Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKZ7_LEIBR

TriTrypDb:

LbrM.32.3830 , LBRM2903_320047500

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.633
CLV_C14_Caspase3-7	348	352	PF00656	0.637
CLV_NRD_NRD_1	143	145	PF00675	0.538
CLV_NRD_NRD_1	442	444	PF00675	0.621
CLV_PCSK_KEX2_1	143	145	PF00082	0.590
CLV_PCSK_KEX2_1	151	153	PF00082	0.700
CLV_PCSK_KEX2_1	158	160	PF00082	0.530
CLV_PCSK_KEX2_1	442	444	PF00082	0.660
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.554
CLV_PCSK_PC1ET2_1	158	160	PF00082	0.561
CLV_PCSK_PC7_1	147	153	PF00082	0.538
CLV_PCSK_SKI1_1	225	229	PF00082	0.557
CLV_PCSK_SKI1_1	243	247	PF00082	0.479
CLV_PCSK_SKI1_1	309	313	PF00082	0.337
CLV_PCSK_SKI1_1	388	392	PF00082	0.378
CLV_PCSK_SKI1_1	479	483	PF00082	0.516
CLV_PCSK_SKI1_1	6	10	PF00082	0.649
CLV_Separin_Metazoa	93	97	PF03568	0.575
DEG_APCC_DBOX_1	242	250	PF00400	0.493
DEG_APCC_DBOX_1	478	486	PF00400	0.485
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DEG_SPOP_SBC_1	341	345	PF00917	0.577
DEG_SPOP_SBC_1	362	366	PF00917	0.621
DOC_CKS1_1	163	168	PF01111	0.532
DOC_CYCLIN_RxL_1	422	432	PF00134	0.616
DOC_CYCLIN_RxL_1	476	483	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	13	19	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.577
DOC_MAPK_gen_1	240	248	PF00069	0.567
DOC_MAPK_MEF2A_6	472	480	PF00069	0.556
DOC_PP2B_LxvP_1	106	109	PF13499	0.590
DOC_PP2B_LxvP_1	124	127	PF13499	0.310
DOC_PP2B_LxvP_1	13	16	PF13499	0.511
DOC_PP2B_LxvP_1	198	201	PF13499	0.514
DOC_PP2B_LxvP_1	531	534	PF13499	0.636
DOC_PP4_FxxP_1	163	166	PF00568	0.525
DOC_PP4_FxxP_1	233	236	PF00568	0.549
DOC_PP4_FxxP_1	301	304	PF00568	0.493
DOC_USP7_MATH_1	135	139	PF00917	0.613
DOC_USP7_MATH_1	253	257	PF00917	0.455
DOC_USP7_MATH_1	281	285	PF00917	0.306
DOC_USP7_MATH_1	341	345	PF00917	0.572
DOC_USP7_MATH_1	349	353	PF00917	0.695
DOC_USP7_MATH_1	363	367	PF00917	0.668
DOC_USP7_MATH_1	451	455	PF00917	0.641
DOC_USP7_MATH_1	466	470	PF00917	0.799
DOC_USP7_MATH_1	520	524	PF00917	0.599
DOC_USP7_MATH_1	53	57	PF00917	0.691
DOC_USP7_MATH_1	65	69	PF00917	0.705
DOC_USP7_UBL2_3	276	280	PF12436	0.355
DOC_WW_Pin1_4	157	162	PF00397	0.522
DOC_WW_Pin1_4	300	305	PF00397	0.371
DOC_WW_Pin1_4	390	395	PF00397	0.675
DOC_WW_Pin1_4	431	436	PF00397	0.513
DOC_WW_Pin1_4	46	51	PF00397	0.590
DOC_WW_Pin1_4	472	477	PF00397	0.667
DOC_WW_Pin1_4	480	485	PF00397	0.577
DOC_WW_Pin1_4	503	508	PF00397	0.532
DOC_WW_Pin1_4	555	560	PF00397	0.549
DOC_WW_Pin1_4	61	66	PF00397	0.689
DOC_WW_Pin1_4	87	92	PF00397	0.555
LIG_14-3-3_CanoR_1	143	147	PF00244	0.413
LIG_14-3-3_CanoR_1	220	225	PF00244	0.575
