AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKY5_LEIBR

TriTrypDb:

LbrM.32.3700 , LBRM2903_320045200

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HKY5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKY5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.380
CLV_C14_Caspase3-7	360	364	PF00656	0.251
CLV_C14_Caspase3-7	383	387	PF00656	0.262
CLV_PCSK_KEX2_1	550	552	PF00082	0.554
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.554
CLV_PCSK_SKI1_1	104	108	PF00082	0.590
CLV_PCSK_SKI1_1	303	307	PF00082	0.494
CLV_PCSK_SKI1_1	395	399	PF00082	0.484
CLV_PCSK_SKI1_1	490	494	PF00082	0.430
CLV_PCSK_SKI1_1	562	566	PF00082	0.394
CLV_PCSK_SKI1_1	86	90	PF00082	0.585
DEG_APCC_DBOX_1	302	310	PF00400	0.307
DEG_APCC_DBOX_1	561	569	PF00400	0.378
DEG_SPOP_SBC_1	131	135	PF00917	0.274
DOC_ANK_TNKS_1	180	187	PF00023	0.328
DOC_CDC14_PxL_1	312	320	PF14671	0.370
DOC_CDC14_PxL_1	325	333	PF14671	0.343
DOC_CYCLIN_RxL_1	389	403	PF00134	0.379
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.342
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	398	401	PF00134	0.216
DOC_MAPK_gen_1	68	74	PF00069	0.343
DOC_MAPK_HePTP_8	559	571	PF00069	0.193
DOC_MAPK_MEF2A_6	108	115	PF00069	0.370
DOC_MAPK_MEF2A_6	303	310	PF00069	0.353
DOC_MAPK_MEF2A_6	558	567	PF00069	0.267
DOC_MAPK_MEF2A_6	86	93	PF00069	0.376
DOC_MAPK_NFAT4_5	303	311	PF00069	0.348
DOC_MAPK_NFAT4_5	562	570	PF00069	0.363
DOC_PP1_RVXF_1	283	289	PF00149	0.331
DOC_PP1_RVXF_1	509	515	PF00149	0.315
DOC_PP1_RVXF_1	69	75	PF00149	0.358
DOC_PP2B_LxvP_1	397	400	PF13499	0.310
DOC_PP2B_PxIxI_1	97	103	PF00149	0.237
DOC_PP4_FxxP_1	3	6	PF00568	0.414
DOC_PP4_FxxP_1	531	534	PF00568	0.379
DOC_USP7_MATH_1	118	122	PF00917	0.347
DOC_USP7_MATH_1	131	135	PF00917	0.363
DOC_USP7_MATH_1	136	140	PF00917	0.325
DOC_USP7_MATH_1	404	408	PF00917	0.413
DOC_USP7_MATH_1	41	45	PF00917	0.441
DOC_USP7_MATH_2	52	58	PF00917	0.327
DOC_WW_Pin1_4	121	126	PF00397	0.338
DOC_WW_Pin1_4	132	137	PF00397	0.308
DOC_WW_Pin1_4	26	31	PF00397	0.537
DOC_WW_Pin1_4	479	484	PF00397	0.384
DOC_WW_Pin1_4	48	53	PF00397	0.406
LIG_14-3-3_CanoR_1	257	265	PF00244	0.388
LIG_14-3-3_CanoR_1	417	427	PF00244	0.322
LIG_14-3-3_CanoR_1	47	52	PF00244	0.375
LIG_14-3-3_CanoR_1	594	600	PF00244	0.657
LIG_14-3-3_CanoR_1	71	77	PF00244	0.328
LIG_Actin_WH2_2	458	473	PF00022	0.415
LIG_BIR_II_1	1	5	PF00653	0.578
LIG_BRCT_BRCA1_1	595	599	PF00533	0.614
LIG_CtBP_PxDLS_1	161	165	PF00389	0.328
LIG_deltaCOP1_diTrp_1	527	531	PF00928	0.327
LIG_EH1_1	73	81	PF00400	0.377
LIG_FHA_1	17	23	PF00498	0.490
LIG_FHA_1	30	36	PF00498	0.332
LIG_FHA_1	430	436	PF00498	0.346
LIG_FHA_1	437	443	PF00498	0.347
LIG_FHA_1	480	486	PF00498	0.362
LIG_FHA_1	56	62	PF00498	0.427
LIG_FHA_2	180	186	PF00498	0.326
LIG_FHA_2	381	387	PF00498	0.431
LIG_FHA_2	537	543	PF00498	0.379
LIG_Integrin_RGD_1	543	545	PF01839	0.599
LIG_LIR_Apic_2	219	223	PF02991	0.321
LIG_LIR_Apic_2	530	534	PF02991	0.353
LIG_LIR_Gen_1	227	237	PF02991	0.302
LIG_LIR_Gen_1	90	100	PF02991	0.375
LIG_LIR_Nem_3	227	232	PF02991	0.268
LIG_LIR_Nem_3	597	603	PF02991	0.601
LIG_LYPXL_S_1	314	318	PF13949	0.517
LIG_LYPXL_yS_3	315	318	PF13949	0.366
LIG_SH2_CRK	581	585	PF00017	0.481
LIG_SH2_CRK	592	596	PF00017	0.624
LIG_SH2_CRK	600	604	PF00017	0.567
LIG_SH2_GRB2like	600	603	PF00017	0.605
LIG_SH2_NCK_1	359	363	PF00017	0.359
LIG_SH2_NCK_1	592	596	PF00017	0.645
LIG_SH2_SRC	220	223	PF00017	0.357
LIG_SH2_STAT3	137	140	PF00017	0.360
LIG_SH2_STAT3	333	336	PF00017	0.253
LIG_SH2_STAT5	231	234	PF00017	0.265
LIG_SH2_STAT5	352	355	PF00017	0.339
LIG_SH2_STAT5	578	581	PF00017	0.305
LIG_SH2_STAT5	583	586	PF00017	0.539
LIG_SH3_3	310	316	PF00018	0.321
LIG_SH3_3	471	477	PF00018	0.401
LIG_SUMO_SIM_par_1	13	19	PF11976	0.458
LIG_SUMO_SIM_par_1	214	219	PF11976	0.301
LIG_SUMO_SIM_par_1	243	250	PF11976	0.241
LIG_SUMO_SIM_par_1	31	38	PF11976	0.341
LIG_SUMO_SIM_par_1	434	439	PF11976	0.329
LIG_WRC_WIRS_1	385	390	PF05994	0.555
LIG_WRC_WIRS_1	405	410	PF05994	0.208
MOD_CK1_1	121	127	PF00069	0.519
MOD_CK1_1	165	171	PF00069	0.418
MOD_CK1_1	281	287	PF00069	0.424
MOD_CK1_1	29	35	PF00069	0.569
MOD_CK1_1	387	393	PF00069	0.486
MOD_CK1_1	4	10	PF00069	0.476
MOD_CK1_1	403	409	PF00069	0.299
MOD_CK1_1	421	427	PF00069	0.603
MOD_CK1_1	593	599	PF00069	0.554
MOD_CK2_1	48	54	PF00069	0.483
MOD_Cter_Amidation	548	551	PF01082	0.459
MOD_GlcNHglycan	167	170	PF01048	0.444
MOD_GlcNHglycan	353	356	PF01048	0.493
MOD_GlcNHglycan	402	405	PF01048	0.496
MOD_GlcNHglycan	420	423	PF01048	0.564
MOD_GlcNHglycan	537	542	PF01048	0.706
MOD_GlcNHglycan	573	576	PF01048	0.473
MOD_GSK3_1	126	133	PF00069	0.459
MOD_GSK3_1	142	149	PF00069	0.304
MOD_GSK3_1	25	32	PF00069	0.634
MOD_GSK3_1	380	387	PF00069	0.513
MOD_GSK3_1	399	406	PF00069	0.364
MOD_GSK3_1	41	48	PF00069	0.374
MOD_GSK3_1	533	540	PF00069	0.435
MOD_N-GLC_1	131	136	PF02516	0.539
MOD_N-GLC_1	162	167	PF02516	0.496
MOD_N-GLC_1	429	434	PF02516	0.454
MOD_NEK2_1	1	6	PF00069	0.578
MOD_NEK2_1	16	21	PF00069	0.524
MOD_NEK2_1	162	167	PF00069	0.431
MOD_NEK2_1	286	291	PF00069	0.471
MOD_NEK2_1	317	322	PF00069	0.438
MOD_NEK2_1	418	423	PF00069	0.564
MOD_NEK2_1	461	466	PF00069	0.475
MOD_NEK2_1	590	595	PF00069	0.682
MOD_NEK2_2	404	409	PF00069	0.244
MOD_NEK2_2	549	554	PF00069	0.422
MOD_PIKK_1	136	142	PF00454	0.470
MOD_PIKK_1	421	427	PF00454	0.469
MOD_PIKK_1	429	435	PF00454	0.432
MOD_PIKK_1	449	455	PF00454	0.280
MOD_PKA_2	118	124	PF00069	0.413
MOD_PKA_2	416	422	PF00069	0.439
MOD_PKA_2	590	596	PF00069	0.574
MOD_PKA_2	70	76	PF00069	0.405
MOD_Plk_1	162	168	PF00069	0.417
MOD_Plk_4	123	129	PF00069	0.488
MOD_Plk_4	16	22	PF00069	0.553
MOD_Plk_4	195	201	PF00069	0.342
MOD_Plk_4	327	333	PF00069	0.308
MOD_Plk_4	87	93	PF00069	0.345
MOD_ProDKin_1	121	127	PF00069	0.416
MOD_ProDKin_1	132	138	PF00069	0.369
MOD_ProDKin_1	26	32	PF00069	0.541
MOD_ProDKin_1	479	485	PF00069	0.474
MOD_ProDKin_1	48	54	PF00069	0.507
MOD_SUMO_rev_2	209	214	PF00179	0.254
TRG_DiLeu_BaEn_2	122	128	PF01217	0.305
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.370
TRG_ENDOCYTIC_2	229	232	PF00928	0.327
TRG_ENDOCYTIC_2	315	318	PF00928	0.416
TRG_ENDOCYTIC_2	581	584	PF00928	0.463
TRG_ENDOCYTIC_2	592	595	PF00928	0.468
TRG_ENDOCYTIC_2	600	603	PF00928	0.468
TRG_ER_FFAT_2	121	133	PF00635	0.446
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I361	Leptomonas seymouri	52%	100%
A0A0S4JGY4	Bodo saltans	25%	98%
A0A1X0NRX3	Trypanosomatidae	29%	100%
A0A3Q8IFS8	Leishmania donovani	76%	100%
A0A422P343	Trypanosoma rangeli	34%	100%
A4I8G4	Leishmania infantum	77%	100%
E9B3C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q4T2	Leishmania major	75%	100%
V5DMC3	Trypanosoma cruzi	32%	100%