TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKZ1_LEIBR

TriTrypDb:

LbrM.32.3770 , LBRM2903_320046600

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.757
CLV_C14_Caspase3-7	323	327	PF00656	0.563
CLV_NRD_NRD_1	25	27	PF00675	0.714
CLV_NRD_NRD_1	392	394	PF00675	0.490
CLV_NRD_NRD_1	433	435	PF00675	0.476
CLV_PCSK_KEX2_1	12	14	PF00082	0.681
CLV_PCSK_KEX2_1	24	26	PF00082	0.699
CLV_PCSK_KEX2_1	391	393	PF00082	0.448
CLV_PCSK_KEX2_1	433	435	PF00082	0.417
CLV_PCSK_KEX2_1	7	9	PF00082	0.695
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.714
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.448
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.725
CLV_PCSK_PC7_1	20	26	PF00082	0.498
CLV_PCSK_PC7_1	8	14	PF00082	0.506
CLV_PCSK_SKI1_1	13	17	PF00082	0.745
CLV_PCSK_SKI1_1	225	229	PF00082	0.423
CLV_PCSK_SKI1_1	364	368	PF00082	0.542
CLV_PCSK_SKI1_1	70	74	PF00082	0.424
CLV_Separin_Metazoa	17	21	PF03568	0.605
DEG_APCC_DBOX_1	12	20	PF00400	0.746
DEG_APCC_DBOX_1	444	452	PF00400	0.481
DEG_SPOP_SBC_1	498	502	PF00917	0.456
DOC_CYCLIN_RxL_1	222	232	PF00134	0.438
DOC_CYCLIN_yClb5_NLxxxL_5	471	480	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	522	525	PF00134	0.336
DOC_MAPK_DCC_7	12	21	PF00069	0.638
DOC_MAPK_MEF2A_6	243	251	PF00069	0.452
DOC_MAPK_MEF2A_6	270	277	PF00069	0.363
DOC_MAPK_MEF2A_6	492	499	PF00069	0.458
DOC_MAPK_NFAT4_5	270	278	PF00069	0.407
DOC_PP2B_LxvP_1	19	22	PF13499	0.725
DOC_PP2B_LxvP_1	466	469	PF13499	0.420
DOC_PP2B_LxvP_1	522	525	PF13499	0.336
DOC_PP4_FxxP_1	15	18	PF00568	0.720
DOC_USP7_MATH_1	103	107	PF00917	0.562
DOC_USP7_MATH_1	11	15	PF00917	0.665
DOC_USP7_MATH_1	168	172	PF00917	0.542
DOC_USP7_MATH_1	291	295	PF00917	0.405
DOC_USP7_MATH_1	38	42	PF00917	0.612
DOC_USP7_MATH_1	383	387	PF00917	0.595
DOC_USP7_MATH_1	498	502	PF00917	0.682
DOC_USP7_MATH_1	503	507	PF00917	0.709
DOC_USP7_MATH_1	530	534	PF00917	0.419
DOC_USP7_MATH_1	619	623	PF00917	0.510
DOC_USP7_UBL2_3	266	270	PF12436	0.419
DOC_USP7_UBL2_3	363	367	PF12436	0.561
DOC_WW_Pin1_4	106	111	PF00397	0.615
DOC_WW_Pin1_4	31	36	PF00397	0.700
DOC_WW_Pin1_4	511	516	PF00397	0.582
LIG_14-3-3_CanoR_1	165	173	PF00244	0.400
LIG_14-3-3_CanoR_1	184	194	PF00244	0.361
LIG_14-3-3_CanoR_1	198	206	PF00244	0.415
LIG_14-3-3_CanoR_1	209	217	PF00244	0.320
LIG_14-3-3_CanoR_1	407	416	PF00244	0.476
LIG_14-3-3_CanoR_1	433	437	PF00244	0.448
LIG_14-3-3_CanoR_1	445	449	PF00244	0.400
LIG_BIR_II_1	1	5	PF00653	0.626
LIG_BIR_III_2	300	304	PF00653	0.300
LIG_BRCT_BRCA1_1	610	614	PF00533	0.422
LIG_deltaCOP1_diTrp_1	49	53	PF00928	0.315
LIG_eIF4E_1	272	278	PF01652	0.445
