PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HL01_LEIBR

TriTrypDb:

LbrM.32.3870 , LBRM2903_320048100

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HL01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HL01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	163	165	PF00675	0.342
CLV_NRD_NRD_1	7	9	PF00675	0.385
CLV_PCSK_KEX2_1	163	165	PF00082	0.342
CLV_PCSK_KEX2_1	7	9	PF00082	0.385
CLV_PCSK_PC7_1	159	165	PF00082	0.338
CLV_PCSK_SKI1_1	2	6	PF00082	0.399
CLV_PCSK_SKI1_1	238	242	PF00082	0.405
DEG_Nend_UBRbox_1	1	4	PF02207	0.402
DEG_SPOP_SBC_1	123	127	PF00917	0.332
DEG_SPOP_SBC_1	55	59	PF00917	0.536
DOC_CKS1_1	213	218	PF01111	0.448
DOC_MAPK_gen_1	7	14	PF00069	0.470
DOC_MAPK_MEF2A_6	115	122	PF00069	0.332
DOC_PP2B_LxvP_1	192	195	PF13499	0.436
DOC_USP7_MATH_1	55	59	PF00917	0.801
DOC_USP7_MATH_1	92	96	PF00917	0.686
DOC_WW_Pin1_4	212	217	PF00397	0.556
DOC_WW_Pin1_4	226	231	PF00397	0.371
DOC_WW_Pin1_4	84	89	PF00397	0.679
DOC_WW_Pin1_4	90	95	PF00397	0.709
DOC_WW_Pin1_4	99	104	PF00397	0.551
LIG_14-3-3_CanoR_1	124	129	PF00244	0.453
LIG_BRCT_BRCA1_1	125	129	PF00533	0.493
LIG_BRCT_BRCA1_1	132	136	PF00533	0.362
LIG_CaM_IQ_9	13	28	PF13499	0.389
LIG_DLG_GKlike_1	124	132	PF00625	0.354
LIG_FHA_1	239	245	PF00498	0.347
LIG_FHA_2	111	117	PF00498	0.489
LIG_FHA_2	14	20	PF00498	0.385
LIG_FHA_2	250	256	PF00498	0.418
LIG_FHA_2	84	90	PF00498	0.681
LIG_LIR_Apic_2	212	216	PF02991	0.559
LIG_LIR_Apic_2	245	250	PF02991	0.437
LIG_LIR_Gen_1	234	244	PF02991	0.355
LIG_LIR_Nem_3	126	132	PF02991	0.601
LIG_LIR_Nem_3	205	211	PF02991	0.359
LIG_LIR_Nem_3	234	239	PF02991	0.355
LIG_LIR_Nem_3	241	246	PF02991	0.341
LIG_Pex14_1	172	176	PF04695	0.491
LIG_RPA_C_Fungi	3	15	PF08784	0.375
LIG_SH2_PTP2	140	143	PF00017	0.400
LIG_SH2_PTP2	243	246	PF00017	0.444
LIG_SH2_STAP1	152	156	PF00017	0.443
LIG_SH2_STAT5	140	143	PF00017	0.400
LIG_SH2_STAT5	152	155	PF00017	0.528
LIG_SH2_STAT5	208	211	PF00017	0.357
LIG_SH2_STAT5	214	217	PF00017	0.415
LIG_SH2_STAT5	243	246	PF00017	0.393
LIG_SH2_STAT5	247	250	PF00017	0.445
LIG_SH3_1	159	165	PF00018	0.494
LIG_SH3_3	103	109	PF00018	0.681
LIG_SH3_3	159	165	PF00018	0.477
LIG_SH3_3	185	191	PF00018	0.354
LIG_SUMO_SIM_par_1	190	197	PF11976	0.396
LIG_TRAF2_1	15	18	PF00917	0.509
MOD_CDC14_SPxK_1	87	90	PF00782	0.639
MOD_CDK_SPxK_1	84	90	PF00069	0.645
MOD_CDK_SPxxK_3	226	233	PF00069	0.464
MOD_CK1_1	110	116	PF00069	0.338
MOD_CK1_1	150	156	PF00069	0.395
MOD_CK1_1	178	184	PF00069	0.418
MOD_CK1_1	76	82	PF00069	0.619
MOD_CK1_1	95	101	PF00069	0.547
MOD_CK2_1	110	116	PF00069	0.623
MOD_CK2_1	13	19	PF00069	0.528
MOD_CK2_1	151	157	PF00069	0.468
MOD_CK2_1	226	232	PF00069	0.340
MOD_CK2_1	249	255	PF00069	0.404
MOD_GlcNHglycan	109	112	PF01048	0.418
MOD_GlcNHglycan	132	135	PF01048	0.495
MOD_GlcNHglycan	145	148	PF01048	0.478
MOD_GlcNHglycan	270	273	PF01048	0.622
MOD_GlcNHglycan	58	61	PF01048	0.777
MOD_GlcNHglycan	65	69	PF01048	0.732
MOD_GlcNHglycan	94	97	PF01048	0.749
MOD_GlcNHglycan	99	102	PF01048	0.747
MOD_GSK3_1	143	150	PF00069	0.409
MOD_GSK3_1	34	41	PF00069	0.573
MOD_GSK3_1	76	83	PF00069	0.649
MOD_GSK3_1	95	102	PF00069	0.535
MOD_N-GLC_1	73	78	PF02516	0.744
MOD_NEK2_1	122	127	PF00069	0.467
MOD_NEK2_1	225	230	PF00069	0.470
MOD_NEK2_1	268	273	PF00069	0.577
MOD_NEK2_1	27	32	PF00069	0.591
MOD_PIKK_1	13	19	PF00454	0.398
MOD_PKA_2	123	129	PF00069	0.565
MOD_PKA_2	178	184	PF00069	0.427
MOD_PKA_2	38	44	PF00069	0.549
MOD_Plk_1	73	79	PF00069	0.579
MOD_Plk_4	124	130	PF00069	0.557
MOD_Plk_4	132	138	PF00069	0.577
MOD_Plk_4	204	210	PF00069	0.377
MOD_ProDKin_1	212	218	PF00069	0.557
MOD_ProDKin_1	226	232	PF00069	0.367
MOD_ProDKin_1	84	90	PF00069	0.681
MOD_ProDKin_1	95	101	PF00069	0.630
TRG_DiLeu_BaEn_1	18	23	PF01217	0.603
TRG_DiLeu_BaEn_4	18	24	PF01217	0.559
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.356
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.263
TRG_DiLeu_LyEn_5	18	23	PF01217	0.519
TRG_ENDOCYTIC_2	140	143	PF00928	0.423
TRG_ENDOCYTIC_2	208	211	PF00928	0.348
TRG_ENDOCYTIC_2	243	246	PF00928	0.444
TRG_ER_diArg_1	162	164	PF00400	0.375
TRG_Pf-PMV_PEXEL_1	21	26	PF00026	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBT8	Leptomonas seymouri	56%	99%
A0A1X0NRX1	Trypanosomatidae	43%	100%
A0A3Q8IG98	Leishmania donovani	78%	100%
A0A3R7P3C4	Trypanosoma rangeli	49%	100%
A4I8I2	Leishmania infantum	78%	100%
E9B3E2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q4R0	Leishmania major	78%	100%