LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Robl_LC7 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Robl_LC7 domain-containing protein
Gene product:
Roadblock/LC7 domain containing protein, putative
Species:
Leishmania braziliensis
UniProt:
A4HKZ6_LEIBR
TriTrypDb:
LbrM.32.3820 , LBRM2903_320047400 *
Length:
126

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 9
GO:0005868 cytoplasmic dynein complex 4 9
GO:0005874 microtubule 6 9
GO:0005875 microtubule associated complex 2 9
GO:0030286 dynein complex 3 9
GO:0032991 protein-containing complex 1 9
GO:0099080 supramolecular complex 2 9
GO:0099081 supramolecular polymer 3 9
GO:0099512 supramolecular fiber 4 9
GO:0099513 polymeric cytoskeletal fiber 5 9
GO:0110165 cellular anatomical entity 1 9
GO:1902494 catalytic complex 2 9

Expansion

Sequence features

A4HKZ6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ6

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 9
GO:0007018 microtubule-based movement 3 9
GO:0009987 cellular process 1 9
Molecular functions
Term Name Level Count
GO:0005488 binding 1 9
GO:0005515 protein binding 2 9
GO:0045505 dynein intermediate chain binding 3 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 102 106 PF00082 0.441
CLV_PCSK_SKI1_1 17 21 PF00082 0.309
DEG_APCC_DBOX_1 101 109 PF00400 0.461
DEG_SCF_FBW7_1 60 67 PF00400 0.192
DOC_CKS1_1 61 66 PF01111 0.192
DOC_CKS1_1 85 90 PF01111 0.382
DOC_CYCLIN_RxL_1 99 107 PF00134 0.466
DOC_MAPK_MEF2A_6 17 24 PF00069 0.387
DOC_USP7_MATH_1 64 68 PF00917 0.364
DOC_USP7_UBL2_3 77 81 PF12436 0.228
DOC_WW_Pin1_4 60 65 PF00397 0.218
DOC_WW_Pin1_4 84 89 PF00397 0.428
DOC_WW_Pin1_4 91 96 PF00397 0.329
LIG_14-3-3_CanoR_1 100 105 PF00244 0.416
LIG_14-3-3_CanoR_1 111 118 PF00244 0.397
LIG_BIR_II_1 1 5 PF00653 0.482
LIG_BRCT_BRCA1_1 112 116 PF00533 0.474
LIG_FHA_1 1 7 PF00498 0.544
LIG_FHA_1 14 20 PF00498 0.232
LIG_LIR_Gen_1 34 44 PF02991 0.255
LIG_LIR_Gen_1 46 55 PF02991 0.203
LIG_LIR_Nem_3 34 39 PF02991 0.255
LIG_SH2_STAP1 47 51 PF00017 0.292
LIG_SH2_STAT5 15 18 PF00017 0.295
LIG_SH3_3 118 124 PF00018 0.469
LIG_SH3_3 82 88 PF00018 0.362
LIG_SUMO_SIM_anti_2 93 100 PF11976 0.488
LIG_TRAF2_1 90 93 PF00917 0.597
MOD_CDK_SPxK_1 60 66 PF00069 0.192
MOD_CK2_1 91 97 PF00069 0.481
MOD_Cter_Amidation 79 82 PF01082 0.174
MOD_GlcNHglycan 73 76 PF01048 0.402
MOD_GSK3_1 39 46 PF00069 0.411
MOD_GSK3_1 60 67 PF00069 0.321
MOD_NEK2_1 39 44 PF00069 0.357
MOD_PKA_2 110 116 PF00069 0.396
MOD_PKA_2 32 38 PF00069 0.286
MOD_Plk_1 39 45 PF00069 0.301
MOD_ProDKin_1 60 66 PF00069 0.218
MOD_ProDKin_1 84 90 PF00069 0.424
MOD_ProDKin_1 91 97 PF00069 0.327
MOD_SUMO_for_1 76 79 PF00179 0.174
TRG_ENDOCYTIC_2 47 50 PF00928 0.292
TRG_ER_diArg_1 99 102 PF00400 0.384
TRG_Pf-PMV_PEXEL_1 102 107 PF00026 0.413
TRG_Pf-PMV_PEXEL_1 41 45 PF00026 0.339

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5D8 Leptomonas seymouri 71% 98%
A0A0N0P8V1 Leptomonas seymouri 25% 100%
A0A0S4JND4 Bodo saltans 36% 100%
A0A1X0P773 Trypanosomatidae 27% 100%
A0A3Q8IJQ7 Leishmania donovani 25% 100%
A0A422P0L4 Trypanosoma rangeli 28% 100%
A4H9K8 Leishmania braziliensis 25% 95%
A4HXX4 Leishmania infantum 25% 100%
C9ZZS8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0AAN8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
E9B3D6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 99%
V5B5T5 Trypanosoma cruzi 42% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS