RWD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine hydrolase (FSH1)/50S ribosome-binding GTPase/GTPase of unknown function C-terminal, putative

Species:

Leishmania braziliensis

UniProt:

A4HKV6_LEIBR

TriTrypDb:

LbrM.32.3400 , LBRM2903_320042000

Length:

968

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKV6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	445	449	PF00656	0.723
CLV_C14_Caspase3-7	495	499	PF00656	0.425
CLV_C14_Caspase3-7	628	632	PF00656	0.427
CLV_C14_Caspase3-7	68	72	PF00656	0.357
CLV_MEL_PAP_1	692	698	PF00089	0.430
CLV_NRD_NRD_1	131	133	PF00675	0.393
CLV_NRD_NRD_1	170	172	PF00675	0.307
CLV_NRD_NRD_1	436	438	PF00675	0.714
CLV_NRD_NRD_1	582	584	PF00675	0.242
CLV_NRD_NRD_1	694	696	PF00675	0.476
CLV_NRD_NRD_1	773	775	PF00675	0.321
CLV_NRD_NRD_1	945	947	PF00675	0.491
CLV_PCSK_FUR_1	580	584	PF00082	0.227
CLV_PCSK_KEX2_1	131	133	PF00082	0.394
CLV_PCSK_KEX2_1	430	432	PF00082	0.549
CLV_PCSK_KEX2_1	436	438	PF00082	0.697
CLV_PCSK_KEX2_1	582	584	PF00082	0.242
CLV_PCSK_KEX2_1	694	696	PF00082	0.476
CLV_PCSK_KEX2_1	904	906	PF00082	0.443
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.363
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.443
CLV_PCSK_SKI1_1	131	135	PF00082	0.292
CLV_PCSK_SKI1_1	15	19	PF00082	0.369
CLV_PCSK_SKI1_1	193	197	PF00082	0.453
CLV_PCSK_SKI1_1	437	441	PF00082	0.520
CLV_PCSK_SKI1_1	676	680	PF00082	0.423
CLV_PCSK_SKI1_1	904	908	PF00082	0.281
CLV_Separin_Metazoa	239	243	PF03568	0.470
CLV_Separin_Metazoa	407	411	PF03568	0.464
DEG_APCC_DBOX_1	803	811	PF00400	0.378
DEG_APCC_DBOX_1	904	912	PF00400	0.307
DEG_SPOP_SBC_1	187	191	PF00917	0.197
DEG_SPOP_SBC_1	272	276	PF00917	0.510
DEG_SPOP_SBC_1	950	954	PF00917	0.375
DOC_CDC14_PxL_1	160	168	PF14671	0.297
DOC_CYCLIN_RxL_1	1	11	PF00134	0.197
DOC_CYCLIN_RxL_1	101	112	PF00134	0.410
DOC_CYCLIN_RxL_1	190	198	PF00134	0.197
DOC_CYCLIN_yCln2_LP_2	349	355	PF00134	0.392
DOC_CYCLIN_yCln2_LP_2	726	732	PF00134	0.394
DOC_MAPK_gen_1	322	332	PF00069	0.493
DOC_MAPK_gen_1	580	588	PF00069	0.427
DOC_MAPK_gen_1	725	734	PF00069	0.389
DOC_MAPK_gen_1	891	900	PF00069	0.420
DOC_MAPK_HePTP_8	722	734	PF00069	0.356
DOC_MAPK_MEF2A_6	725	734	PF00069	0.337
DOC_MAPK_MEF2A_6	764	772	PF00069	0.386
DOC_PP1_RVXF_1	191	197	PF00149	0.197
DOC_PP1_RVXF_1	292	298	PF00149	0.410
