Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HKW7_LEIBR

TriTrypDb:

LbrM.32.3510 , LBRM2903_320043200

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.504
CLV_C14_Caspase3-7	17	21	PF00656	0.517
CLV_C14_Caspase3-7	257	261	PF00656	0.416
CLV_C14_Caspase3-7	534	538	PF00656	0.487
CLV_C14_Caspase3-7	620	624	PF00656	0.525
CLV_NRD_NRD_1	165	167	PF00675	0.664
CLV_NRD_NRD_1	200	202	PF00675	0.583
CLV_NRD_NRD_1	358	360	PF00675	0.508
CLV_NRD_NRD_1	363	365	PF00675	0.509
CLV_NRD_NRD_1	74	76	PF00675	0.810
CLV_NRD_NRD_1	79	81	PF00675	0.740
CLV_PCSK_FUR_1	198	202	PF00082	0.581
CLV_PCSK_KEX2_1	165	167	PF00082	0.664
CLV_PCSK_KEX2_1	200	202	PF00082	0.583
CLV_PCSK_KEX2_1	358	360	PF00082	0.508
CLV_PCSK_KEX2_1	74	76	PF00082	0.810
CLV_PCSK_KEX2_1	79	81	PF00082	0.740
CLV_PCSK_PC7_1	75	81	PF00082	0.673
CLV_PCSK_SKI1_1	230	234	PF00082	0.377
CLV_PCSK_SKI1_1	377	381	PF00082	0.562
CLV_PCSK_SKI1_1	42	46	PF00082	0.510
CLV_PCSK_SKI1_1	74	78	PF00082	0.657
DEG_APCC_DBOX_1	229	237	PF00400	0.419
DEG_SCF_FBW7_1	429	436	PF00400	0.654
DEG_SCF_FBW7_1	61	66	PF00400	0.523
DOC_CDC14_PxL_1	378	386	PF14671	0.530
DOC_CKS1_1	167	172	PF01111	0.580
DOC_CKS1_1	491	496	PF01111	0.480
DOC_CKS1_1	507	512	PF01111	0.464
DOC_CYCLIN_yClb1_LxF_4	481	486	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	44	50	PF00134	0.500
DOC_MAPK_DCC_7	480	489	PF00069	0.564
DOC_MAPK_gen_1	246	256	PF00069	0.460
DOC_MAPK_gen_1	288	296	PF00069	0.404
DOC_MAPK_gen_1	364	372	PF00069	0.457
DOC_MAPK_gen_1	480	489	PF00069	0.483
DOC_MAPK_MEF2A_6	249	256	PF00069	0.466
DOC_MAPK_MEF2A_6	288	296	PF00069	0.325
DOC_MAPK_MEF2A_6	480	489	PF00069	0.564
DOC_PP4_FxxP_1	379	382	PF00568	0.533
DOC_PP4_MxPP_1	479	482	PF00568	0.608
DOC_USP7_MATH_1	149	153	PF00917	0.588
DOC_USP7_MATH_1	177	181	PF00917	0.525
DOC_USP7_MATH_1	224	228	PF00917	0.462
DOC_USP7_MATH_1	232	236	PF00917	0.360
DOC_USP7_MATH_1	252	256	PF00917	0.450
DOC_USP7_MATH_1	284	288	PF00917	0.343
DOC_USP7_MATH_1	420	424	PF00917	0.706
DOC_USP7_MATH_1	433	437	PF00917	0.601
DOC_USP7_MATH_1	442	446	PF00917	0.574
DOC_USP7_MATH_1	501	505	PF00917	0.626
DOC_USP7_MATH_1	556	560	PF00917	0.693
DOC_USP7_MATH_1	571	575	PF00917	0.499
DOC_USP7_MATH_1	63	67	PF00917	0.590
DOC_WW_Pin1_4	140	145	PF00397	0.731
DOC_WW_Pin1_4	152	157	PF00397	0.664
DOC_WW_Pin1_4	166	171	PF00397	0.500
DOC_WW_Pin1_4	189	194	PF00397	0.619
DOC_WW_Pin1_4	416	421	PF00397	0.508
DOC_WW_Pin1_4	423	428	PF00397	0.605
DOC_WW_Pin1_4	429	434	PF00397	0.601
DOC_WW_Pin1_4	438	443	PF00397	0.560
DOC_WW_Pin1_4	450	455	PF00397	0.564
DOC_WW_Pin1_4	457	462	PF00397	0.571
DOC_WW_Pin1_4	490	495	PF00397	0.686
DOC_WW_Pin1_4	506	511	PF00397	0.465
DOC_WW_Pin1_4	538	543	PF00397	0.567
DOC_WW_Pin1_4	59	64	PF00397	0.516
LIG_14-3-3_CanoR_1	14	24	PF00244	0.669
LIG_14-3-3_CanoR_1	219	229	PF00244	0.539
LIG_14-3-3_CanoR_1	246	252	PF00244	0.392
LIG_14-3-3_CanoR_1	42	47	PF00244	0.540
LIG_14-3-3_CanoR_1	618	622	PF00244	0.549
LIG_AP2alpha_1	486	490	PF02296	0.482
LIG_Clathr_ClatBox_1	369	373	PF01394	0.525
LIG_Clathr_ClatBox_1	599	603	PF01394	0.573
LIG_eIF4E_1	231	237	PF01652	0.483
LIG_FHA_1	145	151	PF00498	0.565
LIG_FHA_1	167	173	PF00498	0.641
LIG_FHA_1	31	37	PF00498	0.581
LIG_FHA_1	39	45	PF00498	0.592
LIG_FHA_1	491	497	PF00498	0.481
LIG_FHA_1	507	513	PF00498	0.465
LIG_FHA_1	52	58	PF00498	0.561
LIG_FHA_1	531	537	PF00498	0.482
LIG_FHA_1	87	93	PF00498	0.616
LIG_FHA_2	134	140	PF00498	0.502
LIG_FHA_2	182	188	PF00498	0.604
LIG_FHA_2	255	261	PF00498	0.421
LIG_FHA_2	401	407	PF00498	0.641
LIG_FHA_2	430	436	PF00498	0.668
LIG_FHA_2	532	538	PF00498	0.627
LIG_FHA_2	618	624	PF00498	0.524
LIG_LIR_Apic_2	410	414	PF02991	0.633
LIG_LIR_Apic_2	45	51	PF02991	0.496
LIG_LIR_Apic_2	509	514	PF02991	0.502
LIG_LIR_Gen_1	255	262	PF02991	0.485
LIG_LIR_Gen_1	412	422	PF02991	0.571
LIG_LIR_Gen_1	473	484	PF02991	0.491
LIG_LIR_Nem_3	297	302	PF02991	0.403
LIG_LIR_Nem_3	412	418	PF02991	0.564
LIG_LIR_Nem_3	572	578	PF02991	0.577
LIG_Pex14_2	486	490	PF04695	0.482
LIG_SH2_PTP2	291	294	PF00017	0.394
LIG_SH2_PTP2	48	51	PF00017	0.500
LIG_SH2_PTP2	511	514	PF00017	0.644
LIG_SH2_STAP1	125	129	PF00017	0.538
LIG_SH2_STAP1	330	334	PF00017	0.461
LIG_SH2_STAP1	385	389	PF00017	0.550
LIG_SH2_STAT3	212	215	PF00017	0.482
LIG_SH2_STAT5	135	138	PF00017	0.583
LIG_SH2_STAT5	267	270	PF00017	0.432
LIG_SH2_STAT5	291	294	PF00017	0.394
LIG_SH2_STAT5	411	414	PF00017	0.630
LIG_SH2_STAT5	48	51	PF00017	0.500
LIG_SH2_STAT5	511	514	PF00017	0.580
LIG_SH2_STAT5	578	581	PF00017	0.581
LIG_SH3_1	511	517	PF00018	0.570
LIG_SH3_3	138	144	PF00018	0.581
LIG_SH3_3	164	170	PF00018	0.609
LIG_SH3_3	386	392	PF00018	0.553
LIG_SH3_3	46	52	PF00018	0.613
LIG_SH3_3	479	485	PF00018	0.564
LIG_SH3_3	511	517	PF00018	0.546
LIG_SUMO_SIM_anti_2	596	601	PF11976	0.546
