Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKX3_LEIBR

TriTrypDb:

LbrM.32.3570 , LBRM2903_320043900

Length:

816

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKX3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKX3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.431
CLV_C14_Caspase3-7	147	151	PF00656	0.438
CLV_C14_Caspase3-7	495	499	PF00656	0.518
CLV_C14_Caspase3-7	714	718	PF00656	0.564
CLV_NRD_NRD_1	287	289	PF00675	0.575
CLV_NRD_NRD_1	504	506	PF00675	0.679
CLV_NRD_NRD_1	611	613	PF00675	0.586
CLV_NRD_NRD_1	683	685	PF00675	0.565
CLV_NRD_NRD_1	777	779	PF00675	0.518
CLV_PCSK_KEX2_1	287	289	PF00082	0.575
CLV_PCSK_KEX2_1	611	613	PF00082	0.586
CLV_PCSK_KEX2_1	683	685	PF00082	0.572
CLV_PCSK_KEX2_1	777	779	PF00082	0.691
CLV_PCSK_KEX2_1	814	816	PF00082	0.756
CLV_PCSK_PC1ET2_1	814	816	PF00082	0.635
CLV_PCSK_SKI1_1	161	165	PF00082	0.661
CLV_PCSK_SKI1_1	250	254	PF00082	0.593
CLV_PCSK_SKI1_1	287	291	PF00082	0.478
CLV_PCSK_SKI1_1	355	359	PF00082	0.491
CLV_PCSK_SKI1_1	381	385	PF00082	0.633
CLV_PCSK_SKI1_1	424	428	PF00082	0.583
CLV_PCSK_SKI1_1	449	453	PF00082	0.501
CLV_PCSK_SKI1_1	663	667	PF00082	0.506
CLV_PCSK_SKI1_1	689	693	PF00082	0.608
CLV_PCSK_SKI1_1	724	728	PF00082	0.500
DEG_SPOP_SBC_1	171	175	PF00917	0.549
DEG_SPOP_SBC_1	8	12	PF00917	0.511
DOC_CYCLIN_RxL_1	352	361	PF00134	0.491
DOC_CYCLIN_RxL_1	446	456	PF00134	0.494
DOC_CYCLIN_yCln2_LP_2	253	259	PF00134	0.549
DOC_CYCLIN_yCln2_LP_2	482	488	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	756	762	PF00134	0.572
DOC_MAPK_FxFP_2	439	442	PF00069	0.496
DOC_MAPK_gen_1	447	454	PF00069	0.577
DOC_PP1_RVXF_1	187	193	PF00149	0.525
DOC_PP1_RVXF_1	661	668	PF00149	0.502
DOC_PP2B_LxvP_1	168	171	PF13499	0.569
DOC_PP2B_LxvP_1	482	485	PF13499	0.496
DOC_PP2B_LxvP_1	571	574	PF13499	0.640
DOC_PP4_FxxP_1	439	442	PF00568	0.496
DOC_PP4_FxxP_1	669	672	PF00568	0.545
DOC_USP7_MATH_1	156	160	PF00917	0.486
DOC_USP7_MATH_1	229	233	PF00917	0.518
DOC_USP7_MATH_1	396	400	PF00917	0.682
DOC_USP7_MATH_1	418	422	PF00917	0.538
DOC_USP7_MATH_1	445	449	PF00917	0.521
DOC_USP7_MATH_1	490	494	PF00917	0.659
DOC_USP7_MATH_1	51	55	PF00917	0.658
DOC_USP7_MATH_1	549	553	PF00917	0.521
DOC_USP7_MATH_1	576	580	PF00917	0.734
DOC_USP7_MATH_1	656	660	PF00917	0.623
DOC_USP7_MATH_1	702	706	PF00917	0.695
DOC_WW_Pin1_4	252	257	PF00397	0.527
DOC_WW_Pin1_4	266	271	PF00397	0.620
DOC_WW_Pin1_4	390	395	PF00397	0.711
DOC_WW_Pin1_4	507	512	PF00397	0.623
DOC_WW_Pin1_4	531	536	PF00397	0.752
DOC_WW_Pin1_4	56	61	PF00397	0.671
DOC_WW_Pin1_4	598	603	PF00397	0.615
DOC_WW_Pin1_4	691	696	PF00397	0.772
DOC_WW_Pin1_4	70	75	PF00397	0.482
DOC_WW_Pin1_4	755	760	PF00397	0.671
LIG_14-3-3_CanoR_1	157	164	PF00244	0.517
