Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania braziliensis

UniProt:

A4HKY1_LEIBR

TriTrypDb:

LbrM.32.3660 , LBRM2903_320044800

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKY1

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.581
CLV_C14_Caspase3-7	158	162	PF00656	0.522
CLV_C14_Caspase3-7	357	361	PF00656	0.381
CLV_C14_Caspase3-7	428	432	PF00656	0.208
CLV_NRD_NRD_1	225	227	PF00675	0.653
CLV_NRD_NRD_1	264	266	PF00675	0.547
CLV_NRD_NRD_1	336	338	PF00675	0.543
CLV_NRD_NRD_1	351	353	PF00675	0.332
CLV_NRD_NRD_1	506	508	PF00675	0.610
CLV_NRD_NRD_1	562	564	PF00675	0.445
CLV_NRD_NRD_1	659	661	PF00675	0.475
CLV_NRD_NRD_1	700	702	PF00675	0.569
CLV_NRD_NRD_1	71	73	PF00675	0.611
CLV_PCSK_FUR_1	260	264	PF00082	0.381
CLV_PCSK_KEX2_1	210	212	PF00082	0.468
CLV_PCSK_KEX2_1	227	229	PF00082	0.552
CLV_PCSK_KEX2_1	262	264	PF00082	0.549
CLV_PCSK_KEX2_1	336	338	PF00082	0.551
CLV_PCSK_KEX2_1	351	353	PF00082	0.334
CLV_PCSK_KEX2_1	506	508	PF00082	0.610
CLV_PCSK_KEX2_1	562	564	PF00082	0.432
CLV_PCSK_KEX2_1	658	660	PF00082	0.514
CLV_PCSK_KEX2_1	70	72	PF00082	0.619
CLV_PCSK_KEX2_1	700	702	PF00082	0.569
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.541
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.552
CLV_PCSK_PC7_1	258	264	PF00082	0.533
CLV_PCSK_PC7_1	66	72	PF00082	0.627
CLV_PCSK_SKI1_1	264	268	PF00082	0.422
CLV_PCSK_SKI1_1	351	355	PF00082	0.405
CLV_PCSK_SKI1_1	389	393	PF00082	0.397
CLV_PCSK_SKI1_1	506	510	PF00082	0.608
CLV_PCSK_SKI1_1	548	552	PF00082	0.419
CLV_PCSK_SKI1_1	582	586	PF00082	0.262
CLV_PCSK_SKI1_1	660	664	PF00082	0.441
DEG_APCC_DBOX_1	594	602	PF00400	0.436
DEG_APCC_DBOX_1	658	666	PF00400	0.465
DEG_APCC_DBOX_1	70	78	PF00400	0.508
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DEG_SPOP_SBC_1	36	40	PF00917	0.692
DEG_SPOP_SBC_1	48	52	PF00917	0.543
DOC_CDC14_PxL_1	57	65	PF14671	0.602
DOC_CDC14_PxL_1	643	651	PF14671	0.258
DOC_CDC14_PxL_1	684	692	PF14671	0.422
DOC_CKS1_1	266	271	PF01111	0.527
DOC_CKS1_1	81	86	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	266	272	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	663	669	PF00134	0.387
DOC_MAPK_gen_1	658	667	PF00069	0.464
DOC_MAPK_gen_1	70	79	PF00069	0.509
DOC_MAPK_MEF2A_6	435	444	PF00069	0.346
DOC_MAPK_MEF2A_6	639	646	PF00069	0.402
DOC_MAPK_MEF2A_6	658	667	PF00069	0.382
DOC_PP1_RVXF_1	580	587	PF00149	0.498
DOC_PP2B_LxvP_1	644	647	PF13499	0.337
DOC_PP2B_LxvP_1	663	666	PF13499	0.388
DOC_PP4_FxxP_1	200	203	PF00568	0.588
DOC_USP7_MATH_1	108	112	PF00917	0.691
