Putative RNA-binding, protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding, protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKZ0_LEIBR

TriTrypDb:

LbrM.32.3760 , LBRM2903_320046500

Length:

567

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.764
CLV_C14_Caspase3-7	441	445	PF00656	0.543
CLV_MEL_PAP_1	56	62	PF00089	0.415
CLV_NRD_NRD_1	374	376	PF00675	0.511
CLV_NRD_NRD_1	386	388	PF00675	0.513
CLV_NRD_NRD_1	391	393	PF00675	0.535
CLV_NRD_NRD_1	58	60	PF00675	0.553
CLV_NRD_NRD_1	74	76	PF00675	0.462
CLV_PCSK_FUR_1	374	378	PF00082	0.518
CLV_PCSK_FUR_1	383	387	PF00082	0.525
CLV_PCSK_KEX2_1	373	375	PF00082	0.508
CLV_PCSK_KEX2_1	376	378	PF00082	0.520
CLV_PCSK_KEX2_1	383	385	PF00082	0.531
CLV_PCSK_KEX2_1	386	388	PF00082	0.513
CLV_PCSK_KEX2_1	390	392	PF00082	0.529
CLV_PCSK_KEX2_1	58	60	PF00082	0.567
CLV_PCSK_KEX2_1	74	76	PF00082	0.476
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.508
CLV_PCSK_PC1ET2_1	376	378	PF00082	0.520
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.529
CLV_PCSK_PC7_1	379	385	PF00082	0.564
CLV_PCSK_PC7_1	386	392	PF00082	0.482
CLV_PCSK_SKI1_1	178	182	PF00082	0.543
CLV_PCSK_SKI1_1	197	201	PF00082	0.584
CLV_PCSK_SKI1_1	387	391	PF00082	0.537
CLV_PCSK_SKI1_1	392	396	PF00082	0.518
CLV_PCSK_SKI1_1	472	476	PF00082	0.269
CLV_PCSK_SKI1_1	50	54	PF00082	0.459
CLV_PCSK_SKI1_1	82	86	PF00082	0.511
DEG_APCC_DBOX_1	49	57	PF00400	0.446
DEG_APCC_DBOX_1	81	89	PF00400	0.485
DEG_Nend_UBRbox_2	1	3	PF02207	0.502
DEG_SCF_FBW7_2	115	121	PF00400	0.528
DEG_SPOP_SBC_1	132	136	PF00917	0.691
DEG_SPOP_SBC_1	204	208	PF00917	0.460
DEG_SPOP_SBC_1	407	411	PF00917	0.529
DOC_CDC14_PxL_1	151	159	PF14671	0.519
DOC_CDC14_PxL_1	17	25	PF14671	0.553
DOC_CKS1_1	115	120	PF01111	0.622
DOC_CKS1_1	255	260	PF01111	0.314
DOC_CYCLIN_RxL_1	194	205	PF00134	0.586
DOC_MAPK_MEF2A_6	312	319	PF00069	0.392
DOC_PP1_RVXF_1	195	202	PF00149	0.584
DOC_PP2B_LxvP_1	548	551	PF13499	0.451
DOC_PP4_FxxP_1	201	204	PF00568	0.598
DOC_USP7_MATH_1	126	130	PF00917	0.664
DOC_USP7_MATH_1	365	369	PF00917	0.487
DOC_USP7_MATH_1	407	411	PF00917	0.559
DOC_USP7_MATH_1	62	66	PF00917	0.523
DOC_WW_Pin1_4	105	110	PF00397	0.627
DOC_WW_Pin1_4	114	119	PF00397	0.610
DOC_WW_Pin1_4	135	140	PF00397	0.657
DOC_WW_Pin1_4	171	176	PF00397	0.667
DOC_WW_Pin1_4	218	223	PF00397	0.412
DOC_WW_Pin1_4	254	259	PF00397	0.401
LIG_14-3-3_CanoR_1	354	364	PF00244	0.442
LIG_14-3-3_CanoR_1	391	395	PF00244	0.461
LIG_14-3-3_CanoR_1	485	489	PF00244	0.469
LIG_14-3-3_CanoR_1	502	507	PF00244	0.469
LIG_14-3-3_CanoR_1	522	527	PF00244	0.463
LIG_14-3-3_CanoR_1	82	88	PF00244	0.423
