Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0564, putative

Species:

Leishmania braziliensis

UniProt:

A4HKY6_LEIBR

TriTrypDb:

LbrM.32.3720 , LBRM2903_320045900 , LBRM2903_320046000

Length:

802

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKY6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.681
CLV_C14_Caspase3-7	464	468	PF00656	0.636
CLV_C14_Caspase3-7	724	728	PF00656	0.729
CLV_C14_Caspase3-7	736	740	PF00656	0.692
CLV_C14_Caspase3-7	784	788	PF00656	0.648
CLV_C14_Caspase3-7	797	801	PF00656	0.724
CLV_NRD_NRD_1	143	145	PF00675	0.764
CLV_NRD_NRD_1	154	156	PF00675	0.659
CLV_NRD_NRD_1	17	19	PF00675	0.707
CLV_NRD_NRD_1	184	186	PF00675	0.606
CLV_NRD_NRD_1	194	196	PF00675	0.456
CLV_NRD_NRD_1	414	416	PF00675	0.384
CLV_NRD_NRD_1	473	475	PF00675	0.436
CLV_NRD_NRD_1	496	498	PF00675	0.364
CLV_NRD_NRD_1	566	568	PF00675	0.436
CLV_NRD_NRD_1	60	62	PF00675	0.630
CLV_NRD_NRD_1	87	89	PF00675	0.650
CLV_PCSK_FUR_1	182	186	PF00082	0.671
CLV_PCSK_FUR_1	42	46	PF00082	0.422
CLV_PCSK_KEX2_1	142	144	PF00082	0.764
CLV_PCSK_KEX2_1	154	156	PF00082	0.643
CLV_PCSK_KEX2_1	17	19	PF00082	0.707
CLV_PCSK_KEX2_1	184	186	PF00082	0.672
CLV_PCSK_KEX2_1	414	416	PF00082	0.384
CLV_PCSK_KEX2_1	44	46	PF00082	0.483
CLV_PCSK_KEX2_1	448	450	PF00082	0.239
CLV_PCSK_KEX2_1	473	475	PF00082	0.436
CLV_PCSK_KEX2_1	495	497	PF00082	0.371
CLV_PCSK_KEX2_1	568	570	PF00082	0.436
CLV_PCSK_KEX2_1	656	658	PF00082	0.695
CLV_PCSK_KEX2_1	763	765	PF00082	0.786
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.418
CLV_PCSK_PC1ET2_1	448	450	PF00082	0.239
CLV_PCSK_PC1ET2_1	495	497	PF00082	0.433
CLV_PCSK_PC1ET2_1	568	570	PF00082	0.436
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.695
CLV_PCSK_PC1ET2_1	763	765	PF00082	0.583
CLV_PCSK_PC7_1	138	144	PF00082	0.757
CLV_PCSK_PC7_1	40	46	PF00082	0.426
CLV_PCSK_PC7_1	564	570	PF00082	0.384
CLV_PCSK_SKI1_1	101	105	PF00082	0.652
CLV_PCSK_SKI1_1	121	125	PF00082	0.369
CLV_PCSK_SKI1_1	134	138	PF00082	0.682
CLV_PCSK_SKI1_1	20	24	PF00082	0.715
CLV_PCSK_SKI1_1	293	297	PF00082	0.561
CLV_PCSK_SKI1_1	399	403	PF00082	0.842
CLV_PCSK_SKI1_1	441	445	PF00082	0.357
CLV_PCSK_SKI1_1	508	512	PF00082	0.239
CLV_PCSK_SKI1_1	639	643	PF00082	0.657
CLV_PCSK_SKI1_1	656	660	PF00082	0.660
CLV_PCSK_SKI1_1	786	790	PF00082	0.664
DEG_APCC_DBOX_1	120	128	PF00400	0.702
DEG_COP1_1	317	326	PF00400	0.601
DEG_Nend_UBRbox_1	1	4	PF02207	0.457
DEG_SPOP_SBC_1	285	289	PF00917	0.572
DEG_SPOP_SBC_1	369	373	PF00917	0.585
DOC_CKS1_1	302	307	PF01111	0.760
DOC_CYCLIN_yCln2_LP_2	35	41	PF00134	0.446
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.439
DOC_MAPK_DCC_7	33	41	PF00069	0.450
DOC_MAPK_gen_1	118	127	PF00069	0.698
