Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKX4_LEIBR

TriTrypDb:

LbrM.32.3580 , LBRM2903_320044100

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HKX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.372
CLV_PCSK_KEX2_1	159	161	PF00082	0.360
CLV_PCSK_KEX2_1	172	174	PF00082	0.478
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.477
CLV_PCSK_SKI1_1	121	125	PF00082	0.342
CLV_PCSK_SKI1_1	160	164	PF00082	0.455
CLV_PCSK_SKI1_1	173	177	PF00082	0.452
DOC_CKS1_1	223	228	PF01111	0.662
DOC_CKS1_1	6	11	PF01111	0.482
DOC_CYCLIN_RxL_1	140	151	PF00134	0.583
DOC_CYCLIN_RxL_1	156	167	PF00134	0.660
DOC_MAPK_JIP1_4	108	114	PF00069	0.499
DOC_MAPK_MEF2A_6	108	116	PF00069	0.488
DOC_PP1_RVXF_1	119	125	PF00149	0.452
DOC_PP1_RVXF_1	88	94	PF00149	0.529
DOC_PP2B_PxIxI_1	131	137	PF00149	0.508
DOC_WW_Pin1_4	2	7	PF00397	0.550
DOC_WW_Pin1_4	222	227	PF00397	0.645
LIG_14-3-3_CanoR_1	160	170	PF00244	0.591
LIG_BIR_II_1	1	5	PF00653	0.519
LIG_BRCT_BRCA1_1	167	171	PF00533	0.640
LIG_EH1_1	155	163	PF00400	0.568
LIG_eIF4E_1	42	48	PF01652	0.462
LIG_FHA_1	174	180	PF00498	0.645
LIG_FHA_1	208	214	PF00498	0.736
LIG_FHA_2	178	184	PF00498	0.629
LIG_FHA_2	41	47	PF00498	0.375
LIG_LIR_Gen_1	110	119	PF02991	0.474
LIG_LIR_Gen_1	130	141	PF02991	0.550
LIG_LIR_Nem_3	110	114	PF02991	0.490
LIG_LIR_Nem_3	130	136	PF02991	0.546
LIG_LIR_Nem_3	73	77	PF02991	0.215
LIG_SH2_PTP2	133	136	PF00017	0.512
LIG_SH2_STAT5	133	136	PF00017	0.491
LIG_SH2_STAT5	42	45	PF00017	0.383
LIG_SH2_STAT5	85	88	PF00017	0.402
LIG_SH3_3	220	226	PF00018	0.644
LIG_SH3_3	3	9	PF00018	0.480
LIG_SH3_3	72	78	PF00018	0.280
LIG_SUMO_SIM_par_1	142	149	PF11976	0.578
LIG_TRAF2_1	180	183	PF00917	0.626
LIG_TYR_ITIM	131	136	PF00017	0.539
LIG_WRC_WIRS_1	71	76	PF05994	0.341
MOD_CK1_1	127	133	PF00069	0.499
MOD_CK1_1	152	158	PF00069	0.575
MOD_CK1_1	164	170	PF00069	0.696
MOD_CK1_1	2	8	PF00069	0.536
MOD_CK2_1	177	183	PF00069	0.631
MOD_GlcNHglycan	126	129	PF01048	0.320
MOD_GlcNHglycan	199	202	PF01048	0.474
MOD_GlcNHglycan	27	30	PF01048	0.708
MOD_GlcNHglycan	87	90	PF01048	0.496
MOD_GSK3_1	1	8	PF00069	0.532
MOD_GSK3_1	161	168	PF00069	0.589
MOD_GSK3_1	173	180	PF00069	0.645
MOD_GSK3_1	36	43	PF00069	0.402
MOD_N-GLC_1	152	157	PF02516	0.376
MOD_N-GLC_1	197	202	PF02516	0.469
MOD_NEK2_1	1	6	PF00069	0.559
MOD_NEK2_1	124	129	PF00069	0.515
MOD_NEK2_1	161	166	PF00069	0.580
MOD_NEK2_1	171	176	PF00069	0.577
MOD_NEK2_1	227	232	PF00069	0.604
MOD_NEK2_1	70	75	PF00069	0.217
MOD_PIKK_1	161	167	PF00454	0.571
MOD_PIKK_1	202	208	PF00454	0.755
MOD_PIKK_1	234	240	PF00454	0.777
MOD_PKA_2	107	113	PF00069	0.669
MOD_PKA_2	149	155	PF00069	0.660
MOD_PKA_2	165	171	PF00069	0.632
MOD_PKA_2	202	208	PF00069	0.725
MOD_Plk_1	152	158	PF00069	0.575
MOD_Plk_4	107	113	PF00069	0.581
MOD_Plk_4	165	171	PF00069	0.655
MOD_Plk_4	70	76	PF00069	0.276
MOD_ProDKin_1	2	8	PF00069	0.550
MOD_ProDKin_1	222	228	PF00069	0.648
TRG_DiLeu_BaEn_1	183	188	PF01217	0.614
TRG_DiLeu_LyEn_5	183	188	PF01217	0.670
TRG_ENDOCYTIC_2	133	136	PF00928	0.544
TRG_ENDOCYTIC_2	232	235	PF00928	0.670
TRG_ER_diArg_1	158	160	PF00400	0.567
TRG_NES_CRM1_1	22	36	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX5	Leptomonas seymouri	87%	100%
A0A0S4J8L9	Bodo saltans	55%	100%
A0A1X0NRU5	Trypanosomatidae	66%	100%
A0A3Q8IGH3	Leishmania donovani	89%	100%
A0A422P2X7	Trypanosoma rangeli	64%	100%
A4I8F4	Leishmania infantum	89%	100%
D0AAR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E9B3B2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q4U3	Leishmania major	90%	100%
V5BVM8	Trypanosoma cruzi	66%	100%