LIG_SUMO_SIM_anti_2	612	618	PF11976	0.457
LIG_SUMO_SIM_par_1	596	601	PF11976	0.546
LIG_TRAF2_1	186	189	PF00917	0.521
LIG_TRAF2_1	301	304	PF00917	0.481
LIG_TRAF2_1	69	72	PF00917	0.667
LIG_WRC_WIRS_1	599	604	PF05994	0.637
LIG_WW_3	480	484	PF00397	0.630
MOD_CDK_SPK_2	59	64	PF00069	0.521
MOD_CK1_1	104	110	PF00069	0.554
MOD_CK1_1	133	139	PF00069	0.578
MOD_CK1_1	143	149	PF00069	0.555
MOD_CK1_1	152	158	PF00069	0.591
MOD_CK1_1	16	22	PF00069	0.728
MOD_CK1_1	160	166	PF00069	0.510
MOD_CK1_1	181	187	PF00069	0.598
MOD_CK1_1	247	253	PF00069	0.383
MOD_CK1_1	280	286	PF00069	0.442
MOD_CK1_1	336	342	PF00069	0.488
MOD_CK1_1	400	406	PF00069	0.641
MOD_CK1_1	423	429	PF00069	0.603
MOD_CK1_1	436	442	PF00069	0.591
MOD_CK1_1	462	468	PF00069	0.631
MOD_CK1_1	538	544	PF00069	0.529
MOD_CK1_1	574	580	PF00069	0.494
MOD_CK1_1	66	72	PF00069	0.798
MOD_CK1_1	82	88	PF00069	0.544
MOD_CK2_1	124	130	PF00069	0.560
MOD_CK2_1	181	187	PF00069	0.506
MOD_CK2_1	314	320	PF00069	0.499
MOD_CK2_1	400	406	PF00069	0.641
MOD_CK2_1	429	435	PF00069	0.616
MOD_CK2_1	570	576	PF00069	0.577
MOD_CK2_1	606	612	PF00069	0.482
MOD_CK2_1	66	72	PF00069	0.809
MOD_Cter_Amidation	72	75	PF01082	0.521
MOD_DYRK1A_RPxSP_1	166	170	PF00069	0.579
MOD_GlcNHglycan	104	107	PF01048	0.553
MOD_GlcNHglycan	151	154	PF01048	0.591
MOD_GlcNHglycan	263	266	PF01048	0.567
MOD_GlcNHglycan	279	282	PF01048	0.441
MOD_GlcNHglycan	3	6	PF01048	0.743
MOD_GlcNHglycan	448	451	PF01048	0.728
MOD_GlcNHglycan	544	547	PF01048	0.653
MOD_GlcNHglycan	554	557	PF01048	0.571
MOD_GSK3_1	140	147	PF00069	0.639
MOD_GSK3_1	155	162	PF00069	0.532
MOD_GSK3_1	16	23	PF00069	0.629
MOD_GSK3_1	177	184	PF00069	0.634
MOD_GSK3_1	220	227	PF00069	0.409
MOD_GSK3_1	261	268	PF00069	0.534
MOD_GSK3_1	280	287	PF00069	0.338
MOD_GSK3_1	30	37	PF00069	0.516
MOD_GSK3_1	310	317	PF00069	0.470
MOD_GSK3_1	320	327	PF00069	0.434
MOD_GSK3_1	38	45	PF00069	0.550
MOD_GSK3_1	397	404	PF00069	0.528
MOD_GSK3_1	416	423	PF00069	0.623
MOD_GSK3_1	425	432	PF00069	0.589
MOD_GSK3_1	438	445	PF00069	0.554
MOD_GSK3_1	446	453	PF00069	0.708
MOD_GSK3_1	455	462	PF00069	0.569
MOD_GSK3_1	497	504	PF00069	0.493
MOD_GSK3_1	531	538	PF00069	0.575
MOD_GSK3_1	552	559	PF00069	0.617
MOD_GSK3_1	570	577	PF00069	0.469
MOD_GSK3_1	59	66	PF00069	0.666
MOD_GSK3_1	598	605	PF00069	0.643
MOD_GSK3_1	82	89	PF00069	0.577
MOD_N-GLC_1	202	207	PF02516	0.580
