Conserved oligomeric Golgi complex subunit 5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Golgi transport complex subunit 5, putative

Species:

Leishmania braziliensis

UniProt:

A4HKW4_LEIBR

TriTrypDb:

LbrM.32.3480 , LBRM2903_320042900

Length:

1036

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0017119	Golgi transport complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0099023	vesicle tethering complex	2	9
GO:0110165	cellular anatomical entity	1	8
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HKW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKW4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006891	intra-Golgi vesicle-mediated transport	6	9
GO:0016192	vesicle-mediated transport	4	9
GO:0048193	Golgi vesicle transport	5	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.464
CLV_C14_Caspase3-7	498	502	PF00656	0.454
CLV_C14_Caspase3-7	893	897	PF00656	0.448
CLV_NRD_NRD_1	244	246	PF00675	0.493
CLV_NRD_NRD_1	321	323	PF00675	0.480
CLV_NRD_NRD_1	449	451	PF00675	0.550
CLV_NRD_NRD_1	488	490	PF00675	0.497
CLV_NRD_NRD_1	998	1000	PF00675	0.533
CLV_PCSK_KEX2_1	243	245	PF00082	0.428
CLV_PCSK_KEX2_1	321	323	PF00082	0.498
CLV_PCSK_KEX2_1	361	363	PF00082	0.412
CLV_PCSK_KEX2_1	42	44	PF00082	0.367
CLV_PCSK_KEX2_1	449	451	PF00082	0.493
CLV_PCSK_KEX2_1	488	490	PF00082	0.538
CLV_PCSK_KEX2_1	694	696	PF00082	0.528
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.412
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.367
CLV_PCSK_PC1ET2_1	694	696	PF00082	0.504
CLV_PCSK_SKI1_1	174	178	PF00082	0.446
CLV_PCSK_SKI1_1	19	23	PF00082	0.325
CLV_PCSK_SKI1_1	245	249	PF00082	0.511
CLV_PCSK_SKI1_1	273	277	PF00082	0.657
CLV_PCSK_SKI1_1	299	303	PF00082	0.427
CLV_PCSK_SKI1_1	316	320	PF00082	0.424
CLV_PCSK_SKI1_1	366	370	PF00082	0.408
CLV_PCSK_SKI1_1	566	570	PF00082	0.529
CLV_PCSK_SKI1_1	774	778	PF00082	0.530
CLV_PCSK_SKI1_1	785	789	PF00082	0.459
CLV_PCSK_SKI1_1	790	794	PF00082	0.445
CLV_PCSK_SKI1_1	816	820	PF00082	0.512
CLV_Separin_Metazoa	246	250	PF03568	0.466
DEG_APCC_DBOX_1	244	252	PF00400	0.474
DEG_APCC_DBOX_1	488	496	PF00400	0.403
DEG_APCC_DBOX_1	694	702	PF00400	0.434
DEG_APCC_DBOX_1	773	781	PF00400	0.496
DEG_Nend_Nbox_1	1	3	PF02207	0.472
DEG_ODPH_VHL_1	837	849	PF01847	0.272
DEG_SPOP_SBC_1	204	208	PF00917	0.560
DEG_SPOP_SBC_1	741	745	PF00917	0.350
DEG_SPOP_SBC_1	979	983	PF00917	0.490
DOC_CYCLIN_RxL_1	313	323	PF00134	0.527
DOC_CYCLIN_yClb3_PxF_3	914	922	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	912	918	PF00134	0.455
DOC_MAPK_gen_1	296	305	PF00069	0.301
DOC_MAPK_gen_1	361	369	PF00069	0.408
DOC_MAPK_HePTP_8	293	305	PF00069	0.264
