Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HKW3_LEIBR

TriTrypDb:

LbrM.32.3470 , LBRM2903_320042800

Length:

675

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKW3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.478
CLV_NRD_NRD_1	222	224	PF00675	0.481
CLV_NRD_NRD_1	292	294	PF00675	0.562
CLV_NRD_NRD_1	396	398	PF00675	0.459
CLV_PCSK_KEX2_1	12	14	PF00082	0.566
CLV_PCSK_KEX2_1	222	224	PF00082	0.481
CLV_PCSK_KEX2_1	291	293	PF00082	0.574
CLV_PCSK_KEX2_1	395	397	PF00082	0.556
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.566
CLV_PCSK_SKI1_1	12	16	PF00082	0.511
CLV_PCSK_SKI1_1	169	173	PF00082	0.425
CLV_PCSK_SKI1_1	179	183	PF00082	0.363
CLV_PCSK_SKI1_1	222	226	PF00082	0.384
CLV_PCSK_SKI1_1	299	303	PF00082	0.465
CLV_PCSK_SKI1_1	328	332	PF00082	0.399
CLV_PCSK_SKI1_1	336	340	PF00082	0.375
CLV_PCSK_SKI1_1	499	503	PF00082	0.446
CLV_PCSK_SKI1_1	536	540	PF00082	0.359
CLV_PCSK_SKI1_1	619	623	PF00082	0.441
CLV_Separin_Metazoa	333	337	PF03568	0.392
DEG_APCC_DBOX_1	327	335	PF00400	0.402
DEG_APCC_DBOX_1	38	46	PF00400	0.493
DEG_APCC_DBOX_1	498	506	PF00400	0.435
DEG_APCC_DBOX_1	614	622	PF00400	0.447
DEG_SCF_FBW7_1	657	664	PF00400	0.435
DOC_CDC14_PxL_1	411	419	PF14671	0.535
DOC_CKS1_1	658	663	PF01111	0.527
DOC_CYCLIN_RxL_1	325	333	PF00134	0.477
DOC_CYCLIN_RxL_1	401	410	PF00134	0.450
DOC_CYCLIN_RxL_1	499	507	PF00134	0.434
DOC_CYCLIN_RxL_1	68	78	PF00134	0.461
DOC_CYCLIN_yClb5_NLxxxL_5	613	622	PF00134	0.308
DOC_CYCLIN_yClb5_NLxxxL_5	71	79	PF00134	0.456
DOC_MAPK_gen_1	177	185	PF00069	0.311
DOC_MAPK_MEF2A_6	169	176	PF00069	0.426
DOC_MAPK_MEF2A_6	177	185	PF00069	0.378
DOC_MAPK_MEF2A_6	412	419	PF00069	0.617
DOC_MAPK_MEF2A_6	495	504	PF00069	0.442
DOC_MAPK_MEF2A_6	552	561	PF00069	0.470
DOC_MAPK_RevD_3	640	653	PF00069	0.321
DOC_PP1_RVXF_1	316	323	PF00149	0.471
DOC_PP1_RVXF_1	402	409	PF00149	0.433
DOC_USP7_MATH_1	520	524	PF00917	0.459
DOC_WW_Pin1_4	105	110	PF00397	0.468
DOC_WW_Pin1_4	2	7	PF00397	0.605
DOC_WW_Pin1_4	226	231	PF00397	0.472
DOC_WW_Pin1_4	281	286	PF00397	0.650
DOC_WW_Pin1_4	432	437	PF00397	0.548
DOC_WW_Pin1_4	545	550	PF00397	0.355
DOC_WW_Pin1_4	657	662	PF00397	0.493
LIG_14-3-3_CanoR_1	120	124	PF00244	0.396
LIG_14-3-3_CanoR_1	141	151	PF00244	0.406
LIG_14-3-3_CanoR_1	231	237	PF00244	0.339
LIG_14-3-3_CanoR_1	247	251	PF00244	0.322
LIG_14-3-3_CanoR_1	395	400	PF00244	0.513
LIG_14-3-3_CanoR_1	503	512	PF00244	0.365
LIG_14-3-3_CanoR_1	536	545	PF00244	0.394
LIG_Actin_WH2_2	69	84	PF00022	0.396
LIG_APCC_ABBA_1	310	315	PF00400	0.438
LIG_Clathr_ClatBox_1	180	184	PF01394	0.306
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.435
LIG_eIF4E_1	175	181	PF01652	0.451
LIG_FHA_1	109	115	PF00498	0.343
LIG_FHA_1	120	126	PF00498	0.436
LIG_FHA_1	13	19	PF00498	0.473
LIG_FHA_1	143	149	PF00498	0.404
LIG_FHA_1	180	186	PF00498	0.434
LIG_FHA_1	215	221	PF00498	0.497
LIG_FHA_1	227	233	PF00498	0.516
LIG_FHA_1	238	244	PF00498	0.367
LIG_FHA_1	3	9	PF00498	0.585
LIG_FHA_1	425	431	PF00498	0.544
LIG_FHA_1	461	467	PF00498	0.448
LIG_FHA_1	571	577	PF00498	0.490
LIG_FHA_1	580	586	PF00498	0.385
LIG_FHA_1	587	593	PF00498	0.307
LIG_FHA_1	76	82	PF00498	0.412
LIG_FHA_2	162	168	PF00498	0.506
LIG_FHA_2	233	239	PF00498	0.375
LIG_FHA_2	270	276	PF00498	0.592
LIG_FHA_2	282	288	PF00498	0.614
LIG_FHA_2	377	383	PF00498	0.432
LIG_LIR_Apic_2	249	253	PF02991	0.377
LIG_LIR_Gen_1	111	118	PF02991	0.371
LIG_LIR_Gen_1	129	137	PF02991	0.352
LIG_LIR_Gen_1	551	562	PF02991	0.456
LIG_LIR_LC3C_4	353	356	PF02991	0.505
LIG_LIR_Nem_3	111	115	PF02991	0.543
LIG_LIR_Nem_3	126	131	PF02991	0.371
LIG_LIR_Nem_3	295	301	PF02991	0.501
LIG_LIR_Nem_3	3	7	PF02991	0.545
LIG_LIR_Nem_3	304	310	PF02991	0.364
LIG_LIR_Nem_3	409	414	PF02991	0.532
LIG_LIR_Nem_3	63	67	PF02991	0.464
LIG_LYPXL_yS_3	654	657	PF13949	0.336
LIG_NRBOX	501	507	PF00104	0.425
LIG_PCNA_TLS_4	169	176	PF02747	0.426
LIG_PDZ_Class_3	670	675	PF00595	0.552
LIG_Pex14_2	64	68	PF04695	0.413
LIG_PTB_Apo_2	21	28	PF02174	0.421
LIG_RPA_C_Fungi	505	517	PF08784	0.300
LIG_SH2_CRK	307	311	PF00017	0.303
LIG_SH2_STAP1	387	391	PF00017	0.505
LIG_SH2_STAP1	587	591	PF00017	0.313
LIG_SH2_STAT5	102	105	PF00017	0.323
LIG_SH2_STAT5	175	178	PF00017	0.448
LIG_SH2_STAT5	250	253	PF00017	0.455
LIG_SH2_STAT5	4	7	PF00017	0.595
LIG_SH2_STAT5	554	557	PF00017	0.371
LIG_SH2_STAT5	92	95	PF00017	0.409
LIG_SH3_2	277	282	PF14604	0.529
LIG_SH3_3	274	280	PF00018	0.678
LIG_Sin3_3	208	215	PF02671	0.305
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.446
LIG_SUMO_SIM_anti_2	207	214	PF11976	0.516
LIG_SUMO_SIM_anti_2	353	358	PF11976	0.508
LIG_SUMO_SIM_par_1	179	184	PF11976	0.311
LIG_SUMO_SIM_par_1	462	468	PF11976	0.341
LIG_SUMO_SIM_par_1	589	594	PF11976	0.405
LIG_TRAF2_1	490	493	PF00917	0.418
LIG_TRAF2_1	529	532	PF00917	0.550
LIG_TRAF2_2	268	273	PF00917	0.566
LIG_UBA3_1	75	82	PF00899	0.390
MOD_CDK_SPK_2	226	231	PF00069	0.462
MOD_CDK_SPxxK_3	281	288	PF00069	0.644
MOD_CDK_SPxxK_3	545	552	PF00069	0.425
MOD_CK1_1	108	114	PF00069	0.442
MOD_CK1_1	214	220	PF00069	0.411
MOD_CK1_1	40	46	PF00069	0.403
MOD_CK1_1	548	554	PF00069	0.430
MOD_CK2_1	161	167	PF00069	0.460
MOD_CK2_1	232	238	PF00069	0.370
MOD_CK2_1	269	275	PF00069	0.591
MOD_CK2_1	281	287	PF00069	0.620
MOD_CK2_1	376	382	PF00069	0.443
MOD_CK2_1	487	493	PF00069	0.426
MOD_CK2_1	520	526	PF00069	0.467
MOD_CMANNOS	322	325	PF00535	0.495
MOD_Cter_Amidation	669	672	PF01082	0.553
MOD_GlcNHglycan	103	106	PF01048	0.434
MOD_GlcNHglycan	206	209	PF01048	0.397
MOD_GlcNHglycan	260	263	PF01048	0.482
MOD_GlcNHglycan	33	36	PF01048	0.436
MOD_GlcNHglycan	420	423	PF01048	0.456
MOD_GSK3_1	101	108	PF00069	0.440
MOD_GSK3_1	154	161	PF00069	0.311
MOD_GSK3_1	179	186	PF00069	0.443
MOD_GSK3_1	232	239	PF00069	0.383
MOD_GSK3_1	346	353	PF00069	0.513
MOD_GSK3_1	358	365	PF00069	0.647
MOD_GSK3_1	520	527	PF00069	0.585
MOD_GSK3_1	537	544	PF00069	0.435
MOD_GSK3_1	587	594	PF00069	0.338
MOD_GSK3_1	657	664	PF00069	0.435
MOD_GSK3_1	8	15	PF00069	0.565
MOD_LATS_1	10	16	PF00433	0.539
MOD_N-GLC_1	23	28	PF02516	0.426
MOD_NEK2_1	232	237	PF00069	0.347
MOD_NEK2_1	301	306	PF00069	0.408
MOD_NEK2_1	31	36	PF00069	0.548
MOD_NEK2_1	316	321	PF00069	0.398
MOD_NEK2_1	346	351	PF00069	0.526
MOD_NEK2_1	406	411	PF00069	0.517
MOD_NEK2_1	511	516	PF00069	0.415
MOD_NEK2_1	579	584	PF00069	0.319
MOD_NEK2_1	586	591	PF00069	0.335
MOD_NEK2_1	75	80	PF00069	0.507
MOD_NEK2_1	90	95	PF00069	0.284
MOD_PIKK_1	301	307	PF00454	0.318
MOD_PIKK_1	346	352	PF00454	0.466
MOD_PIKK_1	441	447	PF00454	0.485
MOD_PIKK_1	537	543	PF00454	0.317
MOD_PIKK_1	663	669	PF00454	0.626
MOD_PK_1	487	493	PF00069	0.349
MOD_PKA_1	12	18	PF00069	0.575
MOD_PKA_1	395	401	PF00069	0.514
MOD_PKA_2	119	125	PF00069	0.383
MOD_PKA_2	12	18	PF00069	0.575
MOD_PKA_2	154	160	PF00069	0.303
MOD_PKA_2	236	242	PF00069	0.403
MOD_PKA_2	246	252	PF00069	0.373
MOD_PKA_2	395	401	PF00069	0.514
MOD_PKB_1	485	493	PF00069	0.368
MOD_Plk_1	23	29	PF00069	0.447
MOD_Plk_1	286	292	PF00069	0.599
MOD_Plk_1	294	300	PF00069	0.436
MOD_Plk_1	473	479	PF00069	0.342
MOD_Plk_1	520	526	PF00069	0.521
MOD_Plk_2-3	521	527	PF00069	0.468
MOD_Plk_4	119	125	PF00069	0.383
MOD_Plk_4	147	153	PF00069	0.446
MOD_Plk_4	246	252	PF00069	0.438
MOD_Plk_4	350	356	PF00069	0.499
MOD_Plk_4	460	466	PF00069	0.337
MOD_Plk_4	587	593	PF00069	0.402
MOD_ProDKin_1	105	111	PF00069	0.464
MOD_ProDKin_1	2	8	PF00069	0.598
MOD_ProDKin_1	226	232	PF00069	0.467
MOD_ProDKin_1	281	287	PF00069	0.646
MOD_ProDKin_1	432	438	PF00069	0.547
MOD_ProDKin_1	545	551	PF00069	0.354
MOD_ProDKin_1	657	663	PF00069	0.507
MOD_SUMO_for_1	357	360	PF00179	0.507
MOD_SUMO_rev_2	490	497	PF00179	0.435
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.371
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.469
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.432
TRG_DiLeu_BaLyEn_6	507	512	PF01217	0.293
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.393
TRG_ENDOCYTIC_2	131	134	PF00928	0.363
TRG_ENDOCYTIC_2	307	310	PF00928	0.364
TRG_ENDOCYTIC_2	411	414	PF00928	0.542
TRG_ENDOCYTIC_2	554	557	PF00928	0.436
TRG_ENDOCYTIC_2	654	657	PF00928	0.336
TRG_ER_diArg_1	18	21	PF00400	0.587
TRG_ER_diArg_1	200	203	PF00400	0.334
TRG_ER_diArg_1	222	224	PF00400	0.481
TRG_ER_diArg_1	290	293	PF00400	0.577
TRG_ER_diArg_1	394	397	PF00400	0.460
TRG_ER_diLys_1	671	675	PF00400	0.552
TRG_ER_KDEL_1	672	675	PF00810	0.552
TRG_NES_CRM1_1	41	52	PF08389	0.327
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.507
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	487	492	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY7	Leptomonas seymouri	38%	100%
A0A3S7X637	Leishmania donovani	76%	100%
A4I8E3	Leishmania infantum	76%	100%
E9B3A1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q4V4	Leishmania major	76%	100%