LIG_14-3-3_CanoR_1	193	201	PF00244	0.597
LIG_14-3-3_CanoR_1	209	219	PF00244	0.560
LIG_14-3-3_CanoR_1	340	349	PF00244	0.503
LIG_14-3-3_CanoR_1	447	452	PF00244	0.538
LIG_14-3-3_CanoR_1	518	524	PF00244	0.538
LIG_14-3-3_CanoR_1	55	60	PF00244	0.665
LIG_14-3-3_CanoR_1	628	634	PF00244	0.539
LIG_14-3-3_CanoR_1	651	658	PF00244	0.588
LIG_14-3-3_CanoR_1	741	749	PF00244	0.593
LIG_Actin_WH2_2	173	191	PF00022	0.535
LIG_BIR_III_2	655	659	PF00653	0.523
LIG_BRCT_BRCA1_1	61	65	PF00533	0.679
LIG_Clathr_ClatBox_1	357	361	PF01394	0.496
LIG_CSL_BTD_1	541	544	PF09270	0.505
LIG_DLG_GKlike_1	447	454	PF00625	0.494
LIG_EVH1_1	168	172	PF00568	0.488
LIG_FHA_1	122	128	PF00498	0.543
LIG_FHA_1	173	179	PF00498	0.567
LIG_FHA_1	234	240	PF00498	0.544
LIG_FHA_1	39	45	PF00498	0.572
LIG_FHA_1	407	413	PF00498	0.656
LIG_FHA_1	566	572	PF00498	0.566
LIG_FHA_1	575	581	PF00498	0.471
LIG_FHA_1	617	623	PF00498	0.510
LIG_FHA_1	628	634	PF00498	0.527
LIG_FHA_1	660	666	PF00498	0.524
LIG_FHA_1	67	73	PF00498	0.652
LIG_FHA_1	797	803	PF00498	0.510
LIG_FHA_2	142	148	PF00498	0.520
LIG_FHA_2	194	200	PF00498	0.569
LIG_FHA_2	363	369	PF00498	0.509
LIG_FHA_2	405	411	PF00498	0.582
LIG_FHA_2	451	457	PF00498	0.627
LIG_FHA_2	47	53	PF00498	0.689
LIG_FHA_2	490	496	PF00498	0.507
LIG_FHA_2	56	62	PF00498	0.593
LIG_FHA_2	705	711	PF00498	0.548
LIG_FHA_2	734	740	PF00498	0.506
LIG_FHA_2	787	793	PF00498	0.515
LIG_FHA_2	9	15	PF00498	0.573
LIG_LIR_Apic_2	438	442	PF02991	0.497
LIG_LIR_Gen_1	13	23	PF02991	0.663
LIG_LIR_Gen_1	410	420	PF02991	0.502
LIG_LIR_Gen_1	64	75	PF02991	0.713
LIG_LIR_Nem_3	13	19	PF02991	0.659
LIG_MAD2	89	97	PF02301	0.439
LIG_NRBOX	218	224	PF00104	0.483
LIG_Rb_LxCxE_1	132	147	PF01857	0.448
LIG_RPA_C_Fungi	152	164	PF08784	0.455
LIG_SH2_CRK	16	20	PF00017	0.789
LIG_SH2_NCK_1	483	487	PF00017	0.497
LIG_SH2_NCK_1	772	776	PF00017	0.451
LIG_SH2_SRC	483	486	PF00017	0.496
LIG_SH2_SRC	772	775	PF00017	0.529
LIG_SH2_STAP1	16	20	PF00017	0.668
LIG_SH2_STAP1	201	205	PF00017	0.494
LIG_SH2_STAP1	772	776	PF00017	0.532
LIG_SH2_STAT5	143	146	PF00017	0.438
LIG_SH2_STAT5	16	19	PF00017	0.665
LIG_SH2_STAT5	343	346	PF00017	0.503
LIG_SH2_STAT5	413	416	PF00017	0.508
LIG_SH2_STAT5	693	696	PF00017	0.516
LIG_SH3_3	122	128	PF00018	0.439
LIG_SH3_3	166	172	PF00018	0.517
LIG_SH3_3	497	503	PF00018	0.656
LIG_SH3_3	538	544	PF00018	0.672
LIG_SH3_3	570	576	PF00018	0.613
LIG_SH3_3	633	639	PF00018	0.538
LIG_SH3_3	71	77	PF00018	0.551
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.436
LIG_SUMO_SIM_par_1	114	120	PF11976	0.436
LIG_SUMO_SIM_par_1	173	181	PF11976	0.544
LIG_SUMO_SIM_par_1	296	303	PF11976	0.644
LIG_SUMO_SIM_par_1	356	361	PF11976	0.491
LIG_SUMO_SIM_par_1	450	458	PF11976	0.507
LIG_SUMO_SIM_par_1	798	805	PF11976	0.504
LIG_TRAF2_1	801	804	PF00917	0.499
LIG_WRC_WIRS_1	419	424	PF05994	0.488
MOD_CDC14_SPxK_1	534	537	PF00782	0.508
MOD_CDK_SPxK_1	531	537	PF00069	0.509
MOD_CDK_SPxxK_3	266	273	PF00069	0.501
MOD_CK1_1	218	224	PF00069	0.734
MOD_CK1_1	280	286	PF00069	0.597
MOD_CK1_1	385	391	PF00069	0.687
MOD_CK1_1	400	406	PF00069	0.518
MOD_CK1_1	450	456	PF00069	0.570
MOD_CK1_1	493	499	PF00069	0.594
MOD_CK1_1	54	60	PF00069	0.642
MOD_CK1_1	581	587	PF00069	0.623
MOD_CK1_1	631	637	PF00069	0.601
MOD_CK1_1	641	647	PF00069	0.681
MOD_CK1_1	659	665	PF00069	0.594
MOD_CK1_1	722	728	PF00069	0.607
MOD_CK1_1	805	811	PF00069	0.560
MOD_CK1_1	9	15	PF00069	0.557
MOD_CK2_1	131	137	PF00069	0.553
MOD_CK2_1	141	147	PF00069	0.515
MOD_CK2_1	193	199	PF00069	0.703
MOD_CK2_1	210	216	PF00069	0.731
MOD_CK2_1	404	410	PF00069	0.584
MOD_CK2_1	450	456	PF00069	0.609
MOD_CK2_1	46	52	PF00069	0.659
MOD_CK2_1	489	495	PF00069	0.504
MOD_CK2_1	55	61	PF00069	0.568
MOD_CK2_1	587	593	PF00069	0.550
MOD_CK2_1	694	700	PF00069	0.584
MOD_CK2_1	7	13	PF00069	0.587
MOD_CK2_1	708	714	PF00069	0.616
MOD_CK2_1	733	739	PF00069	0.529
MOD_CK2_1	768	774	PF00069	0.548
MOD_CK2_1	798	804	PF00069	0.506
MOD_DYRK1A_RPxSP_1	390	394	PF00069	0.552
MOD_GlcNHglycan	153	156	PF01048	0.586
MOD_GlcNHglycan	377	380	PF01048	0.645
MOD_GlcNHglycan	390	393	PF01048	0.800
MOD_GlcNHglycan	416	419	PF01048	0.526
MOD_GlcNHglycan	456	460	PF01048	0.572
MOD_GlcNHglycan	476	479	PF01048	0.674
MOD_GlcNHglycan	49	52	PF01048	0.628
MOD_GlcNHglycan	507	510	PF01048	0.747
MOD_GlcNHglycan	583	586	PF01048	0.587
MOD_GlcNHglycan	589	592	PF01048	0.599
MOD_GlcNHglycan	605	608	PF01048	0.525
MOD_GlcNHglycan	646	649	PF01048	0.689
MOD_GlcNHglycan	659	662	PF01048	0.569
MOD_GlcNHglycan	676	679	PF01048	0.445
MOD_GlcNHglycan	741	744	PF01048	0.551
MOD_GlcNHglycan	784	787	PF01048	0.675
MOD_GlcNHglycan	810	813	PF01048	0.576
MOD_GSK3_1	172	179	PF00069	0.507
MOD_GSK3_1	19	26	PF00069	0.472
MOD_GSK3_1	193	200	PF00069	0.607
MOD_GSK3_1	2	9	PF00069	0.590
MOD_GSK3_1	229	236	PF00069	0.625
MOD_GSK3_1	34	41	PF00069	0.649
MOD_GSK3_1	381	388	PF00069	0.745
MOD_GSK3_1	390	397	PF00069	0.688
MOD_GSK3_1	398	405	PF00069	0.570
MOD_GSK3_1	414	421	PF00069	0.576
MOD_GSK3_1	427	434	PF00069	0.606
MOD_GSK3_1	43	50	PF00069	0.553
MOD_GSK3_1	489	496	PF00069	0.558
MOD_GSK3_1	507	514	PF00069	0.599
MOD_GSK3_1	51	58	PF00069	0.533
MOD_GSK3_1	574	581	PF00069	0.602
MOD_GSK3_1	594	601	PF00069	0.556
MOD_GSK3_1	61	68	PF00069	0.599
MOD_GSK3_1	627	634	PF00069	0.611
MOD_GSK3_1	638	645	PF00069	0.635
MOD_GSK3_1	689	696	PF00069	0.567
MOD_GSK3_1	704	711	PF00069	0.717
MOD_GSK3_1	741	748	PF00069	0.697
MOD_GSK3_1	782	789	PF00069	0.506
MOD_GSK3_1	798	805	PF00069	0.635
MOD_N-GLC_1	24	29	PF02516	0.507
MOD_N-GLC_1	427	432	PF02516	0.540
MOD_N-GLC_1	628	633	PF02516	0.578
MOD_N-GLC_1	745	750	PF02516	0.524
MOD_N-GLC_2	640	642	PF02516	0.548
MOD_NEK2_1	227	232	PF00069	0.630
MOD_NEK2_1	342	347	PF00069	0.594
MOD_NEK2_1	386	391	PF00069	0.570
MOD_NEK2_1	398	403	PF00069	0.556
MOD_NEK2_1	412	417	PF00069	0.657
MOD_NEK2_1	422	427	PF00069	0.647
MOD_NEK2_1	474	479	PF00069	0.586
MOD_NEK2_1	594	599	PF00069	0.553
MOD_NEK2_1	605	610	PF00069	0.578
MOD_NEK2_1	65	70	PF00069	0.610
MOD_NEK2_1	798	803	PF00069	0.508
MOD_NEK2_1	82	87	PF00069	0.480
MOD_NEK2_2	121	126	PF00069	0.526
MOD_NEK2_2	215	220	PF00069	0.486
MOD_NEK2_2	745	750	PF00069	0.524
MOD_OFUCOSY	489	494	PF10250	0.502
MOD_PIKK_1	229	235	PF00454	0.520
MOD_PIKK_1	631	637	PF00454	0.677
MOD_PIKK_1	793	799	PF00454	0.521
MOD_PKA_1	505	511	PF00069	0.531
MOD_PKA_2	156	162	PF00069	0.538
MOD_PKA_2	54	60	PF00069	0.597
MOD_PKA_2	627	633	PF00069	0.517
MOD_PKA_2	650	656	PF00069	0.529
MOD_Plk_1	131	137	PF00069	0.448
MOD_Plk_1	14	20	PF00069	0.506
MOD_Plk_1	197	203	PF00069	0.496
MOD_Plk_1	215	221	PF00069	0.434
MOD_Plk_1	280	286	PF00069	0.580
MOD_Plk_1	381	387	PF00069	0.637
MOD_Plk_1	427	433	PF00069	0.501
MOD_Plk_1	628	634	PF00069	0.552
MOD_Plk_1	689	695	PF00069	0.494
MOD_Plk_1	745	751	PF00069	0.521
MOD_Plk_2-3	114	120	PF00069	0.436
MOD_Plk_2-3	199	205	PF00069	0.497
MOD_Plk_2-3	277	283	PF00069	0.498
MOD_Plk_2-3	709	715	PF00069	0.544
MOD_Plk_4	114	120	PF00069	0.436
MOD_Plk_4	14	20	PF00069	0.663
MOD_Plk_4	218	224	PF00069	0.506
MOD_Plk_4	422	428	PF00069	0.581
MOD_Plk_4	519	525	PF00069	0.599
MOD_Plk_4	61	67	PF00069	0.519
MOD_ProDKin_1	252	258	PF00069	0.524
MOD_ProDKin_1	266	272	PF00069	0.620
MOD_ProDKin_1	390	396	PF00069	0.710
MOD_ProDKin_1	507	513	PF00069	0.623
MOD_ProDKin_1	531	537	PF00069	0.754
MOD_ProDKin_1	56	62	PF00069	0.671
MOD_ProDKin_1	598	604	PF00069	0.615
MOD_ProDKin_1	691	697	PF00069	0.774
MOD_ProDKin_1	70	76	PF00069	0.478
MOD_ProDKin_1	755	761	PF00069	0.672
MOD_SUMO_rev_2	366	371	PF00179	0.506
MOD_SUMO_rev_2	659	667	PF00179	0.506
TRG_DiLeu_BaEn_2	60	66	PF01217	0.523
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.490
TRG_DiLeu_BaLyEn_6	566	571	PF01217	0.524
TRG_DiLeu_BaLyEn_6	669	674	PF01217	0.543
TRG_DiLeu_LyEn_5	267	272	PF01217	0.500
TRG_ENDOCYTIC_2	16	19	PF00928	0.719
TRG_ENDOCYTIC_2	343	346	PF00928	0.503
TRG_ENDOCYTIC_2	413	416	PF00928	0.508
TRG_ENDOCYTIC_2	483	486	PF00928	0.505
TRG_ER_diArg_1	187	190	PF00400	0.497
TRG_ER_diArg_1	446	449	PF00400	0.563
TRG_ER_diArg_1	610	612	PF00400	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC13	Leptomonas seymouri	32%	97%
A0A3S7X647	Leishmania donovani	48%	98%
A4I8F3	Leishmania infantum	48%	98%
E9B3B1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
Q4Q4U4	Leishmania major	47%	100%