Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HKZ5_LEIBR

TriTrypDb:

LbrM.32.3810 , LBRM2903_320047300

Length:

449

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.505
CLV_C14_Caspase3-7	373	377	PF00656	0.782
CLV_NRD_NRD_1	246	248	PF00675	0.719
CLV_NRD_NRD_1	273	275	PF00675	0.590
CLV_NRD_NRD_1	32	34	PF00675	0.542
CLV_NRD_NRD_1	342	344	PF00675	0.631
CLV_NRD_NRD_1	355	357	PF00675	0.748
CLV_NRD_NRD_1	370	372	PF00675	0.606
CLV_NRD_NRD_1	410	412	PF00675	0.802
CLV_PCSK_FUR_1	368	372	PF00082	0.585
CLV_PCSK_KEX2_1	246	248	PF00082	0.719
CLV_PCSK_KEX2_1	32	34	PF00082	0.542
CLV_PCSK_KEX2_1	342	344	PF00082	0.640
CLV_PCSK_KEX2_1	354	356	PF00082	0.754
CLV_PCSK_KEX2_1	368	370	PF00082	0.620
CLV_PCSK_KEX2_1	410	412	PF00082	0.783
CLV_PCSK_KEX2_1	419	421	PF00082	0.669
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.812
CLV_PCSK_SKI1_1	172	176	PF00082	0.632
CLV_PCSK_SKI1_1	44	48	PF00082	0.513
DEG_MDM2_SWIB_1	220	228	PF02201	0.693
DEG_Nend_Nbox_1	1	3	PF02207	0.768
DEG_SPOP_SBC_1	147	151	PF00917	0.487
DEG_SPOP_SBC_1	389	393	PF00917	0.624
DOC_CDC14_PxL_1	190	198	PF14671	0.536
DOC_CYCLIN_RxL_1	74	87	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.480
DOC_PP1_RVXF_1	42	49	PF00149	0.473
DOC_PP2B_LxvP_1	47	50	PF13499	0.489
DOC_USP7_MATH_1	101	105	PF00917	0.673
DOC_USP7_MATH_1	155	159	PF00917	0.618
DOC_USP7_MATH_1	192	196	PF00917	0.779
DOC_USP7_MATH_1	250	254	PF00917	0.570
DOC_USP7_MATH_1	317	321	PF00917	0.623
DOC_USP7_MATH_1	374	378	PF00917	0.719
DOC_USP7_MATH_1	389	393	PF00917	0.567
DOC_WW_Pin1_4	230	235	PF00397	0.513
DOC_WW_Pin1_4	315	320	PF00397	0.685
DOC_WW_Pin1_4	390	395	PF00397	0.793
LIG_14-3-3_CanoR_1	120	130	PF00244	0.609
LIG_14-3-3_CanoR_1	172	181	PF00244	0.461
LIG_14-3-3_CanoR_1	227	233	PF00244	0.476
LIG_14-3-3_CanoR_1	255	261	PF00244	0.552
LIG_14-3-3_CanoR_1	388	394	PF00244	0.594
LIG_14-3-3_CanoR_1	425	435	PF00244	0.657
LIG_14-3-3_CanoR_1	444	449	PF00244	0.707
LIG_Actin_WH2_2	156	174	PF00022	0.684
LIG_BRCT_BRCA1_1	157	161	PF00533	0.440
LIG_BRCT_BRCA1_1	58	62	PF00533	0.486
LIG_CSL_BTD_1	47	50	PF09270	0.489
LIG_FHA_1	125	131	PF00498	0.448
LIG_FHA_1	2	8	PF00498	0.517
LIG_FHA_1	316	322	PF00498	0.575
LIG_FHA_2	428	434	PF00498	0.558
LIG_FHA_2	92	98	PF00498	0.771
LIG_GBD_Chelix_1	206	214	PF00786	0.716
LIG_GBD_Chelix_1	53	61	PF00786	0.718
LIG_HP1_1	435	439	PF01393	0.520
LIG_LIR_Gen_1	175	186	PF02991	0.476
LIG_LIR_Gen_1	8	14	PF02991	0.549
LIG_LIR_LC3C_4	433	438	PF02991	0.528
LIG_LIR_Nem_3	175	181	PF02991	0.460
LIG_LIR_Nem_3	8	13	PF02991	0.548
LIG_MYND_1	278	282	PF01753	0.571
LIG_Pex14_1	213	217	PF04695	0.698
LIG_Pex14_2	217	221	PF04695	0.688
LIG_SH2_STAT3	299	302	PF00017	0.724
LIG_SH2_STAT5	216	219	PF00017	0.570
LIG_SH2_STAT5	300	303	PF00017	0.469
LIG_SH3_3	138	144	PF00018	0.711
LIG_SH3_3	188	194	PF00018	0.644
LIG_SH3_3	357	363	PF00018	0.622
LIG_Sin3_3	129	136	PF02671	0.477
LIG_SUMO_SIM_par_1	435	441	PF11976	0.675
MOD_CK1_1	149	155	PF00069	0.544
MOD_CK1_1	195	201	PF00069	0.773
MOD_CK1_1	230	236	PF00069	0.742
MOD_CK1_1	239	245	PF00069	0.603
MOD_CK1_1	3	9	PF00069	0.727
MOD_CK1_1	320	326	PF00069	0.658
MOD_CK1_1	345	351	PF00069	0.586
MOD_CK1_1	377	383	PF00069	0.826
MOD_CK1_1	392	398	PF00069	0.544
MOD_CK2_1	150	156	PF00069	0.504
MOD_CK2_1	257	263	PF00069	0.563
MOD_CK2_1	91	97	PF00069	0.568
MOD_GlcNHglycan	156	160	PF01048	0.637
MOD_GlcNHglycan	348	351	PF01048	0.654
MOD_GlcNHglycan	65	68	PF01048	0.737
MOD_GlcNHglycan	86	89	PF01048	0.799
MOD_GSK3_1	1	8	PF00069	0.498
MOD_GSK3_1	101	108	PF00069	0.604
MOD_GSK3_1	146	153	PF00069	0.681
MOD_GSK3_1	236	243	PF00069	0.698
MOD_GSK3_1	250	257	PF00069	0.637
MOD_GSK3_1	342	349	PF00069	0.566
MOD_GSK3_1	374	381	PF00069	0.821
MOD_GSK3_1	388	395	PF00069	0.587
MOD_GSK3_1	91	98	PF00069	0.695
MOD_LATS_1	340	346	PF00433	0.555
MOD_NEK2_1	173	178	PF00069	0.695
MOD_NEK2_1	181	186	PF00069	0.627
MOD_NEK2_1	228	233	PF00069	0.717
MOD_NEK2_1	310	315	PF00069	0.554
MOD_NEK2_1	84	89	PF00069	0.542
MOD_PIKK_1	101	107	PF00454	0.829
MOD_PIKK_1	16	22	PF00454	0.457
MOD_PIKK_1	36	42	PF00454	0.577
MOD_PIKK_1	403	409	PF00454	0.538
MOD_PIKK_1	5	11	PF00454	0.461
MOD_PKA_1	342	348	PF00069	0.559
MOD_PKA_2	105	111	PF00069	0.636
MOD_PKA_2	121	127	PF00069	0.407
MOD_PKA_2	239	245	PF00069	0.629
MOD_PKA_2	254	260	PF00069	0.714
MOD_PKA_2	342	348	PF00069	0.559
MOD_PKA_2	374	380	PF00069	0.630
MOD_PKB_1	120	128	PF00069	0.482
MOD_Plk_1	115	121	PF00069	0.616
MOD_Plk_1	155	161	PF00069	0.710
MOD_Plk_4	105	111	PF00069	0.568
MOD_Plk_4	192	198	PF00069	0.747
MOD_Plk_4	276	282	PF00069	0.696
MOD_ProDKin_1	230	236	PF00069	0.521
MOD_ProDKin_1	315	321	PF00069	0.688
MOD_ProDKin_1	390	396	PF00069	0.790
TRG_DiLeu_BaLyEn_6	395	400	PF01217	0.553
TRG_DiLeu_BaLyEn_6	80	85	PF01217	0.531
TRG_ER_diArg_1	119	122	PF00400	0.758
TRG_ER_diArg_1	31	33	PF00400	0.546
TRG_ER_diArg_1	354	356	PF00400	0.734
TRG_ER_diArg_1	368	371	PF00400	0.688
TRG_ER_diArg_1	443	446	PF00400	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7T2	Leishmania donovani	57%	100%
A4I8H5	Leishmania infantum	57%	100%
E9B3D5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
Q4Q4R7	Leishmania major	58%	98%