DOC_PP1_RVXF_1	723	729	PF00149	0.449
DOC_PP1_RVXF_1	762	768	PF00149	0.421
DOC_PP1_RVXF_1	889	896	PF00149	0.346
DOC_PP2B_LxvP_1	38	41	PF13499	0.357
DOC_PP2B_LxvP_1	456	459	PF13499	0.647
DOC_PP4_FxxP_1	154	157	PF00568	0.280
DOC_PP4_FxxP_1	297	300	PF00568	0.413
DOC_SPAK_OSR1_1	894	898	PF12202	0.336
DOC_USP7_MATH_1	114	118	PF00917	0.197
DOC_USP7_MATH_1	150	154	PF00917	0.338
DOC_USP7_MATH_1	178	182	PF00917	0.342
DOC_USP7_MATH_1	220	224	PF00917	0.397
DOC_USP7_MATH_1	272	276	PF00917	0.580
DOC_USP7_MATH_1	393	397	PF00917	0.783
DOC_USP7_MATH_1	481	485	PF00917	0.455
DOC_USP7_MATH_1	494	498	PF00917	0.466
DOC_USP7_MATH_1	546	550	PF00917	0.531
DOC_USP7_MATH_1	556	560	PF00917	0.580
DOC_USP7_MATH_1	575	579	PF00917	0.509
DOC_USP7_MATH_1	859	863	PF00917	0.414
DOC_USP7_UBL2_3	943	947	PF12436	0.310
DOC_WW_Pin1_4	633	638	PF00397	0.533
DOC_WW_Pin1_4	682	687	PF00397	0.388
DOC_WW_Pin1_4	815	820	PF00397	0.415
DOC_WW_Pin1_4	823	828	PF00397	0.399
DOC_WW_Pin1_4	922	927	PF00397	0.733
LIG_14-3-3_CanoR_1	140	147	PF00244	0.367
LIG_14-3-3_CanoR_1	410	414	PF00244	0.414
LIG_14-3-3_CanoR_1	501	506	PF00244	0.384
LIG_14-3-3_CanoR_1	662	672	PF00244	0.525
LIG_14-3-3_CanoR_1	815	819	PF00244	0.426
LIG_14-3-3_CanoR_1	830	838	PF00244	0.268
LIG_Actin_WH2_2	719	737	PF00022	0.330
LIG_APCC_ABBA_1	22	27	PF00400	0.355
LIG_APCC_ABBA_1	261	266	PF00400	0.498
LIG_APCC_ABBAyCdc20_2	260	266	PF00400	0.444
LIG_BRCT_BRCA1_1	180	184	PF00533	0.297
LIG_BRCT_BRCA1_1	483	487	PF00533	0.453
LIG_BRCT_BRCA1_1	503	507	PF00533	0.350
LIG_BRCT_BRCA1_1	577	581	PF00533	0.496
LIG_BRCT_BRCA1_1	787	791	PF00533	0.197
LIG_BRCT_BRCA1_1	961	965	PF00533	0.321
LIG_Clathr_ClatBox_1	35	39	PF01394	0.355
LIG_Clathr_ClatBox_1	892	896	PF01394	0.332
LIG_FHA_1	12	18	PF00498	0.297
LIG_FHA_1	189	195	PF00498	0.234
LIG_FHA_1	277	283	PF00498	0.400
LIG_FHA_1	344	350	PF00498	0.510
LIG_FHA_1	354	360	PF00498	0.494
LIG_FHA_1	466	472	PF00498	0.441
LIG_FHA_1	560	566	PF00498	0.469
LIG_FHA_1	664	670	PF00498	0.508
LIG_FHA_1	703	709	PF00498	0.475
LIG_FHA_1	760	766	PF00498	0.421
LIG_FHA_1	779	785	PF00498	0.405
LIG_FHA_1	830	836	PF00498	0.344
LIG_FHA_1	866	872	PF00498	0.502
LIG_FHA_1	933	939	PF00498	0.702
LIG_FHA_1	946	952	PF00498	0.529
LIG_FHA_2	250	256	PF00498	0.494
LIG_FHA_2	263	269	PF00498	0.532
LIG_FHA_2	402	408	PF00498	0.475