DOC_USP7_MATH_1	160	164	PF00917	0.662
DOC_USP7_MATH_1	203	207	PF00917	0.400
DOC_USP7_MATH_1	23	27	PF00917	0.591
DOC_USP7_MATH_1	238	242	PF00917	0.395
DOC_USP7_MATH_1	49	53	PF00917	0.597
DOC_USP7_MATH_1	522	526	PF00917	0.619
DOC_USP7_MATH_1	89	93	PF00917	0.635
DOC_WW_Pin1_4	156	161	PF00397	0.704
DOC_WW_Pin1_4	19	24	PF00397	0.781
DOC_WW_Pin1_4	265	270	PF00397	0.643
DOC_WW_Pin1_4	31	36	PF00397	0.712
DOC_WW_Pin1_4	416	421	PF00397	0.257
DOC_WW_Pin1_4	520	525	PF00397	0.584
DOC_WW_Pin1_4	713	718	PF00397	0.581
DOC_WW_Pin1_4	80	85	PF00397	0.763
LIG_14-3-3_CanoR_1	202	212	PF00244	0.529
LIG_14-3-3_CanoR_1	263	269	PF00244	0.563
LIG_14-3-3_CanoR_1	369	373	PF00244	0.377
LIG_14-3-3_CanoR_1	389	395	PF00244	0.312
LIG_14-3-3_CanoR_1	435	444	PF00244	0.346
LIG_14-3-3_CanoR_1	460	469	PF00244	0.416
LIG_14-3-3_CanoR_1	495	499	PF00244	0.410
LIG_14-3-3_CanoR_1	582	587	PF00244	0.259
LIG_Actin_WH2_2	359	375	PF00022	0.447
LIG_ActinCP_TwfCPI_2	200	210	PF01115	0.541
LIG_AP2alpha_2	193	195	PF02296	0.598
LIG_FHA_1	134	140	PF00498	0.703
LIG_FHA_1	150	156	PF00498	0.719
LIG_FHA_1	245	251	PF00498	0.581
LIG_FHA_1	43	49	PF00498	0.536
LIG_FHA_1	500	506	PF00498	0.695
LIG_FHA_1	545	551	PF00498	0.439
LIG_FHA_2	10	16	PF00498	0.510
LIG_FHA_2	177	183	PF00498	0.676
LIG_FHA_2	397	403	PF00498	0.377
LIG_FHA_2	417	423	PF00498	0.171
LIG_FHA_2	426	432	PF00498	0.371
LIG_GSK3_LRP6_1	80	85	PF00069	0.663
LIG_LIR_Apic_2	198	203	PF02991	0.584
LIG_LIR_Gen_1	408	416	PF02991	0.362
LIG_LIR_Gen_1	484	493	PF02991	0.372
LIG_LIR_Nem_3	408	414	PF02991	0.362
LIG_LIR_Nem_3	464	469	PF02991	0.357
LIG_LIR_Nem_3	484	489	PF02991	0.205
LIG_LIR_Nem_3	55	60	PF02991	0.570
LIG_LYPXL_yS_3	687	690	PF13949	0.493
LIG_MYND_1	514	518	PF01753	0.477
LIG_NRBOX	484	490	PF00104	0.357
LIG_NRBOX	694	700	PF00104	0.417
LIG_PCNA_yPIPBox_3	482	495	PF02747	0.389
LIG_Pex14_1	706	710	PF04695	0.328
LIG_Pex14_2	53	57	PF04695	0.476
LIG_PTAP_UEV_1	517	522	PF05743	0.557
LIG_SH2_CRK	2	6	PF00017	0.474
LIG_SH2_CRK	312	316	PF00017	0.328
LIG_SH2_CRK	411	415	PF00017	0.298
LIG_SH2_CRK	609	613	PF00017	0.528
LIG_SH2_GRB2like	411	414	PF00017	0.298
LIG_SH2_NCK_1	307	311	PF00017	0.322
LIG_SH2_NCK_1	609	613	PF00017	0.528
LIG_SH2_NCK_1	710	714	PF00017	0.374
LIG_SH2_SRC	307	310	PF00017	0.220
LIG_SH2_SRC	411	414	PF00017	0.357
LIG_SH2_STAP1	233	237	PF00017	0.424
LIG_SH2_STAP1	307	311	PF00017	0.319
LIG_SH2_STAP1	370	374	PF00017	0.388
LIG_SH2_STAP1	411	415	PF00017	0.358
LIG_SH2_STAP1	445	449	PF00017	0.357
LIG_SH2_STAP1	469	473	PF00017	0.233
LIG_SH2_STAP1	710	714	PF00017	0.428
LIG_SH2_STAT3	233	236	PF00017	0.479
LIG_SH2_STAT5	170	173	PF00017	0.652
LIG_SH2_STAT5	303	306	PF00017	0.409
LIG_SH2_STAT5	320	323	PF00017	0.332
LIG_SH2_STAT5	338	341	PF00017	0.419
LIG_SH2_STAT5	37	40	PF00017	0.602
LIG_SH2_STAT5	490	493	PF00017	0.433
LIG_SH2_STAT5	691	694	PF00017	0.418
LIG_SH3_3	515	521	PF00018	0.558
LIG_SH3_3	74	80	PF00018	0.626
LIG_SUMO_SIM_anti_2	674	681	PF11976	0.443
LIG_SUMO_SIM_par_1	402	409	PF11976	0.292
LIG_SUMO_SIM_par_1	674	681	PF11976	0.429
LIG_TRAF2_1	612	615	PF00917	0.548
LIG_WRC_WIRS_1	391	396	PF05994	0.357
LIG_WRC_WIRS_1	54	59	PF05994	0.511
LIG_WRC_WIRS_1	583	588	PF05994	0.249
MOD_CK1_1	118	124	PF00069	0.630
MOD_CK1_1	159	165	PF00069	0.683
MOD_CK1_1	241	247	PF00069	0.403
MOD_CK1_1	25	31	PF00069	0.755
MOD_CK1_1	277	283	PF00069	0.646
MOD_CK1_1	368	374	PF00069	0.434
MOD_CK1_1	39	45	PF00069	0.557
MOD_CK1_1	500	506	PF00069	0.564
MOD_CK1_1	52	58	PF00069	0.684
MOD_CK1_1	637	643	PF00069	0.523
MOD_CK2_1	1	7	PF00069	0.617
MOD_CK2_1	160	166	PF00069	0.659
MOD_CK2_1	176	182	PF00069	0.641
MOD_CK2_1	320	326	PF00069	0.446
MOD_CK2_1	444	450	PF00069	0.327
MOD_CK2_1	464	470	PF00069	0.171
MOD_CK2_1	705	711	PF00069	0.501
MOD_CK2_1	734	740	PF00069	0.523
MOD_GlcNHglycan	112	115	PF01048	0.656
MOD_GlcNHglycan	117	120	PF01048	0.666
MOD_GlcNHglycan	122	125	PF01048	0.622
MOD_GlcNHglycan	139	142	PF01048	0.776
MOD_GlcNHglycan	205	208	PF01048	0.607
MOD_GlcNHglycan	286	289	PF01048	0.405
MOD_GlcNHglycan	29	32	PF01048	0.665
MOD_GlcNHglycan	518	521	PF01048	0.669
MOD_GlcNHglycan	524	527	PF01048	0.696
MOD_GlcNHglycan	529	532	PF01048	0.721
MOD_GlcNHglycan	578	581	PF01048	0.423
MOD_GlcNHglycan	654	657	PF01048	0.498
MOD_GSK3_1	1	8	PF00069	0.717
MOD_GSK3_1	110	117	PF00069	0.668
MOD_GSK3_1	126	133	PF00069	0.589
MOD_GSK3_1	149	156	PF00069	0.704
MOD_GSK3_1	15	22	PF00069	0.637
MOD_GSK3_1	23	30	PF00069	0.641
MOD_GSK3_1	280	287	PF00069	0.603
MOD_GSK3_1	31	38	PF00069	0.642
MOD_GSK3_1	390	397	PF00069	0.307
MOD_GSK3_1	48	55	PF00069	0.660
MOD_GSK3_1	494	501	PF00069	0.449
MOD_GSK3_1	512	519	PF00069	0.655
MOD_GSK3_1	532	539	PF00069	0.577
MOD_GSK3_1	544	551	PF00069	0.437
MOD_GSK3_1	578	585	PF00069	0.553
MOD_GSK3_1	625	632	PF00069	0.493
MOD_GSK3_1	713	720	PF00069	0.560
MOD_GSK3_1	730	737	PF00069	0.530
MOD_N-GLC_1	651	656	PF02516	0.405
MOD_NEK2_1	1	6	PF00069	0.476
MOD_NEK2_1	115	120	PF00069	0.646
MOD_NEK2_1	394	399	PF00069	0.332
MOD_NEK2_1	444	449	PF00069	0.367
MOD_NEK2_1	471	476	PF00069	0.293
MOD_NEK2_1	498	503	PF00069	0.548
MOD_NEK2_1	53	58	PF00069	0.531
MOD_NEK2_1	667	672	PF00069	0.542
MOD_NEK2_1	734	739	PF00069	0.656
MOD_NEK2_2	320	325	PF00069	0.460
MOD_NEK2_2	377	382	PF00069	0.226
MOD_NEK2_2	494	499	PF00069	0.337
MOD_PIKK_1	277	283	PF00454	0.609
MOD_PIKK_1	430	436	PF00454	0.353
MOD_PIKK_1	461	467	PF00454	0.408
MOD_PIKK_1	734	740	PF00454	0.523
MOD_PKA_1	264	270	PF00069	0.471
MOD_PKA_2	264	270	PF00069	0.464
MOD_PKA_2	368	374	PF00069	0.375
MOD_PKA_2	394	400	PF00069	0.298
MOD_PKA_2	494	500	PF00069	0.411
MOD_PKA_2	610	616	PF00069	0.591
MOD_PKB_1	226	234	PF00069	0.598
MOD_PKB_1	262	270	PF00069	0.425
MOD_Plk_1	160	166	PF00069	0.535
MOD_Plk_1	228	234	PF00069	0.522
MOD_Plk_1	241	247	PF00069	0.308
MOD_Plk_1	613	619	PF00069	0.574
MOD_Plk_1	637	643	PF00069	0.523
MOD_Plk_1	730	736	PF00069	0.511
MOD_Plk_4	299	305	PF00069	0.347
MOD_Plk_4	444	450	PF00069	0.368
MOD_Plk_4	481	487	PF00069	0.362
MOD_Plk_4	49	55	PF00069	0.580
MOD_Plk_4	5	11	PF00069	0.650
MOD_Plk_4	500	506	PF00069	0.691
MOD_Plk_4	512	518	PF00069	0.551
MOD_Plk_4	613	619	PF00069	0.496
MOD_Plk_4	686	692	PF00069	0.394
MOD_Plk_4	705	711	PF00069	0.478
MOD_ProDKin_1	156	162	PF00069	0.702
MOD_ProDKin_1	19	25	PF00069	0.781
MOD_ProDKin_1	265	271	PF00069	0.649
MOD_ProDKin_1	31	37	PF00069	0.707
MOD_ProDKin_1	416	422	PF00069	0.257
MOD_ProDKin_1	520	526	PF00069	0.587
MOD_ProDKin_1	713	719	PF00069	0.586
MOD_ProDKin_1	80	86	PF00069	0.762
TRG_DiLeu_BaEn_1	326	331	PF01217	0.453
TRG_DiLeu_BaEn_1	358	363	PF01217	0.478
TRG_DiLeu_BaEn_1	674	679	PF01217	0.429
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.541
TRG_DiLeu_BaLyEn_6	639	644	PF01217	0.485
TRG_ENDOCYTIC_2	2	5	PF00928	0.474
TRG_ENDOCYTIC_2	411	414	PF00928	0.298
TRG_ENDOCYTIC_2	445	448	PF00928	0.298
TRG_ENDOCYTIC_2	687	690	PF00928	0.543
TRG_ER_diArg_1	225	228	PF00400	0.537
TRG_ER_diArg_1	262	265	PF00400	0.606
TRG_ER_diArg_1	336	338	PF00400	0.529
TRG_ER_diArg_1	350	352	PF00400	0.326
TRG_ER_diArg_1	505	507	PF00400	0.621
TRG_ER_diArg_1	562	564	PF00400	0.445
TRG_ER_diArg_1	63	66	PF00400	0.576
TRG_ER_diArg_1	658	660	PF00400	0.518
TRG_ER_diArg_1	69	72	PF00400	0.580
TRG_ER_diArg_1	699	701	PF00400	0.563
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.454
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U7	Leptomonas seymouri	53%	90%
A0A3S7X618	Leishmania donovani	80%	91%
A4I8G1	Leishmania infantum	80%	91%
E9B3B9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	91%
Q4Q4T6	Leishmania major	82%	100%
V5BQX7	Trypanosoma cruzi	30%	100%