LeishMANIAdb
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Leucine rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Leucine rich repeat-containing protein
Gene product:
Leucine Rich repeats (2 copies), putative
Species:
Leishmania braziliensis
UniProt:
A4HKW1_LEIBR
TriTrypDb:
LbrM.32.3450 , LBRM2903_320042600 *
Length:
822

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005929 cilium 4 10
GO:0042995 cell projection 2 10
GO:0043226 organelle 2 10
GO:0043227 membrane-bounded organelle 3 10
GO:0110165 cellular anatomical entity 1 11
GO:0120025 plasma membrane bounded cell projection 3 10
GO:0005930 axoneme 2 1

Expansion

Sequence features

A4HKW1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKW1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 309 313 PF00656 0.567
CLV_C14_Caspase3-7 380 384 PF00656 0.363
CLV_C14_Caspase3-7 56 60 PF00656 0.635
CLV_NRD_NRD_1 409 411 PF00675 0.359
CLV_NRD_NRD_1 503 505 PF00675 0.446
CLV_NRD_NRD_1 509 511 PF00675 0.454
CLV_NRD_NRD_1 516 518 PF00675 0.452
CLV_NRD_NRD_1 698 700 PF00675 0.616
CLV_NRD_NRD_1 793 795 PF00675 0.656
CLV_PCSK_KEX2_1 108 110 PF00082 0.819
CLV_PCSK_KEX2_1 373 375 PF00082 0.624
CLV_PCSK_KEX2_1 409 411 PF00082 0.359
CLV_PCSK_KEX2_1 503 505 PF00082 0.446
CLV_PCSK_KEX2_1 509 511 PF00082 0.445
CLV_PCSK_KEX2_1 606 608 PF00082 0.755
CLV_PCSK_KEX2_1 698 700 PF00082 0.612
CLV_PCSK_KEX2_1 744 746 PF00082 0.727
CLV_PCSK_KEX2_1 793 795 PF00082 0.714
CLV_PCSK_PC1ET2_1 108 110 PF00082 0.551
CLV_PCSK_PC1ET2_1 373 375 PF00082 0.615
CLV_PCSK_PC1ET2_1 606 608 PF00082 0.755
CLV_PCSK_PC1ET2_1 744 746 PF00082 0.727
CLV_PCSK_PC7_1 694 700 PF00082 0.555
CLV_PCSK_PC7_1 789 795 PF00082 0.640
CLV_PCSK_SKI1_1 100 104 PF00082 0.705
CLV_PCSK_SKI1_1 228 232 PF00082 0.654
CLV_PCSK_SKI1_1 510 514 PF00082 0.528
CLV_PCSK_SKI1_1 686 690 PF00082 0.446
CLV_PCSK_SKI1_1 699 703 PF00082 0.482
DEG_APCC_DBOX_1 434 442 PF00400 0.321
DEG_Nend_Nbox_1 1 3 PF02207 0.486
DEG_SCF_FBW7_1 118 125 PF00400 0.573
DEG_SCF_SKP2-CKS1_1 93 100 PF00560 0.530
DEG_SPOP_SBC_1 735 739 PF00917 0.650
DOC_CKS1_1 119 124 PF01111 0.619
DOC_CKS1_1 47 52 PF01111 0.535
DOC_CYCLIN_RxL_1 694 704 PF00134 0.463
DOC_MAPK_gen_1 178 187 PF00069 0.437
DOC_MAPK_gen_1 458 468 PF00069 0.307
DOC_MAPK_MEF2A_6 178 187 PF00069 0.442
DOC_PP2B_LxvP_1 584 587 PF13499 0.650
DOC_PP2B_LxvP_1 724 727 PF13499 0.550
DOC_USP7_MATH_1 290 294 PF00917 0.675
DOC_USP7_MATH_1 305 309 PF00917 0.470