LIG_FHA_2	413	419	PF00498	0.264
LIG_FHA_2	46	52	PF00498	0.400
LIG_FHA_2	506	512	PF00498	0.517
LIG_FHA_2	562	568	PF00498	0.384
LIG_FHA_2	626	632	PF00498	0.391
LIG_FHA_2	640	646	PF00498	0.246
LIG_GBD_Chelix_1	863	871	PF00786	0.399
LIG_Integrin_RGD_1	253	255	PF01839	0.381
LIG_LIR_Apic_2	153	157	PF02991	0.265
LIG_LIR_Gen_1	317	323	PF02991	0.545
LIG_LIR_Gen_1	484	494	PF02991	0.442
LIG_LIR_Gen_1	504	514	PF02991	0.350
LIG_LIR_Gen_1	655	663	PF02991	0.346
LIG_LIR_Gen_1	766	772	PF02991	0.426
LIG_LIR_Gen_1	86	95	PF02991	0.421
LIG_LIR_Nem_3	181	187	PF02991	0.410
LIG_LIR_Nem_3	317	321	PF02991	0.629
LIG_LIR_Nem_3	484	490	PF02991	0.442
LIG_LIR_Nem_3	504	510	PF02991	0.350
LIG_LIR_Nem_3	567	573	PF02991	0.451
LIG_LIR_Nem_3	655	661	PF02991	0.351
LIG_LIR_Nem_3	677	682	PF02991	0.434
LIG_LIR_Nem_3	766	770	PF02991	0.432
LIG_LIR_Nem_3	856	860	PF02991	0.311
LIG_MAD2	959	967	PF02301	0.323
LIG_MLH1_MIPbox_1	483	487	PF16413	0.455
LIG_Pex14_2	297	301	PF04695	0.424
LIG_Pex14_2	89	93	PF04695	0.292
LIG_REV1ctd_RIR_1	811	818	PF16727	0.355
LIG_SH2_CRK	658	662	PF00017	0.376
LIG_SH2_GRB2like	658	661	PF00017	0.348
LIG_SH2_PTP2	723	726	PF00017	0.452
LIG_SH2_STAP1	323	327	PF00017	0.439
LIG_SH2_STAT5	105	108	PF00017	0.322
LIG_SH2_STAT5	337	340	PF00017	0.474
LIG_SH2_STAT5	353	356	PF00017	0.480
LIG_SH2_STAT5	413	416	PF00017	0.453
LIG_SH2_STAT5	522	525	PF00017	0.496
LIG_SH2_STAT5	723	726	PF00017	0.364
LIG_SH2_STAT5	777	780	PF00017	0.366
LIG_SH3_3	256	262	PF00018	0.372
LIG_SH3_3	487	493	PF00018	0.446
LIG_SH3_3	666	672	PF00018	0.511
LIG_SH3_3	754	760	PF00018	0.385
LIG_SH3_3	77	83	PF00018	0.427
LIG_SH3_3	913	919	PF00018	0.647
LIG_SH3_3	925	931	PF00018	0.712
LIG_SH3_3	933	939	PF00018	0.693
LIG_SUMO_SIM_anti_2	362	369	PF11976	0.389
LIG_SUMO_SIM_par_1	273	283	PF11976	0.511
LIG_SUMO_SIM_par_1	308	313	PF11976	0.391
LIG_SUMO_SIM_par_1	365	372	PF11976	0.293
LIG_SUMO_SIM_par_1	450	457	PF11976	0.505
LIG_SUMO_SIM_par_1	934	940	PF11976	0.467
LIG_TRAF2_1	177	180	PF00917	0.439
LIG_TRAF2_1	360	363	PF00917	0.284
LIG_TRAF2_1	819	822	PF00917	0.382
LIG_UBA3_1	730	736	PF00899	0.457
LIG_WRC_WIRS_1	810	815	PF05994	0.355
LIG_WRC_WIRS_1	854	859	PF05994	0.393
MOD_CDK_SPxxK_3	823	830	PF00069	0.197
MOD_CK1_1	11	17	PF00069	0.438
MOD_CK1_1	189	195	PF00069	0.382
MOD_CK1_1	221	227	PF00069	0.422
MOD_CK1_1	273	279	PF00069	0.634
