START domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKZ3_LEIBR

TriTrypDb:

LbrM.32.3790 , LBRM2903_320046900

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.534
CLV_C14_Caspase3-7	18	22	PF00656	0.761
CLV_C14_Caspase3-7	184	188	PF00656	0.501
CLV_C14_Caspase3-7	224	228	PF00656	0.632
CLV_NRD_NRD_1	24	26	PF00675	0.594
CLV_NRD_NRD_1	55	57	PF00675	0.452
CLV_PCSK_KEX2_1	126	128	PF00082	0.610
CLV_PCSK_KEX2_1	24	26	PF00082	0.594
CLV_PCSK_KEX2_1	57	59	PF00082	0.383
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.610
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.441
CLV_PCSK_SKI1_1	117	121	PF00082	0.320
CLV_PCSK_SKI1_1	39	43	PF00082	0.548
CLV_PCSK_SKI1_1	46	50	PF00082	0.518
DEG_SCF_FBW7_2	1	8	PF00400	0.579
DOC_CKS1_1	160	165	PF01111	0.630
DOC_MAPK_gen_1	126	134	PF00069	0.546
DOC_MAPK_gen_1	24	32	PF00069	0.674
DOC_MAPK_gen_1	258	266	PF00069	0.613
DOC_MAPK_MEF2A_6	258	266	PF00069	0.357
DOC_USP7_MATH_1	107	111	PF00917	0.633
DOC_USP7_MATH_1	226	230	PF00917	0.631
DOC_USP7_MATH_1	48	52	PF00917	0.330
DOC_USP7_UBL2_3	268	272	PF12436	0.363
DOC_WW_Pin1_4	1	6	PF00397	0.579
DOC_WW_Pin1_4	138	143	PF00397	0.340
DOC_WW_Pin1_4	144	149	PF00397	0.354
DOC_WW_Pin1_4	159	164	PF00397	0.624
LIG_14-3-3_CanoR_1	149	155	PF00244	0.590
LIG_14-3-3_CanoR_1	39	49	PF00244	0.422
LIG_14-3-3_CanoR_1	80	86	PF00244	0.478
LIG_eIF4E_1	113	119	PF01652	0.592
LIG_FHA_1	184	190	PF00498	0.508
LIG_FHA_1	40	46	PF00498	0.305
LIG_FHA_1	80	86	PF00498	0.448
LIG_FHA_1	88	94	PF00498	0.419
LIG_FHA_2	18	24	PF00498	0.602
LIG_FHA_2	198	204	PF00498	0.384
LIG_LIR_Gen_1	153	161	PF02991	0.597
LIG_LIR_Gen_1	34	45	PF02991	0.620
LIG_LIR_Gen_1	59	70	PF02991	0.579
LIG_LIR_Nem_3	153	157	PF02991	0.597
LIG_LIR_Nem_3	34	40	PF02991	0.536
LIG_LIR_Nem_3	59	65	PF02991	0.554
LIG_NRBOX	156	162	PF00104	0.604
LIG_Pex14_2	49	53	PF04695	0.353
LIG_SH2_CRK	115	119	PF00017	0.583
LIG_SH2_CRK	139	143	PF00017	0.465
LIG_SH2_CRK	154	158	PF00017	0.435
LIG_SH2_CRK	218	222	PF00017	0.588
LIG_SH2_GRB2like	280	283	PF00017	0.691
LIG_SH2_STAP1	115	119	PF00017	0.503
LIG_SH2_STAP1	62	66	PF00017	0.569
LIG_SH2_STAT5	154	157	PF00017	0.600
LIG_SH2_STAT5	199	202	PF00017	0.659
LIG_TRAF2_1	15	18	PF00917	0.826
LIG_TYR_ITIM	152	157	PF00017	0.595
LIG_TYR_ITIM	60	65	PF00017	0.337
LIG_UBA3_1	262	270	PF00899	0.370
MOD_CDK_SPK_2	144	149	PF00069	0.370
MOD_CK1_1	292	298	PF00069	0.551
MOD_CK1_1	51	57	PF00069	0.335
MOD_CK2_1	197	203	PF00069	0.371
MOD_GlcNHglycan	50	53	PF01048	0.600
MOD_GSK3_1	228	235	PF00069	0.586
MOD_GSK3_1	47	54	PF00069	0.604
MOD_N-GLC_1	130	135	PF02516	0.592
MOD_N-GLC_1	216	221	PF02516	0.340
MOD_NEK2_1	47	52	PF00069	0.607
MOD_NEK2_1	65	70	PF00069	0.295
MOD_NEK2_1	79	84	PF00069	0.572
MOD_PIKK_1	290	296	PF00454	0.541
MOD_PKA_1	207	213	PF00069	0.646
MOD_PKA_2	171	177	PF00069	0.760
MOD_PKA_2	79	85	PF00069	0.458
MOD_Plk_1	130	136	PF00069	0.591
MOD_Plk_1	216	222	PF00069	0.338
MOD_Plk_2-3	17	23	PF00069	0.761
MOD_Plk_2-3	250	256	PF00069	0.615
MOD_Plk_4	185	191	PF00069	0.375
MOD_Plk_4	216	222	PF00069	0.594
MOD_Plk_4	228	234	PF00069	0.413
MOD_ProDKin_1	1	7	PF00069	0.579
MOD_ProDKin_1	138	144	PF00069	0.351
MOD_ProDKin_1	159	165	PF00069	0.625
MOD_SUMO_rev_2	61	71	PF00179	0.550
MOD_SUMO_rev_2	94	103	PF00179	0.366
TRG_DiLeu_BaLyEn_6	114	119	PF01217	0.484
TRG_ENDOCYTIC_2	115	118	PF00928	0.587
TRG_ENDOCYTIC_2	154	157	PF00928	0.600
TRG_ENDOCYTIC_2	218	221	PF00928	0.589
TRG_ENDOCYTIC_2	62	65	PF00928	0.601
TRG_ER_diArg_1	55	58	PF00400	0.386
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH56	Leishmania donovani	76%	100%
A4I8H4	Leishmania infantum	76%	100%
E9AEG9	Leishmania major	73%	67%
E9B3D4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%