Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKY7_LEIBR

TriTrypDb:

LbrM.32.3730 , LBRM2903_320046100

Length:

715

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	574	578	PF00656	0.581
CLV_NRD_NRD_1	14	16	PF00675	0.769
CLV_NRD_NRD_1	227	229	PF00675	0.591
CLV_NRD_NRD_1	28	30	PF00675	0.623
CLV_NRD_NRD_1	458	460	PF00675	0.661
CLV_NRD_NRD_1	622	624	PF00675	0.446
CLV_PCSK_KEX2_1	14	16	PF00082	0.761
CLV_PCSK_KEX2_1	227	229	PF00082	0.634
CLV_PCSK_KEX2_1	262	264	PF00082	0.443
CLV_PCSK_KEX2_1	27	29	PF00082	0.664
CLV_PCSK_KEX2_1	457	459	PF00082	0.660
CLV_PCSK_KEX2_1	622	624	PF00082	0.446
CLV_PCSK_KEX2_1	71	73	PF00082	0.388
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.443
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.388
CLV_PCSK_SKI1_1	136	140	PF00082	0.532
CLV_PCSK_SKI1_1	29	33	PF00082	0.389
CLV_PCSK_SKI1_1	622	626	PF00082	0.430
CLV_PCSK_SKI1_1	644	648	PF00082	0.483
CLV_Separin_Metazoa	645	649	PF03568	0.322
DEG_APCC_DBOX_1	28	36	PF00400	0.379
DEG_APCC_DBOX_1	621	629	PF00400	0.428
DEG_APCC_DBOX_1	643	651	PF00400	0.329
DEG_Nend_UBRbox_2	1	3	PF02207	0.570
DEG_SCF_FBW7_1	16	21	PF00400	0.499
DEG_SCF_TRCP1_1	79	84	PF00400	0.408
DEG_SPOP_SBC_1	299	303	PF00917	0.484
DEG_SPOP_SBC_1	476	480	PF00917	0.491
DOC_CKS1_1	611	616	PF01111	0.447
DOC_CYCLIN_yClb1_LxF_4	654	659	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	611	617	PF00134	0.447
DOC_MAPK_gen_1	622	628	PF00069	0.423
DOC_MAPK_gen_1	648	657	PF00069	0.336
DOC_MAPK_MEF2A_6	166	174	PF00069	0.556
DOC_MAPK_MEF2A_6	300	308	PF00069	0.382
DOC_MAPK_MEF2A_6	651	659	PF00069	0.328
DOC_MAPK_RevD_3	608	623	PF00069	0.432
DOC_PP1_RVXF_1	414	420	PF00149	0.482
DOC_PP1_RVXF_1	654	660	PF00149	0.401
DOC_PP2B_LxvP_1	609	612	PF13499	0.516
DOC_PP4_FxxP_1	154	157	PF00568	0.549
DOC_PP4_FxxP_1	173	176	PF00568	0.563
DOC_USP7_MATH_1	128	132	PF00917	0.449
DOC_USP7_MATH_1	16	20	PF00917	0.551
DOC_USP7_MATH_1	183	187	PF00917	0.601
DOC_USP7_MATH_1	196	200	PF00917	0.534
DOC_USP7_MATH_1	219	223	PF00917	0.458
DOC_USP7_MATH_1	234	238	PF00917	0.795
DOC_USP7_MATH_1	476	480	PF00917	0.546
DOC_USP7_MATH_1	513	517	PF00917	0.503
DOC_USP7_MATH_1	553	557	PF00917	0.535
DOC_USP7_MATH_1	587	591	PF00917	0.427
DOC_USP7_MATH_1	700	704	PF00917	0.651
DOC_USP7_MATH_1	77	81	PF00917	0.398
DOC_WW_Pin1_4	14	19	PF00397	0.499
DOC_WW_Pin1_4	160	165	PF00397	0.639
DOC_WW_Pin1_4	179	184	PF00397	0.556
DOC_WW_Pin1_4	215	220	PF00397	0.530
DOC_WW_Pin1_4	22	27	PF00397	0.661
DOC_WW_Pin1_4	318	323	PF00397	0.520
DOC_WW_Pin1_4	538	543	PF00397	0.630
DOC_WW_Pin1_4	610	615	PF00397	0.544