MOD_CK1_1	302	308	PF00069	0.579
MOD_CK1_1	549	555	PF00069	0.513
MOD_CK1_1	559	565	PF00069	0.461
MOD_CK1_1	57	63	PF00069	0.392
MOD_CK1_1	914	920	PF00069	0.660
MOD_CK2_1	240	246	PF00069	0.556
MOD_CK2_1	262	268	PF00069	0.466
MOD_CK2_1	401	407	PF00069	0.515
MOD_CK2_1	412	418	PF00069	0.371
MOD_CK2_1	505	511	PF00069	0.470
MOD_CK2_1	638	644	PF00069	0.528
MOD_Cter_Amidation	169	172	PF01082	0.322
MOD_GlcNHglycan	179	183	PF01048	0.360
MOD_GlcNHglycan	334	337	PF01048	0.497
MOD_GlcNHglycan	376	379	PF01048	0.550
MOD_GlcNHglycan	479	482	PF01048	0.245
MOD_GlcNHglycan	548	551	PF01048	0.347
MOD_GlcNHglycan	558	561	PF01048	0.266
MOD_GlcNHglycan	65	70	PF01048	0.388
MOD_GlcNHglycan	679	682	PF01048	0.470
MOD_GlcNHglycan	75	78	PF01048	0.344
MOD_GlcNHglycan	781	784	PF01048	0.278
MOD_GlcNHglycan	787	790	PF01048	0.333
MOD_GlcNHglycan	873	876	PF01048	0.404
MOD_GSK3_1	110	117	PF00069	0.316
MOD_GSK3_1	262	269	PF00069	0.493
MOD_GSK3_1	270	277	PF00069	0.519
MOD_GSK3_1	278	285	PF00069	0.486
MOD_GSK3_1	299	306	PF00069	0.508
MOD_GSK3_1	310	317	PF00069	0.522
MOD_GSK3_1	465	472	PF00069	0.490
MOD_GSK3_1	477	484	PF00069	0.458
MOD_GSK3_1	501	508	PF00069	0.474
MOD_GSK3_1	54	61	PF00069	0.357
MOD_GSK3_1	555	562	PF00069	0.589
MOD_GSK3_1	648	655	PF00069	0.434
MOD_GSK3_1	670	677	PF00069	0.451
MOD_GSK3_1	779	786	PF00069	0.297
MOD_GSK3_1	809	816	PF00069	0.388
MOD_GSK3_1	917	924	PF00069	0.693
MOD_GSK3_1	937	944	PF00069	0.585
MOD_GSK3_1	945	952	PF00069	0.470
MOD_NEK2_1	218	223	PF00069	0.469
MOD_NEK2_1	240	245	PF00069	0.435
MOD_NEK2_1	270	275	PF00069	0.566
MOD_NEK2_1	282	287	PF00069	0.474
MOD_NEK2_1	409	414	PF00069	0.300
MOD_NEK2_1	54	59	PF00069	0.301
MOD_NEK2_1	561	566	PF00069	0.530
MOD_NEK2_1	73	78	PF00069	0.484
MOD_NEK2_1	770	775	PF00069	0.417
MOD_NEK2_1	787	792	PF00069	0.455
MOD_NEK2_1	799	804	PF00069	0.252
MOD_NEK2_1	8	13	PF00069	0.456
MOD_NEK2_1	813	818	PF00069	0.381
MOD_NEK2_1	828	833	PF00069	0.409
MOD_NEK2_1	87	92	PF00069	0.275
MOD_NEK2_1	871	876	PF00069	0.256
MOD_NEK2_1	911	916	PF00069	0.576
MOD_NEK2_1	93	98	PF00069	0.292
MOD_NEK2_1	941	946	PF00069	0.409
MOD_NEK2_2	482	487	PF00069	0.442
MOD_NEK2_2	524	529	PF00069	0.479
MOD_NEK2_2	853	858	PF00069	0.309
MOD_OFUCOSY	548	553	PF10250	0.184
MOD_PIKK_1	114	120	PF00454	0.264
MOD_PIKK_1	140	146	PF00454	0.197
MOD_PIKK_1	393	399	PF00454	0.779
