Ribosomal RNA-processing protein 43

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exosome-associated protein 2, putative

Species:

Leishmania braziliensis

UniProt:

A4HKY9_LEIBR

TriTrypDb:

LbrM.32.3750 , LBRM2903_320046400

Length:

312

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000178	exosome (RNase complex)	4	11
GO:0032991	protein-containing complex	1	11
GO:1902494	catalytic complex	2	11
GO:1905354	exoribonuclease complex	3	11
GO:0000176	nuclear exosome (RNase complex)	3	1
GO:0000177	cytoplasmic exosome (RNase complex)	5	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HKY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKY9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006401	RNA catabolic process	5	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0019439	aromatic compound catabolic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034655	nucleobase-containing compound catabolic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0044270	cellular nitrogen compound catabolic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0046700	heterocycle catabolic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901361	organic cyclic compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:0000291	nuclear-transcribed mRNA catabolic process, exonucleolytic	8	1
GO:0000459	exonucleolytic trimming involved in rRNA processing	8	1
GO:0000467	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	9	1
GO:0000469	cleavage involved in rRNA processing	7	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006364	rRNA processing	8	1
GO:0006399	tRNA metabolic process	7	1
GO:0006402	mRNA catabolic process	6	1
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009896	positive regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016071	mRNA metabolic process	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0016073	snRNA metabolic process	7	1
GO:0016075	rRNA catabolic process	7	1
GO:0016078	tRNA catabolic process	7	1
GO:0016180	snRNA processing	8	1
GO:0017148	negative regulation of translation	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031125	rRNA 3'-end processing	9	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031331	positive regulation of cellular catabolic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'	9	1
GO:0034470	ncRNA processing	7	1
GO:0034472	snRNA 3'-end processing	8	1
GO:0034473	U1 snRNA 3'-end processing	9	1
GO:0034475	U4 snRNA 3'-end processing	9	1
GO:0034476	U5 snRNA 3'-end processing	9	1
GO:0034660	ncRNA metabolic process	6	1
GO:0034661	ncRNA catabolic process	6	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0043633	polyadenylation-dependent RNA catabolic process	6	1
GO:0043634	polyadenylation-dependent ncRNA catabolic process	7	1
GO:0043928	exonucleolytic catabolism of deadenylated mRNA	9	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050779	RNA destabilization	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0061014	positive regulation of mRNA catabolic process	7	1
GO:0061157	mRNA destabilization	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071025	RNA surveillance	6	1
GO:0071027	nuclear RNA surveillance	7	1
GO:0071028	nuclear mRNA surveillance	8	1
GO:0071029	nuclear ncRNA surveillance	7	1
GO:0071035	nuclear polyadenylation-dependent rRNA catabolic process	8	1
GO:0071038	nuclear polyadenylation-dependent tRNA catabolic process	8	1
GO:0071042	nuclear polyadenylation-dependent mRNA catabolic process	7	1
GO:0071046	nuclear polyadenylation-dependent ncRNA catabolic process	8	1
GO:0071047	polyadenylation-dependent mRNA catabolic process	6	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	7	1
GO:0106354	tRNA surveillance	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903313	positive regulation of mRNA metabolic process	7	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016787	hydrolase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	161	165	PF00656	0.559
CLV_C14_Caspase3-7	74	78	PF00656	0.658
CLV_NRD_NRD_1	306	308	PF00675	0.497
CLV_PCSK_KEX2_1	31	33	PF00082	0.438
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.438
CLV_PCSK_SKI1_1	249	253	PF00082	0.218
CLV_PCSK_SKI1_1	307	311	PF00082	0.443
CLV_PCSK_SKI1_1	31	35	PF00082	0.553
DOC_PP2B_LxvP_1	102	105	PF13499	0.540
DOC_PP2B_LxvP_1	211	214	PF13499	0.478
DOC_USP7_MATH_1	131	135	PF00917	0.495
DOC_USP7_MATH_1	17	21	PF00917	0.576
DOC_USP7_MATH_1	275	279	PF00917	0.378
DOC_USP7_MATH_1	70	74	PF00917	0.744
LIG_14-3-3_CanoR_1	249	257	PF00244	0.475
LIG_Actin_WH2_2	181	199	PF00022	0.454
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BIR_III_4	88	92	PF00653	0.542
LIG_Clathr_ClatBox_1	189	193	PF01394	0.540
LIG_DLG_GKlike_1	197	205	PF00625	0.531
LIG_FHA_1	252	258	PF00498	0.499
LIG_FHA_1	265	271	PF00498	0.408
LIG_FHA_1	287	293	PF00498	0.342
LIG_FHA_1	5	11	PF00498	0.547
LIG_FHA_2	159	165	PF00498	0.540
LIG_FHA_2	253	259	PF00498	0.506
LIG_FHA_2	72	78	PF00498	0.670
LIG_LIR_Gen_1	138	143	PF02991	0.540
LIG_LIR_Nem_3	133	139	PF02991	0.550
LIG_LIR_Nem_3	239	243	PF02991	0.516
LIG_SH2_NCK_1	86	90	PF00017	0.533
LIG_SH2_STAP1	15	19	PF00017	0.572
LIG_SH2_STAP1	86	90	PF00017	0.506
LIG_SH2_STAT5	158	161	PF00017	0.517
LIG_SH2_STAT5	86	89	PF00017	0.345
LIG_SH3_3	101	107	PF00018	0.470
LIG_SH3_3	116	122	PF00018	0.452
LIG_SUMO_SIM_par_1	186	191	PF11976	0.521
LIG_SUMO_SIM_par_1	266	272	PF11976	0.464
LIG_TRAF2_1	256	259	PF00917	0.454
LIG_WRC_WIRS_1	136	141	PF05994	0.426
LIG_WRC_WIRS_1	189	194	PF05994	0.411
MOD_CK1_1	145	151	PF00069	0.349
MOD_CK1_1	170	176	PF00069	0.399
MOD_CK2_1	170	176	PF00069	0.445
MOD_CK2_1	252	258	PF00069	0.379
MOD_CK2_1	268	274	PF00069	0.391
MOD_GlcNHglycan	127	130	PF01048	0.410
MOD_GlcNHglycan	144	147	PF01048	0.426
MOD_GlcNHglycan	15	18	PF01048	0.583
MOD_GlcNHglycan	302	305	PF01048	0.450
MOD_GlcNHglycan	49	52	PF01048	0.620
MOD_GSK3_1	131	138	PF00069	0.412
MOD_GSK3_1	141	148	PF00069	0.381
MOD_GSK3_1	264	271	PF00069	0.301
MOD_GSK3_1	275	282	PF00069	0.406
MOD_GSK3_1	286	293	PF00069	0.501
MOD_GSK3_1	6	13	PF00069	0.636
MOD_GSK3_1	71	78	PF00069	0.580
MOD_NEK2_1	142	147	PF00069	0.452
MOD_NEK2_1	167	172	PF00069	0.363
MOD_NEK2_1	300	305	PF00069	0.369
MOD_NEK2_2	275	280	PF00069	0.200
MOD_PIKK_1	167	173	PF00454	0.453
MOD_PIKK_1	286	292	PF00454	0.330
MOD_PIKK_1	293	299	PF00454	0.276
MOD_Plk_1	167	173	PF00069	0.390
MOD_Plk_1	252	258	PF00069	0.337
MOD_Plk_4	158	164	PF00069	0.322
MOD_Plk_4	170	176	PF00069	0.288
MOD_Plk_4	38	44	PF00069	0.464
MOD_SUMO_rev_2	73	81	PF00179	0.638
TRG_DiLeu_BaEn_1	272	277	PF01217	0.424
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.474
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.363
TRG_ENDOCYTIC_2	136	139	PF00928	0.426
TRG_ER_diArg_1	214	217	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Z5	Leptomonas seymouri	68%	100%
A0A0S4J9X0	Bodo saltans	34%	100%
A0A1X0NRW1	Trypanosomatidae	39%	100%
A0A3R7N361	Trypanosoma rangeli	40%	100%
A0A3S7X628	Leishmania donovani	84%	100%
A4I8H0	Leishmania infantum	84%	100%
D0AAP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B3D0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O26778	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O74918	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q05636	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	22%	100%
Q0W2Y7	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	25%	100%
Q4Q4S6	Leishmania major	83%	100%
Q5XJQ5	Danio rerio	27%	79%
V5B5R5	Trypanosoma cruzi	39%	100%