DOC_USP7_MATH_1 311 315 PF00917 0.771
DOC_USP7_MATH_1 599 603 PF00917 0.811
DOC_USP7_MATH_1 631 635 PF00917 0.705
DOC_USP7_MATH_1 735 739 PF00917 0.730
DOC_USP7_UBL2_3 369 373 PF12436 0.499
DOC_USP7_UBL2_3 84 88 PF12436 0.753
DOC_USP7_UBL2_3 96 100 PF12436 0.567
DOC_WW_Pin1_4 118 123 PF00397 0.666
DOC_WW_Pin1_4 176 181 PF00397 0.574
DOC_WW_Pin1_4 229 234 PF00397 0.611
DOC_WW_Pin1_4 46 51 PF00397 0.583
DOC_WW_Pin1_4 492 497 PF00397 0.353
DOC_WW_Pin1_4 578 583 PF00397 0.721
DOC_WW_Pin1_4 595 600 PF00397 0.827
DOC_WW_Pin1_4 727 732 PF00397 0.745
DOC_WW_Pin1_4 755 760 PF00397 0.679
DOC_WW_Pin1_4 94 99 PF00397 0.678
LIG_14-3-3_CanoR_1 181 186 PF00244 0.434
LIG_14-3-3_CanoR_1 21 29 PF00244 0.415
LIG_14-3-3_CanoR_1 228 233 PF00244 0.515
LIG_14-3-3_CanoR_1 259 264 PF00244 0.607
LIG_14-3-3_CanoR_1 289 299 PF00244 0.651
LIG_14-3-3_CanoR_1 409 414 PF00244 0.573
LIG_14-3-3_CanoR_1 461 469 PF00244 0.242
LIG_14-3-3_CanoR_1 517 523 PF00244 0.415
LIG_14-3-3_CanoR_1 607 612 PF00244 0.745
LIG_14-3-3_CanoR_1 752 760 PF00244 0.773
LIG_14-3-3_CanoR_1 793 797 PF00244 0.582
LIG_14-3-3_CanoR_1 805 811 PF00244 0.418
LIG_BRCT_BRCA1_1 247 251 PF00533 0.592
LIG_Clathr_ClatBox_1 154 158 PF01394 0.396
LIG_DLG_GKlike_1 259 267 PF00625 0.505
LIG_EVH1_1 584 588 PF00568 0.614
LIG_FHA_1 122 128 PF00498 0.510
LIG_FHA_1 229 235 PF00498 0.560
LIG_FHA_1 263 269 PF00498 0.740
LIG_FHA_1 32 38 PF00498 0.621
LIG_FHA_1 477 483 PF00498 0.433
LIG_FHA_1 579 585 PF00498 0.779
LIG_FHA_1 706 712 PF00498 0.722
LIG_FHA_1 721 727 PF00498 0.737
LIG_FHA_1 748 754 PF00498 0.607
LIG_FHA_2 21 27 PF00498 0.454
LIG_FHA_2 279 285 PF00498 0.715
LIG_FHA_2 325 331 PF00498 0.594
LIG_FHA_2 352 358 PF00498 0.591
LIG_FHA_2 378 384 PF00498 0.356
LIG_FHA_2 492 498 PF00498 0.419
LIG_FHA_2 511 517 PF00498 0.461
LIG_FHA_2 614 620 PF00498 0.538
LIG_FHA_2 673 679 PF00498 0.532
LIG_FHA_2 705 711 PF00498 0.652
LIG_FHA_2 793 799 PF00498 0.658
LIG_LIR_Apic_2 174 180 PF02991 0.564
LIG_LIR_Apic_2 337 343 PF02991 0.600
LIG_LIR_Gen_1 12 20 PF02991 0.491
LIG_LIR_Gen_1 123 134 PF02991 0.460
LIG_LIR_Gen_1 168 177 PF02991 0.422
LIG_LIR_Gen_1 26 37 PF02991 0.428
LIG_LIR_Gen_1 531 538 PF02991 0.427
LIG_LIR_Gen_1 684 693 PF02991 0.552
LIG_LIR_Nem_3 12 16 PF02991 0.379
LIG_LIR_Nem_3 123 129 PF02991 0.554
LIG_LIR_Nem_3 168 172 PF02991 0.425
LIG_LIR_Nem_3 26 32 PF02991 0.446
LIG_LIR_Nem_3 344 349 PF02991 0.471
LIG_LIR_Nem_3 399 403 PF02991 0.603
LIG_LIR_Nem_3 531 535 PF02991 0.443
LIG_LIR_Nem_3 684 690 PF02991 0.550
LIG_MAD2 35 43 PF02301 0.653
LIG_NRBOX 455 461 PF00104 0.455
LIG_PDZ_Class_1 817 822 PF00595 0.483
LIG_SH2_CRK 169 173 PF00017 0.543
LIG_SH2_CRK 177 181 PF00017 0.583
LIG_SH2_CRK 29 33 PF00017 0.444
LIG_SH2_PTP2 126 129 PF00017 0.526
LIG_SH2_PTP2 687 690 PF00017 0.543
LIG_SH2_STAP1 532 536 PF00017 0.524
LIG_SH2_STAT3 342 345 PF00017 0.577
LIG_SH2_STAT3 541 544 PF00017 0.593
LIG_SH2_STAT5 126 129 PF00017 0.534
LIG_SH2_STAT5 340 343 PF00017 0.586
LIG_SH2_STAT5 346 349 PF00017 0.606
LIG_SH2_STAT5 506 509 PF00017 0.492
LIG_SH2_STAT5 541 544 PF00017 0.517
LIG_SH2_STAT5 687 690 PF00017 0.543
LIG_SH3_1 146 152 PF00018 0.544
LIG_SH3_2 588 593 PF14604 0.711
LIG_SH3_3 113 119 PF00018 0.769
LIG_SH3_3 146 152 PF00018 0.546
LIG_SH3_3 219 225 PF00018 0.621
LIG_SH3_3 34 40 PF00018 0.656
LIG_SH3_3 490 496 PF00018 0.343
LIG_SH3_3 579 585 PF00018 0.737
LIG_SH3_3 764 770 PF00018 0.615
LIG_SUMO_SIM_anti_2 156 161 PF11976 0.523
LIG_SUMO_SIM_anti_2 675 681 PF11976 0.571
LIG_SUMO_SIM_par_1 153 158 PF11976 0.397
LIG_SUMO_SIM_par_1 477 487 PF11976 0.360
LIG_SUMO_SIM_par_1 521 528 PF11976 0.507
LIG_SUMO_SIM_par_1 713 719 PF11976 0.685
LIG_SUMO_SIM_par_1 722 730 PF11976 0.736
LIG_TRAF2_1 110 113 PF00917 0.677
LIG_TRAF2_1 513 516 PF00917 0.492
LIG_TYR_ITSM 342 349 PF00017 0.377
LIG_WRC_WIRS_1 246 251 PF05994 0.651
LIG_WRC_WIRS_1 485 490 PF05994 0.400
LIG_WW_2 40 43 PF00397 0.684
LIG_WW_3 114 118 PF00397 0.554
MOD_CDC14_SPxK_1 495 498 PF00782 0.363
MOD_CDK_SPK_2 176 181 PF00069 0.574
MOD_CDK_SPxK_1 492 498 PF00069 0.356
MOD_CDK_SPxK_1 94 100 PF00069 0.682
MOD_CK1_1 153 159 PF00069 0.405
MOD_CK1_1 165 171 PF00069 0.450
MOD_CK1_1 229 235 PF00069 0.541
MOD_CK1_1 250 256 PF00069 0.677
MOD_CK1_1 262 268 PF00069 0.716
MOD_CK1_1 577 583 PF00069 0.737
MOD_CK1_1 598 604 PF00069 0.750
MOD_CK1_1 610 616 PF00069 0.681
MOD_CK1_1 626 632 PF00069 0.593
MOD_CK1_1 665 671 PF00069 0.639
MOD_CK1_1 725 731 PF00069 0.715
MOD_CK1_1 747 753 PF00069 0.762
MOD_CK1_1 78 84 PF00069 0.720
MOD_CK1_1 816 822 PF00069 0.476
MOD_CK2_1 20 26 PF00069 0.445
MOD_CK2_1 272 278 PF00069 0.519
MOD_CK2_1 303 309 PF00069 0.536
MOD_CK2_1 324 330 PF00069 0.746
MOD_CK2_1 351 357 PF00069 0.527
MOD_CK2_1 433 439 PF00069 0.543
MOD_CK2_1 491 497 PF00069 0.556
MOD_CK2_1 510 516 PF00069 0.322
MOD_CK2_1 560 566 PF00069 0.772
MOD_CK2_1 613 619 PF00069 0.544
MOD_CK2_1 672 678 PF00069 0.532
MOD_CK2_1 704 710 PF00069 0.591
MOD_CK2_1 734 740 PF00069 0.738
MOD_CK2_1 792 798 PF00069 0.658
MOD_Cter_Amidation 371 374 PF01082 0.591
MOD_Cter_Amidation 742 745 PF01082 0.523
MOD_GlcNHglycan 12 16 PF01048 0.476
MOD_GlcNHglycan 164 167 PF01048 0.520
MOD_GlcNHglycan 240 244 PF01048 0.685
MOD_GlcNHglycan 252 255 PF01048 0.766
MOD_GlcNHglycan 274 277 PF01048 0.720
MOD_GlcNHglycan 281 284 PF01048 0.711
MOD_GlcNHglycan 29 32 PF01048 0.401
MOD_GlcNHglycan 296 299 PF01048 0.726
MOD_GlcNHglycan 561 565 PF01048 0.656
MOD_GlcNHglycan 601 604 PF01048 0.734
MOD_GlcNHglycan 626 629 PF01048 0.741
MOD_GlcNHglycan 633 636 PF01048 0.739
MOD_GlcNHglycan 639 642 PF01048 0.683
MOD_GlcNHglycan 66 69 PF01048 0.729
MOD_GlcNHglycan 746 749 PF01048 0.708
MOD_GlcNHglycan 89 92 PF01048 0.710
MOD_GSK3_1 118 125 PF00069 0.652
MOD_GSK3_1 16 23 PF00069 0.492
MOD_GSK3_1 241 248 PF00069 0.623
MOD_GSK3_1 27 34 PF00069 0.459
MOD_GSK3_1 272 279 PF00069 0.604
MOD_GSK3_1 290 297 PF00069 0.648
MOD_GSK3_1 311 318 PF00069 0.656
MOD_GSK3_1 433 440 PF00069 0.421
MOD_GSK3_1 524 531 PF00069 0.524
MOD_GSK3_1 552 559 PF00069 0.572
MOD_GSK3_1 574 581 PF00069 0.705
MOD_GSK3_1 593 600 PF00069 0.819
MOD_GSK3_1 601 608 PF00069 0.636
MOD_GSK3_1 623 630 PF00069 0.674
MOD_GSK3_1 631 638 PF00069 0.693
MOD_GSK3_1 722 729 PF00069 0.710
MOD_GSK3_1 730 737 PF00069 0.734
MOD_GSK3_1 74 81 PF00069 0.691
MOD_GSK3_1 747 754 PF00069 0.739
MOD_GSK3_1 788 795 PF00069 0.636
MOD_GSK3_1 813 820 PF00069 0.652
MOD_N-GLC_1 574 579 PF02516 0.716
MOD_N-GLC_1 806 811 PF02516 0.576
MOD_N-GLC_1 813 818 PF02516 0.542
MOD_NEK2_1 16 21 PF00069 0.510
MOD_NEK2_1 239 244 PF00069 0.691
MOD_NEK2_1 476 481 PF00069 0.420
MOD_NEK2_1 484 489 PF00069 0.397
MOD_NEK2_1 576 581 PF00069 0.615
MOD_NEK2_1 637 642 PF00069 0.636
MOD_NEK2_1 75 80 PF00069 0.795
MOD_NEK2_1 762 767 PF00069 0.753
MOD_NEK2_2 264 269 PF00069 0.515
MOD_PIKK_1 253 259 PF00454 0.692
MOD_PIKK_1 303 309 PF00454 0.755
MOD_PIKK_1 341 347 PF00454 0.589
MOD_PIKK_1 351 357 PF00454 0.599
MOD_PIKK_1 377 383 PF00454 0.392
MOD_PIKK_1 433 439 PF00454 0.543
MOD_PIKK_1 460 466 PF00454 0.213
MOD_PIKK_1 518 524 PF00454 0.387
MOD_PIKK_1 539 545 PF00454 0.582
MOD_PIKK_1 567 573 PF00454 0.761
MOD_PK_1 181 187 PF00069 0.447
MOD_PK_1 607 613 PF00069 0.562
MOD_PKA_1 409 415 PF00069 0.327
MOD_PKA_1 606 612 PF00069 0.745
MOD_PKA_1 744 750 PF00069 0.728
MOD_PKA_2 20 26 PF00069 0.416
MOD_PKA_2 409 415 PF00069 0.327
MOD_PKA_2 460 466 PF00069 0.242
MOD_PKA_2 606 612 PF00069 0.745
MOD_PKA_2 646 652 PF00069 0.510
MOD_PKA_2 744 750 PF00069 0.786
MOD_PKA_2 75 81 PF00069 0.778
MOD_PKA_2 751 757 PF00069 0.553
MOD_PKA_2 788 794 PF00069 0.638
MOD_PKA_2 816 822 PF00069 0.476
MOD_PKB_1 301 309 PF00069 0.537
MOD_Plk_1 11 17 PF00069 0.513
MOD_Plk_1 311 317 PF00069 0.655
MOD_Plk_1 574 580 PF00069 0.717
MOD_Plk_1 593 599 PF00069 0.485
MOD_Plk_1 665 671 PF00069 0.478
MOD_Plk_1 806 812 PF00069 0.584
MOD_Plk_2-3 528 534 PF00069 0.542
MOD_Plk_2-3 710 716 PF00069 0.663
MOD_Plk_2-3 792 798 PF00069 0.640
MOD_Plk_4 122 128 PF00069 0.436
MOD_Plk_4 150 156 PF00069 0.412
MOD_Plk_4 165 171 PF00069 0.426
MOD_Plk_4 264 270 PF00069 0.508
MOD_Plk_4 334 340 PF00069 0.494
MOD_Plk_4 672 678 PF00069 0.439
MOD_Plk_4 686 692 PF00069 0.575
MOD_Plk_4 710 716 PF00069 0.663
MOD_Plk_4 763 769 PF00069 0.684
MOD_ProDKin_1 118 124 PF00069 0.649
MOD_ProDKin_1 176 182 PF00069 0.568
MOD_ProDKin_1 229 235 PF00069 0.614
MOD_ProDKin_1 46 52 PF00069 0.583
MOD_ProDKin_1 492 498 PF00069 0.356
MOD_ProDKin_1 578 584 PF00069 0.721
MOD_ProDKin_1 595 601 PF00069 0.827
MOD_ProDKin_1 727 733 PF00069 0.745
MOD_ProDKin_1 755 761 PF00069 0.679
MOD_ProDKin_1 94 100 PF00069 0.682
MOD_SUMO_rev_2 293 298 PF00179 0.560
MOD_SUMO_rev_2 365 375 PF00179 0.627
MOD_SUMO_rev_2 514 520 PF00179 0.584
TRG_DiLeu_BaEn_1 455 460 PF01217 0.282
TRG_DiLeu_BaLyEn_6 230 235 PF01217 0.493
TRG_DiLeu_BaLyEn_6 520 525 PF01217 0.605
TRG_DiLeu_LyEn_5 455 460 PF01217 0.282
TRG_ENDOCYTIC_2 126 129 PF00928 0.497
TRG_ENDOCYTIC_2 13 16 PF00928 0.469
TRG_ENDOCYTIC_2 131 134 PF00928 0.521
TRG_ENDOCYTIC_2 169 172 PF00928 0.413
TRG_ENDOCYTIC_2 29 32 PF00928 0.342
TRG_ENDOCYTIC_2 346 349 PF00928 0.445
TRG_ENDOCYTIC_2 532 535 PF00928 0.426
TRG_ENDOCYTIC_2 687 690 PF00928 0.543
TRG_ER_diArg_1 300 303 PF00400 0.551
TRG_ER_diArg_1 32 35 PF00400 0.386
TRG_ER_diArg_1 408 410 PF00400 0.335
TRG_ER_diArg_1 508 510 PF00400 0.484
TRG_ER_diArg_1 698 700 PF00400 0.607
TRG_ER_diArg_1 778 781 PF00400 0.546

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4C3 Leptomonas seymouri 47% 98%
A0A1X0NTH1 Trypanosomatidae 30% 100%
A0A3Q8IHB8 Leishmania donovani 73% 100%
A0A422NYL4 Trypanosoma rangeli 34% 100%
A4I8E1 Leishmania infantum 74% 100%
D0AAT2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
E9B399 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 100%
Q4Q4V6 Leishmania major 74% 100%
V5BVG4 Trypanosoma cruzi 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS