Cytoplasmic dynein 2 light intermediate chain 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light intermediate chain, putative

Species:

Leishmania braziliensis

UniProt:

A4HKW8_LEIBR

TriTrypDb:

LbrM.32.3520 , LBRM2903_320043300

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005868	cytoplasmic dynein complex	4	11
GO:0005875	microtubule associated complex	2	11
GO:0005929	cilium	4	10
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:1902494	catalytic complex	2	11
GO:0005815	microtubule organizing center	2	4
GO:0005930	axoneme	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

A4HKW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKW8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035721	intraciliary retrograde transport	4	11
GO:0035735	intraciliary transport involved in cilium assembly	4	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.423
CLV_MEL_PAP_1	202	208	PF00089	0.450
CLV_NRD_NRD_1	138	140	PF00675	0.430
CLV_NRD_NRD_1	200	202	PF00675	0.329
CLV_NRD_NRD_1	385	387	PF00675	0.586
CLV_NRD_NRD_1	403	405	PF00675	0.328
CLV_NRD_NRD_1	414	416	PF00675	0.419
CLV_PCSK_KEX2_1	124	126	PF00082	0.655
CLV_PCSK_KEX2_1	138	140	PF00082	0.351
CLV_PCSK_KEX2_1	200	202	PF00082	0.292
CLV_PCSK_KEX2_1	240	242	PF00082	0.414
CLV_PCSK_KEX2_1	385	387	PF00082	0.501
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.679
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.414
CLV_PCSK_SKI1_1	124	128	PF00082	0.594
CLV_PCSK_SKI1_1	223	227	PF00082	0.443
CLV_PCSK_SKI1_1	79	83	PF00082	0.551
DEG_APCC_DBOX_1	240	248	PF00400	0.342
DOC_CKS1_1	166	171	PF01111	0.303
DOC_MAPK_DCC_7	243	252	PF00069	0.296
DOC_MAPK_gen_1	294	301	PF00069	0.436
DOC_MAPK_MEF2A_6	243	252	PF00069	0.295
DOC_PP4_FxxP_1	304	307	PF00568	0.378
DOC_PP4_FxxP_1	395	398	PF00568	0.452
DOC_USP7_MATH_1	118	122	PF00917	0.529
DOC_USP7_MATH_1	137	141	PF00917	0.500
DOC_USP7_MATH_1	215	219	PF00917	0.396
DOC_USP7_MATH_1	28	32	PF00917	0.653
DOC_USP7_MATH_1	337	341	PF00917	0.419
DOC_USP7_MATH_1	422	426	PF00917	0.548
DOC_USP7_MATH_1	5	9	PF00917	0.765
DOC_WW_Pin1_4	165	170	PF00397	0.315
DOC_WW_Pin1_4	217	222	PF00397	0.374
LIG_14-3-3_CanoR_1	109	115	PF00244	0.501
LIG_14-3-3_CanoR_1	125	134	PF00244	0.587
LIG_14-3-3_CanoR_1	138	146	PF00244	0.328
LIG_14-3-3_CanoR_1	205	213	PF00244	0.494
LIG_AP2alpha_1	363	367	PF02296	0.263
LIG_AP2alpha_2	381	383	PF02296	0.494
LIG_BIR_III_2	365	369	PF00653	0.296
LIG_CtBP_PxDLS_1	47	51	PF00389	0.489
LIG_deltaCOP1_diTrp_1	357	363	PF00928	0.417
LIG_FHA_1	102	108	PF00498	0.316
LIG_FHA_1	127	133	PF00498	0.401
LIG_FHA_1	247	253	PF00498	0.295
LIG_FHA_1	68	74	PF00498	0.442
LIG_FHA_1	76	82	PF00498	0.417
LIG_FHA_2	128	134	PF00498	0.420
LIG_FHA_2	217	223	PF00498	0.396
LIG_FHA_2	313	319	PF00498	0.499
LIG_Integrin_RGD_1	260	262	PF01839	0.435
LIG_LIR_Apic_2	302	307	PF02991	0.402
LIG_LIR_Apic_2	357	362	PF02991	0.386
LIG_LIR_Apic_2	392	398	PF02991	0.456
LIG_LIR_Gen_1	329	339	PF02991	0.384
LIG_LIR_Gen_1	72	81	PF02991	0.396
LIG_LIR_LC3C_4	249	253	PF02991	0.258
LIG_LIR_LC3C_4	90	95	PF02991	0.437
LIG_LIR_Nem_3	292	298	PF02991	0.442
LIG_LIR_Nem_3	329	334	PF02991	0.335
LIG_LIR_Nem_3	72	77	PF02991	0.392
LIG_Pex14_1	359	363	PF04695	0.410
LIG_Pex14_2	304	308	PF04695	0.355
LIG_Pex14_2	363	367	PF04695	0.419