DOC_WW_Pin1_4	617	622	PF00397	0.515
LIG_14-3-3_CanoR_1	118	122	PF00244	0.562
LIG_14-3-3_CanoR_1	150	155	PF00244	0.657
LIG_14-3-3_CanoR_1	294	300	PF00244	0.529
LIG_14-3-3_CanoR_1	312	319	PF00244	0.690
LIG_14-3-3_CanoR_1	42	48	PF00244	0.447
LIG_14-3-3_CanoR_1	464	469	PF00244	0.614
LIG_14-3-3_CanoR_1	470	475	PF00244	0.618
LIG_14-3-3_CanoR_1	623	629	PF00244	0.419
LIG_14-3-3_CanoR_1	667	675	PF00244	0.350
LIG_BRCT_BRCA1_1	288	292	PF00533	0.556
LIG_CaM_NSCaTE_8	117	124	PF13499	0.482
LIG_CSL_BTD_1	499	502	PF09270	0.529
LIG_EH1_1	351	359	PF00400	0.438
LIG_FHA_1	182	188	PF00498	0.494
LIG_FHA_1	203	209	PF00498	0.639
LIG_FHA_1	299	305	PF00498	0.592
LIG_FHA_1	312	318	PF00498	0.508
LIG_FHA_1	638	644	PF00498	0.486
LIG_FHA_1	691	697	PF00498	0.451
LIG_FHA_2	361	367	PF00498	0.618
LIG_FHA_2	535	541	PF00498	0.665
LIG_FHA_2	572	578	PF00498	0.573
LIG_LIR_Apic_2	153	157	PF02991	0.536
LIG_LIR_Apic_2	503	508	PF02991	0.489
LIG_LIR_Gen_1	120	130	PF02991	0.400
LIG_LIR_Gen_1	61	67	PF02991	0.442
LIG_LIR_LC3C_4	307	310	PF02991	0.348
LIG_LIR_Nem_3	120	125	PF02991	0.400
LIG_LIR_Nem_3	472	477	PF02991	0.495
LIG_LIR_Nem_3	61	66	PF02991	0.440
LIG_LIR_Nem_3	703	708	PF02991	0.403
LIG_LYPXL_S_1	380	384	PF13949	0.492
LIG_LYPXL_yS_3	381	384	PF13949	0.497
LIG_MAD2	29	37	PF02301	0.515
LIG_Pex14_1	500	504	PF04695	0.514
LIG_Pex14_2	154	158	PF04695	0.626
LIG_SH2_CRK	122	126	PF00017	0.398
LIG_SH2_CRK	63	67	PF00017	0.426
LIG_SH2_CRK	708	712	PF00017	0.450
LIG_SH2_NCK_1	708	712	PF00017	0.450
LIG_SH2_STAP1	63	67	PF00017	0.426
LIG_SH2_STAP1	708	712	PF00017	0.292
LIG_SH2_STAT5	209	212	PF00017	0.491
LIG_SH2_STAT5	63	66	PF00017	0.420
LIG_SH3_2	23	28	PF14604	0.633
LIG_SH3_3	20	26	PF00018	0.717
LIG_SH3_3	27	33	PF00018	0.519
LIG_SH3_3	323	329	PF00018	0.503
LIG_SH3_3	433	439	PF00018	0.604
LIG_SH3_3	445	451	PF00018	0.496
LIG_SH3_3	496	502	PF00018	0.542
LIG_SH3_3	539	545	PF00018	0.706
LIG_SH3_3	547	553	PF00018	0.518
LIG_SUMO_SIM_anti_2	353	358	PF11976	0.495
LIG_SUMO_SIM_par_1	306	311	PF11976	0.435
LIG_SUMO_SIM_par_1	339	345	PF11976	0.484
LIG_SUMO_SIM_par_1	624	630	PF11976	0.424
LIG_SUMO_SIM_par_1	692	699	PF11976	0.454
LIG_TRAF2_1	334	337	PF00917	0.441
LIG_TYR_ITIM	706	711	PF00017	0.452
LIG_UBA3_1	255	262	PF00899	0.561
LIG_WRC_WIRS_1	284	289	PF05994	0.378
LIG_WRC_WIRS_1	501	506	PF05994	0.500
MOD_CDC14_SPxK_1	25	28	PF00782	0.615
MOD_CDK_SPK_2	22	27	PF00069	0.649
MOD_CDK_SPK_2	617	622	PF00069	0.446
MOD_CDK_SPxK_1	160	166	PF00069	0.627
MOD_CDK_SPxK_1	22	28	PF00069	0.640
MOD_CDK_SPxK_1	538	544	PF00069	0.698
MOD_CDK_SPxK_1	617	623	PF00069	0.440
MOD_CDK_SPxxK_3	22	29	PF00069	0.635
