Putative DEAD/DEAH box helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKZ2_LEIBR

TriTrypDb:

LbrM.32.3780 , LBRM2903_320046800

Length:

684

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004386	helicase activity	2	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0140657	ATP-dependent activity	1	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	420	424	PF00656	0.760
CLV_C14_Caspase3-7	475	479	PF00656	0.503
CLV_NRD_NRD_1	2	4	PF00675	0.657
CLV_NRD_NRD_1	220	222	PF00675	0.308
CLV_NRD_NRD_1	261	263	PF00675	0.356
CLV_NRD_NRD_1	270	272	PF00675	0.296
CLV_NRD_NRD_1	344	346	PF00675	0.475
CLV_NRD_NRD_1	501	503	PF00675	0.545
CLV_NRD_NRD_1	513	515	PF00675	0.556
CLV_NRD_NRD_1	537	539	PF00675	0.701
CLV_NRD_NRD_1	587	589	PF00675	0.503
CLV_NRD_NRD_1	664	666	PF00675	0.471
CLV_PCSK_FUR_1	499	503	PF00082	0.419
CLV_PCSK_KEX2_1	14	16	PF00082	0.611
CLV_PCSK_KEX2_1	220	222	PF00082	0.308
CLV_PCSK_KEX2_1	259	261	PF00082	0.347
CLV_PCSK_KEX2_1	267	269	PF00082	0.288
CLV_PCSK_KEX2_1	344	346	PF00082	0.475
CLV_PCSK_KEX2_1	4	6	PF00082	0.615
CLV_PCSK_KEX2_1	43	45	PF00082	0.608
CLV_PCSK_KEX2_1	499	501	PF00082	0.542
CLV_PCSK_KEX2_1	537	539	PF00082	0.701
CLV_PCSK_KEX2_1	587	589	PF00082	0.546
CLV_PCSK_KEX2_1	664	666	PF00082	0.501
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.634
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.349
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.312
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.638
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.683
CLV_PCSK_PC7_1	256	262	PF00082	0.400
CLV_PCSK_SKI1_1	204	208	PF00082	0.290
CLV_PCSK_SKI1_1	220	224	PF00082	0.290
CLV_PCSK_SKI1_1	314	318	PF00082	0.320
CLV_PCSK_SKI1_1	345	349	PF00082	0.469
CLV_PCSK_SKI1_1	36	40	PF00082	0.714
CLV_PCSK_SKI1_1	387	391	PF00082	0.519
CLV_PCSK_SKI1_1	49	53	PF00082	0.662
CLV_PCSK_SKI1_1	5	9	PF00082	0.504
CLV_PCSK_SKI1_1	643	647	PF00082	0.548
CLV_Separin_Metazoa	225	229	PF03568	0.531
DEG_APCC_DBOX_1	399	407	PF00400	0.528
DEG_Nend_Nbox_1	1	3	PF02207	0.717
DEG_SIAH_1	75	83	PF03145	0.628
DEG_SPOP_SBC_1	117	121	PF00917	0.716
DEG_SPOP_SBC_1	577	581	PF00917	0.474
DOC_CKS1_1	248	253	PF01111	0.474
DOC_CKS1_1	39	44	PF01111	0.478
DOC_CYCLIN_RxL_1	311	320	PF00134	0.591
DOC_CYCLIN_RxL_1	344	356	PF00134	0.624
DOC_CYCLIN_RxL_1	9	22	PF00134	0.700
DOC_MAPK_gen_1	164	173	PF00069	0.490
DOC_MAPK_gen_1	318	328	PF00069	0.502
DOC_MAPK_gen_1	499	508	PF00069	0.403