LIG_Actin_WH2_2	188	205	PF00022	0.447
LIG_BRCT_BRCA1_1	491	495	PF00533	0.469
LIG_DLG_GKlike_1	522	530	PF00625	0.582
LIG_eIF4E_1	521	527	PF01652	0.545
LIG_EVH1_1	548	552	PF00568	0.462
LIG_FHA_1	183	189	PF00498	0.507
LIG_FHA_1	219	225	PF00498	0.449
LIG_FHA_1	269	275	PF00498	0.420
LIG_FHA_1	328	334	PF00498	0.496
LIG_FHA_1	65	71	PF00498	0.586
LIG_FHA_2	148	154	PF00498	0.651
LIG_FHA_2	464	470	PF00498	0.469
LIG_FHA_2	478	484	PF00498	0.469
LIG_FHA_2	64	70	PF00498	0.461
LIG_GBD_Chelix_1	48	56	PF00786	0.412
LIG_LIR_Gen_1	86	91	PF02991	0.433
LIG_LIR_Nem_3	241	246	PF02991	0.465
LIG_LIR_Nem_3	519	524	PF02991	0.454
LIG_LIR_Nem_3	86	90	PF02991	0.499
LIG_NRBOX	470	476	PF00104	0.469
LIG_PCNA_PIPBox_1	81	90	PF02747	0.554
LIG_PDZ_Class_2	562	567	PF00595	0.481
LIG_PDZ_Wminus1_1	565	567	PF00595	0.466
LIG_PTB_Apo_2	515	522	PF02174	0.516
LIG_PTB_Phospho_1	515	521	PF10480	0.516
LIG_REV1ctd_RIR_1	198	203	PF16727	0.523
LIG_SH2_CRK	38	42	PF00017	0.539
LIG_SH2_CRK	478	482	PF00017	0.469
LIG_SH2_CRK	524	528	PF00017	0.395
LIG_SH2_NCK_1	524	528	PF00017	0.459
LIG_SH2_STAP1	24	28	PF00017	0.484
LIG_SH2_STAT5	225	228	PF00017	0.434
LIG_SH2_STAT5	242	245	PF00017	0.406
LIG_SH2_STAT5	262	265	PF00017	0.374
LIG_SH2_STAT5	288	291	PF00017	0.351
LIG_SH2_STAT5	310	313	PF00017	0.473
LIG_SH2_STAT5	422	425	PF00017	0.528
LIG_SH3_3	120	126	PF00018	0.735
LIG_SH3_3	152	158	PF00018	0.512
LIG_SH3_3	176	182	PF00018	0.695
LIG_SH3_3	543	549	PF00018	0.468
LIG_SUMO_SIM_anti_2	533	539	PF11976	0.460
LIG_SUMO_SIM_par_1	291	298	PF11976	0.364
LIG_SUMO_SIM_par_1	536	543	PF11976	0.475
LIG_TRAF2_1	118	121	PF00917	0.527
LIG_TRAF2_1	414	417	PF00917	0.606
LIG_TRAF2_1	505	508	PF00917	0.469
LIG_TRFH_1	200	204	PF08558	0.450
LIG_TYR_ITIM	36	41	PF00017	0.396
LIG_WRC_WIRS_1	84	89	PF05994	0.412
MOD_CDK_SPxK_1	135	141	PF00069	0.628
MOD_CDK_SPxxK_3	105	112	PF00069	0.498
MOD_CDK_SPxxK_3	171	178	PF00069	0.686
MOD_CK1_1	108	114	PF00069	0.559
MOD_CK1_1	174	180	PF00069	0.696
MOD_CK1_1	238	244	PF00069	0.338
MOD_CK1_1	358	364	PF00069	0.558
MOD_CK1_1	368	374	PF00069	0.431
MOD_CK1_1	403	409	PF00069	0.602
MOD_CK1_1	426	432	PF00069	0.791
MOD_CK1_1	433	439	PF00069	0.632
MOD_CK1_1	525	531	PF00069	0.443
MOD_CK1_1	63	69	PF00069	0.444
MOD_CK1_1	99	105	PF00069	0.597
MOD_CK2_1	108	114	PF00069	0.588
MOD_CK2_1	147	153	PF00069	0.660
MOD_CK2_1	409	415	PF00069	0.588
MOD_CK2_1	436	442	PF00069	0.668
MOD_CK2_1	477	483	PF00069	0.469
MOD_CK2_1	502	508	PF00069	0.472
MOD_CK2_1	63	69	PF00069	0.455
MOD_GlcNHglycan	126	129	PF01048	0.646
MOD_GlcNHglycan	165	168	PF01048	0.678
MOD_GlcNHglycan	169	172	PF01048	0.636
