ER membrane protein complex subunit 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab5-interacting protein (Rab5ip), putative

Species:

Leishmania braziliensis

UniProt:

A4HKU4_LEIBR

TriTrypDb:

LbrM.32.3270 , LBRM2903_320040600

Length:

107

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:0072546	EMC complex	3	11
GO:0098796	membrane protein complex	2	11
GO:0140534	endoplasmic reticulum protein-containing complex	2	11

Expansion

Sequence features

A4HKU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HKU4

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000045	autophagosome assembly	6	1
GO:0007033	vacuole organization	5	1
GO:0022607	cellular component assembly	4	1
GO:0070925	organelle assembly	5	1
GO:1905037	autophagosome organization	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_USP7_MATH_1	100	104	PF00917	0.229
DOC_USP7_MATH_1	54	58	PF00917	0.260
LIG_BRCT_BRCA1_1	77	81	PF00533	0.519
LIG_EH1_1	80	88	PF00400	0.532
LIG_FHA_1	75	81	PF00498	0.505
LIG_FHA_1	90	96	PF00498	0.207
LIG_LIR_Gen_1	56	63	PF02991	0.328
LIG_LIR_Gen_1	92	101	PF02991	0.329
LIG_LIR_Nem_3	41	47	PF02991	0.280
LIG_LIR_Nem_3	92	96	PF02991	0.333
LIG_LIR_Nem_3	98	104	PF02991	0.306
LIG_PDZ_Class_2	102	107	PF00595	0.326
LIG_Pex14_1	44	48	PF04695	0.263
LIG_Pex14_1	97	101	PF04695	0.306
LIG_SH2_CRK	101	105	PF00017	0.315
LIG_SH2_NCK_1	101	105	PF00017	0.315
LIG_SH2_NCK_1	17	21	PF00017	0.623
LIG_SH2_PTP2	93	96	PF00017	0.417
LIG_SH2_STAP1	101	105	PF00017	0.315
LIG_SH2_STAP1	17	21	PF00017	0.600
LIG_SH2_STAT5	93	96	PF00017	0.300
LIG_TYR_ITIM	99	104	PF00017	0.384
LIG_WRC_WIRS_1	55	60	PF05994	0.348
MOD_GlcNHglycan	87	90	PF01048	0.400
MOD_GSK3_1	75	82	PF00069	0.491
MOD_GSK3_1	85	92	PF00069	0.240
MOD_NEK2_1	38	43	PF00069	0.293
MOD_NEK2_1	95	100	PF00069	0.313
MOD_NEK2_2	100	105	PF00069	0.232
MOD_Plk_4	100	106	PF00069	0.235
MOD_Plk_4	16	22	PF00069	0.575
MOD_Plk_4	25	31	PF00069	0.385
MOD_Plk_4	89	95	PF00069	0.303
TRG_ENDOCYTIC_2	101	104	PF00928	0.303
TRG_ENDOCYTIC_2	17	20	PF00928	0.584
TRG_ENDOCYTIC_2	93	96	PF00928	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P905	Leptomonas seymouri	78%	100%
A0A1X0NRR3	Trypanosomatidae	53%	100%
A0A3Q8IG59	Leishmania donovani	86%	100%
A0A422NYQ7	Trypanosoma rangeli	50%	100%
A4I8C3	Leishmania infantum	86%	100%
D0AAU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B382	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O59764	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	99%
Q1ZXH4	Dictyostelium discoideum	30%	87%
Q4Q4X3	Leishmania major	85%	100%
V5BVN7	Trypanosoma cruzi	49%	100%