Roc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras family, putative

Species:

Leishmania braziliensis

UniProt:

A4HKV0_LEIBR

TriTrypDb:

LbrM.32.3340 , LBRM2903_320041400

Length:

824

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKV0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKV0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	769	773	PF00656	0.727
CLV_NRD_NRD_1	266	268	PF00675	0.585
CLV_NRD_NRD_1	339	341	PF00675	0.538
CLV_NRD_NRD_1	443	445	PF00675	0.520
CLV_NRD_NRD_1	63	65	PF00675	0.389
CLV_NRD_NRD_1	667	669	PF00675	0.496
CLV_NRD_NRD_1	79	81	PF00675	0.343
CLV_NRD_NRD_1	812	814	PF00675	0.537
CLV_PCSK_FUR_1	810	814	PF00082	0.561
CLV_PCSK_KEX2_1	166	168	PF00082	0.230
CLV_PCSK_KEX2_1	266	268	PF00082	0.585
CLV_PCSK_KEX2_1	338	340	PF00082	0.481
CLV_PCSK_KEX2_1	63	65	PF00082	0.410
CLV_PCSK_KEX2_1	667	669	PF00082	0.496
CLV_PCSK_KEX2_1	810	812	PF00082	0.538
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.230
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.481
CLV_PCSK_SKI1_1	107	111	PF00082	0.430
CLV_PCSK_SKI1_1	13	17	PF00082	0.589
CLV_PCSK_SKI1_1	139	143	PF00082	0.342
CLV_PCSK_SKI1_1	183	187	PF00082	0.343
CLV_PCSK_SKI1_1	326	330	PF00082	0.392
CLV_PCSK_SKI1_1	365	369	PF00082	0.278
CLV_PCSK_SKI1_1	454	458	PF00082	0.449
CLV_PCSK_SKI1_1	572	576	PF00082	0.498
CLV_PCSK_SKI1_1	64	68	PF00082	0.359
CLV_PCSK_SKI1_1	812	816	PF00082	0.563
DEG_APCC_DBOX_1	448	456	PF00400	0.383
DEG_APCC_DBOX_1	609	617	PF00400	0.469
DEG_Nend_UBRbox_1	1	4	PF02207	0.793
DEG_ODPH_VHL_1	540	553	PF01847	0.419
DEG_SCF_FBW7_1	232	238	PF00400	0.534
DEG_SPOP_SBC_1	236	240	PF00917	0.767
DEG_SPOP_SBC_1	24	28	PF00917	0.768
DEG_SPOP_SBC_1	96	100	PF00917	0.343
DOC_CKS1_1	232	237	PF01111	0.534
DOC_CKS1_1	415	420	PF01111	0.496
DOC_CKS1_1	531	536	PF01111	0.520
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	486	492	PF00134	0.387
DOC_MAPK_DCC_7	46	56	PF00069	0.655
DOC_MAPK_gen_1	538	545	PF00069	0.400
DOC_MAPK_gen_1	547	555	PF00069	0.399
DOC_MAPK_gen_1	569	579	PF00069	0.498
DOC_MAPK_gen_1	608	615	PF00069	0.449
DOC_MAPK_MEF2A_6	547	555	PF00069	0.498
DOC_PP1_RVXF_1	452	458	PF00149	0.391
DOC_PP1_RVXF_1	51	57	PF00149	0.619
DOC_PP1_RVXF_1	550	556	PF00149	0.392
DOC_PP2B_LxvP_1	715	718	PF13499	0.623
DOC_PP2B_LxvP_1	748	751	PF13499	0.482
DOC_PP4_FxxP_1	457	460	PF00568	0.406
DOC_USP7_MATH_1	236	240	PF00917	0.792
DOC_USP7_MATH_1	24	28	PF00917	0.705
DOC_USP7_MATH_1	641	645	PF00917	0.458
DOC_USP7_MATH_1	672	676	PF00917	0.435
DOC_USP7_MATH_1	766	770	PF00917	0.647
DOC_USP7_UBL2_3	208	212	PF12436	0.441
DOC_WW_Pin1_4	228	233	PF00397	0.663
DOC_WW_Pin1_4	246	251	PF00397	0.651
DOC_WW_Pin1_4	414	419	PF00397	0.482
DOC_WW_Pin1_4	526	531	PF00397	0.398
DOC_WW_Pin1_4	637	642	PF00397	0.514
DOC_WW_Pin1_4	753	758	PF00397	0.562
DOC_WW_Pin1_4	817	822	PF00397	0.728
LIG_14-3-3_CanoR_1	372	378	PF00244	0.345
LIG_14-3-3_CanoR_1	403	409	PF00244	0.471
LIG_14-3-3_CanoR_1	63	69	PF00244	0.230
LIG_14-3-3_CanoR_1	667	671	PF00244	0.470
LIG_14-3-3_CanoR_1	719	725	PF00244	0.546
LIG_14-3-3_CanoR_1	97	104	PF00244	0.426
LIG_APCC_ABBA_1	622	627	PF00400	0.376
LIG_APCC_ABBAyCdc20_2	621	627	PF00400	0.376
LIG_BRCT_BRCA1_1	25	29	PF00533	0.577
LIG_BRCT_BRCA1_1	84	88	PF00533	0.443
LIG_deltaCOP1_diTrp_1	560	566	PF00928	0.394
LIG_FHA_1	113	119	PF00498	0.301
LIG_FHA_1	131	137	PF00498	0.365
LIG_FHA_1	232	238	PF00498	0.570
LIG_FHA_1	277	283	PF00498	0.417
LIG_FHA_1	473	479	PF00498	0.300
LIG_FHA_1	654	660	PF00498	0.343
LIG_FHA_1	721	727	PF00498	0.568
LIG_FHA_1	97	103	PF00498	0.343
LIG_FHA_2	187	193	PF00498	0.343
LIG_FHA_2	32	38	PF00498	0.537
LIG_FHA_2	779	785	PF00498	0.576
LIG_FHA_2	98	104	PF00498	0.225
LIG_LIR_Apic_2	521	526	PF02991	0.406
LIG_LIR_Gen_1	140	150	PF02991	0.338
LIG_LIR_Gen_1	351	359	PF02991	0.488
LIG_LIR_Gen_1	376	383	PF02991	0.348
LIG_LIR_Gen_1	410	419	PF02991	0.518
LIG_LIR_Gen_1	495	505	PF02991	0.490
LIG_LIR_Gen_1	554	562	PF02991	0.397
LIG_LIR_Nem_3	140	145	PF02991	0.338
LIG_LIR_Nem_3	174	179	PF02991	0.340
LIG_LIR_Nem_3	376	380	PF02991	0.345
LIG_LIR_Nem_3	410	414	PF02991	0.488
LIG_LIR_Nem_3	495	500	PF02991	0.481
LIG_LIR_Nem_3	554	558	PF02991	0.380
LIG_LIR_Nem_3	560	566	PF02991	0.361
LIG_MYND_1	526	530	PF01753	0.410
LIG_NRBOX	654	660	PF00104	0.488
LIG_PCNA_yPIPBox_3	2	15	PF02747	0.523
LIG_PCNA_yPIPBox_3	565	574	PF02747	0.436
LIG_Pex14_1	377	381	PF04695	0.361
LIG_Pex14_2	142	146	PF04695	0.343
LIG_Pex14_2	562	566	PF04695	0.247
LIG_REV1ctd_RIR_1	86	93	PF16727	0.401
LIG_SH2_CRK	662	666	PF00017	0.391
LIG_SH2_CRK	752	756	PF00017	0.564
LIG_SH2_SRC	524	527	PF00017	0.523
LIG_SH2_SRC	580	583	PF00017	0.596
LIG_SH2_SRC	71	74	PF00017	0.399
LIG_SH2_SRC	785	788	PF00017	0.449
LIG_SH2_STAP1	411	415	PF00017	0.443
LIG_SH2_STAT3	14	17	PF00017	0.634
LIG_SH2_STAT5	134	137	PF00017	0.435
LIG_SH2_STAT5	14	17	PF00017	0.534
LIG_SH2_STAT5	216	219	PF00017	0.413
LIG_SH2_STAT5	303	306	PF00017	0.447
LIG_SH2_STAT5	381	384	PF00017	0.370
LIG_SH2_STAT5	430	433	PF00017	0.487
LIG_SH2_STAT5	447	450	PF00017	0.375
LIG_SH2_STAT5	524	527	PF00017	0.390
LIG_SH2_STAT5	747	750	PF00017	0.429
LIG_SH2_STAT5	785	788	PF00017	0.505
LIG_SH3_3	229	235	PF00018	0.641
LIG_SH3_3	392	398	PF00018	0.481
LIG_SH3_3	502	508	PF00018	0.505
LIG_SH3_3	576	582	PF00018	0.524
LIG_SH3_3	668	674	PF00018	0.434
LIG_SUMO_SIM_anti_2	389	396	PF11976	0.437
LIG_SUMO_SIM_par_1	183	189	PF11976	0.443
LIG_SUMO_SIM_par_1	488	493	PF11976	0.459
LIG_SUMO_SIM_par_1	721	727	PF11976	0.568
LIG_TRAF2_1	124	127	PF00917	0.368
LIG_TRAF2_1	162	165	PF00917	0.277
LIG_TRAF2_1	602	605	PF00917	0.509
LIG_TRFH_1	555	559	PF08558	0.365
LIG_TYR_ITIM	69	74	PF00017	0.399
LIG_UBA3_1	141	147	PF00899	0.328
LIG_UBA3_1	300	309	PF00899	0.476
LIG_UBA3_1	330	338	PF00899	0.455
MOD_CDC14_SPxK_1	249	252	PF00782	0.498
MOD_CDC14_SPxK_1	756	759	PF00782	0.660
MOD_CDK_SPK_2	637	642	PF00069	0.514
MOD_CDK_SPxK_1	246	252	PF00069	0.514
MOD_CDK_SPxK_1	753	759	PF00069	0.617
MOD_CK1_1	128	134	PF00069	0.372
MOD_CK1_1	224	230	PF00069	0.591
MOD_CK1_1	239	245	PF00069	0.758
MOD_CK1_1	248	254	PF00069	0.765
MOD_CK1_1	27	33	PF00069	0.761
MOD_CK1_1	276	282	PF00069	0.432
MOD_CK1_1	407	413	PF00069	0.498
MOD_CK1_1	633	639	PF00069	0.429
MOD_CK1_1	689	695	PF00069	0.543
MOD_CK1_1	737	743	PF00069	0.525
MOD_CK2_1	146	152	PF00069	0.357
MOD_CK2_1	360	366	PF00069	0.419
MOD_CK2_1	430	436	PF00069	0.485
MOD_CK2_1	526	532	PF00069	0.302
MOD_CK2_1	778	784	PF00069	0.591
MOD_CK2_1	97	103	PF00069	0.279
MOD_GlcNHglycan	148	151	PF01048	0.365
MOD_GlcNHglycan	157	160	PF01048	0.313
MOD_GlcNHglycan	29	32	PF01048	0.549
MOD_GlcNHglycan	292	295	PF01048	0.406
MOD_GlcNHglycan	297	300	PF01048	0.363
MOD_GlcNHglycan	404	407	PF01048	0.256
MOD_GlcNHglycan	635	638	PF01048	0.521
MOD_GlcNHglycan	709	712	PF01048	0.568
MOD_GlcNHglycan	772	775	PF01048	0.671
MOD_GSK3_1	130	137	PF00069	0.343
MOD_GSK3_1	2	9	PF00069	0.730
MOD_GSK3_1	224	231	PF00069	0.560
MOD_GSK3_1	23	30	PF00069	0.674
MOD_GSK3_1	235	242	PF00069	0.670
MOD_GSK3_1	248	255	PF00069	0.663
MOD_GSK3_1	31	38	PF00069	0.687
MOD_GSK3_1	514	521	PF00069	0.547
MOD_GSK3_1	526	533	PF00069	0.510
MOD_GSK3_1	633	640	PF00069	0.489
MOD_GSK3_1	687	694	PF00069	0.523
MOD_GSK3_1	766	773	PF00069	0.741
MOD_LATS_1	62	68	PF00433	0.230
MOD_N-GLC_1	224	229	PF02516	0.575
MOD_NEK2_1	155	160	PF00069	0.343
MOD_NEK2_1	186	191	PF00069	0.343
MOD_NEK2_1	237	242	PF00069	0.795
MOD_NEK2_1	273	278	PF00069	0.386
MOD_NEK2_1	29	34	PF00069	0.709
MOD_NEK2_1	404	409	PF00069	0.389
MOD_NEK2_1	47	52	PF00069	0.596
MOD_NEK2_1	480	485	PF00069	0.308
MOD_NEK2_1	720	725	PF00069	0.471
MOD_NEK2_1	734	739	PF00069	0.365
MOD_NEK2_1	797	802	PF00069	0.526
MOD_NEK2_2	75	80	PF00069	0.343
MOD_OFUCOSY	735	741	PF10250	0.520
MOD_PIKK_1	514	520	PF00454	0.585
MOD_PIKK_1	55	61	PF00454	0.349
MOD_PIKK_1	672	678	PF00454	0.324
MOD_PIKK_1	718	724	PF00454	0.564
MOD_PK_1	759	765	PF00069	0.772
MOD_PKA_1	64	70	PF00069	0.230
MOD_PKA_2	402	408	PF00069	0.485
MOD_PKA_2	609	615	PF00069	0.485
MOD_PKA_2	641	647	PF00069	0.567
MOD_PKA_2	666	672	PF00069	0.503
MOD_PKA_2	718	724	PF00069	0.491
MOD_PKA_2	96	102	PF00069	0.399
MOD_PKB_1	53	61	PF00069	0.366
MOD_Plk_1	105	111	PF00069	0.480
MOD_Plk_1	137	143	PF00069	0.343
MOD_Plk_1	252	258	PF00069	0.492
MOD_Plk_1	472	478	PF00069	0.322
MOD_Plk_4	130	136	PF00069	0.344
MOD_Plk_4	252	258	PF00069	0.492
MOD_Plk_4	404	410	PF00069	0.500
MOD_Plk_4	575	581	PF00069	0.487
MOD_Plk_4	6	12	PF00069	0.489
MOD_Plk_4	609	615	PF00069	0.485
MOD_Plk_4	630	636	PF00069	0.485
MOD_Plk_4	720	726	PF00069	0.491
MOD_ProDKin_1	228	234	PF00069	0.672
MOD_ProDKin_1	246	252	PF00069	0.650
MOD_ProDKin_1	414	420	PF00069	0.487
MOD_ProDKin_1	526	532	PF00069	0.405
MOD_ProDKin_1	637	643	PF00069	0.511
MOD_ProDKin_1	753	759	PF00069	0.579
MOD_ProDKin_1	817	823	PF00069	0.731
MOD_SUMO_rev_2	158	168	PF00179	0.230
TRG_DiLeu_BaEn_1	114	119	PF01217	0.230
TRG_DiLeu_BaEn_1	389	394	PF01217	0.443
TRG_DiLeu_BaEn_1	482	487	PF01217	0.482
TRG_DiLeu_BaEn_1	496	501	PF01217	0.538
TRG_DiLeu_BaEn_1	727	732	PF01217	0.415
TRG_DiLeu_BaEn_2	137	143	PF01217	0.443
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.504
TRG_ENDOCYTIC_2	303	306	PF00928	0.481
TRG_ENDOCYTIC_2	411	414	PF00928	0.438
TRG_ENDOCYTIC_2	662	665	PF00928	0.384
TRG_ENDOCYTIC_2	71	74	PF00928	0.399
TRG_ENDOCYTIC_2	747	750	PF00928	0.429
TRG_ER_diArg_1	266	268	PF00400	0.601
TRG_ER_diArg_1	52	55	PF00400	0.554
TRG_ER_diArg_1	549	552	PF00400	0.463
TRG_ER_diArg_1	597	600	PF00400	0.561
TRG_ER_diArg_1	810	813	PF00400	0.561
TRG_NES_CRM1_1	295	310	PF08389	0.277
TRG_NLS_MonoExtC_3	337	342	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.278
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9V2	Leptomonas seymouri	77%	82%
A0A1X0NT83	Trypanosomatidae	51%	82%
A0A3S5H7S9	Leishmania donovani	89%	100%
A0A422NYM8	Trypanosoma rangeli	48%	84%
A4I8C9	Leishmania infantum	89%	100%
E9B388	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4W7	Leishmania major	89%	100%
V5DM76	Trypanosoma cruzi	48%	93%