DOC_MAPK_MEF2A_6	296	305	PF00069	0.264
DOC_MAPK_MEF2A_6	361	369	PF00069	0.457
DOC_MAPK_MEF2A_6	375	383	PF00069	0.324
DOC_MAPK_MEF2A_6	82	91	PF00069	0.385
DOC_MAPK_NFAT4_5	362	370	PF00069	0.469
DOC_PP2B_LxvP_1	192	195	PF13499	0.566
DOC_PP2B_LxvP_1	723	726	PF13499	0.286
DOC_PP2B_LxvP_1	912	915	PF13499	0.438
DOC_USP7_MATH_1	1019	1023	PF00917	0.515
DOC_USP7_MATH_1	133	137	PF00917	0.567
DOC_USP7_MATH_1	204	208	PF00917	0.699
DOC_USP7_MATH_1	21	25	PF00917	0.336
DOC_USP7_MATH_1	210	214	PF00917	0.648
DOC_USP7_MATH_1	217	221	PF00917	0.385
DOC_USP7_MATH_1	368	372	PF00917	0.444
DOC_USP7_MATH_1	548	552	PF00917	0.430
DOC_USP7_MATH_1	650	654	PF00917	0.624
DOC_USP7_MATH_1	704	708	PF00917	0.296
DOC_USP7_MATH_1	741	745	PF00917	0.567
DOC_USP7_MATH_1	765	769	PF00917	0.498
DOC_USP7_MATH_1	945	949	PF00917	0.474
DOC_USP7_MATH_1	979	983	PF00917	0.567
DOC_USP7_MATH_2	465	471	PF00917	0.518
DOC_WW_Pin1_4	333	338	PF00397	0.421
DOC_WW_Pin1_4	465	470	PF00397	0.643
DOC_WW_Pin1_4	544	549	PF00397	0.531
DOC_WW_Pin1_4	6	11	PF00397	0.222
DOC_WW_Pin1_4	757	762	PF00397	0.523
DOC_WW_Pin1_4	821	826	PF00397	0.470
DOC_WW_Pin1_4	830	835	PF00397	0.360
DOC_WW_Pin1_4	943	948	PF00397	0.562
LIG_14-3-3_CanoR_1	120	125	PF00244	0.342
LIG_14-3-3_CanoR_1	142	148	PF00244	0.385
LIG_14-3-3_CanoR_1	234	240	PF00244	0.440
LIG_14-3-3_CanoR_1	296	302	PF00244	0.337
LIG_14-3-3_CanoR_1	355	360	PF00244	0.521
LIG_14-3-3_CanoR_1	488	492	PF00244	0.544
LIG_14-3-3_CanoR_1	597	607	PF00244	0.402
LIG_14-3-3_CanoR_1	61	65	PF00244	0.454
LIG_14-3-3_CanoR_1	74	80	PF00244	0.295
LIG_14-3-3_CanoR_1	785	794	PF00244	0.424
LIG_14-3-3_CanoR_1	820	825	PF00244	0.586
LIG_14-3-3_CanoR_1	867	872	PF00244	0.389
LIG_Actin_WH2_2	1000	1015	PF00022	0.295
LIG_Actin_WH2_2	107	122	PF00022	0.292
LIG_Actin_WH2_2	233	251	PF00022	0.466
LIG_Actin_WH2_2	578	596	PF00022	0.441
LIG_Actin_WH2_2	8	25	PF00022	0.385
LIG_AP2alpha_1	787	791	PF02296	0.452
LIG_APCC_ABBA_1	49	54	PF00400	0.210
LIG_BRCT_BRCA1_1	1021	1025	PF00533	0.315
LIG_BRCT_BRCA1_1	8	12	PF00533	0.222
LIG_CaM_IQ_9	777	792	PF13499	0.467
LIG_Clathr_ClatBox_1	331	335	PF01394	0.467
LIG_eIF4E_1	808	814	PF01652	0.250
LIG_eIF4E_1	918	924	PF01652	0.251
LIG_EVH1_1	607	611	PF00568	0.427
LIG_FHA_1	106	112	PF00498	0.441
LIG_FHA_1	133	139	PF00498	0.455
LIG_FHA_1	159	165	PF00498	0.400
LIG_FHA_1	210	216	PF00498	0.533
LIG_FHA_1	287	293	PF00498	0.374
LIG_FHA_1	298	304	PF00498	0.437
LIG_FHA_1	306	312	PF00498	0.321
LIG_FHA_1	347	353	PF00498	0.420
LIG_FHA_1	405	411	PF00498	0.598
LIG_FHA_1	46	52	PF00498	0.272
LIG_FHA_1	474	480	PF00498	0.640
LIG_FHA_1	503	509	PF00498	0.481
LIG_FHA_1	563	569	PF00498	0.422
