GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GTP-binding protein

Gene product:

Miro-like protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKW6_LEIBR

TriTrypDb:

LbrM.32.3500 , LBRM2903_320043100

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4HKW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKW6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0003924	GTPase activity	7	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.563
CLV_C14_Caspase3-7	64	68	PF00656	0.441
CLV_NRD_NRD_1	59	61	PF00675	0.382
CLV_PCSK_KEX2_1	59	61	PF00082	0.352
CLV_PCSK_KEX2_1	71	73	PF00082	0.313
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.376
CLV_PCSK_SKI1_1	187	191	PF00082	0.371
CLV_PCSK_SKI1_1	60	64	PF00082	0.450
DOC_MAPK_gen_1	69	77	PF00069	0.303
DOC_MAPK_MEF2A_6	69	77	PF00069	0.391
DOC_PP1_RVXF_1	57	64	PF00149	0.459
DOC_USP7_MATH_1	13	17	PF00917	0.319
DOC_USP7_MATH_1	148	152	PF00917	0.550
DOC_USP7_UBL2_3	167	171	PF12436	0.576
DOC_WW_Pin1_4	28	33	PF00397	0.218
LIG_BIR_II_1	1	5	PF00653	0.488
LIG_BIR_III_4	130	134	PF00653	0.569
LIG_BRCT_BRCA1_1	182	186	PF00533	0.429
LIG_FHA_1	119	125	PF00498	0.441
LIG_FHA_1	20	26	PF00498	0.406
LIG_FHA_1	37	43	PF00498	0.267
LIG_FHA_1	68	74	PF00498	0.400
LIG_FHA_2	175	181	PF00498	0.394
LIG_FHA_2	45	51	PF00498	0.390
LIG_Pex14_1	118	122	PF04695	0.298
LIG_Pex14_2	186	190	PF04695	0.350
LIG_SH3_3	100	106	PF00018	0.330
LIG_SH3_3	160	166	PF00018	0.471
LIG_SH3_3	7	13	PF00018	0.331
MOD_CDK_SPxxK_3	28	35	PF00069	0.327
MOD_CK1_1	16	22	PF00069	0.271
MOD_CK1_1	81	87	PF00069	0.463
MOD_CK2_1	197	203	PF00069	0.394
MOD_CK2_1	44	50	PF00069	0.390
MOD_GlcNHglycan	15	18	PF01048	0.317
MOD_GlcNHglycan	25	28	PF01048	0.441
MOD_GlcNHglycan	63	66	PF01048	0.399
MOD_GlcNHglycan	79	83	PF01048	0.360
MOD_GSK3_1	13	20	PF00069	0.333
MOD_GSK3_1	148	155	PF00069	0.517
MOD_GSK3_1	193	200	PF00069	0.307
MOD_GSK3_1	50	57	PF00069	0.435
MOD_N-GLC_1	124	129	PF02516	0.538
MOD_NEK2_1	193	198	PF00069	0.482
MOD_Plk_1	113	119	PF00069	0.441
MOD_Plk_1	175	181	PF00069	0.394
MOD_Plk_2-3	52	58	PF00069	0.216
MOD_Plk_4	113	119	PF00069	0.441
MOD_Plk_4	193	199	PF00069	0.486
MOD_ProDKin_1	28	34	PF00069	0.218
MOD_SUMO_rev_2	64	70	PF00179	0.441
TRG_DiLeu_BaEn_3	3	9	PF01217	0.424
TRG_DiLeu_BaEn_4	205	211	PF01217	0.447
TRG_ER_diArg_1	59	61	PF00400	0.441
TRG_NES_CRM1_1	128	141	PF08389	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD06	Leptomonas seymouri	84%	100%
A0A0S4JFN8	Bodo saltans	50%	100%
A0A1X0NRS7	Trypanosomatidae	55%	100%
A0A3Q8IH30	Leishmania donovani	93%	100%
A0A3R7MSK5	Trypanosoma rangeli	57%	100%
A4I8E6	Leishmania infantum	92%	100%
D0AAS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B3A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q381A3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	57%	100%
Q4Q4V1	Leishmania major	94%	100%
Q4R4K5	Macaca fascicularis	28%	100%
Q567Y6	Danio rerio	29%	100%
Q5E9J4	Bos taurus	27%	100%
Q5FVJ7	Rattus norvegicus	28%	100%
Q5M8K8	Xenopus tropicalis	26%	100%
Q9DAI2	Mus musculus	28%	100%
Q9H7X7	Homo sapiens	29%	100%
V5BR15	Trypanosoma cruzi	59%	100%