EngB-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania braziliensis

UniProt:

A4HKU7_LEIBR

TriTrypDb:

LbrM.32.3310 , LBRM2903_320041000

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HKU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU7

PDB structure(s): 7am2_BV

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0017076	purine nucleotide binding	4	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	527	531	PF00656	0.539
CLV_C14_Caspase3-7	585	589	PF00656	0.562
CLV_MEL_PAP_1	35	41	PF00089	0.449
CLV_NRD_NRD_1	108	110	PF00675	0.287
CLV_NRD_NRD_1	244	246	PF00675	0.778
CLV_NRD_NRD_1	381	383	PF00675	0.603
CLV_NRD_NRD_1	500	502	PF00675	0.771
CLV_NRD_NRD_1	665	667	PF00675	0.567
CLV_NRD_NRD_1	671	673	PF00675	0.490
CLV_NRD_NRD_1	684	686	PF00675	0.486
CLV_PCSK_FUR_1	242	246	PF00082	0.763
CLV_PCSK_FUR_1	663	667	PF00082	0.624
CLV_PCSK_KEX2_1	108	110	PF00082	0.287
CLV_PCSK_KEX2_1	175	177	PF00082	0.294
CLV_PCSK_KEX2_1	244	246	PF00082	0.763
CLV_PCSK_KEX2_1	381	383	PF00082	0.601
CLV_PCSK_KEX2_1	500	502	PF00082	0.771
CLV_PCSK_KEX2_1	665	667	PF00082	0.506
CLV_PCSK_KEX2_1	686	688	PF00082	0.526
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.294
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.518
CLV_PCSK_SKI1_1	372	376	PF00082	0.397
CLV_PCSK_SKI1_1	493	497	PF00082	0.748
CLV_PCSK_SKI1_1	566	570	PF00082	0.653
CLV_PCSK_SKI1_1	66	70	PF00082	0.547
CLV_PCSK_SKI1_1	730	734	PF00082	0.444
CLV_PCSK_SKI1_1	745	749	PF00082	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DEG_SPOP_SBC_1	417	421	PF00917	0.531
DOC_CKS1_1	135	140	PF01111	0.490
DOC_CKS1_1	455	460	PF01111	0.553
DOC_CYCLIN_RxL_1	161	172	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	571	577	PF00134	0.679
DOC_MAPK_gen_1	17	27	PF00069	0.498
DOC_MAPK_gen_1	204	213	PF00069	0.554
DOC_MAPK_MEF2A_6	594	601	PF00069	0.544
DOC_PP1_RVXF_1	119	126	PF00149	0.490
DOC_PP1_RVXF_1	173	180	PF00149	0.490
DOC_PP1_RVXF_1	316	322	PF00149	0.346
DOC_PP2B_LxvP_1	571	574	PF13499	0.701
DOC_PP4_FxxP_1	253	256	PF00568	0.573
DOC_PP4_FxxP_1	349	352	PF00568	0.434
DOC_USP7_MATH_1	292	296	PF00917	0.536
DOC_USP7_MATH_1	34	38	PF00917	0.681
DOC_USP7_MATH_1	345	349	PF00917	0.422
DOC_USP7_MATH_1	432	436	PF00917	0.749
DOC_USP7_MATH_1	477	481	PF00917	0.577
DOC_USP7_MATH_1	616	620	PF00917	0.486
DOC_WW_Pin1_4	113	118	PF00397	0.411
DOC_WW_Pin1_4	134	139	PF00397	0.490
DOC_WW_Pin1_4	184	189	PF00397	0.561
DOC_WW_Pin1_4	252	257	PF00397	0.516
DOC_WW_Pin1_4	454	459	PF00397	0.678
DOC_WW_Pin1_4	547	552	PF00397	0.646
DOC_WW_Pin1_4	587	592	PF00397	0.477
LIG_14-3-3_CanoR_1	13	19	PF00244	0.693
LIG_14-3-3_CanoR_1	186	192	PF00244	0.516
LIG_14-3-3_CanoR_1	20	25	PF00244	0.709
LIG_14-3-3_CanoR_1	206	212	PF00244	0.561
LIG_14-3-3_CanoR_1	381	389	PF00244	0.553
LIG_14-3-3_CanoR_1	447	455	PF00244	0.698
LIG_14-3-3_CanoR_1	500	505	PF00244	0.757
LIG_14-3-3_CanoR_1	566	574	PF00244	0.494
LIG_14-3-3_CanoR_1	594	600	PF00244	0.515
LIG_14-3-3_CanoR_1	663	671	PF00244	0.498
LIG_Actin_WH2_2	155	171	PF00022	0.545
LIG_Actin_WH2_2	386	402	PF00022	0.495
LIG_Actin_WH2_2	5	22	PF00022	0.565
LIG_Actin_WH2_2	53	71	PF00022	0.441
LIG_BRCT_BRCA1_1	159	163	PF00533	0.561
LIG_Clathr_ClatBox_1	132	136	PF01394	0.531
LIG_Clathr_ClatBox_1	393	397	PF01394	0.477
LIG_Clathr_ClatBox_1	627	631	PF01394	0.506
LIG_DCNL_PONY_1	1	4	PF03556	0.630
LIG_deltaCOP1_diTrp_1	483	490	PF00928	0.520
LIG_DLG_GKlike_1	500	507	PF00625	0.516
LIG_eIF4E_1	308	314	PF01652	0.437
LIG_eIF4E_1	624	630	PF01652	0.507
LIG_FHA_1	117	123	PF00498	0.490
LIG_FHA_1	20	26	PF00498	0.585
LIG_FHA_1	275	281	PF00498	0.476
LIG_FHA_1	308	314	PF00498	0.437
LIG_FHA_1	373	379	PF00498	0.513
LIG_FHA_1	418	424	PF00498	0.691
LIG_FHA_1	443	449	PF00498	0.648
LIG_FHA_1	48	54	PF00498	0.352
LIG_FHA_1	558	564	PF00498	0.638
LIG_FHA_2	212	218	PF00498	0.561
LIG_FHA_2	400	406	PF00498	0.714
LIG_FHA_2	583	589	PF00498	0.517
LIG_IRF3_LxIS_1	8	15	PF10401	0.616
LIG_LIR_Apic_2	250	256	PF02991	0.562
LIG_LIR_Apic_2	328	332	PF02991	0.446
LIG_LIR_Apic_2	347	352	PF02991	0.267
LIG_LIR_Apic_2	697	702	PF02991	0.460
LIG_LIR_Gen_1	270	280	PF02991	0.428
LIG_LIR_Gen_1	503	511	PF02991	0.608
LIG_LIR_Nem_3	160	166	PF02991	0.498
LIG_LIR_Nem_3	217	223	PF02991	0.552
LIG_LIR_Nem_3	270	275	PF02991	0.372
LIG_LIR_Nem_3	503	507	PF02991	0.604
LIG_LIR_Nem_3	676	682	PF02991	0.345
LIG_LIR_Nem_3	83	87	PF02991	0.366
LIG_NRBOX	3	9	PF00104	0.729
LIG_PCNA_yPIPBox_3	356	370	PF02747	0.472
LIG_Pex14_1	638	642	PF04695	0.426
LIG_Pex14_2	159	163	PF04695	0.490
LIG_PTB_Apo_2	55	62	PF02174	0.538
LIG_Rb_LxCxE_1	310	328	PF01857	0.331
LIG_REV1ctd_RIR_1	676	685	PF16727	0.348
LIG_SH2_CRK	329	333	PF00017	0.473
LIG_SH2_CRK	543	547	PF00017	0.551
LIG_SH2_NCK_1	329	333	PF00017	0.454
LIG_SH2_NCK_1	543	547	PF00017	0.551
LIG_SH2_SRC	329	332	PF00017	0.470
LIG_SH2_STAP1	624	628	PF00017	0.512
LIG_SH2_STAT3	223	226	PF00017	0.588
LIG_SH2_STAT3	308	311	PF00017	0.452