DOC_MAPK_gen_1	182	190	PF00069	0.676
DOC_MAPK_gen_1	414	422	PF00069	0.584
DOC_MAPK_gen_1	88	94	PF00069	0.377
DOC_MAPK_JIP1_4	457	463	PF00069	0.439
DOC_MAPK_MEF2A_6	163	171	PF00069	0.742
DOC_MAPK_MEF2A_6	414	422	PF00069	0.636
DOC_MAPK_MEF2A_6	763	772	PF00069	0.574
DOC_MAPK_RevD_3	459	474	PF00069	0.571
DOC_MAPK_RevD_3	773	786	PF00069	0.667
DOC_PP1_RVXF_1	185	191	PF00149	0.679
DOC_PP2B_LxvP_1	338	341	PF13499	0.530
DOC_PP2B_LxvP_1	482	485	PF13499	0.557
DOC_PP2B_LxvP_1	773	776	PF13499	0.687
DOC_PP4_FxxP_1	621	624	PF00568	0.775
DOC_PP4_MxPP_1	279	282	PF00568	0.538
DOC_USP7_MATH_1	235	239	PF00917	0.527
DOC_USP7_MATH_1	274	278	PF00917	0.629
DOC_USP7_MATH_1	284	288	PF00917	0.852
DOC_USP7_MATH_1	29	33	PF00917	0.654
DOC_USP7_MATH_1	295	299	PF00917	0.653
DOC_USP7_MATH_1	316	320	PF00917	0.696
DOC_USP7_MATH_1	347	351	PF00917	0.747
DOC_USP7_MATH_1	386	390	PF00917	0.749
DOC_USP7_MATH_1	465	469	PF00917	0.511
DOC_USP7_MATH_1	475	479	PF00917	0.564
DOC_USP7_MATH_1	757	761	PF00917	0.779
DOC_USP7_MATH_1	766	770	PF00917	0.653
DOC_USP7_MATH_2	694	700	PF00917	0.588
DOC_WW_Pin1_4	209	214	PF00397	0.775
DOC_WW_Pin1_4	287	292	PF00397	0.737
DOC_WW_Pin1_4	296	301	PF00397	0.637
DOC_WW_Pin1_4	314	319	PF00397	0.686
DOC_WW_Pin1_4	373	378	PF00397	0.778
DOC_WW_Pin1_4	487	492	PF00397	0.605
DOC_WW_Pin1_4	499	504	PF00397	0.526
DOC_WW_Pin1_4	512	517	PF00397	0.482
DOC_WW_Pin1_4	64	69	PF00397	0.619
DOC_WW_Pin1_4	704	709	PF00397	0.625
DOC_WW_Pin1_4	752	757	PF00397	0.774
DOC_WW_Pin1_4	762	767	PF00397	0.648
LIG_14-3-3_CanoR_1	111	117	PF00244	0.675
LIG_14-3-3_CanoR_1	195	203	PF00244	0.690
LIG_14-3-3_CanoR_1	2	11	PF00244	0.435
LIG_14-3-3_CanoR_1	449	459	PF00244	0.439
LIG_14-3-3_CanoR_1	474	484	PF00244	0.636
LIG_14-3-3_CanoR_1	567	575	PF00244	0.636
LIG_14-3-3_CanoR_1	657	662	PF00244	0.673
LIG_14-3-3_CanoR_1	702	708	PF00244	0.599
LIG_Actin_WH2_2	105	120	PF00022	0.671
LIG_EVH1_2	70	74	PF00568	0.751
LIG_FHA_1	315	321	PF00498	0.559
LIG_FHA_1	378	384	PF00498	0.721
LIG_FHA_1	450	456	PF00498	0.439
LIG_FHA_1	529	535	PF00498	0.636
LIG_FHA_2	135	141	PF00498	0.730
LIG_FHA_2	234	240	PF00498	0.526
LIG_FHA_2	403	409	PF00498	0.457
LIG_FHA_2	577	583	PF00498	0.439
LIG_FHA_2	782	788	PF00498	0.575
LIG_LIR_Gen_1	106	117	PF02991	0.509
LIG_LIR_Nem_3	10	14	PF02991	0.497
LIG_LIR_Nem_3	106	112	PF02991	0.510
LIG_LIR_Nem_3	410	416	PF02991	0.524
LIG_LIR_Nem_3	660	664	PF02991	0.497
LIG_LYPXL_yS_3	661	664	PF13949	0.506
LIG_Pex14_2	433	437	PF04695	0.636
LIG_PTAP_UEV_1	378	383	PF05743	0.553
LIG_PTAP_UEV_1	690	695	PF05743	0.572
LIG_SH2_GRB2like	535	538	PF00017	0.439
LIG_SH2_NCK_1	219	223	PF00017	0.699
LIG_SH2_STAP1	535	539	PF00017	0.636
LIG_SH2_STAP1	78	82	PF00017	0.678
LIG_SH2_STAT3	416	419	PF00017	0.636
LIG_SH2_STAT3	538	541	PF00017	0.571
LIG_SH2_STAT5	4	7	PF00017	0.709
LIG_SH2_STAT5	538	541	PF00017	0.571
LIG_SH2_STAT5	573	576	PF00017	0.636
LIG_SH3_1	155	161	PF00018	0.553
LIG_SH3_1	65	71	PF00018	0.766
LIG_SH3_2	158	163	PF14604	0.545
LIG_SH3_3	155	161	PF00018	0.553
LIG_SH3_3	277	283	PF00018	0.809
LIG_SH3_3	294	300	PF00018	0.685
LIG_SH3_3	302	308	PF00018	0.694
LIG_SH3_3	320	326	PF00018	0.627
LIG_SH3_3	328	334	PF00018	0.699
LIG_SH3_3	354	360	PF00018	0.691
LIG_SH3_3	363	369	PF00018	0.635
LIG_SH3_3	376	382	PF00018	0.681
LIG_SH3_3	397	403	PF00018	0.594
LIG_SH3_3	425	431	PF00018	0.636
LIG_SH3_3	452	458	PF00018	0.636
LIG_SH3_3	65	71	PF00018	0.766
LIG_SH3_3	688	694	PF00018	0.578
LIG_SH3_3	772	778	PF00018	0.774
LIG_SH3_4	402	409	PF00018	0.254
LIG_TRAF2_1	694	697	PF00917	0.787
LIG_TYR_ITIM	659	664	PF00017	0.490
LIG_UBA3_1	35	44	PF00899	0.462
LIG_UBA3_1	641	646	PF00899	0.412
LIG_WW_2	334	337	PF00397	0.743
MOD_CDC14_SPxK_1	214	217	PF00782	0.804
MOD_CDC14_SPxK_1	290	293	PF00782	0.556
MOD_CDK_SPxK_1	211	217	PF00069	0.787
MOD_CDK_SPxK_1	287	293	PF00069	0.562
MOD_CK1_1	223	229	PF00069	0.515
MOD_CK1_1	287	293	PF00069	0.765
MOD_CK1_1	298	304	PF00069	0.608
MOD_CK1_1	350	356	PF00069	0.563
MOD_CK1_1	373	379	PF00069	0.780
MOD_CK1_1	388	394	PF00069	0.647
MOD_CK1_1	515	521	PF00069	0.571
MOD_CK1_1	706	712	PF00069	0.732
MOD_CK1_1	715	721	PF00069	0.734
MOD_CK1_1	725	731	PF00069	0.604
MOD_CK1_1	733	739	PF00069	0.656
MOD_CK1_1	740	746	PF00069	0.596
MOD_CK1_1	748	754	PF00069	0.618
MOD_CK1_1	759	765	PF00069	0.606
MOD_CK1_1	792	798	PF00069	0.771
MOD_CK2_1	116	122	PF00069	0.677
MOD_CK2_1	134	140	PF00069	0.426
MOD_CK2_1	175	181	PF00069	0.652
MOD_CK2_1	233	239	PF00069	0.538
MOD_CK2_1	576	582	PF00069	0.439
MOD_CK2_1	641	647	PF00069	0.653
MOD_Cter_Amidation	471	474	PF01082	0.436
MOD_Cter_Amidation	493	496	PF01082	0.384
MOD_GlcNHglycan	112	115	PF01048	0.672
MOD_GlcNHglycan	241	244	PF01048	0.536
MOD_GlcNHglycan	361	364	PF01048	0.749
MOD_GlcNHglycan	372	375	PF01048	0.749
MOD_GlcNHglycan	391	394	PF01048	0.659
MOD_GlcNHglycan	463	466	PF01048	0.436
MOD_GlcNHglycan	477	480	PF01048	0.270
MOD_GlcNHglycan	491	494	PF01048	0.285
MOD_GlcNHglycan	505	508	PF01048	0.270
MOD_GlcNHglycan	517	520	PF01048	0.413
MOD_GlcNHglycan	570	573	PF01048	0.436
MOD_GlcNHglycan	747	750	PF01048	0.683
MOD_GSK3_1	190	197	PF00069	0.614
MOD_GSK3_1	220	227	PF00069	0.523
MOD_GSK3_1	235	242	PF00069	0.514
MOD_GSK3_1	296	303	PF00069	0.749
MOD_GSK3_1	364	371	PF00069	0.613
MOD_GSK3_1	373	380	PF00069	0.722
MOD_GSK3_1	385	392	PF00069	0.588
MOD_GSK3_1	461	468	PF00069	0.439
MOD_GSK3_1	499	506	PF00069	0.468
MOD_GSK3_1	508	515	PF00069	0.474
MOD_GSK3_1	539	546	PF00069	0.584
MOD_GSK3_1	718	725	PF00069	0.791
MOD_GSK3_1	729	736	PF00069	0.643
MOD_GSK3_1	737	744	PF00069	0.544
MOD_GSK3_1	745	752	PF00069	0.564
MOD_GSK3_1	762	769	PF00069	0.608
MOD_GSK3_1	792	799	PF00069	0.769
MOD_N-GLC_1	728	733	PF02516	0.581
MOD_N-GLC_1	740	745	PF02516	0.555
MOD_NEK2_1	190	195	PF00069	0.576
MOD_NEK2_1	233	238	PF00069	0.530
MOD_NEK2_1	370	375	PF00069	0.580
MOD_NEK2_1	459	464	PF00069	0.444
MOD_NEK2_1	650	655	PF00069	0.414
MOD_NEK2_2	253	258	PF00069	0.579
MOD_NEK2_2	418	423	PF00069	0.636
MOD_PIKK_1	402	408	PF00454	0.531
MOD_PIKK_1	528	534	PF00454	0.636
MOD_PKA_1	568	574	PF00069	0.636
MOD_PKA_2	110	116	PF00069	0.673
MOD_PKA_2	117	123	PF00069	0.569
MOD_PKA_2	194	200	PF00069	0.681
MOD_PKA_2	465	471	PF00069	0.504
MOD_PKA_2	521	527	PF00069	0.636
MOD_PKA_2	568	574	PF00069	0.636
MOD_PKA_2	596	602	PF00069	0.636
MOD_PKB_1	142	150	PF00069	0.780
MOD_Plk_1	18	24	PF00069	0.435
MOD_Plk_1	459	465	PF00069	0.478
MOD_Plk_1	508	514	PF00069	0.557
MOD_Plk_1	543	549	PF00069	0.584
MOD_Plk_1	581	587	PF00069	0.439
MOD_Plk_1	733	739	PF00069	0.583
MOD_Plk_1	792	798	PF00069	0.771
MOD_Plk_2-3	576	582	PF00069	0.439
MOD_Plk_4	347	353	PF00069	0.546
MOD_Plk_4	70	76	PF00069	0.739
MOD_ProDKin_1	209	215	PF00069	0.778
MOD_ProDKin_1	287	293	PF00069	0.739
MOD_ProDKin_1	296	302	PF00069	0.639
MOD_ProDKin_1	314	320	PF00069	0.687
MOD_ProDKin_1	373	379	PF00069	0.771
MOD_ProDKin_1	487	493	PF00069	0.605
MOD_ProDKin_1	499	505	PF00069	0.526
MOD_ProDKin_1	512	518	PF00069	0.482
MOD_ProDKin_1	64	70	PF00069	0.614
MOD_ProDKin_1	704	710	PF00069	0.622
MOD_ProDKin_1	752	758	PF00069	0.775
MOD_ProDKin_1	762	768	PF00069	0.645
MOD_SUMO_for_1	103	106	PF00179	0.382
MOD_SUMO_rev_2	464	471	PF00179	0.610
MOD_SUMO_rev_2	696	701	PF00179	0.698
TRG_DiLeu_BaEn_1	31	36	PF01217	0.733
TRG_DiLeu_BaEn_2	185	191	PF01217	0.679
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.766
TRG_DiLeu_BaLyEn_6	258	263	PF01217	0.519
TRG_ENDOCYTIC_2	661	664	PF00928	0.506
TRG_ENDOCYTIC_2	78	81	PF00928	0.682
TRG_ER_diArg_1	141	144	PF00400	0.761
TRG_ER_diArg_1	182	185	PF00400	0.672
TRG_ER_diArg_1	39	42	PF00400	0.714
TRG_ER_diArg_1	413	415	PF00400	0.584
TRG_ER_diArg_1	473	475	PF00400	0.636
TRG_ER_diArg_1	566	569	PF00400	0.636
TRG_ER_diArg_1	99	102	PF00400	0.656
TRG_NLS_MonoExtN_4	564	571	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	583	587	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IJN1	Leishmania donovani	73%	100%
A4I8G7	Leishmania infantum	73%	100%
E9B3C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	99%
E9B3C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4Q4S9	Leishmania major	71%	100%