LIG_Rb_pABgroove_1	382	390	PF01858	0.449
LIG_SH2_STAT5	111	114	PF00017	0.432
LIG_SH2_STAT5	275	278	PF00017	0.348
LIG_SH3_3	163	169	PF00018	0.307
LIG_SH3_3	304	310	PF00018	0.440
LIG_SH3_3	41	47	PF00018	0.595
LIG_SH3_3	63	69	PF00018	0.473
LIG_SH3_3	93	99	PF00018	0.247
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.404
LIG_TRAF2_1	183	186	PF00917	0.450
LIG_TRAF2_1	288	291	PF00917	0.413
LIG_TRAF2_1	35	38	PF00917	0.646
LIG_UBA3_1	399	407	PF00899	0.347
LIG_WRC_WIRS_1	111	116	PF05994	0.524
MOD_CDK_SPxK_1	217	223	PF00069	0.377
MOD_CK1_1	10	16	PF00069	0.699
MOD_CK1_1	101	107	PF00069	0.426
MOD_CK1_1	113	119	PF00069	0.498
MOD_CK1_1	207	213	PF00069	0.461
MOD_CK1_1	29	35	PF00069	0.591
MOD_CK1_1	347	353	PF00069	0.559
MOD_CK2_1	17	23	PF00069	0.662
MOD_CK2_1	216	222	PF00069	0.421
MOD_CK2_1	285	291	PF00069	0.380
MOD_CK2_1	312	318	PF00069	0.423
MOD_GlcNHglycan	100	103	PF01048	0.328
MOD_GlcNHglycan	116	119	PF01048	0.577
MOD_GlcNHglycan	244	247	PF01048	0.320
MOD_GlcNHglycan	347	350	PF01048	0.489
MOD_GlcNHglycan	9	12	PF01048	0.559
MOD_GSK3_1	109	116	PF00069	0.413
MOD_GSK3_1	242	249	PF00069	0.338
MOD_GSK3_1	285	292	PF00069	0.335
MOD_GSK3_1	29	36	PF00069	0.719
MOD_GSK3_1	344	351	PF00069	0.411
MOD_GSK3_1	7	14	PF00069	0.540
MOD_GSK3_1	98	105	PF00069	0.450
MOD_N-GLC_1	29	34	PF02516	0.593
MOD_N-GLC_1	299	304	PF02516	0.369
MOD_N-GLC_1	337	342	PF02516	0.482
MOD_N-GLC_1	416	421	PF02516	0.469
MOD_N-GLC_1	422	427	PF02516	0.548
MOD_N-GLC_1	60	65	PF02516	0.596
MOD_N-GLC_1	75	80	PF02516	0.477
MOD_NEK2_1	114	119	PF00069	0.504
MOD_NEK2_1	132	137	PF00069	0.410
MOD_NEK2_1	157	162	PF00069	0.349
MOD_NEK2_1	242	247	PF00069	0.349
MOD_NEK2_1	269	274	PF00069	0.304
MOD_NEK2_1	299	304	PF00069	0.369
MOD_NEK2_1	399	404	PF00069	0.522
MOD_PIKK_1	157	163	PF00454	0.389
MOD_PIKK_1	207	213	PF00454	0.514
MOD_PIKK_1	60	66	PF00454	0.441
MOD_PKA_1	415	421	PF00069	0.503
MOD_PKA_2	137	143	PF00069	0.457
MOD_PKA_2	204	210	PF00069	0.456
MOD_PKA_2	242	248	PF00069	0.344
MOD_PKA_2	327	333	PF00069	0.421
MOD_Plk_1	132	138	PF00069	0.386
MOD_Plk_1	299	305	PF00069	0.381
MOD_Plk_1	337	343	PF00069	0.461
MOD_Plk_1	60	66	PF00069	0.412
MOD_Plk_2-3	327	333	PF00069	0.365
MOD_Plk_4	102	108	PF00069	0.287
MOD_Plk_4	193	199	PF00069	0.325
MOD_Plk_4	246	252	PF00069	0.300
MOD_Plk_4	327	333	PF00069	0.421
MOD_ProDKin_1	165	171	PF00069	0.311
MOD_ProDKin_1	217	223	PF00069	0.377
MOD_SUMO_rev_2	235	242	PF00179	0.432
MOD_SUMO_rev_2	374	379	PF00179	0.554
TRG_ENDOCYTIC_2	111	114	PF00928	0.500
TRG_ER_diArg_1	199	201	PF00400	0.392
TRG_ER_diArg_1	241	244	PF00400	0.322
TRG_ER_diArg_1	384	386	PF00400	0.640
TRG_NLS_MonoExtN_4	237	244	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.682
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN3	Leptomonas seymouri	81%	100%
A0A0S4JG99	Bodo saltans	53%	100%
A0A1X0NS84	Trypanosomatidae	53%	100%
A0A3R7P067	Trypanosoma rangeli	53%	100%
A0A3S5H7T0	Leishmania donovani	84%	100%
A4I8E8	Leishmania infantum	84%	100%
D0AAS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9B3A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q32KV4	Bos taurus	27%	100%
Q4Q4U9	Leishmania major	84%	99%
Q6AY43	Rattus norvegicus	26%	100%
Q7SXY4	Danio rerio	28%	100%
Q7XA07	Chlamydomonas reinhardtii	24%	100%
Q8K0T2	Mus musculus	26%	100%
Q8TCX1	Homo sapiens	25%	100%