MOD_GlcNHglycan	357	360	PF01048	0.568
MOD_GlcNHglycan	367	370	PF01048	0.451
MOD_GlcNHglycan	400	405	PF01048	0.511
MOD_GlcNHglycan	444	447	PF01048	0.535
MOD_GlcNHglycan	489	494	PF01048	0.269
MOD_GlcNHglycan	527	530	PF01048	0.371
MOD_GlcNHglycan	60	63	PF01048	0.655
MOD_GSK3_1	126	133	PF00069	0.718
MOD_GSK3_1	163	170	PF00069	0.781
MOD_GSK3_1	277	284	PF00069	0.397
MOD_GSK3_1	364	371	PF00069	0.446
MOD_GSK3_1	399	406	PF00069	0.586
MOD_GSK3_1	407	414	PF00069	0.614
MOD_GSK3_1	423	430	PF00069	0.721
MOD_GSK3_1	431	438	PF00069	0.618
MOD_GSK3_1	489	496	PF00069	0.469
MOD_GSK3_1	58	65	PF00069	0.552
MOD_GSK3_1	92	99	PF00069	0.623
MOD_NEK2_1	130	135	PF00069	0.576
MOD_NEK2_1	37	42	PF00069	0.474
MOD_NEK2_1	510	515	PF00069	0.491
MOD_NEK2_1	60	65	PF00069	0.571
MOD_NEK2_1	83	88	PF00069	0.418
MOD_PIKK_1	116	122	PF00454	0.614
MOD_PIKK_1	26	32	PF00454	0.560
MOD_PK_1	390	396	PF00069	0.600
MOD_PK_1	502	508	PF00069	0.500
MOD_PKA_1	390	396	PF00069	0.600
MOD_PKA_1	58	64	PF00069	0.427
MOD_PKA_2	167	173	PF00069	0.699
MOD_PKA_2	202	208	PF00069	0.598
MOD_PKA_2	390	396	PF00069	0.600
MOD_PKA_2	484	490	PF00069	0.469
MOD_PKA_2	58	64	PF00069	0.427
MOD_PKA_2	96	102	PF00069	0.605
MOD_Plk_1	235	241	PF00069	0.426
MOD_Plk_1	249	255	PF00069	0.416
MOD_Plk_1	320	326	PF00069	0.408
MOD_Plk_4	238	244	PF00069	0.328
MOD_Plk_4	516	522	PF00069	0.464
MOD_Plk_4	83	89	PF00069	0.587
MOD_ProDKin_1	105	111	PF00069	0.626
MOD_ProDKin_1	114	120	PF00069	0.611
MOD_ProDKin_1	135	141	PF00069	0.658
MOD_ProDKin_1	171	177	PF00069	0.665
MOD_ProDKin_1	218	224	PF00069	0.398
MOD_ProDKin_1	254	260	PF00069	0.406
TRG_DiLeu_BaEn_4	507	513	PF01217	0.516
TRG_DiLeu_BaLyEn_6	152	157	PF01217	0.517
TRG_ENDOCYTIC_2	225	228	PF00928	0.440
TRG_ENDOCYTIC_2	24	27	PF00928	0.483
TRG_ENDOCYTIC_2	246	249	PF00928	0.434
TRG_ENDOCYTIC_2	34	37	PF00928	0.491
TRG_ENDOCYTIC_2	38	41	PF00928	0.471
TRG_ENDOCYTIC_2	478	481	PF00928	0.469
TRG_ENDOCYTIC_2	524	527	PF00928	0.404
TRG_ER_diArg_1	374	377	PF00400	0.517
TRG_ER_diArg_1	382	385	PF00400	0.529
TRG_ER_diArg_1	58	60	PF00400	0.567
TRG_ER_diArg_1	74	76	PF00400	0.462
TRG_NES_CRM1_1	285	297	PF08389	0.290
TRG_NLS_Bipartite_1	373	394	PF00514	0.522
TRG_NLS_MonoExtC_3	374	379	PF00514	0.529
TRG_NLS_MonoExtC_3	386	391	PF00514	0.538
TRG_NLS_MonoExtN_4	373	380	PF00514	0.517
TRG_NLS_MonoExtN_4	384	391	PF00514	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT8	Leptomonas seymouri	54%	100%
A0A3Q8IDF9	Leishmania donovani	79%	100%
A4I8H1	Leishmania infantum	79%	100%
E9B3D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q4S5	Leishmania major	77%	99%