LIG_EVH1_2	524	528	PF00568	0.316
LIG_FHA_1	260	266	PF00498	0.468
LIG_FHA_1	294	300	PF00498	0.444
LIG_FHA_1	420	426	PF00498	0.512
LIG_FHA_1	502	508	PF00498	0.728
LIG_FHA_1	517	523	PF00498	0.470
LIG_FHA_1	553	559	PF00498	0.435
LIG_FHA_2	165	171	PF00498	0.330
LIG_FHA_2	200	206	PF00498	0.468
LIG_FHA_2	209	215	PF00498	0.519
LIG_FHA_2	230	236	PF00498	0.576
LIG_FHA_2	410	416	PF00498	0.488
LIG_LIR_Apic_2	14	18	PF02991	0.718
LIG_LIR_Apic_2	181	186	PF02991	0.490
LIG_LIR_Gen_1	133	142	PF02991	0.458
LIG_LIR_Gen_1	435	444	PF02991	0.362
LIG_LIR_Gen_1	49	58	PF02991	0.515
LIG_LIR_Gen_1	629	637	PF02991	0.255
LIG_LIR_Nem_3	133	137	PF02991	0.595
LIG_LIR_Nem_3	271	275	PF02991	0.446
LIG_LIR_Nem_3	435	439	PF02991	0.383
LIG_LIR_Nem_3	49	53	PF02991	0.530
LIG_LIR_Nem_3	609	615	PF02991	0.513
LIG_LIR_Nem_3	629	635	PF02991	0.202
LIG_NRBOX	276	282	PF00104	0.311
LIG_SH2_CRK	183	187	PF00017	0.477
LIG_SH2_CRK	272	276	PF00017	0.443
LIG_SH2_NCK_1	288	292	PF00017	0.445
LIG_SH2_NCK_1	615	619	PF00017	0.487
LIG_SH2_STAP1	615	619	PF00017	0.472
LIG_SH2_STAT3	635	638	PF00017	0.420
LIG_SH2_STAT5	151	154	PF00017	0.434
LIG_SH2_STAT5	595	598	PF00017	0.422
LIG_SH2_STAT5	615	618	PF00017	0.219
LIG_SH2_STAT5	632	635	PF00017	0.237
LIG_SH3_1	492	498	PF00018	0.456
LIG_SH3_2	35	40	PF14604	0.523
LIG_SH3_3	32	38	PF00018	0.605
LIG_SH3_3	492	498	PF00018	0.456
LIG_SH3_3	560	566	PF00018	0.421
LIG_SH3_3	620	626	PF00018	0.385
LIG_Sin3_3	216	223	PF02671	0.265
LIG_SUMO_SIM_anti_2	214	221	PF11976	0.332
LIG_SUMO_SIM_par_1	218	224	PF11976	0.521
LIG_SUMO_SIM_par_1	274	279	PF11976	0.361
LIG_TRAF2_1	109	112	PF00917	0.558
LIG_TRAF2_1	136	139	PF00917	0.625
LIG_TRAF2_1	28	31	PF00917	0.533
LIG_TRAF2_1	355	358	PF00917	0.482
MOD_CDC14_SPxK_1	37	40	PF00782	0.522
MOD_CDK_SPxK_1	34	40	PF00069	0.523
MOD_CK1_1	106	112	PF00069	0.555
MOD_CK1_1	208	214	PF00069	0.442
MOD_CK1_1	34	40	PF00069	0.770
MOD_CK1_1	501	507	PF00069	0.678
MOD_CK1_1	511	517	PF00069	0.715
MOD_CK1_1	61	67	PF00069	0.680
MOD_CK1_1	92	98	PF00069	0.588
MOD_CK2_1	106	112	PF00069	0.718
MOD_CK2_1	11	17	PF00069	0.654
MOD_CK2_1	164	170	PF00069	0.433
MOD_CK2_1	208	214	PF00069	0.299
MOD_CK2_1	229	235	PF00069	0.582
MOD_CK2_1	24	30	PF00069	0.596
MOD_CK2_1	352	358	PF00069	0.525
MOD_CK2_1	383	389	PF00069	0.542
MOD_CK2_1	409	415	PF00069	0.467
MOD_CK2_1	43	49	PF00069	0.526
MOD_CK2_1	499	505	PF00069	0.460
MOD_CK2_1	614	620	PF00069	0.405
MOD_GlcNHglycan	1	4	PF01048	0.771
MOD_GlcNHglycan	105	108	PF01048	0.763
MOD_GlcNHglycan	142	145	PF01048	0.457
MOD_GlcNHglycan	170	173	PF01048	0.475
MOD_GlcNHglycan	289	292	PF01048	0.309
MOD_GlcNHglycan	323	326	PF01048	0.706
MOD_GlcNHglycan	354	357	PF01048	0.559
MOD_GlcNHglycan	41	44	PF01048	0.585
MOD_GlcNHglycan	45	48	PF01048	0.488
MOD_GlcNHglycan	486	489	PF01048	0.450
MOD_GlcNHglycan	501	504	PF01048	0.707
MOD_GlcNHglycan	516	519	PF01048	0.546
MOD_GlcNHglycan	61	64	PF01048	0.438
MOD_GlcNHglycan	616	619	PF01048	0.356
MOD_GlcNHglycan	91	94	PF01048	0.651
MOD_GSK3_1	164	171	PF00069	0.330
MOD_GSK3_1	208	215	PF00069	0.294
MOD_GSK3_1	276	283	PF00069	0.234
MOD_GSK3_1	287	294	PF00069	0.292
MOD_GSK3_1	34	41	PF00069	0.613
MOD_GSK3_1	415	422	PF00069	0.495
MOD_GSK3_1	497	504	PF00069	0.591
MOD_GSK3_1	88	95	PF00069	0.559
MOD_N-GLC_1	291	296	PF02516	0.391
MOD_N-GLC_1	88	93	PF02516	0.379
MOD_NEK2_1	187	192	PF00069	0.290
MOD_NEK2_1	276	281	PF00069	0.324
MOD_NEK2_1	408	413	PF00069	0.480
MOD_NEK2_1	439	444	PF00069	0.402
MOD_NEK2_1	499	504	PF00069	0.474
MOD_NEK2_1	552	557	PF00069	0.435
MOD_NEK2_1	558	563	PF00069	0.439
MOD_NEK2_1	58	63	PF00069	0.514
MOD_NEK2_1	581	586	PF00069	0.362
MOD_NEK2_1	614	619	PF00069	0.410
MOD_NEK2_2	619	624	PF00069	0.301
MOD_PIKK_1	423	429	PF00454	0.581
MOD_PIKK_1	439	445	PF00454	0.425
MOD_PIKK_1	516	522	PF00454	0.424
MOD_PIKK_1	558	564	PF00454	0.447
MOD_PKA_1	24	30	PF00069	0.536
MOD_PKA_1	362	368	PF00069	0.563
MOD_PKA_2	164	170	PF00069	0.503
MOD_PKA_2	208	214	PF00069	0.297
MOD_PKA_2	229	235	PF00069	0.538
MOD_PKA_2	24	30	PF00069	0.536
MOD_PKA_2	432	438	PF00069	0.443
MOD_PKA_2	444	450	PF00069	0.365
MOD_Plk_1	291	297	PF00069	0.280
MOD_Plk_1	608	614	PF00069	0.403
MOD_Plk_1	619	625	PF00069	0.461
MOD_Plk_2-3	229	235	PF00069	0.488
MOD_Plk_4	229	235	PF00069	0.527
MOD_Plk_4	259	265	PF00069	0.487
MOD_Plk_4	268	274	PF00069	0.447
MOD_Plk_4	276	282	PF00069	0.315
MOD_Plk_4	508	514	PF00069	0.629
MOD_Plk_4	531	537	PF00069	0.397
MOD_ProDKin_1	106	112	PF00069	0.616
MOD_ProDKin_1	31	37	PF00069	0.700
MOD_ProDKin_1	511	517	PF00069	0.579
TRG_DiLeu_BaEn_1	229	234	PF01217	0.329
TRG_DiLeu_BaEn_1	547	552	PF01217	0.367
TRG_DiLeu_BaEn_3	236	242	PF01217	0.252
TRG_DiLeu_BaEn_3	76	82	PF01217	0.497
TRG_DiLeu_BaLyEn_6	553	558	PF01217	0.470
TRG_DiLeu_BaLyEn_6	623	628	PF01217	0.485
TRG_ENDOCYTIC_2	272	275	PF00928	0.444
TRG_ER_diArg_1	24	26	PF00400	0.704
TRG_ER_diArg_1	392	394	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK53	Leptomonas seymouri	58%	99%
A0A1X0NRY3	Trypanosomatidae	28%	100%
A0A3Q8IHE5	Leishmania donovani	74%	100%
A0A422P2Z2	Trypanosoma rangeli	27%	100%
A4I8H2	Leishmania infantum	74%	100%
D0AAP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B3D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q4S4	Leishmania major	72%	100%
V5BQY9	Trypanosoma cruzi	27%	100%