MOD_CK1_1	106	112	PF00069	0.600
MOD_CK1_1	182	188	PF00069	0.626
MOD_CK1_1	199	205	PF00069	0.455
MOD_CK1_1	215	221	PF00069	0.466
MOD_CK1_1	230	236	PF00069	0.609
MOD_CK1_1	298	304	PF00069	0.579
MOD_CK1_1	4	10	PF00069	0.426
MOD_CK1_1	463	469	PF00069	0.588
MOD_CK1_1	492	498	PF00069	0.636
MOD_CK1_1	534	540	PF00069	0.631
MOD_CK1_1	556	562	PF00069	0.494
MOD_CK1_1	594	600	PF00069	0.549
MOD_CK1_1	690	696	PF00069	0.566
MOD_CK2_1	150	156	PF00069	0.555
MOD_CK2_1	331	337	PF00069	0.477
MOD_CK2_1	43	49	PF00069	0.450
MOD_CK2_1	624	630	PF00069	0.461
MOD_Cter_Amidation	69	72	PF01082	0.398
MOD_GlcNHglycan	105	108	PF01048	0.592
MOD_GlcNHglycan	130	133	PF01048	0.510
MOD_GlcNHglycan	142	145	PF01048	0.429
MOD_GlcNHglycan	192	195	PF01048	0.623
MOD_GlcNHglycan	198	201	PF01048	0.612
MOD_GlcNHglycan	2	6	PF01048	0.564
MOD_GlcNHglycan	202	205	PF01048	0.611
MOD_GlcNHglycan	229	232	PF01048	0.688
MOD_GlcNHglycan	236	239	PF01048	0.664
MOD_GlcNHglycan	371	374	PF01048	0.545
MOD_GlcNHglycan	403	406	PF01048	0.523
MOD_GlcNHglycan	479	482	PF01048	0.553
MOD_GlcNHglycan	491	494	PF01048	0.615
MOD_GlcNHglycan	533	536	PF01048	0.659
MOD_GlcNHglycan	555	558	PF01048	0.653
MOD_GlcNHglycan	566	570	PF01048	0.509
MOD_GlcNHglycan	593	596	PF01048	0.595
MOD_GlcNHglycan	604	607	PF01048	0.584
MOD_GlcNHglycan	615	618	PF01048	0.576
MOD_GlcNHglycan	668	671	PF01048	0.391
MOD_GlcNHglycan	79	82	PF01048	0.490
MOD_GSK3_1	10	17	PF00069	0.565
MOD_GSK3_1	128	135	PF00069	0.452
MOD_GSK3_1	136	143	PF00069	0.647
MOD_GSK3_1	177	184	PF00069	0.585
MOD_GSK3_1	18	25	PF00069	0.641
MOD_GSK3_1	195	202	PF00069	0.584
MOD_GSK3_1	213	220	PF00069	0.635
MOD_GSK3_1	230	237	PF00069	0.592
MOD_GSK3_1	295	302	PF00069	0.613
MOD_GSK3_1	318	325	PF00069	0.561
MOD_GSK3_1	36	43	PF00069	0.443
MOD_GSK3_1	382	389	PF00069	0.522
MOD_GSK3_1	428	435	PF00069	0.684
MOD_GSK3_1	460	467	PF00069	0.645
MOD_GSK3_1	513	520	PF00069	0.432
MOD_GSK3_1	523	530	PF00069	0.524
MOD_GSK3_1	534	541	PF00069	0.587
MOD_GSK3_1	587	594	PF00069	0.441
MOD_GSK3_1	613	620	PF00069	0.511
MOD_GSK3_1	662	669	PF00069	0.427
MOD_GSK3_1	77	84	PF00069	0.440
MOD_N-GLC_1	401	406	PF02516	0.533
MOD_N-GLC_2	114	116	PF02516	0.409
MOD_N-GLC_2	93	95	PF02516	0.539
MOD_NEK2_1	10	15	PF00069	0.465
MOD_NEK2_1	177	182	PF00069	0.500
MOD_NEK2_1	190	195	PF00069	0.646
MOD_NEK2_1	283	288	PF00069	0.436
MOD_NEK2_1	304	309	PF00069	0.356
MOD_NEK2_1	419	424	PF00069	0.457
MOD_NEK2_1	477	482	PF00069	0.554
MOD_NEK2_1	523	528	PF00069	0.520
MOD_NEK2_1	531	536	PF00069	0.606
MOD_NEK2_1	615	620	PF00069	0.473
MOD_NEK2_1	666	671	PF00069	0.336
MOD_NEK2_1	701	706	PF00069	0.509
MOD_NEK2_1	89	94	PF00069	0.389
MOD_NEK2_2	117	122	PF00069	0.401
MOD_NEK2_2	662	667	PF00069	0.395
MOD_PIKK_1	220	226	PF00454	0.476
MOD_PIKK_1	286	292	PF00454	0.548
MOD_PIKK_1	492	498	PF00454	0.636
MOD_PIKK_1	534	540	PF00454	0.557
MOD_PK_1	432	438	PF00069	0.520
MOD_PK_1	464	470	PF00069	0.503
MOD_PK_1	544	550	PF00069	0.665
MOD_PKA_1	227	233	PF00069	0.517
MOD_PKA_2	117	123	PF00069	0.659
MOD_PKA_2	227	233	PF00069	0.517
MOD_PKA_2	299	305	PF00069	0.521
MOD_PKA_2	311	317	PF00069	0.653
MOD_PKA_2	367	373	PF00069	0.775
MOD_PKA_2	43	49	PF00069	0.581
MOD_PKA_2	463	469	PF00069	0.697
MOD_PKA_2	666	672	PF00069	0.336
MOD_Plk_1	386	392	PF00069	0.556
MOD_Plk_1	432	438	PF00069	0.629
MOD_Plk_1	587	593	PF00069	0.441
MOD_Plk_1	61	67	PF00069	0.512
MOD_Plk_4	117	123	PF00069	0.394
MOD_Plk_4	150	156	PF00069	0.593
MOD_Plk_4	283	289	PF00069	0.371
MOD_Plk_4	304	310	PF00069	0.347
MOD_Plk_4	36	42	PF00069	0.486
MOD_Plk_4	419	425	PF00069	0.456
MOD_Plk_4	43	49	PF00069	0.489
MOD_Plk_4	464	470	PF00069	0.598
MOD_Plk_4	500	506	PF00069	0.505
MOD_Plk_4	513	519	PF00069	0.430
MOD_Plk_4	556	562	PF00069	0.533
MOD_Plk_4	571	577	PF00069	0.539
MOD_Plk_4	61	67	PF00069	0.326
MOD_Plk_4	701	707	PF00069	0.500
MOD_ProDKin_1	14	20	PF00069	0.501
MOD_ProDKin_1	160	166	PF00069	0.640
MOD_ProDKin_1	179	185	PF00069	0.558
MOD_ProDKin_1	215	221	PF00069	0.520
MOD_ProDKin_1	22	28	PF00069	0.652
MOD_ProDKin_1	318	324	PF00069	0.513
MOD_ProDKin_1	538	544	PF00069	0.631
MOD_ProDKin_1	610	616	PF00069	0.539
MOD_ProDKin_1	617	623	PF00069	0.509
MOD_SUMO_for_1	405	408	PF00179	0.531
MOD_SUMO_rev_2	257	264	PF00179	0.453
TRG_DiLeu_BaEn_1	260	265	PF01217	0.437
TRG_DiLeu_BaEn_1	336	341	PF01217	0.436
TRG_DiLeu_BaEn_1	353	358	PF01217	0.443
TRG_DiLeu_BaEn_1	62	67	PF01217	0.506
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.695
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.523
TRG_DiLeu_BaLyEn_6	346	351	PF01217	0.428
TRG_ENDOCYTIC_2	122	125	PF00928	0.399
TRG_ENDOCYTIC_2	381	384	PF00928	0.497
TRG_ENDOCYTIC_2	63	66	PF00928	0.420
TRG_ENDOCYTIC_2	708	711	PF00928	0.394
TRG_ER_diArg_1	14	16	PF00400	0.640
TRG_ER_diArg_1	26	29	PF00400	0.539
TRG_ER_diArg_1	41	44	PF00400	0.426
TRG_ER_diArg_1	457	459	PF00400	0.660
TRG_ER_diArg_1	621	623	PF00400	0.454
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.616
TRG_Pf-PMV_PEXEL_1	458	462	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC97	Leptomonas seymouri	38%	92%
A0A3Q8IGI2	Leishmania donovani	73%	100%
A4I8G8	Leishmania infantum	73%	100%
E9B3C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	83%
Q4Q4S8	Leishmania major	74%	100%