Putative chaperone protein DNAj

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania braziliensis

UniProt:

A4HKU8_LEIBR

TriTrypDb:

LbrM.32.3320 , LBRM2903_320041100

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HKU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051087	protein-folding chaperone binding	3	1
GO:0051787	misfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.558
CLV_NRD_NRD_1	134	136	PF00675	0.434
CLV_NRD_NRD_1	153	155	PF00675	0.650
CLV_PCSK_KEX2_1	127	129	PF00082	0.530
CLV_PCSK_KEX2_1	133	135	PF00082	0.444
CLV_PCSK_KEX2_1	153	155	PF00082	0.683
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.517
CLV_PCSK_SKI1_1	23	27	PF00082	0.384
DOC_ANK_TNKS_1	299	306	PF00023	0.522
DOC_CKS1_1	177	182	PF01111	0.489
DOC_PP1_RVXF_1	52	59	PF00149	0.274
DOC_USP7_MATH_1	180	184	PF00917	0.587
DOC_USP7_MATH_1	212	216	PF00917	0.615
DOC_USP7_MATH_1	47	51	PF00917	0.350
DOC_WW_Pin1_4	176	181	PF00397	0.493
DOC_WW_Pin1_4	96	101	PF00397	0.636
LIG_14-3-3_CanoR_1	10	15	PF00244	0.577
LIG_14-3-3_CanoR_1	118	126	PF00244	0.547
LIG_14-3-3_CanoR_1	186	192	PF00244	0.512
LIG_14-3-3_CanoR_1	23	30	PF00244	0.368
LIG_14-3-3_CanoR_1	264	274	PF00244	0.581
LIG_APCC_ABBA_1	103	108	PF00400	0.621
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BRCT_BRCA1_1	269	273	PF00533	0.517
LIG_BRCT_BRCA1_1	49	53	PF00533	0.350
LIG_BRCT_BRCA1_2	269	275	PF00533	0.442
LIG_CtBP_PxDLS_1	100	104	PF00389	0.563
LIG_FHA_1	10	16	PF00498	0.495
LIG_FHA_1	121	127	PF00498	0.545
LIG_FHA_1	267	273	PF00498	0.674
LIG_FHA_1	284	290	PF00498	0.541
LIG_FHA_2	185	191	PF00498	0.509
LIG_FHA_2	24	30	PF00498	0.295
LIG_FHA_2	241	247	PF00498	0.619
LIG_FHA_2	288	294	PF00498	0.506
LIG_FHA_2	299	305	PF00498	0.629
LIG_LIR_Apic_2	174	180	PF02991	0.499
LIG_LIR_Apic_2	201	207	PF02991	0.621
LIG_LIR_Gen_1	13	21	PF02991	0.320
LIG_LIR_Nem_3	13	19	PF02991	0.340
LIG_LIR_Nem_3	293	297	PF02991	0.458
LIG_LIR_Nem_3	298	302	PF02991	0.478
LIG_LIR_Nem_3	50	56	PF02991	0.315
LIG_PTB_Apo_2	139	146	PF02174	0.452
LIG_PTB_Apo_2	293	300	PF02174	0.498
LIG_PTB_Phospho_1	293	299	PF10480	0.493
LIG_SH2_CRK	177	181	PF00017	0.491
LIG_SH2_CRK	204	208	PF00017	0.701
LIG_SH2_GRB2like	149	152	PF00017	0.359
LIG_SH2_GRB2like	294	297	PF00017	0.495
LIG_SH2_NCK_1	177	181	PF00017	0.507
LIG_SH2_SRC	149	152	PF00017	0.371
LIG_SH2_SRC	88	91	PF00017	0.536
LIG_SH2_STAP1	283	287	PF00017	0.502
LIG_SUMO_SIM_par_1	284	290	PF11976	0.400
LIG_TRAF2_1	290	293	PF00917	0.369
LIG_TYR_ITIM	14	19	PF00017	0.250
LIG_WRC_WIRS_1	299	304	PF05994	0.559
MOD_CK1_1	162	168	PF00069	0.502
MOD_CK1_1	240	246	PF00069	0.662
MOD_CK1_1	247	253	PF00069	0.639
MOD_CK2_1	119	125	PF00069	0.498
MOD_CK2_1	184	190	PF00069	0.535
MOD_CK2_1	23	29	PF00069	0.315
MOD_CK2_1	240	246	PF00069	0.709
MOD_CK2_1	287	293	PF00069	0.505
MOD_CK2_1	298	304	PF00069	0.503
MOD_CK2_1	61	67	PF00069	0.364
MOD_GlcNHglycan	1	4	PF01048	0.661
MOD_GlcNHglycan	164	167	PF01048	0.686
MOD_GlcNHglycan	187	190	PF01048	0.569
MOD_GlcNHglycan	210	213	PF01048	0.574
MOD_GlcNHglycan	215	218	PF01048	0.644
MOD_GlcNHglycan	219	222	PF01048	0.617
MOD_GlcNHglycan	255	258	PF01048	0.697
MOD_GlcNHglycan	73	76	PF01048	0.517
MOD_GSK3_1	171	178	PF00069	0.718
MOD_GSK3_1	180	187	PF00069	0.523
MOD_GSK3_1	19	26	PF00069	0.424
MOD_GSK3_1	208	215	PF00069	0.590
MOD_GSK3_1	240	247	PF00069	0.624
MOD_GSK3_1	248	255	PF00069	0.632
MOD_GSK3_1	281	288	PF00069	0.605
MOD_N-GLC_1	212	217	PF02516	0.577
MOD_NEK2_1	19	24	PF00069	0.368
MOD_NEK2_1	248	253	PF00069	0.584
MOD_NEK2_1	266	271	PF00069	0.486
MOD_NEK2_1	273	278	PF00069	0.527
MOD_NEK2_1	71	76	PF00069	0.550
MOD_NEK2_1	9	14	PF00069	0.572
MOD_NEK2_2	257	262	PF00069	0.557
MOD_PIKK_1	110	116	PF00454	0.533
MOD_PIKK_1	23	29	PF00454	0.417
MOD_PK_1	10	16	PF00069	0.322
MOD_PKA_2	110	116	PF00069	0.593
MOD_PKA_2	185	191	PF00069	0.560
MOD_PKA_2	9	15	PF00069	0.539
MOD_Plk_1	244	250	PF00069	0.497
MOD_Plk_2-3	298	304	PF00069	0.522
MOD_Plk_4	10	16	PF00069	0.520
MOD_Plk_4	267	273	PF00069	0.566
MOD_ProDKin_1	176	182	PF00069	0.491
MOD_ProDKin_1	96	102	PF00069	0.636
MOD_SUMO_for_1	145	148	PF00179	0.493
MOD_SUMO_rev_2	80	85	PF00179	0.507
TRG_DiLeu_BaEn_4	198	204	PF01217	0.592
TRG_ENDOCYTIC_2	16	19	PF00928	0.314
TRG_ENDOCYTIC_2	299	302	PF00928	0.503
TRG_ENDOCYTIC_2	34	37	PF00928	0.274
TRG_ER_diArg_1	126	128	PF00400	0.536
TRG_ER_diArg_1	153	156	PF00400	0.592
TRG_ER_diArg_1	261	264	PF00400	0.727
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML6	Leptomonas seymouri	56%	100%
A0A0S4ILI1	Bodo saltans	35%	100%
A0A1X0NRT2	Trypanosomatidae	46%	100%
A0A3Q8IHA8	Leishmania donovani	80%	100%
A0A422NYS2	Trypanosoma rangeli	42%	100%
A4I8C7	Leishmania infantum	80%	100%
D0AAU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B386	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q4W9	Leishmania major	78%	100%
V5BL40	Trypanosoma cruzi	45%	100%