LIG_SH2_STAT5	165	168	PF00017	0.485
LIG_SH2_STAT5	308	311	PF00017	0.377
LIG_SH2_STAT5	583	586	PF00017	0.558
LIG_SH2_STAT5	614	617	PF00017	0.392
LIG_SH2_STAT5	682	685	PF00017	0.464
LIG_SH3_3	132	138	PF00018	0.490
LIG_SH3_3	452	458	PF00018	0.548
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.508
LIG_SUMO_SIM_anti_2	625	631	PF11976	0.506
LIG_SUMO_SIM_par_1	130	137	PF11976	0.490
LIG_SUMO_SIM_par_1	392	397	PF11976	0.470
LIG_SUMO_SIM_par_1	559	565	PF11976	0.502
LIG_SUMO_SIM_par_1	595	600	PF11976	0.548
LIG_SUMO_SIM_par_1	625	631	PF11976	0.506
LIG_TRAF2_1	623	626	PF00917	0.564
LIG_WRC_WIRS_1	198	203	PF05994	0.591
LIG_WRC_WIRS_1	346	351	PF05994	0.429
MOD_CDC14_SPxK_1	554	557	PF00782	0.801
MOD_CDK_SPxK_1	551	557	PF00069	0.797
MOD_CDK_SPxxK_3	454	461	PF00069	0.552
MOD_CDK_SPxxK_3	587	594	PF00069	0.470
MOD_CK1_1	113	119	PF00069	0.490
MOD_CK1_1	15	21	PF00069	0.602
MOD_CK1_1	184	190	PF00069	0.591
MOD_CK1_1	255	261	PF00069	0.457
MOD_CK1_1	376	382	PF00069	0.379
MOD_CK1_1	426	432	PF00069	0.741
MOD_CK1_1	544	550	PF00069	0.717
MOD_CK1_1	595	601	PF00069	0.470
MOD_CK1_1	719	725	PF00069	0.657
MOD_CK1_1	743	749	PF00069	0.487
MOD_CK1_1	99	105	PF00069	0.487
MOD_CK2_1	419	425	PF00069	0.783
MOD_CK2_1	73	79	PF00069	0.307
MOD_CK2_1	80	86	PF00069	0.386
MOD_Cter_Amidation	663	666	PF01082	0.482
MOD_GlcNHglycan	112	115	PF01048	0.244
MOD_GlcNHglycan	182	186	PF01048	0.391
MOD_GlcNHglycan	285	288	PF01048	0.540
MOD_GlcNHglycan	378	381	PF01048	0.574
MOD_GlcNHglycan	472	475	PF01048	0.699
MOD_GlcNHglycan	512	515	PF01048	0.752
MOD_GlcNHglycan	546	549	PF01048	0.723
MOD_GlcNHglycan	618	621	PF01048	0.457
MOD_GlcNHglycan	668	671	PF01048	0.537
MOD_GlcNHglycan	742	745	PF01048	0.530
MOD_GSK3_1	113	120	PF00069	0.490
MOD_GSK3_1	15	22	PF00069	0.665
MOD_GSK3_1	180	187	PF00069	0.591
MOD_GSK3_1	207	214	PF00069	0.531
MOD_GSK3_1	313	320	PF00069	0.522
MOD_GSK3_1	372	379	PF00069	0.438
MOD_GSK3_1	419	426	PF00069	0.645
MOD_GSK3_1	427	434	PF00069	0.552
MOD_GSK3_1	43	50	PF00069	0.538
MOD_GSK3_1	442	449	PF00069	0.626
MOD_GSK3_1	453	460	PF00069	0.638
MOD_GSK3_1	547	554	PF00069	0.678
MOD_GSK3_1	95	102	PF00069	0.490
MOD_N-GLC_1	169	174	PF02516	0.363
MOD_N-GLC_1	355	360	PF02516	0.469
MOD_NEK2_1	110	115	PF00069	0.444
MOD_NEK2_1	12	17	PF00069	0.544
MOD_NEK2_1	180	185	PF00069	0.563
MOD_NEK2_1	19	24	PF00069	0.476
MOD_NEK2_1	2	7	PF00069	0.646
MOD_NEK2_1	283	288	PF00069	0.498
MOD_NEK2_1	373	378	PF00069	0.460
MOD_NEK2_1	399	404	PF00069	0.700
MOD_NEK2_1	423	428	PF00069	0.788
MOD_NEK2_1	659	664	PF00069	0.607
MOD_NEK2_1	716	721	PF00069	0.570
MOD_NEK2_1	732	737	PF00069	0.347
MOD_PIKK_1	307	313	PF00454	0.504
MOD_PIKK_1	400	406	PF00454	0.588
MOD_PK_1	20	26	PF00069	0.503
MOD_PK_1	688	694	PF00069	0.576
MOD_PKA_1	381	387	PF00069	0.593
MOD_PKA_1	470	476	PF00069	0.536
MOD_PKA_1	500	506	PF00069	0.515
MOD_PKA_2	12	18	PF00069	0.595
MOD_PKA_2	19	25	PF00069	0.549
MOD_PKA_2	381	387	PF00069	0.546
MOD_PKA_2	446	452	PF00069	0.795
MOD_PKA_2	500	506	PF00069	0.738
MOD_PKA_2	664	670	PF00069	0.611
MOD_PKA_2	751	757	PF00069	0.489
MOD_Plk_1	355	361	PF00069	0.531
MOD_Plk_1	43	49	PF00069	0.407
MOD_Plk_1	477	483	PF00069	0.775
MOD_Plk_1	688	694	PF00069	0.576
MOD_Plk_4	197	203	PF00069	0.591
MOD_Plk_4	2	8	PF00069	0.728
MOD_Plk_4	20	26	PF00069	0.458
MOD_Plk_4	345	351	PF00069	0.429
MOD_Plk_4	419	425	PF00069	0.736
MOD_Plk_4	524	530	PF00069	0.748
MOD_Plk_4	541	547	PF00069	0.618
MOD_Plk_4	557	563	PF00069	0.532
MOD_Plk_4	96	102	PF00069	0.490
MOD_ProDKin_1	113	119	PF00069	0.411
MOD_ProDKin_1	134	140	PF00069	0.490
MOD_ProDKin_1	184	190	PF00069	0.561
MOD_ProDKin_1	252	258	PF00069	0.510
MOD_ProDKin_1	454	460	PF00069	0.677
MOD_ProDKin_1	547	553	PF00069	0.644
MOD_ProDKin_1	587	593	PF00069	0.471
MOD_SUMO_rev_2	364	371	PF00179	0.500
TRG_DiLeu_BaEn_1	625	630	PF01217	0.505
TRG_DiLeu_BaEn_2	269	275	PF01217	0.532
TRG_DiLeu_BaEn_3	196	202	PF01217	0.490
TRG_DiLeu_BaLyEn_6	118	123	PF01217	0.508
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.358
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.747
TRG_ENDOCYTIC_2	165	168	PF00928	0.490
TRG_ENDOCYTIC_2	178	181	PF00928	0.490
TRG_ENDOCYTIC_2	272	275	PF00928	0.454
TRG_ENDOCYTIC_2	543	546	PF00928	0.551
TRG_ENDOCYTIC_2	624	627	PF00928	0.508
TRG_ER_diArg_1	108	110	PF00400	0.487
TRG_ER_diArg_1	143	146	PF00400	0.561
TRG_ER_diArg_1	243	245	PF00400	0.737
TRG_ER_diArg_1	381	383	PF00400	0.603
TRG_ER_diArg_1	490	493	PF00400	0.663
TRG_ER_diArg_1	663	666	PF00400	0.681
TRG_NES_CRM1_1	341	353	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	730	734	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF47	Leptomonas seymouri	59%	98%
A0A1X0NRQ7	Trypanosomatidae	41%	100%
A0A3S7X600	Leishmania donovani	78%	98%
A4I8C6	Leishmania infantum	79%	98%
D0AAU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B385	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4Q4X0	Leishmania major	78%	100%
V5BVC8	Trypanosoma cruzi	43%	100%