Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4HKZ4_LEIBR

TriTrypDb:

LbrM.32.3800 , LBRM2903_320047000 , LBRM2903_320047100

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.442
CLV_C14_Caspase3-7	77	81	PF00656	0.497
CLV_NRD_NRD_1	11	13	PF00675	0.569
CLV_NRD_NRD_1	552	554	PF00675	0.432
CLV_PCSK_KEX2_1	11	13	PF00082	0.569
CLV_PCSK_KEX2_1	454	456	PF00082	0.507
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.507
CLV_PCSK_SKI1_1	117	121	PF00082	0.516
CLV_PCSK_SKI1_1	205	209	PF00082	0.491
CLV_PCSK_SKI1_1	284	288	PF00082	0.341
CLV_PCSK_SKI1_1	421	425	PF00082	0.264
CLV_PCSK_SKI1_1	71	75	PF00082	0.553
CLV_PCSK_SKI1_1	92	96	PF00082	0.432
DEG_APCC_DBOX_1	552	560	PF00400	0.393
DEG_COP1_1	315	323	PF00400	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.431
DOC_CKS1_1	223	228	PF01111	0.509
DOC_CKS1_1	252	257	PF01111	0.420
DOC_CKS1_1	344	349	PF01111	0.272
DOC_CKS1_1	487	492	PF01111	0.466
DOC_CKS1_1	575	580	PF01111	0.444
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.293
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.467
DOC_CYCLIN_yCln2_LP_2	575	581	PF00134	0.438
DOC_MAPK_gen_1	28	36	PF00069	0.487
DOC_MAPK_gen_1	553	559	PF00069	0.379
DOC_MAPK_JIP1_4	313	319	PF00069	0.315
DOC_MAPK_MEF2A_6	31	38	PF00069	0.420
DOC_PP1_RVXF_1	282	288	PF00149	0.353
DOC_PP2B_LxvP_1	261	264	PF13499	0.267
DOC_PP2B_LxvP_1	400	403	PF13499	0.476
DOC_PP2B_LxvP_1	83	86	PF13499	0.482
DOC_PP4_FxxP_1	427	430	PF00568	0.244
DOC_PP4_FxxP_1	471	474	PF00568	0.509
DOC_USP7_MATH_1	207	211	PF00917	0.505
DOC_USP7_MATH_1	347	351	PF00917	0.361
DOC_USP7_MATH_1	384	388	PF00917	0.303
DOC_USP7_MATH_1	457	461	PF00917	0.663
DOC_USP7_UBL2_3	92	96	PF12436	0.438
DOC_WW_Pin1_4	117	122	PF00397	0.518
DOC_WW_Pin1_4	161	166	PF00397	0.496
DOC_WW_Pin1_4	205	210	PF00397	0.552
DOC_WW_Pin1_4	222	227	PF00397	0.471
DOC_WW_Pin1_4	251	256	PF00397	0.413
DOC_WW_Pin1_4	343	348	PF00397	0.261
DOC_WW_Pin1_4	403	408	PF00397	0.372
DOC_WW_Pin1_4	486	491	PF00397	0.467
DOC_WW_Pin1_4	503	508	PF00397	0.469
DOC_WW_Pin1_4	567	572	PF00397	0.479
DOC_WW_Pin1_4	574	579	PF00397	0.458
DOC_WW_Pin1_4	590	595	PF00397	0.357
DOC_WW_Pin1_4	612	617	PF00397	0.468
LIG_14-3-3_CanoR_1	230	235	PF00244	0.781
LIG_14-3-3_CanoR_1	31	35	PF00244	0.529
LIG_14-3-3_CanoR_1	401	407	PF00244	0.372
LIG_APCC_ABBA_1	36	41	PF00400	0.530
LIG_BIR_III_2	456	460	PF00653	0.504
LIG_BRCT_BRCA1_1	234	238	PF00533	0.646
LIG_BRCT_BRCA1_1	607	611	PF00533	0.466
LIG_BRCT_BRCA1_2	234	240	PF00533	0.484
LIG_EH1_1	428	436	PF00400	0.293
LIG_FHA_1	164	170	PF00498	0.491
LIG_FHA_1	223	229	PF00498	0.509
LIG_FHA_1	332	338	PF00498	0.470
LIG_FHA_1	380	386	PF00498	0.368
LIG_FHA_1	4	10	PF00498	0.403
LIG_FHA_1	445	451	PF00498	0.480
LIG_FHA_2	106	112	PF00498	0.474
LIG_FHA_2	156	162	PF00498	0.499
LIG_FHA_2	476	482	PF00498	0.491
LIG_FHA_2	65	71	PF00498	0.439
LIG_FHA_2	98	104	PF00498	0.534
LIG_FXI_DFP_1	39	43	PF00024	0.426
LIG_HP1_1	430	434	PF01393	0.274
LIG_LIR_Apic_2	160	165	PF02991	0.497
LIG_LIR_Apic_2	468	474	PF02991	0.513
LIG_LIR_Gen_1	235	246	PF02991	0.646
LIG_LIR_Gen_1	247	255	PF02991	0.356
LIG_LIR_Gen_1	388	399	PF02991	0.281
LIG_LIR_Nem_3	235	241	PF02991	0.684
LIG_LIR_Nem_3	247	253	PF02991	0.361
LIG_LIR_Nem_3	353	359	PF02991	0.272
LIG_LIR_Nem_3	361	366	PF02991	0.306
LIG_LIR_Nem_3	388	394	PF02991	0.276
LIG_LYPXL_yS_3	356	359	PF13949	0.258
LIG_MLH1_MIPbox_1	608	612	PF16413	0.468
LIG_MYND_1	441	445	PF01753	0.473
LIG_NRBOX	93	99	PF00104	0.435
LIG_Pex14_1	64	68	PF04695	0.439
LIG_Pex14_2	340	344	PF04695	0.258
LIG_SH2_CRK	391	395	PF00017	0.270
LIG_SH2_CRK	597	601	PF00017	0.422
LIG_SH2_NCK_1	102	106	PF00017	0.472
LIG_SH2_NCK_1	391	395	PF00017	0.270
LIG_SH2_NCK_1	493	497	PF00017	0.475
LIG_SH2_STAP1	493	497	PF00017	0.475
LIG_SH2_STAP1	583	587	PF00017	0.407
LIG_SH2_STAT5	133	136	PF00017	0.625
LIG_SH2_STAT5	267	270	PF00017	0.307
LIG_SH2_STAT5	277	280	PF00017	0.399
LIG_SH2_STAT5	363	366	PF00017	0.298
LIG_SH2_STAT5	493	496	PF00017	0.475
LIG_SH2_STAT5	567	570	PF00017	0.476
LIG_SH3_3	101	107	PF00018	0.469
LIG_SH3_3	220	226	PF00018	0.510
LIG_SH3_3	249	255	PF00018	0.281
LIG_SH3_3	354	360	PF00018	0.271
LIG_SH3_3	435	441	PF00018	0.448
LIG_SUMO_SIM_anti_2	315	322	PF11976	0.344
LIG_SUMO_SIM_par_1	446	451	PF11976	0.602
LIG_SUMO_SIM_par_1	525	532	PF11976	0.503
LIG_TRAF2_1	85	88	PF00917	0.459
LIG_TYR_ITIM	540	545	PF00017	0.411
LIG_UBA3_1	146	153	PF00899	0.499
LIG_UBA3_1	94	101	PF00899	0.446
LIG_WRC_WIRS_1	337	342	PF05994	0.276
MOD_CDC14_SPxK_1	406	409	PF00782	0.344
MOD_CDK_SPxK_1	251	257	PF00069	0.291
MOD_CDK_SPxK_1	403	409	PF00069	0.368
MOD_CK1_1	115	121	PF00069	0.524
MOD_CK1_1	192	198	PF00069	0.531
MOD_CK1_1	210	216	PF00069	0.456
MOD_CK1_1	221	227	PF00069	0.640
MOD_CK1_1	29	35	PF00069	0.435
MOD_CK1_1	297	303	PF00069	0.286
MOD_CK1_1	48	54	PF00069	0.386
MOD_CK1_1	57	63	PF00069	0.415
MOD_CK2_1	105	111	PF00069	0.489
MOD_CK2_1	155	161	PF00069	0.500
MOD_CK2_1	172	178	PF00069	0.443
MOD_CK2_1	347	353	PF00069	0.350
MOD_DYRK1A_RPxSP_1	117	121	PF00069	0.516
MOD_GlcNHglycan	196	199	PF01048	0.511
MOD_GlcNHglycan	242	245	PF01048	0.386
MOD_GlcNHglycan	296	299	PF01048	0.275
MOD_GlcNHglycan	360	363	PF01048	0.314
MOD_GlcNHglycan	463	466	PF01048	0.518
MOD_GlcNHglycan	56	59	PF01048	0.722
MOD_GlcNHglycan	587	590	PF01048	0.418
MOD_GSK3_1	115	122	PF00069	0.516
MOD_GSK3_1	123	130	PF00069	0.468