MOD_N-GLC_1	552	557	PF02516	0.504
MOD_NEK2_1	1	6	PF00069	0.633
MOD_NEK2_1	157	162	PF00069	0.603
MOD_NEK2_1	24	29	PF00069	0.538
MOD_NEK2_1	272	277	PF00069	0.452
MOD_NEK2_1	30	35	PF00069	0.507
MOD_NEK2_1	489	494	PF00069	0.619
MOD_NEK2_1	530	535	PF00069	0.476
MOD_NEK2_2	420	425	PF00069	0.593
MOD_OFUCOSY	447	452	PF10250	0.563
MOD_PIKK_1	130	136	PF00454	0.623
MOD_PIKK_1	224	230	PF00454	0.530
MOD_PIKK_1	247	253	PF00454	0.383
MOD_PIKK_1	371	377	PF00454	0.454
MOD_PK_1	79	85	PF00069	0.601
MOD_PKA_1	79	85	PF00069	0.667
MOD_PKA_2	101	107	PF00069	0.532
MOD_PKA_2	13	19	PF00069	0.568
MOD_PKA_2	272	278	PF00069	0.450
MOD_PKA_2	617	623	PF00069	0.606
MOD_PKA_2	79	85	PF00069	0.667
MOD_Plk_1	130	136	PF00069	0.543
MOD_Plk_1	202	208	PF00069	0.467
MOD_Plk_1	420	426	PF00069	0.594
MOD_Plk_1	433	439	PF00069	0.600
MOD_Plk_1	571	577	PF00069	0.496
MOD_Plk_2-3	124	130	PF00069	0.541
MOD_Plk_2-3	314	320	PF00069	0.424
MOD_Plk_4	171	177	PF00069	0.655
MOD_Plk_4	314	320	PF00069	0.640
MOD_Plk_4	333	339	PF00069	0.500
MOD_Plk_4	380	386	PF00069	0.518
MOD_Plk_4	397	403	PF00069	0.677
MOD_Plk_4	420	426	PF00069	0.594
MOD_Plk_4	459	465	PF00069	0.495
MOD_Plk_4	531	537	PF00069	0.482
MOD_Plk_4	574	580	PF00069	0.614
MOD_ProDKin_1	140	146	PF00069	0.730
MOD_ProDKin_1	152	158	PF00069	0.667
MOD_ProDKin_1	166	172	PF00069	0.502
MOD_ProDKin_1	189	195	PF00069	0.613
MOD_ProDKin_1	416	422	PF00069	0.513
MOD_ProDKin_1	423	429	PF00069	0.603
MOD_ProDKin_1	438	444	PF00069	0.558
MOD_ProDKin_1	450	456	PF00069	0.564
MOD_ProDKin_1	457	463	PF00069	0.571
MOD_ProDKin_1	490	496	PF00069	0.687
MOD_ProDKin_1	506	512	PF00069	0.464
MOD_ProDKin_1	538	544	PF00069	0.566
MOD_ProDKin_1	59	65	PF00069	0.518
TRG_DiLeu_BaEn_1	594	599	PF01217	0.483
TRG_DiLeu_BaEn_1	612	617	PF01217	0.462
TRG_DiLeu_BaEn_1	72	77	PF01217	0.523
TRG_DiLeu_LyEn_5	72	77	PF01217	0.523
TRG_ENDOCYTIC_2	291	294	PF00928	0.394
TRG_ER_diArg_1	165	167	PF00400	0.663
TRG_ER_diArg_1	198	201	PF00400	0.583
TRG_ER_diArg_1	358	361	PF00400	0.508
TRG_ER_diArg_1	74	76	PF00400	0.803
TRG_ER_diArg_1	78	80	PF00400	0.744
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	246	251	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM2	Leptomonas seymouri	50%	100%
A0A3S7X620	Leishmania donovani	72%	100%
A4I8E7	Leishmania infantum	71%	100%
E9B3A5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q4V0	Leishmania major	72%	100%