LIG_14-3-3_CanoR_1	342	350	PF00244	0.581
LIG_14-3-3_CanoR_1	472	476	PF00244	0.627
LIG_Actin_WH2_2	376	393	PF00022	0.391
LIG_AP2alpha_2	231	233	PF02296	0.558
LIG_APCC_ABBA_1	164	169	PF00400	0.531
LIG_BRCT_BRCA1_1	159	163	PF00533	0.527
LIG_BRCT_BRCA1_1	255	259	PF00533	0.471
LIG_Clathr_ClatBox_1	189	193	PF01394	0.514
LIG_eIF4E_1	287	293	PF01652	0.318
LIG_FHA_1	195	201	PF00498	0.586
LIG_FHA_1	2	8	PF00498	0.660
LIG_FHA_1	318	324	PF00498	0.384
LIG_FHA_1	424	430	PF00498	0.541
LIG_FHA_2	143	149	PF00498	0.489
LIG_FHA_2	151	157	PF00498	0.591
LIG_FHA_2	163	169	PF00498	0.524
LIG_FHA_2	314	320	PF00498	0.506
LIG_FHA_2	346	352	PF00498	0.636
LIG_FHA_2	373	379	PF00498	0.515
LIG_FHA_2	513	519	PF00498	0.568
LIG_FHA_2	556	562	PF00498	0.559
LIG_FHA_2	74	80	PF00498	0.652
LIG_FHA_2	83	89	PF00498	0.432
LIG_LIR_Apic_2	160	166	PF02991	0.524
LIG_LIR_Apic_2	231	236	PF02991	0.420
LIG_LIR_Apic_2	247	253	PF02991	0.438
LIG_LIR_Apic_2	284	290	PF02991	0.526
LIG_LIR_Apic_2	300	304	PF02991	0.479
LIG_LIR_Gen_1	22	33	PF02991	0.485
LIG_LIR_Nem_3	137	142	PF02991	0.600
LIG_LIR_Nem_3	22	28	PF02991	0.504
LIG_MAD2	6	14	PF02301	0.669
LIG_NRBOX	292	298	PF00104	0.550
LIG_Pex14_2	163	167	PF04695	0.530
LIG_REV1ctd_RIR_1	224	231	PF16727	0.461
LIG_SH2_CRK	250	254	PF00017	0.485
LIG_SH2_CRK	279	283	PF00017	0.491
LIG_SH2_GRB2like	334	337	PF00017	0.433
LIG_SH2_SRC	334	337	PF00017	0.433
LIG_SH2_SRC	413	416	PF00017	0.567
LIG_SH2_STAP1	17	21	PF00017	0.481
LIG_SH2_STAP1	54	58	PF00017	0.519
LIG_SH2_STAT5	25	28	PF00017	0.546
LIG_SH2_STAT5	33	36	PF00017	0.393
LIG_SH2_STAT5	334	337	PF00017	0.681
LIG_SH2_STAT5	413	416	PF00017	0.567
LIG_SH3_3	42	48	PF00018	0.425
LIG_SH3_3	504	510	PF00018	0.660
LIG_SH3_3	67	73	PF00018	0.768
LIG_SH3_3	94	100	PF00018	0.578
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.557
LIG_SUMO_SIM_anti_2	36	41	PF11976	0.534
LIG_SUMO_SIM_par_1	188	197	PF11976	0.514
LIG_SUMO_SIM_par_1	85	90	PF11976	0.395
LIG_TRAF2_1	120	123	PF00917	0.612
LIG_TRAF2_1	154	157	PF00917	0.644
LIG_TRAF2_1	558	561	PF00917	0.440
LIG_UBA3_1	513	519	PF00899	0.618
LIG_WRC_WIRS_1	136	141	PF05994	0.613
LIG_WW_1	14	17	PF00397	0.399
MOD_CDC14_SPxK_1	506	509	PF00782	0.479
MOD_CDK_SPK_2	503	508	PF00069	0.591
MOD_CDK_SPK_2	87	92	PF00069	0.332
MOD_CDK_SPxK_1	503	509	PF00069	0.462
MOD_CDK_SPxxK_3	472	479	PF00069	0.525
MOD_CK1_1	172	178	PF00069	0.608
MOD_CK1_1	300	306	PF00069	0.305
MOD_CK1_1	446	452	PF00069	0.711
MOD_CK1_1	512	518	PF00069	0.619
MOD_CK1_1	523	529	PF00069	0.416
MOD_CK1_1	64	70	PF00069	0.683
MOD_CK1_1	82	88	PF00069	0.377
MOD_CK2_1	142	148	PF00069	0.483
MOD_CK2_1	150	156	PF00069	0.580
MOD_CK2_1	313	319	PF00069	0.492
MOD_CK2_1	371	377	PF00069	0.415
MOD_CK2_1	512	518	PF00069	0.619
MOD_CK2_1	555	561	PF00069	0.559
MOD_CK2_1	82	88	PF00069	0.551
MOD_CMANNOS	307	310	PF00535	0.423
MOD_DYRK1A_RPxSP_1	61	65	PF00069	0.780
MOD_GlcNHglycan	139	142	PF01048	0.390
MOD_GlcNHglycan	177	181	PF01048	0.641
MOD_GlcNHglycan	358	361	PF01048	0.731
MOD_GlcNHglycan	451	454	PF01048	0.630
MOD_GlcNHglycan	468	471	PF01048	0.751
MOD_GlcNHglycan	531	534	PF01048	0.643
MOD_GlcNHglycan	81	84	PF01048	0.513
MOD_GSK3_1	169	176	PF00069	0.784
MOD_GSK3_1	29	36	PF00069	0.554
MOD_GSK3_1	309	316	PF00069	0.472
MOD_GSK3_1	341	348	PF00069	0.632
MOD_GSK3_1	466	473	PF00069	0.787
MOD_GSK3_1	519	526	PF00069	0.348
MOD_GSK3_1	61	68	PF00069	0.675
MOD_GSK3_1	75	82	PF00069	0.528
MOD_LATS_1	340	346	PF00433	0.505
MOD_N-GLC_1	183	188	PF02516	0.564
MOD_NEK2_1	1	6	PF00069	0.614
MOD_NEK2_1	142	147	PF00069	0.457
MOD_NEK2_1	370	375	PF00069	0.570
MOD_NEK2_1	423	428	PF00069	0.538
MOD_NEK2_1	429	434	PF00069	0.573
MOD_PIKK_1	446	452	PF00454	0.548
MOD_PKA_2	142	148	PF00069	0.489
MOD_PKA_2	219	225	PF00069	0.580
MOD_PKA_2	341	347	PF00069	0.710
MOD_PKA_2	471	477	PF00069	0.525
MOD_Plk_1	193	199	PF00069	0.614
MOD_Plk_1	203	209	PF00069	0.651
MOD_Plk_1	318	324	PF00069	0.361
MOD_Plk_1	371	377	PF00069	0.349
MOD_Plk_1	65	71	PF00069	0.691
MOD_Plk_2-3	372	378	PF00069	0.597
MOD_Plk_4	159	165	PF00069	0.528
MOD_Plk_4	29	35	PF00069	0.490
MOD_Plk_4	318	324	PF00069	0.400
MOD_Plk_4	509	515	PF00069	0.637
MOD_Plk_4	82	88	PF00069	0.554
MOD_ProDKin_1	157	163	PF00069	0.524
MOD_ProDKin_1	300	306	PF00069	0.367
MOD_ProDKin_1	390	396	PF00069	0.688
MOD_ProDKin_1	431	437	PF00069	0.515
MOD_ProDKin_1	46	52	PF00069	0.595
MOD_ProDKin_1	472	478	PF00069	0.665
MOD_ProDKin_1	480	486	PF00069	0.566
MOD_ProDKin_1	503	509	PF00069	0.536
MOD_ProDKin_1	555	561	PF00069	0.559
MOD_ProDKin_1	61	67	PF00069	0.690
MOD_ProDKin_1	87	93	PF00069	0.553
MOD_SUMO_rev_2	148	153	PF00179	0.444
TRG_DiLeu_BaEn_1	244	249	PF01217	0.559
TRG_DiLeu_BaEn_1	381	386	PF01217	0.332
TRG_DiLeu_BaEn_2	254	260	PF01217	0.464
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.311
TRG_DiLeu_BaLyEn_6	476	481	PF01217	0.676
TRG_ENDOCYTIC_2	25	28	PF00928	0.546
TRG_ENDOCYTIC_2	279	282	PF00928	0.494
TRG_ENDOCYTIC_2	308	311	PF00928	0.423
TRG_ER_diArg_1	142	144	PF00400	0.599
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2P3	Leptomonas seymouri	38%	100%
A0A0S4JT50	Bodo saltans	23%	100%
A0A3Q8IFU0	Leishmania donovani	72%	100%
A4I8H7	Leishmania infantum	72%	100%
E9B3D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q4R5	Leishmania major	70%	100%