Zinc finger protein 516

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-finger of a C2HC-type, putative

Species:

Leishmania braziliensis

UniProt:

A4HKY8_LEIBR

TriTrypDb:

LbrM.32.3740 , LBRM2903_320046300

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.539
CLV_C14_Caspase3-7	36	40	PF00656	0.393
CLV_NRD_NRD_1	20	22	PF00675	0.601
CLV_NRD_NRD_1	277	279	PF00675	0.598
CLV_NRD_NRD_1	357	359	PF00675	0.561
CLV_NRD_NRD_1	41	43	PF00675	0.536
CLV_NRD_NRD_1	546	548	PF00675	0.581
CLV_NRD_NRD_1	66	68	PF00675	0.619
CLV_PCSK_KEX2_1	100	102	PF00082	0.534
CLV_PCSK_KEX2_1	20	22	PF00082	0.534
CLV_PCSK_KEX2_1	211	213	PF00082	0.552
CLV_PCSK_KEX2_1	277	279	PF00082	0.622
CLV_PCSK_KEX2_1	357	359	PF00082	0.561
CLV_PCSK_KEX2_1	564	566	PF00082	0.655
CLV_PCSK_KEX2_1	66	68	PF00082	0.626
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.530
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.496
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.536
CLV_PCSK_SKI1_1	125	129	PF00082	0.515
CLV_PCSK_SKI1_1	190	194	PF00082	0.300
CLV_PCSK_SKI1_1	307	311	PF00082	0.592
CLV_PCSK_SKI1_1	487	491	PF00082	0.522
DEG_SPOP_SBC_1	392	396	PF00917	0.633
DOC_CDC14_PxL_1	180	188	PF14671	0.219
DOC_CKS1_1	223	228	PF01111	0.643
DOC_CKS1_1	593	598	PF01111	0.345
DOC_CYCLIN_yCln2_LP_2	377	383	PF00134	0.513
DOC_MAPK_gen_1	498	506	PF00069	0.547
DOC_MAPK_MEF2A_6	307	314	PF00069	0.524
DOC_PP1_RVXF_1	99	106	PF00149	0.403
DOC_PP2B_LxvP_1	389	392	PF13499	0.538
DOC_USP7_MATH_1	216	220	PF00917	0.645
DOC_USP7_MATH_1	224	228	PF00917	0.634
DOC_USP7_MATH_1	229	233	PF00917	0.669
DOC_USP7_MATH_1	264	268	PF00917	0.731
DOC_USP7_MATH_1	392	396	PF00917	0.600
DOC_USP7_MATH_1	424	428	PF00917	0.728
DOC_USP7_MATH_1	452	456	PF00917	0.657
DOC_USP7_MATH_1	47	51	PF00917	0.549
DOC_USP7_MATH_1	546	550	PF00917	0.510
DOC_USP7_MATH_1	554	558	PF00917	0.593
DOC_USP7_UBL2_3	307	311	PF12436	0.531
DOC_USP7_UBL2_3	59	63	PF12436	0.686
DOC_WW_Pin1_4	116	121	PF00397	0.527
DOC_WW_Pin1_4	222	227	PF00397	0.637
DOC_WW_Pin1_4	258	263	PF00397	0.654
DOC_WW_Pin1_4	295	300	PF00397	0.540
DOC_WW_Pin1_4	347	352	PF00397	0.660
DOC_WW_Pin1_4	357	362	PF00397	0.655
DOC_WW_Pin1_4	410	415	PF00397	0.580
DOC_WW_Pin1_4	431	436	PF00397	0.643
DOC_WW_Pin1_4	48	53	PF00397	0.574
DOC_WW_Pin1_4	5	10	PF00397	0.583
DOC_WW_Pin1_4	559	564	PF00397	0.721
DOC_WW_Pin1_4	566	571	PF00397	0.713
DOC_WW_Pin1_4	592	597	PF00397	0.353
LIG_14-3-3_CanoR_1	212	220	PF00244	0.555
LIG_14-3-3_CanoR_1	241	251	PF00244	0.732
LIG_14-3-3_CanoR_1	379	384	PF00244	0.536
LIG_14-3-3_CanoR_1	46	52	PF00244	0.571
LIG_14-3-3_CanoR_1	483	491	PF00244	0.546
LIG_14-3-3_CanoR_1	547	553	PF00244	0.471
LIG_14-3-3_CanoR_1	66	73	PF00244	0.579
LIG_BIR_II_1	1	5	PF00653	0.520
LIG_EVH1_2	348	352	PF00568	0.532
LIG_FHA_1	223	229	PF00498	0.600
LIG_FHA_1	29	35	PF00498	0.442
LIG_FHA_1	486	492	PF00498	0.488
LIG_FHA_1	67	73	PF00498	0.451
LIG_FHA_1	85	91	PF00498	0.333
LIG_FHA_2	432	438	PF00498	0.582
LIG_FHA_2	461	467	PF00498	0.650
LIG_FHA_2	6	12	PF00498	0.525
LIG_Integrin_RGD_1	107	109	PF01839	0.507
LIG_LIR_Gen_1	167	177	PF02991	0.443
LIG_LIR_Nem_3	167	172	PF02991	0.458
LIG_LIR_Nem_3	175	180	PF02991	0.453
LIG_LIR_Nem_3	495	500	PF02991	0.541
LIG_NRBOX	33	39	PF00104	0.431
LIG_SH2_CRK	169	173	PF00017	0.447
LIG_SH2_CRK	249	253	PF00017	0.642
LIG_SH2_STAT5	520	523	PF00017	0.360
LIG_SH2_STAT5	79	82	PF00017	0.306
LIG_SH2_STAT5	98	101	PF00017	0.455
LIG_SH3_1	567	573	PF00018	0.659
LIG_SH3_3	109	115	PF00018	0.492
LIG_SH3_3	220	226	PF00018	0.740
LIG_SH3_3	297	303	PF00018	0.623
LIG_SH3_3	314	320	PF00018	0.581
LIG_SH3_3	345	351	PF00018	0.664
LIG_SH3_3	363	369	PF00018	0.499
LIG_SH3_3	432	438	PF00018	0.637
LIG_SH3_3	560	566	PF00018	0.709
LIG_SH3_3	567	573	PF00018	0.556
LIG_SH3_3	590	596	PF00018	0.617
LIG_SH3_4	59	66	PF00018	0.606
LIG_SUMO_SIM_par_1	386	396	PF11976	0.556
LIG_TRAF2_1	281	284	PF00917	0.721
MOD_CDK_SPK_2	5	10	PF00069	0.593
MOD_CDK_SPK_2	559	564	PF00069	0.717
MOD_CDK_SPxK_1	559	565	PF00069	0.693
MOD_CDK_SPxxK_3	592	599	PF00069	0.349
MOD_CK1_1	219	225	PF00069	0.774
MOD_CK1_1	271	277	PF00069	0.841
MOD_CK1_1	332	338	PF00069	0.520
MOD_CK1_1	390	396	PF00069	0.748
MOD_CK1_1	4	10	PF00069	0.599
MOD_CK1_1	413	419	PF00069	0.658
MOD_CK1_1	436	442	PF00069	0.756
MOD_CK1_1	485	491	PF00069	0.614
MOD_CK1_1	50	56	PF00069	0.566
MOD_CK2_1	159	165	PF00069	0.524
MOD_CK2_1	452	458	PF00069	0.574
MOD_CK2_1	460	466	PF00069	0.531
MOD_CK2_1	474	480	PF00069	0.510
MOD_Cter_Amidation	18	21	PF01082	0.535
MOD_GlcNHglycan	1	4	PF01048	0.765
MOD_GlcNHglycan	213	216	PF01048	0.614
MOD_GlcNHglycan	23	28	PF01048	0.500
MOD_GlcNHglycan	230	234	PF01048	0.711
MOD_GlcNHglycan	253	256	PF01048	0.644
MOD_GlcNHglycan	262	265	PF01048	0.768
MOD_GlcNHglycan	307	310	PF01048	0.650
MOD_GlcNHglycan	384	388	PF01048	0.518
MOD_GlcNHglycan	395	398	PF01048	0.644
MOD_GlcNHglycan	453	458	PF01048	0.576
MOD_GlcNHglycan	476	479	PF01048	0.669
MOD_GlcNHglycan	484	487	PF01048	0.693
