LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HKX8_LEIBR
TriTrypDb:
LbrM.32.3620 , LBRM2903_320044500
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4HKX8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKX8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 21 23 PF00675 0.443
CLV_NRD_NRD_1 65 67 PF00675 0.538
CLV_NRD_NRD_1 86 88 PF00675 0.519
CLV_PCSK_KEX2_1 21 23 PF00082 0.339
CLV_PCSK_KEX2_1 65 67 PF00082 0.538
CLV_PCSK_KEX2_1 86 88 PF00082 0.519
CLV_PCSK_PC7_1 17 23 PF00082 0.456
CLV_PCSK_SKI1_1 65 69 PF00082 0.662
DEG_APCC_KENBOX_2 67 71 PF00400 0.336
DOC_USP7_MATH_1 102 106 PF00917 0.425
DOC_USP7_UBL2_3 68 72 PF12436 0.474
LIG_14-3-3_CanoR_1 86 91 PF00244 0.412
LIG_FHA_1 75 81 PF00498 0.442
LIG_FHA_2 74 80 PF00498 0.447
LIG_LIR_Gen_1 8 16 PF02991 0.537
LIG_LIR_Nem_3 8 12 PF02991 0.531
LIG_Pex14_2 47 51 PF04695 0.343
LIG_WRC_WIRS_1 93 98 PF05994 0.443
MOD_CK2_1 73 79 PF00069 0.446
MOD_CK2_1 92 98 PF00069 0.426
MOD_GlcNHglycan 39 42 PF01048 0.298
MOD_PK_1 86 92 PF00069 0.373
MOD_PKA_1 86 92 PF00069 0.314
MOD_PKA_2 86 92 PF00069 0.342
MOD_Plk_1 15 21 PF00069 0.642
TRG_ER_diArg_1 20 22 PF00400 0.628
TRG_ER_diArg_1 65 67 PF00400 0.338
TRG_ER_diArg_1 86 88 PF00400 0.319
TRG_Pf-PMV_PEXEL_1 4 8 PF00026 0.431
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.595

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IJ08 Leptomonas seymouri 81% 100%
A0A0S4J9Y1 Bodo saltans 45% 82%
A0A1X0NTB8 Trypanosomatidae 64% 96%
A0A3Q8IDF0 Leishmania donovani 89% 100%
A0A422P2W9 Trypanosoma rangeli 63% 97%
A4I8F8 Leishmania infantum 89% 100%
E9B3B6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q4T9 Leishmania major 89% 100%
V5BR10 Trypanosoma cruzi 64% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS