SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania braziliensis

UniProt:

A4HKV3_LEIBR

TriTrypDb:

LbrM.32.3370 , LBRM2903_320041700

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKV3

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0019789	SUMO transferase activity	4	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0061665	SUMO ligase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	335	339	PF00656	0.530
CLV_C14_Caspase3-7	350	354	PF00656	0.602
CLV_C14_Caspase3-7	596	600	PF00656	0.440
CLV_NRD_NRD_1	145	147	PF00675	0.407
CLV_NRD_NRD_1	185	187	PF00675	0.646
CLV_NRD_NRD_1	206	208	PF00675	0.639
CLV_NRD_NRD_1	284	286	PF00675	0.495
CLV_NRD_NRD_1	328	330	PF00675	0.569
CLV_NRD_NRD_1	384	386	PF00675	0.622
CLV_NRD_NRD_1	407	409	PF00675	0.506
CLV_NRD_NRD_1	508	510	PF00675	0.385
CLV_NRD_NRD_1	559	561	PF00675	0.566
CLV_NRD_NRD_1	616	618	PF00675	0.534
CLV_PCSK_FUR_1	326	330	PF00082	0.619
CLV_PCSK_FUR_1	614	618	PF00082	0.605
CLV_PCSK_KEX2_1	144	146	PF00082	0.423
CLV_PCSK_KEX2_1	184	186	PF00082	0.596
CLV_PCSK_KEX2_1	206	208	PF00082	0.639
CLV_PCSK_KEX2_1	284	286	PF00082	0.396
CLV_PCSK_KEX2_1	328	330	PF00082	0.535
CLV_PCSK_KEX2_1	384	386	PF00082	0.622
CLV_PCSK_KEX2_1	407	409	PF00082	0.577
CLV_PCSK_KEX2_1	508	510	PF00082	0.385
CLV_PCSK_KEX2_1	559	561	PF00082	0.446
CLV_PCSK_KEX2_1	614	616	PF00082	0.520
CLV_PCSK_PC7_1	611	617	PF00082	0.497
CLV_PCSK_SKI1_1	174	178	PF00082	0.418
CLV_PCSK_SKI1_1	192	196	PF00082	0.488
CLV_PCSK_SKI1_1	545	549	PF00082	0.442
CLV_PCSK_SKI1_1	624	628	PF00082	0.482
DEG_APCC_DBOX_1	407	415	PF00400	0.678
DEG_SCF_FBW7_1	364	371	PF00400	0.500
DEG_SPOP_SBC_1	286	290	PF00917	0.386
DOC_ANK_TNKS_1	614	621	PF00023	0.458
DOC_CKS1_1	211	216	PF01111	0.613
DOC_CYCLIN_RxL_1	540	552	PF00134	0.535
DOC_CYCLIN_yCln2_LP_2	533	539	PF00134	0.260
DOC_MAPK_gen_1	326	336	PF00069	0.613
DOC_PP1_RVXF_1	172	178	PF00149	0.392
DOC_PP2B_LxvP_1	533	536	PF13499	0.423
DOC_PP2B_LxvP_1	604	607	PF13499	0.380
DOC_PP4_FxxP_1	610	613	PF00568	0.411
DOC_SPAK_OSR1_1	579	583	PF12202	0.461
DOC_USP7_MATH_1	245	249	PF00917	0.444
DOC_USP7_MATH_1	27	31	PF00917	0.681
DOC_USP7_MATH_1	368	372	PF00917	0.622
DOC_USP7_MATH_1	376	380	PF00917	0.640
DOC_USP7_MATH_1	437	441	PF00917	0.603
DOC_USP7_MATH_1	463	467	PF00917	0.539
DOC_USP7_MATH_1	47	51	PF00917	0.436
DOC_USP7_MATH_1	512	516	PF00917	0.411
DOC_USP7_MATH_1	618	622	PF00917	0.614
DOC_USP7_MATH_1	642	646	PF00917	0.698
DOC_USP7_MATH_1	656	660	PF00917	0.735
DOC_WW_Pin1_4	198	203	PF00397	0.771
DOC_WW_Pin1_4	210	215	PF00397	0.649
DOC_WW_Pin1_4	364	369	PF00397	0.533
DOC_WW_Pin1_4	387	392	PF00397	0.724
DOC_WW_Pin1_4	432	437	PF00397	0.648
DOC_WW_Pin1_4	64	69	PF00397	0.620
LIG_14-3-3_CanoR_1	189	198	PF00244	0.610
LIG_14-3-3_CanoR_1	206	214	PF00244	0.799
LIG_14-3-3_CanoR_1	284	293	PF00244	0.357
LIG_14-3-3_CanoR_1	649	654	PF00244	0.492
LIG_14-3-3_CterR_2	660	663	PF00244	0.468
LIG_Actin_WH2_2	306	322	PF00022	0.331
LIG_BRCT_BRCA1_1	227	231	PF00533	0.500
LIG_CtBP_PxDLS_1	14	18	PF00389	0.501
LIG_deltaCOP1_diTrp_1	569	575	PF00928	0.402
LIG_FHA_1	306	312	PF00498	0.430
LIG_FHA_1	523	529	PF00498	0.381
LIG_FHA_1	648	654	PF00498	0.492
LIG_FHA_2	130	136	PF00498	0.493
LIG_FHA_2	137	143	PF00498	0.331
LIG_FHA_2	322	328	PF00498	0.665
LIG_FHA_2	330	336	PF00498	0.612
LIG_FHA_2	338	344	PF00498	0.441
LIG_FHA_2	401	407	PF00498	0.545
LIG_FHA_2	652	658	PF00498	0.481
LIG_LIR_Gen_1	228	237	PF02991	0.341
LIG_LIR_Gen_1	260	266	PF02991	0.431
LIG_LIR_Gen_1	345	352	PF02991	0.448
LIG_LIR_Gen_1	373	381	PF02991	0.639
LIG_LIR_Gen_1	546	556	PF02991	0.600
LIG_LIR_Nem_3	228	234	PF02991	0.376
LIG_LIR_Nem_3	343	347	PF02991	0.627
LIG_LIR_Nem_3	373	378	PF02991	0.673
LIG_LIR_Nem_3	552	556	PF02991	0.614
LIG_LIR_Nem_3	633	639	PF02991	0.612
LIG_Pex14_1	571	575	PF04695	0.412
LIG_Pex14_2	177	181	PF04695	0.351
LIG_Pex14_2	580	584	PF04695	0.446
LIG_SH2_CRK	237	241	PF00017	0.467
LIG_SH2_CRK	375	379	PF00017	0.506
LIG_SH2_CRK	544	548	PF00017	0.572
LIG_SH2_CRK	553	557	PF00017	0.568
LIG_SH2_CRK	564	568	PF00017	0.362
LIG_SH2_NCK_1	375	379	PF00017	0.506
LIG_SH2_NCK_1	553	557	PF00017	0.609
LIG_SH2_SRC	564	567	PF00017	0.587
LIG_SH2_STAP1	344	348	PF00017	0.634
LIG_SH2_STAP1	553	557	PF00017	0.537
LIG_SH2_STAT3	123	126	PF00017	0.538
LIG_SH2_STAT3	90	93	PF00017	0.518
LIG_SH2_STAT5	347	350	PF00017	0.651
LIG_SH2_STAT5	537	540	PF00017	0.429
LIG_SH3_3	110	116	PF00018	0.523
LIG_SH3_3	272	278	PF00018	0.444
LIG_SH3_3	388	394	PF00018	0.735
LIG_SH3_3	9	15	PF00018	0.506
LIG_SUMO_SIM_par_1	260	267	PF11976	0.384
LIG_SUMO_SIM_par_1	308	314	PF11976	0.437
LIG_SxIP_EBH_1	65	74	PF03271	0.505
LIG_TRAF2_1	139	142	PF00917	0.419
LIG_TRAF2_1	403	406	PF00917	0.524
LIG_Vh1_VBS_1	286	304	PF01044	0.364
LIG_WRC_WIRS_1	38	43	PF05994	0.534
LIG_WRC_WIRS_1	58	63	PF05994	0.459
MOD_CK1_1	105	111	PF00069	0.639
MOD_CK1_1	158	164	PF00069	0.399
MOD_CK1_1	16	22	PF00069	0.484
MOD_CK1_1	188	194	PF00069	0.572
MOD_CK1_1	210	216	PF00069	0.613
MOD_CK1_1	3	9	PF00069	0.522
MOD_CK1_1	37	43	PF00069	0.532
MOD_CK1_1	371	377	PF00069	0.595
MOD_CK1_1	380	386	PF00069	0.692
MOD_CK1_1	398	404	PF00069	0.482
MOD_CK1_1	514	520	PF00069	0.394
MOD_CK1_1	600	606	PF00069	0.433
MOD_CK2_1	136	142	PF00069	0.441
MOD_CK2_1	146	152	PF00069	0.410
MOD_CK2_1	286	292	PF00069	0.283
MOD_CK2_1	321	327	PF00069	0.573
MOD_CK2_1	329	335	PF00069	0.605
MOD_CK2_1	343	349	PF00069	0.401
MOD_CK2_1	399	405	PF00069	0.526
MOD_CK2_1	543	549	PF00069	0.530
MOD_CK2_1	552	558	PF00069	0.619
MOD_CK2_1	575	581	PF00069	0.296
MOD_CK2_1	651	657	PF00069	0.484
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.609
MOD_GlcNHglycan	105	108	PF01048	0.484
MOD_GlcNHglycan	129	132	PF01048	0.544
MOD_GlcNHglycan	160	163	PF01048	0.469
MOD_GlcNHglycan	23	26	PF01048	0.644
MOD_GlcNHglycan	439	442	PF01048	0.575
MOD_GlcNHglycan	45	48	PF01048	0.576
MOD_GlcNHglycan	50	53	PF01048	0.575
MOD_GlcNHglycan	619	623	PF01048	0.640
MOD_GlcNHglycan	632	635	PF01048	0.433
MOD_GlcNHglycan	640	643	PF01048	0.588
MOD_GlcNHglycan	81	84	PF01048	0.556
MOD_GlcNHglycan	85	88	PF01048	0.563
MOD_GSK3_1	101	108	PF00069	0.573
MOD_GSK3_1	13	20	PF00069	0.506
MOD_GSK3_1	151	158	PF00069	0.348
MOD_GSK3_1	188	195	PF00069	0.552
MOD_GSK3_1	198	205	PF00069	0.607
MOD_GSK3_1	225	232	PF00069	0.383
MOD_GSK3_1	264	271	PF00069	0.384
MOD_GSK3_1	364	371	PF00069	0.618
MOD_GSK3_1	376	383	PF00069	0.565
MOD_GSK3_1	395	402	PF00069	0.727
MOD_GSK3_1	43	50	PF00069	0.561
MOD_GSK3_1	435	442	PF00069	0.629
MOD_GSK3_1	510	517	PF00069	0.405
MOD_GSK3_1	571	578	PF00069	0.284
MOD_GSK3_1	638	645	PF00069	0.747
MOD_GSK3_1	647	654	PF00069	0.496
MOD_GSK3_1	79	86	PF00069	0.594
MOD_N-GLC_1	371	376	PF02516	0.700
MOD_NEK2_1	17	22	PF00069	0.655
MOD_NEK2_1	473	478	PF00069	0.467
MOD_NEK2_1	510	515	PF00069	0.477
MOD_NEK2_1	543	548	PF00069	0.532
MOD_PIKK_1	207	213	PF00454	0.640
MOD_PIKK_1	337	343	PF00454	0.456
MOD_PIKK_1	439	445	PF00454	0.670
MOD_PIKK_1	463	469	PF00454	0.378
MOD_PIKK_1	473	479	PF00454	0.354
MOD_PIKK_1	624	630	PF00454	0.598
MOD_PIKK_1	642	648	PF00454	0.684
MOD_PK_1	385	391	PF00069	0.498
MOD_PKA_1	185	191	PF00069	0.422
MOD_PKA_1	329	335	PF00069	0.411
MOD_PKA_2	185	191	PF00069	0.577
MOD_PKA_2	205	211	PF00069	0.795
MOD_PKA_2	48	54	PF00069	0.498
MOD_PKA_2	648	654	PF00069	0.492
MOD_PKB_1	144	152	PF00069	0.319
MOD_Plk_1	229	235	PF00069	0.281
MOD_Plk_1	371	377	PF00069	0.499
MOD_Plk_2-3	343	349	PF00069	0.621
MOD_Plk_2-3	552	558	PF00069	0.540
MOD_Plk_4	258	264	PF00069	0.431
MOD_Plk_4	296	302	PF00069	0.278
MOD_Plk_4	329	335	PF00069	0.411
MOD_Plk_4	343	349	PF00069	0.401
MOD_Plk_4	37	43	PF00069	0.532
MOD_Plk_4	420	426	PF00069	0.487
MOD_Plk_4	522	528	PF00069	0.354
MOD_Plk_4	600	606	PF00069	0.512
MOD_ProDKin_1	198	204	PF00069	0.771
MOD_ProDKin_1	210	216	PF00069	0.644
MOD_ProDKin_1	364	370	PF00069	0.532
MOD_ProDKin_1	387	393	PF00069	0.725
MOD_ProDKin_1	432	438	PF00069	0.648
MOD_ProDKin_1	64	70	PF00069	0.621
MOD_SUMO_for_1	417	420	PF00179	0.531
MOD_SUMO_for_1	483	486	PF00179	0.511
TRG_DiLeu_BaEn_1	220	225	PF01217	0.575
TRG_ENDOCYTIC_2	237	240	PF00928	0.434
TRG_ENDOCYTIC_2	375	378	PF00928	0.508
TRG_ENDOCYTIC_2	544	547	PF00928	0.554
TRG_ENDOCYTIC_2	553	556	PF00928	0.560
TRG_ENDOCYTIC_2	636	639	PF00928	0.519
TRG_ER_diArg_1	143	146	PF00400	0.321
TRG_ER_diArg_1	184	186	PF00400	0.609
TRG_ER_diArg_1	284	286	PF00400	0.502
TRG_ER_diArg_1	384	387	PF00400	0.626
TRG_ER_diArg_1	507	509	PF00400	0.388
TRG_ER_diArg_1	613	616	PF00400	0.522
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.310
TRG_Pf-PMV_PEXEL_1	545	549	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P907	Leptomonas seymouri	59%	100%
A0A1X0NSE9	Trypanosomatidae	35%	100%
A0A3R7NRN3	Trypanosoma rangeli	38%	100%
A0A3S7X626	Leishmania donovani	84%	100%
A4I8D2	Leishmania infantum	84%	100%
D0AAU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B391	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4W4	Leishmania major	84%	100%
V5B5L3	Trypanosoma cruzi	39%	100%