MOD_GlcNHglycan	577	580	PF01048	0.714
MOD_GSK3_1	1	8	PF00069	0.584
MOD_GSK3_1	207	214	PF00069	0.686
MOD_GSK3_1	218	225	PF00069	0.599
MOD_GSK3_1	260	267	PF00069	0.824
MOD_GSK3_1	269	276	PF00069	0.696
MOD_GSK3_1	343	350	PF00069	0.720
MOD_GSK3_1	371	378	PF00069	0.632
MOD_GSK3_1	379	386	PF00069	0.616
MOD_GSK3_1	387	394	PF00069	0.667
MOD_GSK3_1	415	422	PF00069	0.671
MOD_GSK3_1	433	440	PF00069	0.680
MOD_GSK3_1	555	562	PF00069	0.742
MOD_N-GLC_1	295	300	PF02516	0.718
MOD_N-GLC_1	410	415	PF02516	0.643
MOD_N-GLC_1	492	497	PF02516	0.549
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	126	131	PF00069	0.465
MOD_NEK2_1	28	33	PF00069	0.454
MOD_NEK2_1	371	376	PF00069	0.644
MOD_NEK2_1	460	465	PF00069	0.634
MOD_PKA_1	211	217	PF00069	0.505
MOD_PKA_1	66	72	PF00069	0.484
MOD_PKA_2	211	217	PF00069	0.505
MOD_PKA_2	290	296	PF00069	0.706
MOD_PKA_2	482	488	PF00069	0.533
MOD_PKA_2	546	552	PF00069	0.556
MOD_PKA_2	65	71	PF00069	0.597
MOD_Plk_1	178	184	PF00069	0.467
MOD_Plk_1	332	338	PF00069	0.768
MOD_Plk_1	492	498	PF00069	0.548
MOD_Plk_4	332	338	PF00069	0.520
MOD_Plk_4	371	377	PF00069	0.548
MOD_ProDKin_1	116	122	PF00069	0.529
MOD_ProDKin_1	222	228	PF00069	0.639
MOD_ProDKin_1	258	264	PF00069	0.657
MOD_ProDKin_1	295	301	PF00069	0.542
MOD_ProDKin_1	347	353	PF00069	0.662
MOD_ProDKin_1	357	363	PF00069	0.656
MOD_ProDKin_1	410	416	PF00069	0.579
MOD_ProDKin_1	431	437	PF00069	0.644
MOD_ProDKin_1	48	54	PF00069	0.574
MOD_ProDKin_1	5	11	PF00069	0.583
MOD_ProDKin_1	559	565	PF00069	0.723
MOD_ProDKin_1	566	572	PF00069	0.713
MOD_ProDKin_1	592	598	PF00069	0.347
MOD_SUMO_rev_2	36	45	PF00179	0.422
MOD_SUMO_rev_2	413	420	PF00179	0.540
MOD_SUMO_rev_2	445	452	PF00179	0.671
MOD_SUMO_rev_2	594	600	PF00179	0.513
TRG_DiLeu_BaEn_1	24	29	PF01217	0.502
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.467
TRG_ENDOCYTIC_2	169	172	PF00928	0.456
TRG_ER_diArg_1	357	359	PF00400	0.561
TRG_NLS_Bipartite_1	547	568	PF00514	0.507
TRG_NLS_MonoCore_2	563	568	PF00514	0.529
TRG_NLS_MonoExtC_3	563	568	PF00514	0.529
TRG_NLS_MonoExtN_4	563	568	PF00514	0.529
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.428
TRG_Pf-PMV_PEXEL_1	508	512	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJN9	Leptomonas seymouri	40%	89%
A0A3Q8ITN7	Leishmania donovani	61%	100%
A0A3R7KYA2	Trypanosoma rangeli	31%	100%
A4I8G9	Leishmania infantum	61%	100%
E9B3C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4Q4S7	Leishmania major	61%	100%