Putative cyclin 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative cyclin 6

Gene product:

cyclin 6, putative

Species:

Leishmania braziliensis

UniProt:

A4HKX7_LEIBR

TriTrypDb:

LbrM.32.3610 , LBRM2903_320044400

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HKX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKX7

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0009987	cellular process	1	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	1
GO:0019207	kinase regulator activity	3	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.406
CLV_NRD_NRD_1	280	282	PF00675	0.289
CLV_PCSK_KEX2_1	183	185	PF00082	0.406
CLV_PCSK_KEX2_1	280	282	PF00082	0.297
CLV_PCSK_SKI1_1	191	195	PF00082	0.373
CLV_PCSK_SKI1_1	293	297	PF00082	0.411
CLV_PCSK_SKI1_1	49	53	PF00082	0.325
DEG_APCC_DBOX_1	95	103	PF00400	0.297
DEG_Nend_Nbox_1	1	3	PF02207	0.486
DOC_CKS1_1	154	159	PF01111	0.257
DOC_CKS1_1	209	214	PF01111	0.276
DOC_CYCLIN_RxL_1	287	299	PF00134	0.156
DOC_PP1_RVXF_1	204	211	PF00149	0.285
DOC_PP2B_LxvP_1	152	155	PF13499	0.329
DOC_PP2B_LxvP_1	231	234	PF13499	0.406
DOC_USP7_MATH_1	159	163	PF00917	0.406
DOC_USP7_MATH_1	216	220	PF00917	0.253
DOC_USP7_MATH_1	234	238	PF00917	0.268
DOC_WW_Pin1_4	153	158	PF00397	0.258
DOC_WW_Pin1_4	208	213	PF00397	0.406
DOC_WW_Pin1_4	31	36	PF00397	0.304
LIG_14-3-3_CanoR_1	142	152	PF00244	0.306
LIG_14-3-3_CanoR_1	163	168	PF00244	0.304
LIG_14-3-3_CanoR_1	191	197	PF00244	0.325
LIG_14-3-3_CanoR_1	90	94	PF00244	0.315
LIG_APCC_ABBA_1	63	68	PF00400	0.308
LIG_APCC_ABBAyCdc20_2	62	68	PF00400	0.256
LIG_CSL_BTD_1	116	119	PF09270	0.308
LIG_eIF4E_1	71	77	PF01652	0.406
LIG_FHA_1	23	29	PF00498	0.489
LIG_FHA_1	241	247	PF00498	0.312
LIG_FHA_1	67	73	PF00498	0.303
LIG_FHA_1	89	95	PF00498	0.341
LIG_FHA_2	131	137	PF00498	0.332
LIG_FHA_2	164	170	PF00498	0.361
LIG_FHA_2	176	182	PF00498	0.316
LIG_FHA_2	227	233	PF00498	0.449
LIG_FHA_2	248	254	PF00498	0.318
LIG_LIR_Gen_1	111	121	PF02991	0.156
LIG_LIR_Gen_1	162	173	PF02991	0.406
LIG_LIR_Gen_1	219	227	PF02991	0.324
LIG_LIR_Gen_1	273	283	PF02991	0.296
LIG_LIR_Gen_1	285	296	PF02991	0.314
LIG_LIR_Gen_1	68	77	PF02991	0.291
LIG_LIR_Nem_3	111	116	PF02991	0.311
LIG_LIR_Nem_3	162	168	PF02991	0.294
LIG_LIR_Nem_3	171	176	PF02991	0.322
LIG_LIR_Nem_3	204	208	PF02991	0.326
LIG_LIR_Nem_3	219	224	PF02991	0.269
LIG_LIR_Nem_3	26	32	PF02991	0.476
LIG_LIR_Nem_3	266	270	PF02991	0.280
LIG_LIR_Nem_3	273	279	PF02991	0.268
LIG_LIR_Nem_3	285	291	PF02991	0.292
LIG_LIR_Nem_3	34	40	PF02991	0.255
LIG_LIR_Nem_3	68	74	PF02991	0.291
LIG_SH2_CRK	205	209	PF00017	0.303
LIG_SH2_CRK	276	280	PF00017	0.285
LIG_SH2_GRB2like	267	270	PF00017	0.276
LIG_SH2_NCK_1	249	253	PF00017	0.239
LIG_SH2_NCK_1	32	36	PF00017	0.341
LIG_SH2_SRC	113	116	PF00017	0.285
LIG_SH2_STAP1	113	117	PF00017	0.285
LIG_SH2_STAP1	29	33	PF00017	0.403
LIG_SH2_STAT5	132	135	PF00017	0.332
LIG_SH2_STAT5	249	252	PF00017	0.406
LIG_SH2_STAT5	267	270	PF00017	0.139
LIG_SH2_STAT5	37	40	PF00017	0.292
LIG_SH2_STAT5	71	74	PF00017	0.278
LIG_SH2_STAT5	80	83	PF00017	0.252
LIG_SH3_3	151	157	PF00018	0.269
LIG_SUMO_SIM_par_1	223	229	PF11976	0.276
LIG_SUMO_SIM_par_1	49	54	PF11976	0.307
LIG_TRAF2_1	133	136	PF00917	0.285
LIG_TRAF2_1	178	181	PF00917	0.316
LIG_TYR_ITIM	203	208	PF00017	0.285
LIG_TYR_ITSM	272	279	PF00017	0.285
LIG_TYR_ITSM	67	74	PF00017	0.308
LIG_UBA3_1	224	230	PF00899	0.406
MOD_CK1_1	128	134	PF00069	0.285
MOD_CK1_1	143	149	PF00069	0.261
MOD_CK1_1	20	26	PF00069	0.426
MOD_CK2_1	108	114	PF00069	0.435
MOD_CK2_1	130	136	PF00069	0.308
MOD_CK2_1	163	169	PF00069	0.316
MOD_CK2_1	175	181	PF00069	0.281
MOD_CK2_1	226	232	PF00069	0.441
MOD_CK2_1	247	253	PF00069	0.317
MOD_GlcNHglycan	104	107	PF01048	0.281
MOD_GlcNHglycan	127	130	PF01048	0.267
MOD_GlcNHglycan	19	22	PF01048	0.628
MOD_GlcNHglycan	284	287	PF01048	0.313
MOD_GSK3_1	146	153	PF00069	0.333
MOD_GSK3_1	159	166	PF00069	0.398
MOD_GSK3_1	16	23	PF00069	0.674
MOD_N-GLC_1	16	21	PF02516	0.538
MOD_N-GLC_1	23	28	PF02516	0.442
MOD_NEK2_1	108	113	PF00069	0.168
MOD_NEK2_1	140	145	PF00069	0.289
MOD_NEK2_1	150	155	PF00069	0.303
MOD_NEK2_1	289	294	PF00069	0.401
MOD_NEK2_2	216	221	PF00069	0.275
MOD_PIKK_1	210	216	PF00454	0.304
MOD_PKA_2	150	156	PF00069	0.257
MOD_PKA_2	89	95	PF00069	0.347
MOD_Plk_1	140	146	PF00069	0.239
MOD_Plk_1	23	29	PF00069	0.612
MOD_Plk_1	88	94	PF00069	0.401
MOD_Plk_4	192	198	PF00069	0.370
MOD_Plk_4	216	222	PF00069	0.245
MOD_Plk_4	24	30	PF00069	0.492
MOD_Plk_4	66	72	PF00069	0.291
MOD_Plk_4	89	95	PF00069	0.297
MOD_ProDKin_1	153	159	PF00069	0.258
MOD_ProDKin_1	208	214	PF00069	0.406
MOD_ProDKin_1	31	37	PF00069	0.304
MOD_SUMO_rev_2	199	208	PF00179	0.285
TRG_DiLeu_BaEn_2	168	174	PF01217	0.406
TRG_ENDOCYTIC_2	113	116	PF00928	0.285
TRG_ENDOCYTIC_2	205	208	PF00928	0.281
TRG_ENDOCYTIC_2	276	279	PF00928	0.285
TRG_ENDOCYTIC_2	288	291	PF00928	0.316
TRG_ENDOCYTIC_2	71	74	PF00928	0.283
TRG_ER_diArg_1	279	281	PF00400	0.297
TRG_NES_CRM1_1	54	68	PF08389	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P242	Leptomonas seymouri	84%	72%
A0A0N1PCH1	Leptomonas seymouri	41%	98%
A0A0S4JB51	Bodo saltans	43%	88%
A0A0S4JDL7	Bodo saltans	46%	93%
A0A1X0NNN9	Trypanosomatidae	43%	91%
A0A1X0NS93	Trypanosomatidae	56%	75%
A0A3S7X632	Leishmania donovani	92%	100%
A0A422N0Z8	Trypanosoma rangeli	41%	91%
A0A422P2X2	Trypanosoma rangeli	65%	80%
A0MEB5	Arabidopsis thaliana	34%	93%
A2YH60	Oryza sativa subsp. indica	35%	72%
A4HE79	Leishmania braziliensis	39%	100%
A4I1J3	Leishmania infantum	39%	98%
A4I8F7	Leishmania infantum	92%	100%
E9AXM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	98%
E9B3B5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O48790	Arabidopsis thaliana	37%	78%
O77689	Bos taurus	34%	76%
O93229	Rana japonica	35%	77%
O95067	Homo sapiens	34%	76%
P04962	Spisula solidissima	34%	72%
P07818	Arbacia punctulata	34%	74%
P13350	Xenopus laevis	34%	76%
P13351	Xenopus laevis	35%	77%
P13952	Spisula solidissima	35%	71%
P14635	Homo sapiens	35%	70%
P15206	Marthasterias glacialis	33%	78%
P18606	Xenopus laevis	35%	72%
P20248	Homo sapiens	33%	70%
P24860	Mus musculus	35%	70%
P24861	Patella vulgata	34%	71%
P24862	Patella vulgata	32%	74%
P24865	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	73%
P24870	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	71%
P25010	Daucus carota	33%	89%
P25011	Glycine max	37%	67%
P25012	Glycine max	39%	100%
P25322	Mus musculus	30%	100%
P29332	Gallus gallus	35%	76%
P30183	Arabidopsis thaliana	36%	71%
P30274	Bos taurus	33%	70%
P30276	Mus musculus	34%	76%
P30277	Rattus norvegicus	34%	72%
P30278	Medicago sativa	34%	92%
P30279	Homo sapiens	25%	100%
P30280	Mus musculus	25%	100%
P30281	Homo sapiens	27%	100%
P30282	Mus musculus	27%	100%
P30283	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	70%
P32943	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	80%
P34801	Antirrhinum majus	36%	69%
P36630	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	74%
P37881	Mesocricetus auratus	33%	72%
P37882	Mesocricetus auratus	34%	71%
P37883	Mesocricetus auratus	35%	76%
P39948	Rattus norvegicus	29%	100%
P39963	Gallus gallus	32%	75%
P42524	Dictyostelium discoideum	35%	69%
P42751	Arabidopsis thaliana	28%	89%
P43449	Gallus gallus	34%	77%
P46277	Medicago sativa subsp. varia	35%	71%
P46278	Medicago sativa subsp. varia	34%	70%
P47827	Xenopus laevis	34%	73%
P48961	Rattus norvegicus	26%	100%
P49706	Gallus gallus	24%	100%
P51943	Mus musculus	33%	72%
P51986	Hydra viridissima	33%	72%
P51987	Hydra viridissima	34%	77%
P51988	Hydra vulgaris	35%	84%
P53782	Xenopus laevis	24%	100%
P55169	Gallus gallus	28%	100%
Q01J96	Oryza sativa subsp. indica	33%	72%
Q04827	Rattus norvegicus	25%	100%
Q08301	Cricetulus griseus	34%	71%
Q0D9C7	Oryza sativa subsp. japonica	35%	72%
Q0DH40	Oryza sativa subsp. japonica	38%	67%
Q0DJR9	Oryza sativa subsp. japonica	35%	85%
Q0JIF2	Oryza sativa subsp. japonica	39%	67%
Q0P5D3	Bos taurus	24%	100%
Q10653	Caenorhabditis elegans	32%	84%
Q10654	Caenorhabditis elegans	26%	79%
Q10Q62	Oryza sativa subsp. japonica	27%	75%
Q147G5	Arabidopsis thaliana	34%	69%
Q1LZG6	Bos taurus	34%	71%
Q2QN26	Oryza sativa subsp. japonica	34%	79%
Q38819	Arabidopsis thaliana	32%	67%
Q39067	Arabidopsis thaliana	35%	68%
Q39068	Arabidopsis thaliana	33%	71%
Q39069	Arabidopsis thaliana	38%	73%
Q39070	Arabidopsis thaliana	32%	71%
Q39071	Arabidopsis thaliana	33%	68%
Q3ECW2	Arabidopsis thaliana	34%	82%
Q3MHH5	Bos taurus	26%	100%
Q4Q4U0	Leishmania major	91%	100%
Q4Q9U4	Leishmania major	38%	100%
Q4R7A8	Macaca fascicularis	33%	76%
Q60FX9	Anguilla japonica	36%	77%
Q60FY0	Anguilla japonica	34%	75%
Q61456	Mus musculus	36%	72%
Q6AY13	Rattus norvegicus	36%	72%
Q6K1Z6	Oryza sativa subsp. japonica	28%	78%
Q6K8S0	Oryza sativa subsp. japonica	26%	68%
Q75I54	Oryza sativa subsp. japonica	33%	81%
Q7XSJ6	Oryza sativa subsp. japonica	33%	72%
Q8MUA0	Leishmania donovani	39%	98%
Q8WNW2	Sus scrofa	25%	100%
Q90459	Danio rerio	29%	100%
Q92162	Carassius auratus	34%	76%
Q9C6A9	Arabidopsis thaliana	35%	81%
Q9DG96	Oryzias luzonensis	35%	78%
Q9DG97	Oryzias luzonensis	33%	76%
Q9DG99	Oryzias javanicus	33%	79%
Q9DGA0	Oryzias javanicus	34%	76%
Q9DGA3	Oryzias curvinotus	35%	78%
Q9DGA4	Oryzias curvinotus	35%	76%
Q9FMH5	Arabidopsis thaliana	34%	85%
Q9FVX0	Arabidopsis thaliana	34%	69%
Q9IBG0	Oryzias latipes	35%	78%
Q9IBG1	Oryzias latipes	34%	75%
Q9LDM4	Arabidopsis thaliana	34%	71%
Q9LM91	Arabidopsis thaliana	28%	100%
Q9SA32	Arabidopsis thaliana	34%	77%
Q9SFW6	Arabidopsis thaliana	38%	70%
Q9Z238	Mus musculus	28%	75%
V5BLA1	Trypanosoma cruzi	60%	80%