DOC_MAPK_gen_1	630	640	PF00069	0.456
DOC_MAPK_gen_1	664	671	PF00069	0.546
DOC_MAPK_gen_1	9	18	PF00069	0.723
DOC_MAPK_HePTP_8	8	20	PF00069	0.650
DOC_MAPK_MEF2A_6	11	20	PF00069	0.743
DOC_MAPK_MEF2A_6	153	161	PF00069	0.483
DOC_MAPK_MEF2A_6	321	330	PF00069	0.508
DOC_MAPK_MEF2A_6	633	640	PF00069	0.498
DOC_PP1_RVXF_1	202	208	PF00149	0.490
DOC_PP1_RVXF_1	34	41	PF00149	0.637
DOC_PP2B_LxvP_1	601	604	PF13499	0.472
DOC_PP2B_PxIxI_1	243	249	PF00149	0.527
DOC_PP4_FxxP_1	446	449	PF00568	0.271
DOC_USP7_MATH_1	117	121	PF00917	0.687
DOC_USP7_MATH_1	363	367	PF00917	0.694
DOC_USP7_MATH_1	371	375	PF00917	0.682
DOC_USP7_MATH_1	416	420	PF00917	0.740
DOC_USP7_MATH_1	551	555	PF00917	0.779
DOC_USP7_MATH_1	572	576	PF00917	0.700
DOC_USP7_MATH_1	577	581	PF00917	0.660
DOC_USP7_MATH_1	634	638	PF00917	0.519
DOC_WW_Pin1_4	247	252	PF00397	0.490
DOC_WW_Pin1_4	38	43	PF00397	0.487
DOC_WW_Pin1_4	564	569	PF00397	0.739
LIG_14-3-3_CanoR_1	172	180	PF00244	0.411
LIG_14-3-3_CanoR_1	19	24	PF00244	0.548
LIG_14-3-3_CanoR_1	53	59	PF00244	0.547
LIG_14-3-3_CanoR_1	588	598	PF00244	0.527
LIG_14-3-3_CanoR_1	633	639	PF00244	0.564
LIG_Actin_WH2_2	16	33	PF00022	0.646
LIG_BRCT_BRCA1_1	119	123	PF00533	0.663
LIG_CaM_IQ_9	392	407	PF13499	0.573
LIG_Clathr_ClatBox_1	290	294	PF01394	0.490
LIG_deltaCOP1_diTrp_1	190	198	PF00928	0.537
LIG_deltaCOP1_diTrp_1	252	257	PF00928	0.508
LIG_eIF4E_1	346	352	PF01652	0.601
LIG_FHA_1	152	158	PF00498	0.444
LIG_FHA_1	174	180	PF00498	0.530
LIG_FHA_1	208	214	PF00498	0.490
LIG_FHA_1	221	227	PF00498	0.490
LIG_FHA_1	231	237	PF00498	0.497
LIG_FHA_1	248	254	PF00498	0.403
LIG_FHA_1	285	291	PF00498	0.503
LIG_FHA_1	354	360	PF00498	0.540
LIG_FHA_1	490	496	PF00498	0.554
LIG_FHA_1	605	611	PF00498	0.428
LIG_FHA_1	614	620	PF00498	0.416
LIG_FHA_1	87	93	PF00498	0.334
LIG_FHA_2	247	253	PF00498	0.591
LIG_FHA_2	393	399	PF00498	0.437
LIG_FHA_2	615	621	PF00498	0.554
LIG_GBD_Chelix_1	485	493	PF00786	0.377
LIG_HCF-1_HBM_1	216	219	PF13415	0.561
LIG_LIR_Apic_2	195	200	PF02991	0.561
LIG_LIR_Apic_2	320	325	PF02991	0.531
LIG_LIR_Gen_1	25	33	PF02991	0.594
LIG_LIR_Gen_1	278	285	PF02991	0.536
LIG_LIR_Gen_1	442	449	PF02991	0.538
LIG_LIR_Nem_3	120	126	PF02991	0.566
LIG_LIR_Nem_3	216	222	PF02991	0.531
LIG_LIR_Nem_3	25	30	PF02991	0.584
LIG_LIR_Nem_3	252	258	PF02991	0.494
LIG_LIR_Nem_3	442	446	PF02991	0.541
LIG_LIR_Nem_3	534	539	PF02991	0.653
LIG_MYND_1	412	416	PF01753	0.707
LIG_PCNA_PIPBox_1	130	139	PF02747	0.411
LIG_PCNA_yPIPBox_3	304	317	PF02747	0.499
LIG_PTB_Apo_2	239	246	PF02174	0.561
LIG_PTB_Phospho_1	239	245	PF10480	0.561
LIG_RPA_C_Fungi	256	268	PF08784	0.401
LIG_RPA_C_Fungi	359	371	PF08784	0.637
LIG_SH2_CRK	219	223	PF00017	0.344
LIG_SH2_CRK	322	326	PF00017	0.358
LIG_SH2_PTP2	245	248	PF00017	0.321
LIG_SH2_SRC	94	97	PF00017	0.584
LIG_SH2_STAP1	277	281	PF00017	0.444
LIG_SH2_STAP1	491	495	PF00017	0.449
LIG_SH2_STAT3	138	141	PF00017	0.369
LIG_SH2_STAT5	184	187	PF00017	0.444
LIG_SH2_STAT5	245	248	PF00017	0.344
LIG_SH2_STAT5	319	322	PF00017	0.485
LIG_SH2_STAT5	391	394	PF00017	0.413
LIG_SH2_STAT5	443	446	PF00017	0.530
LIG_SH2_STAT5	484	487	PF00017	0.571
LIG_SH2_STAT5	491	494	PF00017	0.614
LIG_SH2_STAT5	525	528	PF00017	0.470
LIG_SH2_STAT5	94	97	PF00017	0.452
LIG_SH3_3	142	148	PF00018	0.444
LIG_SH3_3	245	251	PF00018	0.321
LIG_SH3_3	39	45	PF00018	0.485
LIG_SH3_3	458	464	PF00018	0.505
LIG_SH3_3	76	82	PF00018	0.502
LIG_SUMO_SIM_anti_2	175	181	PF11976	0.444
LIG_SUMO_SIM_anti_2	286	292	PF11976	0.343
LIG_SUMO_SIM_anti_2	607	613	PF11976	0.422
LIG_SUMO_SIM_anti_2	637	642	PF11976	0.398
LIG_SUMO_SIM_par_1	175	181	PF11976	0.444
LIG_SUMO_SIM_par_1	289	295	PF11976	0.344
LIG_SUMO_SIM_par_1	75	81	PF11976	0.414
LIG_TRAF2_1	395	398	PF00917	0.463
LIG_TRFH_1	279	283	PF08558	0.369
LIG_UBA3_1	133	140	PF00899	0.233
LIG_UBA3_1	312	321	PF00899	0.344
MOD_CDK_SPK_2	38	43	PF00069	0.487
MOD_CDK_SPxK_1	38	44	PF00069	0.486
MOD_CK1_1	105	111	PF00069	0.678
MOD_CK1_1	115	121	PF00069	0.659
MOD_CK1_1	430	436	PF00069	0.730
MOD_CK1_1	564	570	PF00069	0.718
MOD_CK1_1	579	585	PF00069	0.542
MOD_CK1_1	65	71	PF00069	0.419
MOD_CK2_1	19	25	PF00069	0.473
MOD_CK2_1	392	398	PF00069	0.450
MOD_CK2_1	564	570	PF00069	0.529
MOD_CK2_1	614	620	PF00069	0.448
MOD_GlcNHglycan	305	308	PF01048	0.467
MOD_GlcNHglycan	331	334	PF01048	0.344
MOD_GlcNHglycan	365	368	PF01048	0.731
MOD_GlcNHglycan	527	530	PF01048	0.628
MOD_GlcNHglycan	531	534	PF01048	0.613
MOD_GlcNHglycan	542	546	PF01048	0.593
MOD_GlcNHglycan	553	556	PF01048	0.698
MOD_GlcNHglycan	563	566	PF01048	0.713
MOD_GlcNHglycan	643	646	PF01048	0.426
MOD_GSK3_1	111	118	PF00069	0.757
MOD_GSK3_1	207	214	PF00069	0.427
MOD_GSK3_1	25	32	PF00069	0.588
MOD_GSK3_1	299	306	PF00069	0.467
MOD_GSK3_1	331	338	PF00069	0.344
MOD_GSK3_1	371	378	PF00069	0.588
MOD_GSK3_1	406	413	PF00069	0.376
MOD_GSK3_1	426	433	PF00069	0.793
MOD_GSK3_1	525	532	PF00069	0.486
MOD_GSK3_1	572	579	PF00069	0.665
MOD_GSK3_1	589	596	PF00069	0.364
MOD_GSK3_1	59	66	PF00069	0.567
MOD_N-GLC_1	102	107	PF02516	0.622
MOD_N-GLC_1	211	216	PF02516	0.444
MOD_N-GLC_1	230	235	PF02516	0.444
MOD_NEK2_1	173	178	PF00069	0.401
MOD_NEK2_1	207	212	PF00069	0.375
MOD_NEK2_1	317	322	PF00069	0.384
MOD_NEK2_1	335	340	PF00069	0.416
MOD_NEK2_1	407	412	PF00069	0.482
MOD_NEK2_1	576	581	PF00069	0.715
MOD_NEK2_1	583	588	PF00069	0.575
MOD_NEK2_1	59	64	PF00069	0.545
MOD_NEK2_1	641	646	PF00069	0.449
MOD_NEK2_1	652	657	PF00069	0.459
MOD_NEK2_1	99	104	PF00069	0.583
MOD_NEK2_2	589	594	PF00069	0.413
MOD_PIKK_1	392	398	PF00454	0.572
MOD_PIKK_1	472	478	PF00454	0.709
MOD_PIKK_1	553	559	PF00454	0.791
MOD_PIKK_1	86	92	PF00454	0.527
MOD_PK_1	19	25	PF00069	0.692
MOD_PKA_1	220	226	PF00069	0.369
MOD_PKA_2	220	226	PF00069	0.344
MOD_PKA_2	303	309	PF00069	0.463
MOD_PKA_2	317	323	PF00069	0.434
MOD_PKA_2	363	369	PF00069	0.631
MOD_PKA_2	52	58	PF00069	0.556
MOD_PKA_2	583	589	PF00069	0.611
MOD_PKB_1	500	508	PF00069	0.612
MOD_Plk_1	102	108	PF00069	0.615
MOD_Plk_1	489	495	PF00069	0.607
MOD_Plk_1	49	55	PF00069	0.561
MOD_Plk_4	173	179	PF00069	0.401
MOD_Plk_4	531	537	PF00069	0.595
MOD_Plk_4	636	642	PF00069	0.441
MOD_ProDKin_1	247	253	PF00069	0.344
MOD_ProDKin_1	38	44	PF00069	0.482
MOD_ProDKin_1	564	570	PF00069	0.740
TRG_DiLeu_BaEn_2	503	509	PF01217	0.610
TRG_DiLeu_BaEn_4	25	31	PF01217	0.729
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.233
TRG_ENDOCYTIC_2	219	222	PF00928	0.344
TRG_ENDOCYTIC_2	245	248	PF00928	0.321
TRG_ENDOCYTIC_2	443	446	PF00928	0.529
TRG_ER_diArg_1	2	5	PF00400	0.605
TRG_ER_diArg_1	219	221	PF00400	0.369
TRG_ER_diArg_1	260	262	PF00400	0.429
TRG_ER_diArg_1	343	345	PF00400	0.470
TRG_ER_diArg_1	499	502	PF00400	0.569
TRG_ER_diArg_1	536	538	PF00400	0.694
TRG_NES_CRM1_1	483	498	PF08389	0.486
TRG_NES_CRM1_1	602	614	PF08389	0.477
TRG_NLS_MonoCore_2	258	263	PF00514	0.388
TRG_NLS_MonoExtN_4	256	263	PF00514	0.388
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	220	225	PF00026	0.349
TRG_Pf-PMV_PEXEL_1	537	542	PF00026	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I401	Leptomonas seymouri	66%	99%
A0A1X0NSB4	Trypanosomatidae	46%	100%
A0A3R7NUR2	Trypanosoma rangeli	51%	100%
A0A3S7X625	Leishmania donovani	86%	100%
A4I8H3	Leishmania infantum	86%	100%
D0AAP5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B3D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q4S3	Leishmania major	85%	100%