LeishMANIAdb
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CNNM transmembrane domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CNNM transmembrane domain-containing protein
Gene product:
Domain of unknown function DUF21, putative
Species:
Leishmania braziliensis
UniProt:
A4HKU5_LEIBR
TriTrypDb:
LbrM.32.3290 , LBRM2903_320040800
Length:
403

Annotations

LeishMANIAdb annotations

Homologous to plant metal transporters (likely Mg2+ transporters)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HKU5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU5

Function

Biological processes
Term Name Level Count
GO:0010960 magnesium ion homeostasis 8 12
GO:0042592 homeostatic process 3 12
GO:0048878 chemical homeostasis 4 12
GO:0050801 monoatomic ion homeostasis 5 12
GO:0055065 obsolete metal ion homeostasis 7 12
GO:0055080 monoatomic cation homeostasis 6 12
GO:0065007 biological regulation 1 12
GO:0065008 regulation of biological quality 2 12
GO:0072507 obsolete divalent inorganic cation homeostasis 7 12
GO:0098771 inorganic ion homeostasis 6 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 61 63 PF00675 0.264
CLV_NRD_NRD_1 64 66 PF00675 0.268
CLV_PCSK_FUR_1 62 66 PF00082 0.310
CLV_PCSK_KEX2_1 170 172 PF00082 0.488
CLV_PCSK_KEX2_1 253 255 PF00082 0.650
CLV_PCSK_KEX2_1 61 63 PF00082 0.272
CLV_PCSK_KEX2_1 64 66 PF00082 0.279
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.526
CLV_PCSK_PC1ET2_1 253 255 PF00082 0.650
CLV_PCSK_SKI1_1 286 290 PF00082 0.586
CLV_PCSK_SKI1_1 64 68 PF00082 0.300
DEG_APCC_DBOX_1 170 178 PF00400 0.261
DEG_APCC_DBOX_1 63 71 PF00400 0.535
DEG_Nend_UBRbox_2 1 3 PF02207 0.429
DOC_CDC14_PxL_1 302 310 PF14671 0.378
DOC_CYCLIN_yCln2_LP_2 8 14 PF00134 0.453
DOC_CYCLIN_yCln2_LP_2 98 104 PF00134 0.422
DOC_MAPK_DCC_7 301 310 PF00069 0.378
DOC_MAPK_gen_1 301 310 PF00069 0.362
DOC_MAPK_gen_1 61 70 PF00069 0.473
DOC_MAPK_HePTP_8 298 310 PF00069 0.245
DOC_MAPK_HePTP_8 58 70 PF00069 0.521
DOC_MAPK_MEF2A_6 295 302 PF00069 0.436
DOC_MAPK_MEF2A_6 303 310 PF00069 0.402
DOC_MAPK_MEF2A_6 6 14 PF00069 0.441
DOC_MAPK_MEF2A_6 61 70 PF00069 0.493
DOC_MAPK_RevD_3 46 62 PF00069 0.470
DOC_PP1_RVXF_1 153 160 PF00149 0.275
DOC_PP1_RVXF_1 284 291 PF00149 0.399
DOC_PP2B_LxvP_1 308 311 PF13499 0.399
DOC_PP2B_LxvP_1 8 11 PF13499 0.463
DOC_USP7_MATH_1 130 134 PF00917 0.387
DOC_USP7_MATH_1 249 253 PF00917 0.425
DOC_USP7_MATH_1 335 339 PF00917 0.250
DOC_USP7_MATH_1 52 56 PF00917 0.554
DOC_WW_Pin1_4 314 319 PF00397 0.371
DOC_WW_Pin1_4 326 331 PF00397 0.345
DOC_WW_Pin1_4 97 102 PF00397 0.466
LIG_14-3-3_CanoR_1 240 246 PF00244 0.378
LIG_14-3-3_CanoR_1 254 260 PF00244 0.360
LIG_14-3-3_CanoR_1 312 318 PF00244 0.363
LIG_Actin_WH2_2 223 238 PF00022 0.414
LIG_APCC_ABBA_1 112 117 PF00400 0.201
LIG_APCC_ABBA_1 243 248 PF00400 0.392
LIG_APCC_ABBA_1 267 272 PF00400 0.322
LIG_Clathr_ClatBox_1 80 84 PF01394 0.336
LIG_EH1_1 136 144 PF00400 0.449
LIG_eIF4E_1 137 143 PF01652 0.449
LIG_FHA_1 144 150 PF00498 0.297
LIG_FHA_1 22 28 PF00498 0.443
LIG_FHA_1 240 246 PF00498 0.365
LIG_FHA_1 43 49 PF00498 0.379
LIG_FHA_1 77 83 PF00498 0.336
LIG_FHA_1 86 92 PF00498 0.336
LIG_FHA_2 359 365 PF00498 0.420
LIG_IRF3_LxIS_1 32 39 PF10401 0.415
LIG_KLC1_Yacidic_2 364 369 PF13176 0.347
LIG_LIR_Gen_1 15 25 PF02991 0.451
LIG_LIR_LC3C_4 24 28 PF02991 0.449
LIG_LIR_LC3C_4 79 82 PF02991 0.395
LIG_LIR_Nem_3 2 8 PF02991 0.335
LIG_NRBOX 284 290 PF00104 0.398
LIG_NRBOX 94 100 PF00104 0.397
LIG_RPA_C_Fungi 242 254 PF08784 0.502
LIG_SH2_CRK 5 9 PF00017 0.595
LIG_SH2_NCK_1 270 274 PF00017 0.477
LIG_SH2_SRC 367 370 PF00017 0.686
LIG_SH2_STAT5 137 140 PF00017 0.378
LIG_SH2_STAT5 210 213 PF00017 0.398
LIG_SH2_STAT5 229 232 PF00017 0.495
LIG_SH2_STAT5 293 296 PF00017 0.528
LIG_SH2_STAT5 325 328 PF00017 0.538
LIG_SH2_STAT5 367 370 PF00017 0.651
LIG_SH3_1 303 309 PF00018 0.525
LIG_SH3_3 142 148 PF00018 0.431
LIG_SH3_3 270 276 PF00018 0.475
LIG_SH3_3 303 309 PF00018 0.444
LIG_Sin3_3 136 143 PF02671 0.410
LIG_SUMO_SIM_anti_2 108 114 PF11976 0.360
LIG_SUMO_SIM_anti_2 24 30 PF11976 0.427
LIG_SUMO_SIM_anti_2 352 359 PF11976 0.532
LIG_SUMO_SIM_anti_2 79 85 PF11976 0.359
LIG_SUMO_SIM_par_1 10 15 PF11976 0.554
LIG_SUMO_SIM_par_1 140 146 PF11976 0.363
LIG_SUMO_SIM_par_1 222 228 PF11976 0.465
LIG_SUMO_SIM_par_1 36 42 PF11976 0.338
LIG_SUMO_SIM_par_1 78 85 PF11976 0.343
LIG_TYR_ITIM 135 140 PF00017 0.384
LIG_WRC_WIRS_1 379 384 PF05994 0.653
MOD_CK1_1 15 21 PF00069 0.466
MOD_CK1_1 277 283 PF00069 0.342
MOD_CK1_1 314 320 PF00069 0.457
MOD_CK1_1 338 344 PF00069 0.329
MOD_CK1_1 39 45 PF00069 0.348
MOD_CK1_1 85 91 PF00069 0.422
MOD_CK2_1 222 228 PF00069 0.456
MOD_CK2_1 363 369 PF00069 0.581
MOD_CK2_1 97 103 PF00069 0.449
MOD_Cter_Amidation 59 62 PF01082 0.402
MOD_GlcNHglycan 132 135 PF01048 0.327
MOD_GlcNHglycan 164 167 PF01048 0.449
MOD_GlcNHglycan 313 316 PF01048 0.495
MOD_GlcNHglycan 340 343 PF01048 0.486
MOD_GlcNHglycan 349 352 PF01048 0.478
MOD_GlcNHglycan 84 87 PF01048 0.422
MOD_GSK3_1 143 150 PF00069 0.328
MOD_GSK3_1 199 206 PF00069 0.704
MOD_GSK3_1 235 242 PF00069 0.498
MOD_GSK3_1 359 366 PF00069 0.613
MOD_GSK3_1 374 381 PF00069 0.688
MOD_N-GLC_1 162 167 PF02516 0.196
MOD_N-GLC_1 277 282 PF02516 0.422
MOD_NEK2_1 143 148 PF00069 0.305
MOD_NEK2_1 235 240 PF00069 0.513
MOD_NEK2_1 255 260 PF00069 0.505
MOD_NEK2_1 36 41 PF00069 0.376
MOD_NEK2_1 363 368 PF00069 0.607
MOD_NEK2_2 241 246 PF00069 0.473
MOD_PIKK_1 214 220 PF00454 0.540
MOD_PIKK_1 277 283 PF00454 0.445
MOD_PKA_2 199 205 PF00069 0.677
MOD_PKA_2 239 245 PF00069 0.501
MOD_PKA_2 311 317 PF00069 0.496
MOD_Plk_1 12 18 PF00069 0.368
MOD_Plk_1 277 283 PF00069 0.378
MOD_Plk_1 296 302 PF00069 0.430
MOD_Plk_1 363 369 PF00069 0.522
MOD_Plk_4 105 111 PF00069 0.362
MOD_Plk_4 12 18 PF00069 0.306
MOD_Plk_4 230 236 PF00069 0.440
MOD_Plk_4 255 261 PF00069 0.472
MOD_Plk_4 363 369 PF00069 0.543
MOD_Plk_4 374 380 PF00069 0.636
MOD_Plk_4 76 82 PF00069 0.318
MOD_ProDKin_1 314 320 PF00069 0.475
MOD_ProDKin_1 326 332 PF00069 0.439
MOD_ProDKin_1 97 103 PF00069 0.466
TRG_DiLeu_BaEn_1 284 289 PF01217 0.413
TRG_DiLeu_BaEn_4 194 200 PF01217 0.460
TRG_DiLeu_BaLyEn_6 283 288 PF01217 0.487
TRG_DiLeu_BaLyEn_6 303 308 PF01217 0.217
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.422
TRG_DiLeu_LyEn_5 89 94 PF01217 0.422
TRG_ENDOCYTIC_2 137 140 PF00928 0.356
TRG_ENDOCYTIC_2 270 273 PF00928 0.501
TRG_ENDOCYTIC_2 5 8 PF00928 0.594
TRG_ER_diArg_1 300 303 PF00400 0.471
TRG_ER_diArg_1 61 64 PF00400 0.362
TRG_NES_CRM1_1 89 103 PF08389 0.332

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N1 Leptomonas seymouri 67% 100%
A0A0N1I1M9 Leptomonas seymouri 35% 95%
A0A0N1PDI6 Leptomonas seymouri 23% 67%
A0A0S4IPA6 Bodo saltans 26% 100%
A0A0S4IPI7 Bodo saltans 33% 81%
A0A0S4JSF9 Bodo saltans 24% 75%
A0A1X0NRR8 Trypanosomatidae 39% 92%
A0A1X0P1F1 Trypanosomatidae 24% 100%
A0A1X0PAL3 Trypanosomatidae 24% 71%
A0A3Q8IL77 Leishmania donovani 23% 66%
A0A3Q8ITK0 Leishmania donovani 87% 100%
A0A3R7LBY6 Trypanosoma rangeli 25% 100%
A0A422NS01 Trypanosoma rangeli 24% 71%
A0A422NYJ0 Trypanosoma rangeli 38% 86%
A4HAY2 Leishmania braziliensis 23% 68%
A4HIN7 Leishmania braziliensis 26% 100%
A4I8C4 Leishmania infantum 88% 100%
A4IA41 Leishmania infantum 23% 66%
C9ZM59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 72%
E9B177 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B383 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9B555 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 66%
Q4Q2T0 Leishmania major 24% 66%
Q4Q4X2 Leishmania major 87% 100%
Q4V3C7 Arabidopsis thaliana 27% 81%
Q67XQ0 Arabidopsis thaliana 28% 82%
Q8RY60 Arabidopsis thaliana 29% 76%
Q8VZI2 Arabidopsis thaliana 32% 95%
Q9LTD8 Arabidopsis thaliana 28% 81%
Q9ZQR4 Arabidopsis thaliana 27% 95%
Q9ZVS8 Arabidopsis thaliana 28% 81%
V5BKR5 Trypanosoma cruzi 24% 70%
V5DM70 Trypanosoma cruzi 38% 89%
V5DNW3 Trypanosoma cruzi 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS