Dihydrolipoyl dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrolipoamide dehydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKX6_LEIBR

TriTrypDb:

LbrM.32.3600 , LBRM2903_320044300

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 2
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045239	tricarboxylic acid cycle enzyme complex	3	1
GO:0045240	dihydrolipoyl dehydrogenase complex	4	1
GO:0045252	oxoglutarate dehydrogenase complex	4	1

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Expansion

Sequence features

A4HKX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKX6

Function

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Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	12
GO:0019725	cellular homeostasis	2	12
GO:0042592	homeostatic process	3	12
GO:0045454	cell redox homeostasis	3	12
GO:0050789	regulation of biological process	2	12
GO:0050794	regulation of cellular process	3	12
GO:0065007	biological regulation	1	12
GO:0065008	regulation of biological quality	2	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004148	dihydrolipoyl dehydrogenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	12
GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.414
CLV_NRD_NRD_1	283	285	PF00675	0.364
CLV_NRD_NRD_1	3	5	PF00675	0.574
CLV_PCSK_KEX2_1	268	270	PF00082	0.306
CLV_PCSK_KEX2_1	283	285	PF00082	0.393
CLV_PCSK_KEX2_1	3	5	PF00082	0.574
CLV_PCSK_KEX2_1	42	44	PF00082	0.357
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.293
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.357
CLV_PCSK_SKI1_1	168	172	PF00082	0.271

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P491	Leptomonas seymouri	88%	100%
A0A0N1HUA4	Leptomonas seymouri	26%	84%
A0A0N1I1H2	Leptomonas seymouri	28%	97%
A0A0N1IHT7	Leptomonas seymouri	29%	94%
A0A0N1IIN8	Leptomonas seymouri	27%	91%
A0A0S4J6A3	Bodo saltans	31%	96%
A0A0S4JDA8	Bodo saltans	71%	100%
A0A0S4KLJ6	Bodo saltans	27%	76%
A0A1X0NJ18	Trypanosomatidae	25%	74%
A0A1X0NK15	Trypanosomatidae	28%	81%

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