Glutamate-5-semialdehyde dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyrroline-5-carboxylate synthetase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HKV9_LEIBR

TriTrypDb:

LbrM.32.3430 , LBRM2903_320042400

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKV9

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006520	amino acid metabolic process	3	7
GO:0006560	proline metabolic process	6	7
GO:0006561	proline biosynthetic process	7	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0008652	amino acid biosynthetic process	4	7
GO:0009058	biosynthetic process	2	7
GO:0009064	glutamine family amino acid metabolic process	5	7
GO:0009084	glutamine family amino acid biosynthetic process	6	7

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	7
GO:0004350	glutamate-5-semialdehyde dehydrogenase activity	5	7
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	7
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	4	7
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	7
GO:0036094	small molecule binding	2	1
GO:0050661	NADP binding	4	1
GO:0097159	organic cyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.479
CLV_C14_Caspase3-7	326	330	PF00656	0.513
CLV_NRD_NRD_1	371	373	PF00675	0.512
CLV_NRD_NRD_1	468	470	PF00675	0.645
CLV_PCSK_KEX2_1	371	373	PF00082	0.512
CLV_PCSK_KEX2_1	468	470	PF00082	0.405
CLV_PCSK_KEX2_1	77	79	PF00082	0.338
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.316
CLV_PCSK_PC7_1	464	470	PF00082	0.398
CLV_PCSK_SKI1_1	277	281	PF00082	0.439

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y4	Leptomonas seymouri	74%	100%
A0A0N1PBT0	Leptomonas seymouri	27%	71%
A0A0S4JFI4	Bodo saltans	27%	100%
A0A1X0NJJ4	Trypanosomatidae	27%	100%
A0A3Q8ITL0	Leishmania donovani	88%	100%
A0A451EJJ7	Leishmania donovani	28%	73%
A0AI64	Listeria welshimeri serovar 6b (strain ATCC 35897 / DSM 20650 / CIP 8149 / NCTC 11857 / SLCC 5334 / V8)	32%	100%
A0K4I3	Burkholderia cenocepacia (strain HI2424)	38%	100%
A0KNQ8	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	37%	100%
A0LCZ1	Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1)	37%	100%

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