MOD_PIKK_1	817	823	PF00454	0.197
MOD_PIKK_1	93	99	PF00454	0.279
MOD_PKA_1	171	177	PF00069	0.316
MOD_PKA_2	11	17	PF00069	0.215
MOD_PKA_2	110	116	PF00069	0.260
MOD_PKA_2	332	338	PF00069	0.494
MOD_PKA_2	409	415	PF00069	0.304
MOD_PKA_2	814	820	PF00069	0.374
MOD_PKA_2	829	835	PF00069	0.268
MOD_PKA_2	945	951	PF00069	0.476
MOD_Plk_1	254	260	PF00069	0.532
MOD_Plk_1	282	288	PF00069	0.409
MOD_Plk_1	799	805	PF00069	0.244
MOD_Plk_1	808	814	PF00069	0.260
MOD_Plk_4	171	177	PF00069	0.280
MOD_Plk_4	20	26	PF00069	0.377
MOD_Plk_4	254	260	PF00069	0.500
MOD_Plk_4	266	272	PF00069	0.569
MOD_Plk_4	409	415	PF00069	0.561
MOD_Plk_4	482	488	PF00069	0.442
MOD_Plk_4	652	658	PF00069	0.348
MOD_Plk_4	664	670	PF00069	0.432
MOD_Plk_4	809	815	PF00069	0.432
MOD_Plk_4	937	943	PF00069	0.459
MOD_Plk_4	951	957	PF00069	0.256
MOD_ProDKin_1	633	639	PF00069	0.534
MOD_ProDKin_1	682	688	PF00069	0.382
MOD_ProDKin_1	815	821	PF00069	0.415
MOD_ProDKin_1	823	829	PF00069	0.399
MOD_ProDKin_1	922	928	PF00069	0.733
MOD_SUMO_for_1	321	324	PF00179	0.547
MOD_SUMO_rev_2	416	422	PF00179	0.469
TRG_DiLeu_BaEn_1	363	368	PF01217	0.285
TRG_DiLeu_BaEn_1	937	942	PF01217	0.400
TRG_DiLeu_BaEn_2	714	720	PF01217	0.414
TRG_DiLeu_BaEn_4	246	252	PF01217	0.488
TRG_DiLeu_BaLyEn_6	726	731	PF01217	0.237
TRG_DiLeu_BaLyEn_6	824	829	PF01217	0.210
TRG_DiLeu_BaLyEn_6	902	907	PF01217	0.299
TRG_ENDOCYTIC_2	103	106	PF00928	0.362
TRG_ENDOCYTIC_2	570	573	PF00928	0.477
TRG_ENDOCYTIC_2	658	661	PF00928	0.368
TRG_ENDOCYTIC_2	723	726	PF00928	0.364
TRG_ER_diArg_1	130	132	PF00400	0.357
TRG_ER_diArg_1	436	438	PF00400	0.713
TRG_ER_diArg_1	581	583	PF00400	0.498
TRG_ER_diArg_1	693	695	PF00400	0.417
TRG_ER_diArg_1	724	727	PF00400	0.366
TRG_NES_CRM1_1	27	39	PF08389	0.355
TRG_NES_CRM1_1	899	910	PF08389	0.286
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	15	19	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	905	909	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP4	Leptomonas seymouri	62%	100%
A0A0S4IRQ8	Bodo saltans	34%	97%
A0A1X0NRU1	Trypanosomatidae	42%	100%
A0A3Q8IJK7	Leishmania donovani	79%	100%
A4I8D6	Leishmania infantum	79%	100%
D0AAT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B395	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q4W0	Leishmania major	80%	99%
V5BL49	Trypanosoma cruzi	42%	100%