Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKZ9_LEIBR

TriTrypDb:

LbrM.32.3850 , LBRM2903_320047800

Length:

200

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.431
CLV_NRD_NRD_1	27	29	PF00675	0.389
CLV_NRD_NRD_1	59	61	PF00675	0.681
CLV_NRD_NRD_1	7	9	PF00675	0.693
CLV_PCSK_KEX2_1	27	29	PF00082	0.389
CLV_PCSK_KEX2_1	59	61	PF00082	0.675
CLV_PCSK_KEX2_1	7	9	PF00082	0.693
CLV_PCSK_SKI1_1	196	200	PF00082	0.626
CLV_PCSK_SKI1_1	38	42	PF00082	0.455
CLV_PCSK_SKI1_1	67	71	PF00082	0.488
CLV_Separin_Metazoa	106	110	PF03568	0.544
CLV_Separin_Metazoa	68	72	PF03568	0.521
DEG_APCC_DBOX_1	169	177	PF00400	0.549
DEG_APCC_DBOX_1	37	45	PF00400	0.402
DEG_APCC_DBOX_1	66	74	PF00400	0.527
DEG_Nend_UBRbox_3	1	3	PF02207	0.496
DOC_MAPK_gen_1	32	41	PF00069	0.627
DOC_MAPK_RevD_3	164	180	PF00069	0.398
DOC_USP7_MATH_1	133	137	PF00917	0.424
DOC_USP7_MATH_1	89	93	PF00917	0.590
DOC_WW_Pin1_4	156	161	PF00397	0.441
LIG_14-3-3_CanoR_1	170	174	PF00244	0.387
LIG_FHA_1	117	123	PF00498	0.350
LIG_FHA_1	32	38	PF00498	0.596
LIG_FHA_1	98	104	PF00498	0.528
LIG_FHA_2	59	65	PF00498	0.514
LIG_NRBOX	69	75	PF00104	0.533
LIG_PDZ_Class_2	195	200	PF00595	0.482
LIG_SH2_STAP1	118	122	PF00017	0.391
LIG_SH2_STAT5	118	121	PF00017	0.391
LIG_SH2_STAT5	168	171	PF00017	0.401
LIG_SH2_STAT5	22	25	PF00017	0.640
LIG_SH3_3	154	160	PF00018	0.537
LIG_SUMO_SIM_par_1	158	165	PF11976	0.422
LIG_TRAF2_1	40	43	PF00917	0.500
LIG_TRAF2_1	61	64	PF00917	0.441
MOD_CK1_1	136	142	PF00069	0.441
MOD_CK1_1	9	15	PF00069	0.554
MOD_CK2_1	156	162	PF00069	0.567
MOD_CK2_1	168	174	PF00069	0.550
MOD_CK2_1	58	64	PF00069	0.597
MOD_GlcNHglycan	142	146	PF01048	0.589
MOD_GlcNHglycan	91	94	PF01048	0.751
MOD_GSK3_1	136	143	PF00069	0.443
MOD_GSK3_1	190	197	PF00069	0.526
MOD_GSK3_1	80	87	PF00069	0.539
MOD_GSK3_1	9	16	PF00069	0.549
MOD_N-GLC_1	1	6	PF02516	0.532
MOD_NEK2_1	1	6	PF00069	0.490
MOD_PIKK_1	116	122	PF00454	0.488
MOD_PKA_2	169	175	PF00069	0.389
MOD_PKA_2	31	37	PF00069	0.467
MOD_PKA_2	58	64	PF00069	0.393
MOD_PKA_2	6	12	PF00069	0.562
MOD_PKA_2	84	90	PF00069	0.546
MOD_Plk_1	1	7	PF00069	0.491
MOD_Plk_1	133	139	PF00069	0.428
MOD_Plk_4	1	7	PF00069	0.491
MOD_Plk_4	99	105	PF00069	0.402
MOD_ProDKin_1	156	162	PF00069	0.440
MOD_SUMO_rev_2	174	181	PF00179	0.486
TRG_ER_diArg_1	6	8	PF00400	0.698
TRG_NES_CRM1_1	68	82	PF08389	0.547
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVP8	Leptomonas seymouri	31%	97%
A0A3Q8ILP4	Leishmania donovani	62%	100%
A4I8I0	Leishmania infantum	62%	100%
E9B3E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4Q4R2	Leishmania major	64%	100%