STAT3	239	242	PF00017	0.523
LIG_SH2_STAT5	224	227	PF00017	0.652
LIG_SH2_STAT5	239	242	PF00017	0.424
LIG_SH3_3	111	117	PF00018	0.614
LIG_SH3_3	12	18	PF00018	0.625
LIG_SH3_3	207	213	PF00018	0.696
LIG_TRAF2_1	118	121	PF00917	0.573
LIG_TRAF2_1	147	150	PF00917	0.462
LIG_TRAF2_1	88	91	PF00917	0.777
MOD_CK1_1	100	106	PF00069	0.708
MOD_CK1_1	11	17	PF00069	0.815
MOD_CK1_1	234	240	PF00069	0.521
MOD_CK2_1	100	106	PF00069	0.584
MOD_CK2_1	38	44	PF00069	0.606
MOD_CK2_1	70	76	PF00069	0.798
MOD_GlcNHglycan	131	134	PF01048	0.555
MOD_GlcNHglycan	18	21	PF01048	0.549
MOD_GlcNHglycan	2	5	PF01048	0.715
MOD_GlcNHglycan	233	236	PF01048	0.517
MOD_GlcNHglycan	303	306	PF01048	0.632
MOD_GlcNHglycan	40	43	PF01048	0.597
MOD_GlcNHglycan	63	66	PF01048	0.727
MOD_GlcNHglycan	76	80	PF01048	0.713
MOD_GlcNHglycan	8	11	PF01048	0.679
MOD_GlcNHglycan	82	85	PF01048	0.687
MOD_GlcNHglycan	95	98	PF01048	0.503
MOD_GlcNHglycan	99	102	PF01048	0.646
MOD_GSK3_1	14	21	PF00069	0.614
MOD_GSK3_1	209	216	PF00069	0.570
MOD_GSK3_1	223	230	PF00069	0.586
MOD_GSK3_1	38	45	PF00069	0.452
MOD_GSK3_1	61	68	PF00069	0.681
MOD_GSK3_1	70	77	PF00069	0.816
MOD_GSK3_1	93	100	PF00069	0.669
MOD_LATS_1	169	175	PF00433	0.523
MOD_N-GLC_1	106	111	PF02516	0.571
MOD_N-GLC_1	70	75	PF02516	0.793
MOD_NEK2_1	218	223	PF00069	0.565
MOD_NEK2_1	80	85	PF00069	0.639
MOD_PIKK_1	106	112	PF00454	0.573
MOD_PIKK_1	307	313	PF00454	0.754
MOD_PIKK_1	8	14	PF00454	0.695
MOD_PKA_2	245	251	PF00069	0.530
MOD_PKA_2	28	34	PF00069	0.642
MOD_Plk_1	106	112	PF00069	0.690
MOD_Plk_1	59	65	PF00069	0.565
MOD_Plk_1	97	103	PF00069	0.691
MOD_Plk_4	234	240	PF00069	0.621
MOD_ProDKin_1	120	126	PF00069	0.781
MOD_ProDKin_1	14	20	PF00069	0.705
MOD_ProDKin_1	209	215	PF00069	0.454
MOD_SUMO_rev_2	174	184	PF00179	0.693
MOD_SUMO_rev_2	221	230	PF00179	0.649
TRG_DiLeu_BaEn_1	291	296	PF01217	0.482
TRG_ENDOCYTIC_2	215	218	PF00928	0.522
TRG_ER_diArg_1	270	273	PF00400	0.652
TRG_ER_diArg_1	47	50	PF00400	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK58	Leptomonas seymouri	41%	71%
A0A3Q8IJP5	Leishmania donovani	69%	73%
E9AHM4	Leishmania infantum	70%	86%
E9B3E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q4Q9	Leishmania major	70%	99%