LIG_FHA_1	599	605	PF00498	0.309
LIG_FHA_1	640	646	PF00498	0.341
LIG_FHA_1	727	733	PF00498	0.488
LIG_FHA_1	75	81	PF00498	0.325
LIG_FHA_1	842	848	PF00498	0.535
LIG_FHA_1	866	872	PF00498	0.412
LIG_FHA_1	969	975	PF00498	0.522
LIG_FHA_2	144	150	PF00498	0.356
LIG_FHA_2	345	351	PF00498	0.421
LIG_FHA_2	64	70	PF00498	0.307
LIG_GBD_Chelix_1	124	132	PF00786	0.210
LIG_GBD_Chelix_1	809	817	PF00786	0.244
LIG_LIR_Gen_1	1008	1019	PF02991	0.459
LIG_LIR_Gen_1	1028	1035	PF02991	0.468
LIG_LIR_Gen_1	118	128	PF02991	0.385
LIG_LIR_Gen_1	265	276	PF02991	0.523
LIG_LIR_Gen_1	343	352	PF02991	0.401
LIG_LIR_Gen_1	436	444	PF02991	0.458
LIG_LIR_Gen_1	682	691	PF02991	0.601
LIG_LIR_Gen_1	9	20	PF02991	0.379
LIG_LIR_Gen_1	92	102	PF02991	0.328
LIG_LIR_Nem_3	1008	1014	PF02991	0.468
LIG_LIR_Nem_3	1028	1033	PF02991	0.472
LIG_LIR_Nem_3	118	124	PF02991	0.385
LIG_LIR_Nem_3	265	271	PF02991	0.498
LIG_LIR_Nem_3	300	305	PF02991	0.434
LIG_LIR_Nem_3	343	348	PF02991	0.395
LIG_LIR_Nem_3	371	376	PF02991	0.453
LIG_LIR_Nem_3	436	440	PF02991	0.453
LIG_LIR_Nem_3	682	687	PF02991	0.624
LIG_LIR_Nem_3	788	794	PF02991	0.358
LIG_LIR_Nem_3	9	15	PF02991	0.301
LIG_LIR_Nem_3	92	98	PF02991	0.295
LIG_NRBOX	313	319	PF00104	0.356
LIG_NRBOX	581	587	PF00104	0.434
LIG_PCNA_PIPBox_1	431	440	PF02747	0.465
LIG_Pex14_2	787	791	PF04695	0.393
LIG_Rb_LxCxE_1	957	977	PF01857	0.449
LIG_REV1ctd_RIR_1	917	926	PF16727	0.403
LIG_SH2_CRK	268	272	PF00017	0.509
LIG_SH2_CRK	564	568	PF00017	0.401
LIG_SH2_CRK	684	688	PF00017	0.515
LIG_SH2_CRK	95	99	PF00017	0.291
LIG_SH2_NCK_1	462	466	PF00017	0.523
LIG_SH2_NCK_1	638	642	PF00017	0.453
LIG_SH2_STAP1	564	568	PF00017	0.367
LIG_SH2_STAP1	684	688	PF00017	0.581
LIG_SH2_STAP1	841	845	PF00017	0.437
LIG_SH2_STAT3	428	431	PF00017	0.407
LIG_SH2_STAT3	64	67	PF00017	0.307
LIG_SH2_STAT5	145	148	PF00017	0.450
LIG_SH2_STAT5	17	20	PF00017	0.291
LIG_SH2_STAT5	227	230	PF00017	0.455
LIG_SH2_STAT5	330	333	PF00017	0.429
LIG_SH2_STAT5	428	431	PF00017	0.606
LIG_SH2_STAT5	437	440	PF00017	0.470
LIG_SH2_STAT5	564	567	PF00017	0.406
LIG_SH2_STAT5	808	811	PF00017	0.258
LIG_SH2_STAT5	918	921	PF00017	0.257
LIG_SH3_1	605	611	PF00018	0.525
LIG_SH3_1	758	764	PF00018	0.522
LIG_SH3_1	911	917	PF00018	0.474
LIG_SH3_3	474	480	PF00018	0.532
LIG_SH3_3	522	528	PF00018	0.473
LIG_SH3_3	542	548	PF00018	0.635
LIG_SH3_3	605	611	PF00018	0.431
LIG_SH3_3	642	648	PF00018	0.437
LIG_SH3_3	758	764	PF00018	0.680
LIG_SH3_3	822	828	PF00018	0.489
LIG_SH3_3	844	850	PF00018	0.424
LIG_SH3_3	911	917	PF00018	0.440
LIG_SUMO_SIM_anti_2	134	144	PF11976	0.479
LIG_SUMO_SIM_anti_2	436	442	PF11976	0.454
LIG_SUMO_SIM_anti_2	642	647	PF11976	0.339
LIG_TRAF2_1	107	110	PF00917	0.484
LIG_TRAF2_1	259	262	PF00917	0.444
LIG_TRFH_1	607	611	PF08558	0.521
LIG_WRC_WIRS_1	236	241	PF05994	0.441
LIG_WRC_WIRS_1	380	385	PF05994	0.389
LIG_WRC_WIRS_1	572	577	PF05994	0.340
LIG_WW_2	610	613	PF00397	0.460
MOD_CDK_SPK_2	544	549	PF00069	0.470
MOD_CK1_1	143	149	PF00069	0.489
MOD_CK1_1	238	244	PF00069	0.469
MOD_CK1_1	274	280	PF00069	0.595
MOD_CK1_1	333	339	PF00069	0.427
MOD_CK1_1	346	352	PF00069	0.489
MOD_CK1_1	382	388	PF00069	0.494
MOD_CK1_1	406	412	PF00069	0.694
MOD_CK1_1	468	474	PF00069	0.725
MOD_CK1_1	493	499	PF00069	0.349
MOD_CK1_1	632	638	PF00069	0.386
MOD_CK1_1	709	715	PF00069	0.479
MOD_CK1_1	743	749	PF00069	0.590
MOD_CK1_1	750	756	PF00069	0.449
MOD_CK1_1	935	941	PF00069	0.591
MOD_CK1_1	973	979	PF00069	0.399
MOD_CK2_1	143	149	PF00069	0.357
MOD_CK2_1	344	350	PF00069	0.392
MOD_CK2_1	63	69	PF00069	0.307
MOD_CK2_1	704	710	PF00069	0.352
MOD_CK2_1	858	864	PF00069	0.328
MOD_CK2_1	979	985	PF00069	0.700
MOD_GlcNHglycan	135	138	PF01048	0.368
MOD_GlcNHglycan	23	26	PF01048	0.445
MOD_GlcNHglycan	273	276	PF01048	0.562
MOD_GlcNHglycan	279	282	PF01048	0.659
MOD_GlcNHglycan	370	373	PF01048	0.445
MOD_GlcNHglycan	470	473	PF01048	0.670
MOD_GlcNHglycan	522	525	PF01048	0.443
MOD_GlcNHglycan	528	531	PF01048	0.445
MOD_GlcNHglycan	672	675	PF01048	0.680
MOD_GlcNHglycan	718	721	PF01048	0.499
MOD_GlcNHglycan	747	750	PF01048	0.592
MOD_GlcNHglycan	752	755	PF01048	0.664
MOD_GlcNHglycan	860	863	PF01048	0.496
MOD_GlcNHglycan	898	901	PF01048	0.518
MOD_GlcNHglycan	934	937	PF01048	0.534
MOD_GlcNHglycan	947	950	PF01048	0.353
MOD_GlcNHglycan	951	954	PF01048	0.494
MOD_GlcNHglycan	982	985	PF01048	0.655
MOD_GSK3_1	174	181	PF00069	0.488
MOD_GSK3_1	204	211	PF00069	0.636
MOD_GSK3_1	277	284	PF00069	0.614
MOD_GSK3_1	406	413	PF00069	0.644
MOD_GSK3_1	423	430	PF00069	0.595
MOD_GSK3_1	475	482	PF00069	0.695
MOD_GSK3_1	544	551	PF00069	0.719
MOD_GSK3_1	613	620	PF00069	0.422
MOD_GSK3_1	648	655	PF00069	0.590
MOD_GSK3_1	706	713	PF00069	0.421
MOD_GSK3_1	741	748	PF00069	0.487
MOD_GSK3_1	816	823	PF00069	0.445
MOD_GSK3_1	826	833	PF00069	0.612
MOD_GSK3_1	945	952	PF00069	0.369
MOD_GSK3_1	970	977	PF00069	0.479
MOD_LATS_1	31	37	PF00433	0.367
MOD_N-GLC_1	196	201	PF02516	0.499
MOD_N-GLC_2	631	633	PF02516	0.321
MOD_NEK2_1	115	120	PF00069	0.350
MOD_NEK2_1	132	137	PF00069	0.535
MOD_NEK2_1	232	237	PF00069	0.426
MOD_NEK2_1	271	276	PF00069	0.592
MOD_NEK2_1	379	384	PF00069	0.371
MOD_NEK2_1	487	492	PF00069	0.493
MOD_NEK2_1	672	677	PF00069	0.527
MOD_NEK2_1	716	721	PF00069	0.393
MOD_NEK2_1	740	745	PF00069	0.554
MOD_NEK2_1	858	863	PF00069	0.546
MOD_NEK2_1	882	887	PF00069	0.571
MOD_NEK2_1	889	894	PF00069	0.646
MOD_NEK2_1	970	975	PF00069	0.470
MOD_NEK2_2	423	428	PF00069	0.580
MOD_OFUCOSY	628	633	PF10250	0.266
MOD_PIKK_1	105	111	PF00454	0.385
MOD_PIKK_1	321	327	PF00454	0.511
MOD_PIKK_1	427	433	PF00454	0.548
MOD_PIKK_1	481	487	PF00454	0.609
MOD_PIKK_1	490	496	PF00454	0.464
MOD_PIKK_1	63	69	PF00454	0.307
MOD_PIKK_1	650	656	PF00454	0.760
MOD_PIKK_1	726	732	PF00454	0.453
MOD_PIKK_1	779	785	PF00454	0.424
MOD_PIKK_1	938	944	PF00454	0.586
MOD_PKA_1	321	327	PF00069	0.507
MOD_PKA_2	141	147	PF00069	0.391
MOD_PKA_2	269	275	PF00069	0.550
MOD_PKA_2	321	327	PF00069	0.507
MOD_PKA_2	487	493	PF00069	0.532
MOD_PKA_2	520	526	PF00069	0.479
MOD_PKA_2	548	554	PF00069	0.681
MOD_PKA_2	60	66	PF00069	0.385
MOD_PKA_2	73	79	PF00069	0.300
MOD_PKA_2	866	872	PF00069	0.393
MOD_PKB_1	353	361	PF00069	0.474
MOD_Plk_1	1019	1025	PF00069	0.401
MOD_Plk_1	68	74	PF00069	0.307
MOD_Plk_4	235	241	PF00069	0.427
MOD_Plk_4	297	303	PF00069	0.397
MOD_Plk_4	379	385	PF00069	0.393
MOD_Plk_4	423	429	PF00069	0.420
MOD_Plk_4	52	58	PF00069	0.357
MOD_Plk_4	639	645	PF00069	0.301
MOD_Plk_4	867	873	PF00069	0.417
MOD_ProDKin_1	333	339	PF00069	0.425
MOD_ProDKin_1	465	471	PF00069	0.643
MOD_ProDKin_1	544	550	PF00069	0.519
MOD_ProDKin_1	6	12	PF00069	0.222
MOD_ProDKin_1	757	763	PF00069	0.523
MOD_ProDKin_1	821	827	PF00069	0.476
MOD_ProDKin_1	830	836	PF00069	0.356
MOD_ProDKin_1	943	949	PF00069	0.554
MOD_SUMO_for_1	568	571	PF00179	0.301
TRG_AP2beta_CARGO_1	789	798	PF09066	0.456
TRG_DiLeu_BaEn_1	110	115	PF01217	0.373
TRG_DiLeu_BaEn_1	697	702	PF01217	0.436
TRG_DiLeu_BaEn_2	1020	1026	PF01217	0.315
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.404
TRG_DiLeu_BaLyEn_6	848	853	PF01217	0.427
TRG_ENDOCYTIC_2	268	271	PF00928	0.507
TRG_ENDOCYTIC_2	376	379	PF00928	0.390
TRG_ENDOCYTIC_2	437	440	PF00928	0.434
TRG_ENDOCYTIC_2	564	567	PF00928	0.372
TRG_ENDOCYTIC_2	684	687	PF00928	0.520
TRG_ENDOCYTIC_2	928	931	PF00928	0.436
TRG_ENDOCYTIC_2	95	98	PF00928	0.291
TRG_ER_diArg_1	243	245	PF00400	0.509
TRG_ER_diArg_1	448	450	PF00400	0.532
TRG_ER_diArg_1	487	489	PF00400	0.480
TRG_ER_diArg_1	86	89	PF00400	0.385
TRG_ER_diArg_1	911	914	PF00400	0.489
TRG_NES_CRM1_1	246	261	PF08389	0.351
TRG_NES_CRM1_1	959	972	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.387
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX6	Leptomonas seymouri	58%	100%
A0A3S7X634	Leishmania donovani	80%	100%
A4I8E4	Leishmania infantum	80%	100%
D0AAS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B3A2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q4V3	Leishmania major	79%	100%
V5B5P3	Trypanosoma cruzi	29%	100%