MOD_GSK3_1	136	143	PF00069	0.449
MOD_GSK3_1	157	164	PF00069	0.499
MOD_GSK3_1	183	190	PF00069	0.555
MOD_GSK3_1	192	199	PF00069	0.661
MOD_GSK3_1	205	212	PF00069	0.661
MOD_GSK3_1	218	225	PF00069	0.511
MOD_GSK3_1	230	237	PF00069	0.533
MOD_GSK3_1	240	247	PF00069	0.389
MOD_GSK3_1	26	33	PF00069	0.533
MOD_GSK3_1	267	274	PF00069	0.294
MOD_GSK3_1	343	350	PF00069	0.267
MOD_GSK3_1	375	382	PF00069	0.488
MOD_GSK3_1	444	451	PF00069	0.557
MOD_GSK3_1	457	464	PF00069	0.477
MOD_GSK3_1	465	472	PF00069	0.510
MOD_GSK3_1	48	55	PF00069	0.576
MOD_GSK3_1	567	574	PF00069	0.491
MOD_GSK3_1	581	588	PF00069	0.374
MOD_GSK3_1	60	67	PF00069	0.407
MOD_GSK3_1	603	610	PF00069	0.441
MOD_N-GLC_1	136	141	PF02516	0.720
MOD_N-GLC_1	210	215	PF02516	0.646
MOD_N-GLC_1	379	384	PF02516	0.406
MOD_NEK2_1	259	264	PF00069	0.276
MOD_NEK2_1	285	290	PF00069	0.590
MOD_NEK2_1	294	299	PF00069	0.409
MOD_NEK2_1	527	532	PF00069	0.496
MOD_NEK2_1	559	564	PF00069	0.437
MOD_NEK2_1	605	610	PF00069	0.458
MOD_NEK2_1	611	616	PF00069	0.454
MOD_NEK2_1	97	102	PF00069	0.451
MOD_OFUCOSY	296	301	PF10250	0.274
MOD_PIKK_1	23	29	PF00454	0.444
MOD_PIKK_1	379	385	PF00454	0.389
MOD_PIKK_1	529	535	PF00454	0.459
MOD_PIKK_1	581	587	PF00454	0.409
MOD_PIKK_1	603	609	PF00454	0.438
MOD_PKA_2	190	196	PF00069	0.539
MOD_PKA_2	229	235	PF00069	0.708
MOD_PKA_2	30	36	PF00069	0.430
MOD_PKA_2	45	51	PF00069	0.399
MOD_PKA_2	461	467	PF00069	0.515
MOD_Plk_1	115	121	PF00069	0.524
MOD_Plk_1	136	142	PF00069	0.720
MOD_Plk_1	315	321	PF00069	0.355
MOD_Plk_1	466	472	PF00069	0.678
MOD_Plk_1	48	54	PF00069	0.433
MOD_Plk_1	571	577	PF00069	0.453
MOD_Plk_2-3	157	163	PF00069	0.501
MOD_Plk_4	315	321	PF00069	0.468
MOD_Plk_4	347	353	PF00069	0.395
MOD_Plk_4	48	54	PF00069	0.433
MOD_Plk_4	571	577	PF00069	0.453
MOD_Plk_4	607	613	PF00069	0.468
MOD_Plk_4	623	629	PF00069	0.531
MOD_ProDKin_1	117	123	PF00069	0.515
MOD_ProDKin_1	161	167	PF00069	0.495
MOD_ProDKin_1	205	211	PF00069	0.553
MOD_ProDKin_1	222	228	PF00069	0.470
MOD_ProDKin_1	251	257	PF00069	0.418
MOD_ProDKin_1	343	349	PF00069	0.267
MOD_ProDKin_1	403	409	PF00069	0.368
MOD_ProDKin_1	486	492	PF00069	0.467
MOD_ProDKin_1	503	509	PF00069	0.469
MOD_ProDKin_1	567	573	PF00069	0.478
MOD_ProDKin_1	574	580	PF00069	0.463
MOD_ProDKin_1	590	596	PF00069	0.363
MOD_ProDKin_1	612	618	PF00069	0.467
MOD_SUMO_for_1	367	370	PF00179	0.339
MOD_SUMO_rev_2	87	94	PF00179	0.433
TRG_DiLeu_BaEn_1	552	557	PF01217	0.390
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.514
TRG_ENDOCYTIC_2	356	359	PF00928	0.258
TRG_ENDOCYTIC_2	391	394	PF00928	0.271
TRG_ENDOCYTIC_2	542	545	PF00928	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE0	Leptomonas seymouri	39%	100%